Hal M. Hoffman

29.8k total citations · 11 hit papers
152 papers, 17.8k citations indexed

About

Hal M. Hoffman is a scholar working on Molecular Biology, Immunology and Surgery. According to data from OpenAlex, Hal M. Hoffman has authored 152 papers receiving a total of 17.8k indexed citations (citations by other indexed papers that have themselves been cited), including 107 papers in Molecular Biology, 80 papers in Immunology and 21 papers in Surgery. Recurrent topics in Hal M. Hoffman's work include Inflammasome and immune disorders (102 papers), IL-33, ST2, and ILC Pathways (29 papers) and Immune Response and Inflammation (23 papers). Hal M. Hoffman is often cited by papers focused on Inflammasome and immune disorders (102 papers), IL-33, ST2, and ILC Pathways (29 papers) and Immune Response and Inflammation (23 papers). Hal M. Hoffman collaborates with scholars based in United States, Germany and United Kingdom. Hal M. Hoffman's co-authors include James L. Mueller, Alan A. Wanderer, David H. Broide, Matthew D. McGeough, Lori Broderick, Alexander Wree, Richard D. Kolodner, Ariel E. Feldstein, Carla A. Peña and Ali Canbay and has published in prestigious journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

Hal M. Hoffman

148 papers receiving 17.6k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

2012 1.9k citations Hal M. Hoffman et al. profile →
Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome

2001 1.2k citations Hal M. Hoffman, James L. Mueller et al. profile →
NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

2016 946 citations Matthew D. McGeough, Hal M. Hoffman et al. profile →
NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

2013 779 citations Alexander Wree, Akiko Eguchi et al. profile →
Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

2009 680 citations James L. Mueller, Hal M. Hoffman et al. profile →
Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity

2005 556 citations George Y. Liu, Anthony Essex et al. The Journal of Experimental Medicine profile →
From NAFLD to NASH to cirrhosis—new insights into disease mechanisms

2013 491 citations Alexander Wree, Lori Broderick et al. profile →
Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

2022 453 citations Janset Onyuru, Hal M. Hoffman et al. Immunity profile →
Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis

2020 405 citations Aleksandra Leszczynska, Benedikt Kaufmann et al. profile →
NLRP3 inflammasome activation is required for fibrosis development in NAFLD

2014 404 citations Alexander Wree, Matthew D. McGeough et al. profile →
Inflammasome activation leads to Caspase-1–dependent mitochondrial damage and block of mitophagy

2014 391 citations Jiujiu Yu, Hajime Nagasu et al. Proceedings of the National Academy of Sciences profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Hal M. Hoffman United States	60	11.9k	6.5k	4.1k	2.2k	1.6k	152	17.8k
Kate Schroder Australia	58	14.4k 1.2×	9.8k 1.5×	3.6k 0.9×	2.0k 0.9×	1.4k 0.9×	143	23.7k
Naofumi Mukaida Japan	89	7.3k 0.6×	12.5k 1.9×	3.4k 0.8×	2.6k 1.2×	1.1k 0.6×	376	28.4k
Fabio Martinon Switzerland	55	18.5k 1.6×	13.0k 2.0×	3.6k 0.9×	2.9k 1.3×	3.4k 2.1×	98	27.9k
Mohamed Lamkanfi Belgium	69	16.7k 1.4×	10.2k 1.6×	3.1k 0.8×	2.2k 1.0×	1.7k 1.0×	108	22.5k
Jenny P.‐Y. Ting United States	76	15.1k 1.3×	13.4k 2.1×	3.6k 0.9×	2.1k 1.0×	1.1k 0.7×	215	25.6k
Haruki Okamura Japan	62	8.4k 0.7×	11.0k 1.7×	2.5k 0.6×	1.4k 0.6×	323 0.2×	238	18.7k
Fayyaz S. Sutterwala United States	55	8.8k 0.7×	7.3k 1.1×	2.6k 0.6×	1.3k 0.6×	867 0.5×	118	15.5k
Manolis Pasparakis Germany	84	13.4k 1.1×	12.3k 1.9×	3.3k 0.8×	1.5k 0.7×	328 0.2×	193	26.6k
Luigi Franchi United States	51	11.5k 1.0×	8.7k 1.4×	2.4k 0.6×	1.9k 0.9×	983 0.6×	75	17.1k
Aubry Tardivel Switzerland	38	8.9k 0.8×	6.0k 0.9×	1.7k 0.4×	1.7k 0.8×	1.9k 1.2×	54	14.1k

Countries citing papers authored by Hal M. Hoffman

Since Specialization

Citations

This map shows the geographic impact of Hal M. Hoffman's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hal M. Hoffman with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hal M. Hoffman more than expected).

Fields of papers citing papers by Hal M. Hoffman

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hal M. Hoffman. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hal M. Hoffman. The network helps show where Hal M. Hoffman may publish in the future.

Co-authorship network of co-authors of Hal M. Hoffman

This figure shows the co-authorship network connecting the top 25 collaborators of Hal M. Hoffman. A scholar is included among the top collaborators of Hal M. Hoffman based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hal M. Hoffman. Hal M. Hoffman is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Tate, Matthew, Aaron F. Carlin, Joshua Fierer, et al.. (2025). Development of a Mouse Model of Coccidioidomycosis Using an Inhalation Exposure System. Journal of Fungi. 11(8). 599–599.

Onyuru, Janset, et al.. (2023). BRP39 Regulates Neutrophil Recruitment in NLRP3 Inflammasome-Induced Liver Inflammation. Cellular and Molecular Gastroenterology and Hepatology. 17(3). 481–497. 15 indexed citations

Hoffman, Hal M., et al.. (2023). Differential Binding of NLRP3 to non-oxidized and Ox-mtDNA mediates NLRP3 Inflammasome Activation. Communications Biology. 6(1). 578–578. 24 indexed citations

Kaufmann, Benedikt, Laela M. Booshehri, Janset Onyuru, et al.. (2023). Antisense Oligonucleotide Therapy Decreases IL-1β Expression and Prolongs Survival in Mutant Nlrp3 Mice. The Journal of Immunology. 211(2). 287–294. 6 indexed citations

Abud, Edsel M., Yuzhou Zhang, Richard J. Smith, et al.. (2022). Rapid genome sequencing identifies novel variants in complement factor I. Molecular Case Studies. 8(7). a006239–a006239. 2 indexed citations

Shimizu, Chisato, Jihoon Kim, Ming He, et al.. (2022). RNA Sequencing Reveals Beneficial Effects of Atorvastatin on Endothelial Cells in Acute Kawasaki Disease. Journal of the American Heart Association. 11(14). e025408–e025408. 7 indexed citations

Walker, Ulrich A., Hugh H. Tilson, Philip N. Hawkins, et al.. (2021). Long-term safety and effectiveness of canakinumab therapy in patients with cryopyrin-associated periodic syndrome: results from the β-Confident Registry. RMD Open. 7(2). e001663–e001663. 14 indexed citations

Gaudenzio, Nicolas, Nadine Serhan, Ophélie Godon, et al.. (2021). Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome. The Journal of Experimental Medicine. 218(10). 33 indexed citations

Navarro‐Pando, José M., Elísabet Alcocer‐Gómez, Beatriz Castejón‐Vega, et al.. (2021). Inhibition of the NLRP3 inflammasome prevents ovarian aging. Science Advances. 7(1). 128 indexed citations

10.

Ley, Klaus, Hal M. Hoffman, Paul Kubes, et al.. (2018). Neutrophils: New insights and open questions. Science Immunology. 3(30). 371 indexed citations

11.

Lakhdari, Omar, et al.. (2018). TLR Activation Alters Bone Marrow-Derived Macrophage Differentiation. Journal of Innate Immunity. 11(1). 99–108. 4 indexed citations

12.

Johnson, Casey D., Alexander Wree, Davide Povero, et al.. (2016). Hepatic Stellate Cell Specific NLRP3 Inflammasome Activation Results in Spontaneous Fibrosis. RWTH Publications (RWTH Aachen). 1 indexed citations

13.

Kuemmerle‐Deschner, Jasmin, Seza Özen, Pascal N. Tyrrell, et al.. (2015). Development and Validation of Diagnostic Criteria for Cryopyrin Associated Periodic Syndromes. Arthritis & Rheumatism. 1 indexed citations

14.

Yu, Jiujiu, Hajime Nagasu, Tomohiko Murakami, et al.. (2014). Inflammasome activation leads to Caspase-1–dependent mitochondrial damage and block of mitophagy. Proceedings of the National Academy of Sciences. 111(43). 15514–15519. 391 indexed citations breakdown →

15.

Yamasaki, Kenshi, Jun Muto, Kristen R. Taylor, et al.. (2009). NLRP3/Cryopyrin Is Necessary for Interleukin-1β (IL-1β) Release in Response to Hyaluronan, an Endogenous Trigger of Inflammation in Response to Injury. Journal of Biological Chemistry. 284(19). 12762–12771. 225 indexed citations

16.

Brydges, Susannah, James L. Mueller, Matthew D. McGeough, et al.. (2009). Inflammasome-Mediated Disease Animal Models Reveal Roles for Innate but Not Adaptive Immunity. Immunity. 30(6). 875–887. 277 indexed citations

17.

Milhavet, Florian, Laurence Cuisset, Hal M. Hoffman, et al.. (2008). The infevers autoinflammatory mutation online registry: update with new genes and functions. Human Mutation. 29(6). 803–808. 199 indexed citations

18.

Stack, Jeffrey H., Kevin Beaumont, Paul D. Larsen, et al.. (2005). IL-Converting Enzyme/Caspase-1 Inhibitor VX-765 Blocks the Hypersensitive Response to an Inflammatory Stimulus in Monocytes from Familial Cold Autoinflammatory Syndrome Patients. The Journal of Immunology. 175(4). 2630–2634. 163 indexed citations

19.

Liu, George Y., Anthony Essex, John T. Buchanan, et al.. (2005). Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity. The Journal of Experimental Medicine. 202(2). 209–215. 556 indexed citations breakdown →

20.

Touitou, Isabelle, Suzanne Lesage, Michael McDermott, et al.. (2004). Infevers: An evolving mutation database for auto-inflammatory syndromes. Human Mutation. 24(3). 194–198. 234 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact