Heather L. Melrose

6.5k citations

38 papers · 3.7k indexed · 1 hit paper · h-index 29

Physiology top 1%
Neurology top 0.5%
Cellular and Molecular Neuroscience top 1%
Molecular Biology top 10%
Neurology top 1%

Co-authors: Dennis W. Dickson Matthew J. Farrer Shu-Hui Yen Jada Lewis Peter Davies Michael P. Murphy John Hardy Karen Duff
Topics: Parkinson's Disease Mechanisms and Treatments (27 papers)Neurological disorders and treatments (9 papers)Neurological diseases and metabolism (6 papers)
Cited by: Neurology Physiology
Journals: Proceedings of the National Academy of Sciences Nature Genetics Journal of Neuroscience
Partner nations: United States Canada United Kingdom

In The Last Decade

Heather L. Melrose

38 papers receiving 3.6k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

2000 1.0k citations Jada Lewis, Eileen McGowan et al. Nature Genetics profile →

Peers

Countries citing papers authored by Heather L. Melrose

Since Specialization

Citations

This map shows the geographic impact of Heather L. Melrose's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Heather L. Melrose with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Heather L. Melrose more than expected).

Fields of papers citing papers by Heather L. Melrose

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Heather L. Melrose. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Heather L. Melrose. The network helps show where Heather L. Melrose may publish in the future.

Co-authorship network of co-authors of Heather L. Melrose

This figure shows the co-authorship network connecting the top 25 collaborators of Heather L. Melrose. A scholar is included among the top collaborators of Heather L. Melrose based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Heather L. Melrose. Heather L. Melrose is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Gait Deficits and Loss of Striatal Tyrosine Hydroxlase/Trk-B are Restored Following 7,8-Dihydroxyflavone Treatment in a Progressive MPTP Mouse Model of Parkinson’s Disease 2020 ·Neuroscience ·(unknown),William A. Liguore,Madeline J. Churchill,Cindy Moore,Heather L. Melrose,Charles K. Meshul	25
2	Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity 2018 ·npj Parkinson s Disease ·Jillian H. Kluss,Melissa M. Conti,Alice Kaganovich,(unknown),Heather L. Melrose,Mark Cookson,Adamantios Mamais	46
3	Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons 2017 ·Neurobiology of Disease ·Jason Schapansky,Saurabh Khasnavis,Mark P. DeAndrade,Jonathan Nardozzi,(unknown),Justin D. Boyd,John Sanderson,Tim Bartels,Heather L. Melrose,Matthew J. LaVoie	101
4	LRRK2 deficiency impacts ceramide metabolism in brain 2016 ·Biochemical and Biophysical Research Communications ·(unknown),Susanna Cogo,Heather L. Melrose,Luigi Bubacco,Elisa Greggio,Graziano Guella,Laura Civiero,Nicoletta Plotegher	49
5	Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice 2015 ·Neurobiology of Disease ·Mei Yue,Kelly M. Hinkle,Paul Davies,Eugenia Trushina,Fabienne C. Fiesel,(unknown),A. Sebastian Schroeder,(unknown),(unknown),Bahareh Behrouz,S. Lincoln,Joel E. Beevers,Austen J. Milnerwood,Aishe Kurti,Pamela J. McLean,John Denis Fryer,Wolfdieter Springer,Dennis W. Dickson,Matthew J. Farrer,Heather L. Melrose	180
6	LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory 2014 ·Human Molecular Genetics ·Dayne Beccano-Kelly,Mattia Volta,Lise N. Munsie,(unknown),Igor Tatarnikov,(unknown),Patrick Chou,Liping Cao,Sabrina Bergeron,Emma Mitchell,(unknown),Heather L. Melrose,Lucı́a Tapia,Lynn A. Raymond,Matthew J. Farrer,Austen J. Milnerwood	76
7	Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents 2014 ·The Journal of Comparative Neurology ·Andrew B. West,Rita M. Cowell,João Paulo Lima Daher,Mark S. Moehle,Kelly M. Hinkle,Heather L. Melrose,David G. Standaert,Laura A. Volpicelli‐Daley	2
8	Transgenic mice expressing human glucocerebrosidase variants: Utility for the study of Gaucher disease 2013 ·Blood Cells Molecules and Diseases ·(unknown),(unknown),Heather L. Melrose,Leanne K. Hein,Maria Fuller,L. Clarke	25
9	LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors 2012 ·Molecular Neurodegeneration ·Kelly M. Hinkle,Mei Yue,Bahareh Behrouz,Justus C. Dächsel,Sarah Lincoln,(unknown),Joel E. Beevers,Brittany N. Dugger,Beate Winner,Iryna Prots,Caroline Kent,Kenya Nishioka,Wen-Lang Lin,Dennis W. Dickson,Christopher Janus,Matthew J. Farrer,Heather L. Melrose	147
10	Lrrk2 localization in the primate basal ganglia and thalamus: A light and electron microscopic analysis in monkeys 2010 ·Experimental Neurology ·Heyne Lee,Heather L. Melrose,Mei Yue,(unknown),Matthew J. Farrer,Yoland Smith	20
11	ER stress response plays an important role in aggregation of α-synuclein 2010 ·Molecular Neurodegeneration ·Peizhou Jiang,Ming Gan,Abdul Shukkur Ebrahim,Wen-Lang Lin,Heather L. Melrose,Shu-Hui Yen	93
12	In vivo silencing of alpha-synuclein using naked siRNA 2008 ·Molecular Neurodegeneration ·Jada Lewis,Heather L. Melrose,David Bumcrot,Andrew Hope,Cynthia Zehr,Sarah Lincoln,Adam Braithwaite,Zhen He,(unknown),Kelly M. Hinkle,Caroline Kent,Ivanka Toudjarska,Klaus Charissé,Ravi Braich,Rajendra K. Pandey,Michael G. Heckman,Demetrius M. Maraganore,Julia E. Crook,Matthew J. Farrer	112
13	A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease 2007 ·Neuroscience ·Heather L. Melrose,Caroline Kent,Julie P. Taylor,Justus C. Dächsel,Kelly M. Hinkle,S. Lincoln,S.S. Mok,Janetta G. Culvenor,Colin L. Masters,(unknown),(unknown),Zubair Ahmed,Cathy Andorfer,Owen A. Ross,Zbigniew K. Wszołek,(unknown),Dennis W. Dickson,Matthew J. Farrer	91
14	[3H] pregabalin binding is increased in ipsilateral dorsal horn following chronic constriction injury 2007 ·Neuroscience Letters ·Heather L. Melrose,Ross A. Kinloch,Peter J. Cox,Mark J. Field,David Collins,(unknown)	20
15	Identification of the α ₂ -δ-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin 2006 ·Proceedings of the National Academy of Sciences ·Mark J. Field,Peter J. Cox,(unknown),Heather L. Melrose,James Offord,Ti‐Zhi Su,Steve Bramwell,Laura Corradini,Steven England,(unknown),Ross A. Kinloch,Jan Hendrich,Annette Dolphin,Tony Webb,(unknown)	452
16	Anatomical localization of leucine-rich repeat kinase 2 in mouse brain 2006 ·Neuroscience ·Heather L. Melrose,S. Lincoln,(unknown),Dennis W. Dickson,Matthew J. Farrer	101
17	Parkinson’s disease: a rethink of rodent models 2006 ·Experimental Brain Research ·Heather L. Melrose,Sarah Lincoln,(unknown),Matthew J. Farrer	58
18	Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau proteinbreakdown → 2000 ·Nature Genetics ·Jada Lewis,Eileen McGowan,Julia M. Rockwood,Heather L. Melrose,Parimala Nacharaju,Marjon van Slegtenhorst,Katrina Gwinn,Michael P. Murphy,(unknown),(unknown),Karen Duff,John Hardy,(unknown),Wen-Lang Lin,Shu-Hui Yen,Dennis W. Dickson,Peter Davies,(unknown)	1036
19	Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of eletriptan binding at human 5-HT1B and 5-HT1D receptors 1999 ·European Journal of Pharmacology ·Carolyn Napier,Michael Stewart,Heather L. Melrose,Brian Hopkins,Aileen McHarg,Rob Wallis	63
20	Nigrostriatal dopaminergic activities in dementia with lewy bodies in relation to neuroleptic sensitivity: comparisons with parkinson’s disease 1998 ·Biological Psychiatry ·Margaret A. Piggott,Elaine K. Perry,Elizabeth F. Marshall,Ian G. McKeith,Mary K. Johnson,Heather L. Melrose,J.A. Court,Stephen Lloyd,Andrew Fairbairn,Andrew Brown,Paul M. Thompson,Robert H. Perry	49

About Heather L. Melrose

Heather L. Melrose is a scholar working on Neurology, Neurology and Cellular and Molecular Neuroscience, having authored 38 papers that have together received 3.7k indexed citations. Recurring topics across this work include Parkinson's Disease Mechanisms and Treatments (27 papers), Neurological disorders and treatments (9 papers) and Neurological diseases and metabolism (6 papers). The work is most often cited by research in Neurology (1.8k citations), Neurology (764 citations) and Physiology (1.8k citations). Heather L. Melrose has collaborated with scholars based in United States, Canada and United Kingdom. Frequent co-authors include Dennis W. Dickson, Matthew J. Farrer, Shu-Hui Yen, Jada Lewis, Peter Davies, Michael P. Murphy, John Hardy, Karen Duff, Marjon van Slegtenhorst and Katrina Gwinn. Their work appears in journals such as Proceedings of the National Academy of Sciences, Nature Genetics and Journal of Neuroscience.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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