Gregory Stephanopoulos

53.9k total citations · 16 hit papers
440 papers, 37.5k citations indexed

About

Gregory Stephanopoulos is a scholar working on Molecular Biology, Biomedical Engineering and Control and Systems Engineering. According to data from OpenAlex, Gregory Stephanopoulos has authored 440 papers receiving a total of 37.5k indexed citations (citations by other indexed papers that have themselves been cited), including 349 papers in Molecular Biology, 93 papers in Biomedical Engineering and 34 papers in Control and Systems Engineering. Recurrent topics in Gregory Stephanopoulos's work include Microbial Metabolic Engineering and Bioproduction (210 papers), Biofuel production and bioconversion (68 papers) and Enzyme Catalysis and Immobilization (67 papers). Gregory Stephanopoulos is often cited by papers focused on Microbial Metabolic Engineering and Bioproduction (210 papers), Biofuel production and bioconversion (68 papers) and Enzyme Catalysis and Immobilization (67 papers). Gregory Stephanopoulos collaborates with scholars based in United States, Singapore and China. Gregory Stephanopoulos's co-authors include Hal S. Alper, Joanne K. Kelleher, Parayil Kumaran Ajikumar, Joseph J. Vallino, Kangjian Qiao, Maciek R. Antoniewicz, Keith E. J. Tyo, Gerald R. Fink, Kang Zhou and Elke Nevoigt and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Gregory Stephanopoulos

431 papers receiving 36.7k citations

Hit Papers

Reductive glutamine metab... 1994 2026 2004 2015 2011 2010 1994 1998 2010 400 800 1.2k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
    2011 1.4k citations Eric L. Bell, Leonard Guarente et al. profile →
  2. Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli
    2010 1.3k citations Parayil Kumaran Ajikumar, Wenhai Xiao et al. Science profile →
  3. Engineering Cell Shape and Function
    1994 1.2k citations Gregory Stephanopoulos et al. Science profile →
  4. Metabolic Engineering: Principles and Methodologies
    1998 903 citations Gregory Stephanopoulos, Jens Nielsen et al. profile →
  5. Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli.
    2010 808 citations Parayil Kumaran Ajikumar, Wenhai Xiao et al. profile →
  6. Tuning genetic control through promoter engineering
    2005 693 citations Hal S. Alper, Elke Nevoigt et al. Proceedings of the National Academy of Sciences profile →
  7. Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism
    2015 615 citations Gregory Stephanopoulos et al. profile →
  8. Engineering Yeast Transcription Machinery for Improved Ethanol Tolerance and Production
    2006 611 citations Hal S. Alper, Joel F. Moxley et al. Science profile →
  9. Challenges in Engineering Microbes for Biofuels Production
    2007 556 citations Gregory Stephanopoulos Science profile →
  10. Distributing a metabolic pathway among a microbial consortium enhances production of natural products
    2015 540 citations Kang Zhou, Kangjian Qiao et al. profile →
  11. Engineering the push and pull of lipid biosynthesis in oleaginous yeast Yarrowia lipolytica for biofuel production
    2012 539 citations Gregory Stephanopoulos et al. Metabolic Engineering profile →
  12. Improving fatty acids production by engineering dynamic pathway regulation and metabolic control
    2014 400 citations Gregory Stephanopoulos et al. Proceedings of the National Academy of Sciences profile →
  13. Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols
    2013 389 citations Gerald R. Fink, Gregory Stephanopoulos et al. profile →
  14. Lipid production in Yarrowia lipolytica is maximized by engineering cytosolic redox metabolism
    2017 360 citations Kangjian Qiao, Kang Zhou et al. profile →
  15. Engineering Yarrowia lipolytica as a platform for synthesis of drop-in transportation fuels and oleochemicals
    2016 354 citations Kangjian Qiao, Gregory Stephanopoulos et al. Proceedings of the National Academy of Sciences profile →
  16. Removal of lycopene substrate inhibition enables high carotenoid productivity in Yarrowia lipolytica
    2022 164 citations Yongshuo Ma, Nian Liu et al. Nature Communications profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author Last Decade Papers Cites
Gregory Stephanopoulos 29.5k 9.6k 3.1k 2.5k 2.4k 440 37.5k
Jens Nielsen 53.1k 1.8× 17.8k 1.9× 1.8k 0.6× 4.5k 1.8× 3.3k 1.4× 996 66.0k
Bernhard Ø. Palsson 57.8k 2.0× 17.0k 1.8× 1.3k 0.4× 2.1k 0.8× 8.8k 3.7× 786 68.6k
Douglas B. Kell 22.1k 0.7× 5.6k 0.6× 1.2k 0.4× 1.2k 0.5× 2.4k 1.0× 560 40.6k
Li Liu 12.5k 0.4× 4.7k 0.5× 728 0.2× 1.3k 0.5× 1.3k 0.6× 1.2k 26.1k
Sung‐Hoon Kim 17.9k 0.6× 2.2k 0.2× 3.7k 1.2× 2.0k 0.8× 1.9k 0.8× 1.4k 36.3k
Jay D. Keasling 37.8k 1.3× 11.1k 1.2× 274 0.1× 6.1k 2.4× 4.3k 1.8× 579 45.8k
Feng Chen 15.2k 0.5× 3.7k 0.4× 1.1k 0.3× 2.0k 0.8× 812 0.3× 1.0k 41.3k
Royston Goodacre 16.6k 0.6× 7.4k 0.8× 713 0.2× 647 0.3× 989 0.4× 464 30.7k
James C. Liao 17.0k 0.6× 8.3k 0.9× 213 0.1× 473 0.2× 1.7k 0.7× 277 22.9k
Zuo‐Feng Zhang 9.2k 0.3× 747 0.1× 3.4k 1.1× 1.1k 0.4× 1.6k 0.7× 680 29.7k

Countries citing papers authored by Gregory Stephanopoulos

Since Specialization
Citations

This map shows the geographic impact of Gregory Stephanopoulos's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Gregory Stephanopoulos with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Gregory Stephanopoulos more than expected).

Fields of papers citing papers by Gregory Stephanopoulos

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Gregory Stephanopoulos. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Gregory Stephanopoulos. The network helps show where Gregory Stephanopoulos may publish in the future.

Co-authorship network of co-authors of Gregory Stephanopoulos

This figure shows the co-authorship network connecting the top 25 collaborators of Gregory Stephanopoulos. A scholar is included among the top collaborators of Gregory Stephanopoulos based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Gregory Stephanopoulos. Gregory Stephanopoulos is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Ma, Yongshuo, Nian Liu, Per Greisen, et al.. (2022). Removal of lycopene substrate inhibition enables high carotenoid productivity in Yarrowia lipolytica. Nature Communications. 13(1). 572–572. 164 indexed citations breakdown →
2.
Ma, Yongshuo, Jingbo Li, Sanwen Huang, & Gregory Stephanopoulos. (2021). Targeting pathway expression to subcellular organelles improves astaxanthin synthesis in Yarrowia lipolytica. Metabolic Engineering. 68. 152–161. 109 indexed citations
3.
Isidor, Marie S., Wentao Dong, Julia Villarroel, et al.. (2021). Insulin resistance rewires the metabolic gene program and glucose utilization in human white adipocytes. International Journal of Obesity. 46(3). 535–543. 11 indexed citations
4.
Man, Cheuk Him, François Mercier, Nian Liu, et al.. (2021). Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth. Blood. 139(4). 502–522. 27 indexed citations
5.
Dong, Wentao, et al.. (2020). Oxidative pentose phosphate pathway and glucose anaplerosis support maintenance of mitochondrial NADPH pool under mitochondrial oxidative stress. Bioengineering & Translational Medicine. 5(3). e10184–e10184. 48 indexed citations
6.
Li, Jingbo, Yongshuo Ma, Nian Liu, et al.. (2020). Synthesis of high-titer alka(e)nes in Yarrowia lipolytica is enabled by a discovered mechanism. Nature Communications. 11(1). 6198–6198. 45 indexed citations
7.
Li, Zhengjun, et al.. (2018). Metabolic engineering of Escherichia coli for the production of L-malate from xylose. Metabolic Engineering. 48. 25–32. 37 indexed citations
8.
Shaw, A. Joe, Felix H. Lam, Maureen Hamilton, et al.. (2016). Metabolic engineering of microbial competitive advantage for industrial fermentation processes. Science. 353(6299). 583–586. 98 indexed citations
9.
Berrios, Christian, Megha Padi, Mark A. Keibler, et al.. (2016). Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation. PLoS Pathogens. 12(11). e1006020–e1006020. 63 indexed citations
10.
Li, Zhengjun, Kangjian Qiao, Weichao Shi, et al.. (2016). Biosynthesis of poly(glycolate-co-lactate-co-3-hydroxybutyrate) from glucose by metabolically engineered Escherichia coli. Metabolic Engineering. 35. 1–8. 38 indexed citations
11.
Zhang, Haoran, Zhengjun Li, Brian J.G. Pereira, & Gregory Stephanopoulos. (2015). Engineering E. coli–E. coli cocultures for production of muconic acid from glycerol. Microbial Cell Factories. 14(1). 134–134. 84 indexed citations
12.
Lam, Felix H., et al.. (2014). Engineering alcohol tolerance in yeast. Science. 346(6205). 71–75. 164 indexed citations
13.
Fendt, Sarah‐Maria, Eric L. Bell, Mark A. Keibler, et al.. (2013). Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism. Cancer Research. 73(14). 4429–4438. 7 indexed citations
14.
15.
Noguchi, Yasushi, Jamey D. Young, José O. Alemán, et al.. (2011). Tracking cellular metabolomics in lipoapoptosis- and steatosis-developing liver cells. Molecular BioSystems. 7(5). 1409–1419. 9 indexed citations
16.
Taniguchi, Cullen M., Jonathon N. Winnay, Tatsuya Kondo, et al.. (2010). The Phosphoinositide 3-Kinase Regulatory Subunit p85α Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling. Cancer Research. 70(13). 5305–5315. 125 indexed citations
17.
Ajikumar, Parayil Kumaran, Wenhai Xiao, Keith E. J. Tyo, et al.. (2010). Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli. Science. 330(6000). 70–74. 1266 indexed citations breakdown →
18.
Moxley, Joel F., Michael C. Jewett, Maciek R. Antoniewicz, et al.. (2009). Linking high-resolution metabolic flux phenotypes and transcriptional regulation in yeast modulated by the global regulator Gcn4p. Proceedings of the National Academy of Sciences. 106(16). 6477–6482. 129 indexed citations
19.
Alper, Hal S., Joel F. Moxley, Elke Nevoigt, Gerald R. Fink, & Gregory Stephanopoulos. (2006). Engineering Yeast Transcription Machinery for Improved Ethanol Tolerance and Production. Science. 314(5805). 1565–1568. 611 indexed citations breakdown →
20.
Stafford, Daniel, et al.. (2002). Optimizing bioconversion pathways through systems analysis and metabolic engineering. Proceedings of the National Academy of Sciences. 99(4). 1801–1806. 24 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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