Hansruedi Loetscher

6.8k total citations · 3 hit papers
47 papers, 5.6k citations indexed

About

Hansruedi Loetscher is a scholar working on Molecular Biology, Immunology and Physiology. According to data from OpenAlex, Hansruedi Loetscher has authored 47 papers receiving a total of 5.6k indexed citations (citations by other indexed papers that have themselves been cited), including 24 papers in Molecular Biology, 16 papers in Immunology and 13 papers in Physiology. Recurrent topics in Hansruedi Loetscher's work include Immune Response and Inflammation (14 papers), Alzheimer's disease research and treatments (12 papers) and Monoclonal and Polyclonal Antibodies Research (7 papers). Hansruedi Loetscher is often cited by papers focused on Immune Response and Inflammation (14 papers), Alzheimer's disease research and treatments (12 papers) and Monoclonal and Polyclonal Antibodies Research (7 papers). Hansruedi Loetscher collaborates with scholars based in Switzerland, United States and Germany. Hansruedi Loetscher's co-authors include Werner Lesslauer, Manfred Brockhaus, Reiner Gentz, David W. Banner, Yu‐Ching E. Pan, Hans‐Werner Lahm, Hisahiro Tabuchi, Hans-Joachim Schoenfeld, A. D’Arcy and Clemens Broger and has published in prestigious journals such as Nature, Cell and Journal of Biological Chemistry.

In The Last Decade

Hansruedi Loetscher

47 papers receiving 5.4k citations

Hit Papers

3 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation

1993 876 citations David W. Banner, A. D’Arcy et al. Cell profile →
Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor

1990 778 citations Hansruedi Loetscher, Yu‐Ching E. Pan et al. Cell profile →
Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle

2014 438 citations Jens Niewoehner, Bernd Bohrmann et al. Neuron profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Hansruedi Loetscher Switzerland	34	2.4k	2.2k	1.2k	700	639	47	5.6k
Lawrence C. Fritz United States	25	3.6k 1.5×	1.5k 0.7×	985 0.8×	811 1.2×	319 0.5×	33	6.0k
Wilfred A. Jefferies Canada	43	2.2k 0.9×	2.6k 1.2×	981 0.8×	953 1.4×	185 0.3×	109	6.5k
Giorgio Berton Italy	42	2.1k 0.9×	3.1k 1.4×	1.0k 0.9×	615 0.9×	398 0.6×	109	6.3k
Saleh Ibrahim Germany	41	2.7k 1.1×	1.6k 0.7×	597 0.5×	783 1.1×	755 1.2×	202	5.9k
T Maciag United States	44	4.2k 1.7×	959 0.4×	947 0.8×	747 1.1×	1.1k 1.7×	70	7.5k
Antonio Iglesias Germany	33	1.9k 0.8×	2.5k 1.1×	340 0.3×	578 0.8×	237 0.4×	74	5.3k
Roberto Testi Italy	47	4.2k 1.8×	3.0k 1.3×	759 0.7×	795 1.1×	442 0.7×	113	7.4k
Karina Reiß Germany	42	3.2k 1.4×	1.3k 0.6×	1.3k 1.1×	2.0k 2.9×	773 1.2×	71	7.3k
Osamu Hazeki Japan	36	2.9k 1.2×	1.3k 0.6×	658 0.6×	388 0.6×	350 0.5×	89	5.4k
Jacques Bertoglio France	41	3.1k 1.3×	1.9k 0.9×	726 0.6×	1.0k 1.5×	499 0.8×	118	6.1k

Countries citing papers authored by Hansruedi Loetscher

Since Specialization

Citations

This map shows the geographic impact of Hansruedi Loetscher's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hansruedi Loetscher with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hansruedi Loetscher more than expected).

Fields of papers citing papers by Hansruedi Loetscher

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hansruedi Loetscher. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hansruedi Loetscher. The network helps show where Hansruedi Loetscher may publish in the future.

Co-authorship network of co-authors of Hansruedi Loetscher

This figure shows the co-authorship network connecting the top 25 collaborators of Hansruedi Loetscher. A scholar is included among the top collaborators of Hansruedi Loetscher based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hansruedi Loetscher. Hansruedi Loetscher is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Villaseñor, Roberto, Laurence Ozmen, Nadia Messaddeq, et al.. (2016). Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood-Brain Barrier. Scientific Reports. 6(1). 25658–25658. 67 indexed citations

Urich, Eduard, Roland Schmucki, Nadine Ruderisch, et al.. (2015). Cargo Delivery into the Brain by in vivo identified Transport Peptides. Scientific Reports. 5(1). 14104–14104. 37 indexed citations

Niewoehner, Jens, Bernd Bohrmann, Ludovic Collin, et al.. (2014). Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle. Neuron. 81(1). 49–60. 438 indexed citations breakdown →

Lopez‐Lopez, Cristina, Marcelo O. Dietrich, Friedrich Metzger, Hansruedi Loetscher, & Ignacio Torres‐Alemán. (2007). Disturbed Cross Talk between Insulin-Like Growth Factor I and AMP-Activated Protein Kinase as a Possible Cause of Vascular Dysfunction in the Amyloid Precursor Protein/Presenilin 2 Mouse Model of Alzheimer's Disease. Journal of Neuroscience. 27(4). 824–831. 73 indexed citations

Brockhaus, Manfred, Peter Ganz, Walter Huber, et al.. (2007). Thermodynamic Studies on the Interaction of Antibodies with β-Amyloid Peptide. The Journal of Physical Chemistry B. 111(5). 1238–1243. 21 indexed citations

Friedlein, Arno, et al.. (2005). A 13 kDa carboxy‐terminal fragment of ApoE stabilizes Abeta hexamers. Journal of Neurochemistry. 94(5). 1351–1360. 23 indexed citations

James, Michael N.G., et al.. (1999). Crystal structure of the novel aspartic proteinase zymogen proplasmepsin II from plasmodium falciparum.. Nature Structural Biology. 6(1). 32–37. 59 indexed citations

Tyas, Lorraine, Richard P. Moon, Hansruedi Loetscher, et al.. (1998). Plasmepsins I and II from the Malarial Parasite Plasmodium falciparum. Advances in experimental medicine and biology. 436. 407–411. 6 indexed citations

Brockhaus, Manfred, Jürgen Grünberg, Hansruedi Loetscher, et al.. (1998). Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling. Neuroreport. 9(7). 1481–1486. 58 indexed citations

10.

Moon, Richard P., Daniel Bur, Hansruedi Loetscher, et al.. (1998). Studies on Plasmepsins I and II from the Malarial Parasite Plasmodium falciparum and their Exploitation as Drug Targets. Advances in experimental medicine and biology. 436. 397–406. 15 indexed citations

11.

Moon, Richard P., Lorraine Tyas, Ulrich Certa, et al.. (1997). Expression and Characterisation of Plasmepsin I from Plasmodium falciparum. European Journal of Biochemistry. 244(2). 552–560. 89 indexed citations

12.

Poll, Tom van der, Patty M. Jansen, Kimberly J. Van Zee, et al.. (1997). Pretreatment with a 55‐kDa Tumor Necrosis Factor Receptor‐Immunoglobulin Fusion Protein Attenuates Activation of Coagulation, but not of Fibrinolysis, during Lethal Bacteremia in Baboons. The Journal of Infectious Diseases. 176(1). 296–307. 8 indexed citations

13.

Pócsik, Éva, et al.. (1995). Effect of cell cycle on the regulation of the cell surface and secreted forms of type I and type II human tumor necrosis factor receptors. Journal of Cellular Biochemistry. 59(3). 303–316. 13 indexed citations

14.

Rusten, LS, et al.. (1994). Bifunctional effects of tumor necrosis factor alpha (TNF alpha) on the growth of mature and primitive human hematopoietic progenitor cells: involvement of p55 and p75 TNF receptors. Blood. 83(11). 3152–3159. 71 indexed citations

15.

Banner, David W., A. D’Arcy, Reiner Gentz, et al.. (1993). Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation. Cell. 73(3). 431–445. 876 indexed citations breakdown →

16.

Schoenfeld, Hans-Joachim, J.R. Frey, Hansruedi Loetscher, et al.. (1991). Efficient purification of recombinant human tumor necrosis factor beta from Escherichia coli yields biologically active protein with a trimeric structure that binds to both tumor necrosis factor receptors. Journal of Biological Chemistry. 266(6). 3863–3869. 60 indexed citations

17.

Espevik, Terje, Manfred Brockhaus, Hansruedi Loetscher, Unni Nonstad, & Refaat Shalaby. (1990). Characterization of binding and biological effects of monoclonal antibodies against a human tumor necrosis factor receptor.. The Journal of Experimental Medicine. 171(2). 415–426. 231 indexed citations

18.

Dembić, Zlatko, Hansruedi Loetscher, Ueli Gubler, et al.. (1990). Two human TNF receptors have similar extracellular, but distinct intracellular, domain sequences. Cytokine. 2(4). 231–237. 220 indexed citations

19.

Loetscher, Hansruedi, Yu‐Ching E. Pan, Hans‐Werner Lahm, et al.. (1990). Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor. Cell. 61(2). 351–359. 778 indexed citations breakdown →

20.

Shalaby, M R, Anders Sundan, Hansruedi Loetscher, et al.. (1990). Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors.. The Journal of Experimental Medicine. 172(5). 1517–1520. 150 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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