David H. Ledbetter

58.2k citations

335 papers · 24.2k indexed · 7 hit papers · h-index 77

Impact in

Genetics top 0.01%
- Genomic variations and chromosomal abnormalities
- Genetics and Neurodevelopmental Disorders
- Genetic Syndromes and Imprinting
- Genomics and Rare Diseases
Pediatrics, Perinatology and Child Health top 0.05%
- Prenatal Screening and Diagnostics

Papers in

Genetics 221
- Genomic variations and chromosomal abnormalities 126
- Genetic Syndromes and Imprinting 67
- Genetics and Neurodevelopmental Disorders 48
- Genomics and Rare Diseases 34
Pediatrics, Perinatology and Child Health 76
- Prenatal Screening and Diagnostics 61

Co-authors: William B. Dobyns Susan A. Ledbetter Christa Lese Martin Robert L. Nussbaum Peter vanTuinen Frank Greenberg Susan Airhart Susan L. Christian
Journals: Genetics in Medicine (19 papers)Genomics (18 papers)Human Molecular Genetics (14 papers)The American Journal of Human Genetics (11 papers)Cytogenetic and Genome Research (10 papers)
Partner nations: United States United Kingdom Canada

In The Last Decade

David H. Ledbetter

325 papers receiving 23.4k citations

Hit Papers

7 papers align trajectories log scale

Meta-analysis and multidisciplinary consensus statement: exome sequencing is a first-tier clinical diagnostic test for individuals with neurodevelopmental disorders 2019 · 367 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2019 Genetics in Medicine
2015 New England Journal of Medicine
2008 The American Journal of Human Genetics
1996 Science
1993 Nature
1989 Science
1981 New England Journal of Medicine

Peers

Countries citing papers authored by David H. Ledbetter

Since Specialization

Citations

This map shows the geographic impact of David H. Ledbetter's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David H. Ledbetter with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David H. Ledbetter more than expected).

Fields of papers citing papers by David H. Ledbetter

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David H. Ledbetter. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David H. Ledbetter. The network helps show where David H. Ledbetter may publish in the future.

Co-authors

The 25 scholars most cited alongside David H. Ledbetter, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with David H. Ledbetter Line = papers co-authored together David H. Ledbetter links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Monogenic disorders associated with motor speech phenotypes in children and adolescents undergoing clinical exome sequencing Genetics in Medicine ·Marissa W Mitchel, Matthew T. Oetjens, Alexander S. F. Berry, Alicia Johns, Andrés Moreno-De-Luca, Rebecca I. Torene, Natasha T. Strande, Marina T. DiStefano, Lindsay Havens Dyer, Tracy Brandt, Brenda Finucane, David H. Ledbetter, Kyle Retterer, Christa Lese Martin, Scott M. Myers	2025	2
2	A genome-first study of sex chromosome aneuploidies provides evidence of Y chromosome dosage effects on autism risk Nature Communications ·Alexander S. F. Berry, Brenda Finucane, Scott M. Myers, Lauren K. Walsh, John M. Seibert, Christa Lese Martin, David H. Ledbetter, Matthew T. Oetjens	2024	6
3	Advancing Mental Health Research Through Strategic Integration of Transdiagnostic Dimensions and Genomics Biological Psychiatry ·Alysa E. Doyle, Carrie E. Bearden, Raquel E. Gur, David H. Ledbetter, Christa Lese Martin, Thomas H. McCoy, Bogdan Paşaniuc, Roy H. Perlis, Jordan W. Smoller, Lea K. Davis	2024	3
4	A novel application of spectrograms with machine learning can detect patient ventilator dyssynchrony Biomedical Signal Processing and Control ·Ishmael Obeso, Benjamin Yoon, David H. Ledbetter, Melissa Aczon, Eugene Laksana, Alice X. Zhou, R. Andrew Eckberg, Keith Mertan, Robinder G. Khemani, Randall C. Wetzel	2023	7
5	Diagnostic Yield of Exome Sequencing in Cerebral Palsy and Implications for Genetic Testing Guidelines: A Systematic Review and Meta-analysis Obstetrical & Gynecological Survey ·Pedro J. Gonzalez-Mantilla, Yirui Hu, Scott M. Myers, Brenda Finucane, David H. Ledbetter, Christa Lese Martin, Andrés Moreno-De-Luca	2023	3
6	Phenotypic shift in copy number variants: Evidence in 16p11.2 duplication syndrome Genetics in Medicine ·Cora Taylor, Brenda Finucane, Andrés Moreno-De-Luca, Lauren K. Walsh, Alastair J. Martin, David H. Ledbetter	2022	6
7	Diagnostic genetic testing for neurodevelopmental psychiatric disorders: closing the gap between recommendation and clinical implementation Current Opinion in Genetics & Development ·Brenda Finucane, David H. Ledbetter, Jacob Vorstman	2021	28
8	Evaluating heterogeneity in ASD symptomatology, cognitive ability, and adaptive functioning among 16p11.2 CNV carriers Autism Research ·Caitlin M. Hudac, Joanna Bove, Shelley Barber, Michael Duyzend, Ari Wallace, Alastair J. Martin, David H. Ledbetter, Ellen Hanson, Robin P. Goin‐Kochel, LeeAnne Green‐Snyder, Wendy K. Chung, Evan E. Eichler, Raphael Bernier	2020	16
9	Long overdue: including adults with brain disorders in precision health initiatives Current Opinion in Genetics & Development ·Brenda Finucane, Scott M. Myers, Christa Lese Martin, David H. Ledbetter	2020	15
10	Implementation of genomic medicine in a health care delivery system: A value proposition? American Journal of Medical Genetics Part C Seminars in Medical Genetics ·Joanne E. Wade, David H. Ledbetter, Marc S. Williams	2014	12
11	An Optimized Set of Human Telomere Clones for Studying Telomere Integrity and Architecture The American Journal of Human Genetics ·Samantha J.L. Knight, Christa M. Lese, Kathrin S. Precht, Julie A. Kuc, Yi Ning, Sarah Lucas, Regina Regan, Mary Brenan, A Nicod, N. M. Lawrie, D. L. N. Cardy, Huy Nguyen, Thomas J. Hudson, Harold Riethman, David H. Ledbetter, Jonathan Flint	2000	237
12	Subcortical Band Heterotopia in Rare Affected Males Can be Caused by Missense Mutations in DCX (XLIS) or LIS1 Human Molecular Genetics ·Daniela T. Pilz, J. Kuć, Naomichi Matsumoto, Joann Bodurtha, B. Bernadi, C. A. Tassinari, William B. Dobyns, David H. Ledbetter	1999	107
13	A Simple VNTR-PCR Method for Detecting Maternal Cell Contamination in Prenatal Diagnosis Genetic Testing ·Jacqueline R. Batanian, David H. Ledbetter, Raymond G. Fenwick	1998	23
14	Cytogenetic results from the U.S. collaborative study on CVS Prenatal Diagnosis ·David H. Ledbetter, J. M. Zachary, Joe Leigh Simpson, Mitchell S. Golbus, Eugene Pergament, L. Jackson, M J Mahoney, Robert J. Desnick, Joseph D. Schulman, Karen L. Copeland, Y. Verlinsky, T. Yang‐Feng, S. A. Schonberg, A. Babu, Avirachan T. Tharapel, Andrew Dorfmann, Herbert A. Lubs, G G Rhoads, Sarah Fowler, Felix de la Cruz	1992	264
15	First‐trimester biochemical and molecular diagnoses using chorionic villi: High accuracy in the U.S. collaborative study Prenatal Diagnosis ·Robert J. Desnick, Jane L. Schuette, Mitchell S. Golbus, L. Jackson, Herbert A. Lubs, David H. Ledbetter, M J Mahoney, Eugene Pergament, Joe Leigh Simpson, J. M. Zachary, Sarah Fowler, G G Rhoads, Felix de la Cruz	1992	16
16	Localization of the photoreceptor gene ROM1 to human chromosome 11 and mouse chromosome 19: sublocalization to human 11q13 between PGA and PYGM. Europe PMC (PubMed Central) ·R.A. Bascom, Jaime Garcia‐Heras, C L Hsieh, Daniela S. Gerhard, C. Jones, Uta Francke, H.F. Willard, David H. Ledbetter, Roderick R. McInnes	1992	31
17	Isolation of a human chromosome 14-only somatic cell hybrid: Analysis using Alu and LINE-based PCR Genomics ·Adolph Mares, Susan A. Ledbetter, David H. Ledbetter, Robert Roberts, J. Fielding Hejtmancik	1991	6
18	Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa. Journal of Clinical Investigation ·Donna M. Sosnoski, B S Emanuel, Anita L. Hawkins, Peter van Tuinen, David H. Ledbetter, Robert L. Nussbaum, F T Kaos, Elias Schwartz, David R. Phillips, Joel Bennett	1988	68
19	Hypoparathyroidism and T cell immune defect in a patient with 10p deletion syndrome The Journal of Pediatrics ·Frank Greenberg, Cecilia T. Valdés, Howard M. Rosenblatt, John L. Kirkland, David H. Ledbetter	1986	31
20	Human chromosomal assignments for 14 argininosuccinate synthetase pseudogenes: cloned DNAs as reagents for cytogenetic analysis. PubMed Central ·T S Su, Robert L. Nussbaum, Susan Airhart, David H. Ledbetter, T. Mohandas, W E O'Brien, Arthur L. Beaudet	1984	59

About David H. Ledbetter

David H. Ledbetter is a scholar working on Genetics, Pediatrics, Perinatology and Child Health, Molecular Biology, Developmental Biology and Genetics, having authored 335 papers that have together received 24.2k indexed citations. Recurring topics across this work include Genomic variations and chromosomal abnormalities (126 papers), Genetic Syndromes and Imprinting (67 papers), Prenatal Screening and Diagnostics (61 papers), Genetics and Neurodevelopmental Disorders (48 papers), Chromosomal and Genetic Variations (43 papers), Genomics and Rare Diseases (34 papers), Genomics and Chromatin Dynamics (27 papers) and Congenital heart defects research (25 papers). The work is most often cited by research in Genetics (13.4k citations), Pediatrics, Perinatology and Child Health (5.0k citations), Developmental Neuroscience (837 citations), Molecular Biology (12.0k citations) and Cancer Research (1.7k citations). David H. Ledbetter has collaborated with scholars based in United States, United Kingdom and Canada. Frequent co-authors include William B. Dobyns, Susan A. Ledbetter, Christa Lese Martin, Robert L. Nussbaum, Peter vanTuinen, Frank Greenberg, Susan Airhart, Susan L. Christian, Alastair J. Martin and Yi Ning. Their work appears in journals such as Genetics in Medicine, Genomics, Human Molecular Genetics, The American Journal of Human Genetics and Cytogenetic and Genome Research.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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