Helmut Jacobsen

6.3k citations

68 papers · 5.2k indexed · 2 hit papers · h-index 33

Impact in

Virology top 1%
- HIV Research and Treatment
Hepatology top 1%
- Hepatitis C virus research

Papers in

Virology 10
- HIV Research and Treatment 10
Hepatology 11
- Hepatitis C virus research 10

Co-authors: Jan Mous Roland Jakob‐Roetne Ralf Bartenschlager Laurence Ozmen Sibylle Mittnacht Christian Haass Holger Kirchner Jürgen Mestan
Journals: Virology (7 papers)Bioorganic & Medicinal Chemistry Letters (4 papers)Journal of Virology (4 papers)Journal of General Virology (3 papers)Journal of Biological Chemistry (3 papers)
Partner nations: Switzerland Germany United States

In The Last Decade

Helmut Jacobsen

68 papers receiving 5.0k citations

Hit Papers

align trajectories log scale

Alzheimer's Disease: From Pathology to Therapeutic Approaches 2009 · 545 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2009 Angewandte Chemie International Edition
2000 Journal of Neuroscience

Peers

Countries citing papers authored by Helmut Jacobsen

Since Specialization

Citations

This map shows the geographic impact of Helmut Jacobsen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Helmut Jacobsen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Helmut Jacobsen more than expected).

Fields of papers citing papers by Helmut Jacobsen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Helmut Jacobsen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Helmut Jacobsen. The network helps show where Helmut Jacobsen may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Helmut Jacobsen, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Helmut Jacobsen Line = papers co-authored together Helmut Jacobsen links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Cargo Delivery into the Brain by in vivo identified Transport Peptides Scientific Reports ·Eduard Urich, Roland Schmucki, Nadine Ruderisch, Eric Kitas, Ulrich Certa, Helmut Jacobsen, Christophe Schweitzer, Vicky Ooi, Martin Ebeling, Hansruedi Loetscher, Per‐Ola Freskgård	2015	37
2	Combined Treatment with a BACE Inhibitor and Anti-Aβ Antibody Gantenerumab Enhances Amyloid Reduction in APP_LondonMice Journal of Neuroscience ·Helmut Jacobsen, Laurence Ozmen, Antonello Caruso, Robert Narquizian, Hans Hilpert, Björn Jacobsen, Dick Terwel, Hisao Nishijyo, Bernd Bohrmann	2014	68
3	The dynamics of Aβ distribution after γ-secretase inhibitor treatment, as determined by experimental and modelling approaches in a wild type rat Journal of Pharmacokinetics and Pharmacodynamics ·Leon M. Tai, Helmut Jacobsen, Laurence Ozmen, Alexander Flohr, Roland Jakob‐Roetne, Antonello Caruso, Hans Peter Grimm	2012	6
4	Preclinical Profile of a Potent γ-Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties Cancer Research ·Leopoldo Luistro, Wei He, Melissa Smith, Kathryn Packman, Maria Vilenchik, Daisy Carvajal, John G. Roberts, James J. Cai, Windy Berkofsky‐Fessler, Holly Hilton, Michael Linn, Alexander Flohr, Taís Economides Gallina, Helmut Jacobsen, Kelli Glenn, David Heimbrook, John F. Boylan	2009	154
5	Alzheimer's Disease: From Pathology to Therapeutic Approaches Angewandte Chemie International Edition ·Roland Jakob‐Roetne, Helmut Jacobsen Hit paper breakdown →	2009	545
6	Novel orally active, dibenzazepinone-based γ-secretase inhibitors Bioorganic & Medicinal Chemistry Letters ·Jens‐Uwe Peters, Guido Galley, Helmut Jacobsen, Christian Czech, Pascale David‐Pierson, Eric Kitas, Laurence Ozmen	2007	31
7	Cholesterol independent effect of LXR agonist TO‐901317 on gamma‐secretase Journal of Neurochemistry ·Christian Czech, Mark P. Burns, Lilit Vardanian, Angélique Augustin, Helmut Jacobsen, Karlheinz Baumann, G. William Rebeck	2007	23
8	Selective Insolubility of α-Synuclein in Human Lewy Body Diseases Is Recapitulated in a Transgenic Mouse Model American Journal Of Pathology ·Philipp J. Kahle, Manuela Neumann, Laurence Ozmen, Veronika Müller, Sabine Odoy, Noriko Okamoto, Helmut Jacobsen, Takeshi Iwatsubo, John Q. Trojanowski, Hitoshi Takahashi, Koichi Wakabayashi, Nenad Bogdanović, Peter Riederer, Hans A. Kretzschmar, Christian Haass	2001	202
9	Amyloidogenic Function of the Alzheimer's Disease-Associated Presenilin 1 in the Absence of Endoproteolysis Biochemistry ·Harald Steiner, Helmut Romig, Brigitte Pesold, Ghulam Hamdu, Miriam Baader, Martin Citron, Hansruedi Loetscher, Helmut Jacobsen, Christian Haass	1999	76
10	Emergence of resistant variants of HIV in vivo during monotherapy with the proteinase inhibitor saquinavir Journal of Antimicrobial Chemotherapy ·Ukleba M., Helmut Jacobsen, S. Galpin, Alifia Herlina Zulfiana, Lucy Dorrell, Jan Mous, K. Bragman, Jonathan Weber	1997	27
11	Evaluation of hepatitis C virus envelope proteins expressed in E. coli and insect cells for use as tools for antibody screening Journal of Hepatology ·Rania A. Mekary, Almurib, A. Balian, Georg H. Schmid, Jan Mous, Helmut Jacobsen	1997	22
12	Hepatitis C Virus Core Protein: Carboxy-Terminal Boundaries of Two Processed Species Suggest Cleavage by a Signal Peptide Peptidase Virology ·Rania A. Mekary, Hanno Langen, Jan Mous, Helmut Jacobsen	1996	125
13	Tumor Necrosis Factor Receptor p55 Mediates Induction of HIV Type 1 Expression in Chronically Infected U1 Cells AIDS Research and Human Retroviruses ·Güllü Yazkan, Helmut Jacobsen, Hans‐Ruedi LÖTSCHER, Jan Mous	1996	9
14	Purification and in vitro-phospholabeling of secretory envelope proteins E1 and E2 of hepatitis C virus expressed in insect cells Virus Research ·Rania A. Mekary, Georg H. Schmid, Jan Mous, Helmut Jacobsen	1996	22
15	Saquinavir/zidovudine combination in patients with advanced HIV infection and no prior antiretroviral therapy: CD4 + lymphocyte/plasma RNA changes, and emergence of HIV strains with reduced phenotypic sensitivity Antiviral Research ·Stefano Vella, Clementina Maria Galluzzo, Giacomo Giannini, Maria Franca Pirillo, I. B. R. Duncan, Helmut Jacobsen, Massimo Andreoni, Loredana Sarmati, Lucia Ercoli	1996	20
16	Characterization of human immunodeficiency virus type 1 mutantswith decreased sensitivity to proteinase inhibitor Ro 31-8959 Virology ·Helmut Jacobsen, Frantz Lohier, Dean L. Winslow, Jane Craig, Abdelftah Subhy Aboradwan, I. B. R. Duncan, Jan Mous	1995	173
17	An in Vitro Assay for Hepatitis C Virus NS3 Serine Proteinase Virology ·Pascal Bouffard, Ralf Bartenschlager, Jay Singh, Jan Mous, Noel A. Roberts, Helmut Jacobsen	1995	25
18	Different effects of IFNγ and IFNα/β on “immediate early” gene expression of HSV-1 Virology ·Zhang Yi‐Jing, Sibylle Mittnacht, Holger Kirchner, Helmut Jacobsen	1990	31
19	Beta Interferon Subtype 1 Induction by Tumor Necrosis Factor Molecular and Cellular Biology ·Helmut Jacobsen, Jürgen Mestan, Sibylle Mittnacht, Carl W. Dieffenbach	1989	33
20	Interferon Interactions with Thyroid Cells Journal of Interferon Research ·Robert M. Friedman, George Lee, Sidney Shifrin, Mona Lisa, David Epstein, Helmut Jacobsen, Leonard D. Kohn	1982	16

About Helmut Jacobsen

Helmut Jacobsen is a scholar working on Virology, Hepatology, Physiology, Immunology and Cellular and Molecular Neuroscience, having authored 68 papers that have together received 5.2k indexed citations. Recurring topics across this work include Alzheimer's disease research and treatments (20 papers), HIV Research and Treatment (10 papers), Hepatitis C virus research (10 papers), Monoclonal and Polyclonal Antibodies Research (9 papers), Cholinesterase and Neurodegenerative Diseases (9 papers), HIV/AIDS drug development and treatment (8 papers), interferon and immune responses (7 papers) and RNA regulation and disease (6 papers). The work is most often cited by research in Virology (568 citations), Hepatology (918 citations), Neurology (911 citations), Physiology (1.5k citations) and Neurology (394 citations). Helmut Jacobsen has collaborated with scholars based in Switzerland, Germany and United States. Frequent co-authors include Jan Mous, Roland Jakob‐Roetne, Ralf Bartenschlager, Laurence Ozmen, Sibylle Mittnacht, Christian Haass, Holger Kirchner, Jürgen Mestan, Manuela Neumann and Philipp J. Kahle. Their work appears in journals such as Virology, Bioorganic & Medicinal Chemistry Letters, Journal of Virology, Journal of General Virology and Journal of Biological Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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