Keith E. J. Tyo

6.6k total citations · 2 hit papers
70 papers, 4.9k citations indexed

About

Keith E. J. Tyo is a scholar working on Molecular Biology, Biomedical Engineering and Genetics. According to data from OpenAlex, Keith E. J. Tyo has authored 70 papers receiving a total of 4.9k indexed citations (citations by other indexed papers that have themselves been cited), including 62 papers in Molecular Biology, 12 papers in Biomedical Engineering and 9 papers in Genetics. Recurrent topics in Keith E. J. Tyo's work include Microbial Metabolic Engineering and Bioproduction (37 papers), CRISPR and Genetic Engineering (13 papers) and Gene Regulatory Network Analysis (11 papers). Keith E. J. Tyo is often cited by papers focused on Microbial Metabolic Engineering and Bioproduction (37 papers), CRISPR and Genetic Engineering (13 papers) and Gene Regulatory Network Analysis (11 papers). Keith E. J. Tyo collaborates with scholars based in United States, Sweden and China. Keith E. J. Tyo's co-authors include Gregory Stephanopoulos, Parayil Kumaran Ajikumar, Fritz Simeon, Blaine A. Pfeifer, Wenhai Xiao, Yong Wang, Effendi Leonard, Jens Nielsen, Dina Petranović and Zihe Liu and has published in prestigious journals such as Science, Journal of the American Chemical Society and Nucleic Acids Research.

In The Last Decade

Keith E. J. Tyo

67 papers receiving 4.8k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

2010 1.3k citations Parayil Kumaran Ajikumar, Wenhai Xiao et al. Science profile →
Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli.

2010 808 citations Parayil Kumaran Ajikumar, Wenhai Xiao et al. profile →

Peers

Countries citing papers authored by Keith E. J. Tyo

Since Specialization

Citations

This map shows the geographic impact of Keith E. J. Tyo's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Keith E. J. Tyo with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Keith E. J. Tyo more than expected).

Fields of papers citing papers by Keith E. J. Tyo

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Keith E. J. Tyo. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Keith E. J. Tyo. The network helps show where Keith E. J. Tyo may publish in the future.

Co-authorship network of co-authors of Keith E. J. Tyo

This figure shows the co-authorship network connecting the top 25 collaborators of Keith E. J. Tyo. A scholar is included among the top collaborators of Keith E. J. Tyo based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Keith E. J. Tyo. Keith E. J. Tyo is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Merging the computational design of chimeric type I polyketide synthases with enzymatic pathways for chemical biosynthesis 2025 ·Nature Communications ·(unknown), (unknown), (unknown), Vincent Blay, (unknown), (unknown), Keith E. J. Tyo, Linda J. Broadbelt, Aindrila Mukhopadhyay, Jay D. Keasling, Héctor García Martín, Tyler W. H. Backman	0
2	Deconstructing synthetic biology across scales: a conceptual approach for training synthetic biologists 2024 ·Nature Communications ·Ashty S. Karim, (unknown), (unknown), (unknown), Ludmilla Aristilde, Yogesh Goyal, Joshua N. Leonard, Niall M. Mangan, (unknown), Sugyan M. Dixit, Keith E. J. Tyo, Laurie Zoloth, Michael C. Jewett, Susanna Calkins, Neha P. Kamat, Danielle Tullman‐Ercek, Julius B. Lucks	6
3	DORA-XGB: an improved enzymatic reaction feasibility classifier trained using a novel synthetic data approach 2024 ·Molecular Systems Design & Engineering ·(unknown), (unknown), Kevin M. Shebek, Linda J. Broadbelt, Keith E. J. Tyo	2
4	A Massively Parallel In Vivo Assay of TdT Mutants Yields Variants with Altered Nucleotide Insertion Biases 2024 ·ACS Synthetic Biology ·(unknown), (unknown), (unknown), (unknown), Jeremy H. Mills, Keith E. J. Tyo, Chang C. Liu	2
5	Engineering Ca ²⁺ -Dependent DNA Polymerase Activity 2023 ·ACS Synthetic Biology ·Bradley W. Biggs, (unknown), Namita Bhan, (unknown), George M. Church, Keith E. J. Tyo	0
6	A dynamic kinetic model captures cell-free metabolism for improved butanol production 2023 ·Metabolic Engineering ·(unknown), Blake J. Rasor, (unknown), Ashty S. Karim, Michael C. Jewett, Keith E. J. Tyo, Linda J. Broadbelt	13
7	Curating a comprehensive set of enzymatic reaction rules for efficient novel biosynthetic pathway design 2021 ·Metabolic Engineering ·(unknown), Andrew Stine, Keith E. J. Tyo, Linda J. Broadbelt	16
8	Dynamic Control of Gene Expression with Riboregulated Switchable Feedback Promoters 2021 ·ACS Synthetic Biology ·Cameron J. Glasscock, Bradley W. Biggs, (unknown), (unknown), (unknown), (unknown), Min‐Kyoung Kang, Danielle Tullman‐Ercek, Keith E. J. Tyo, Julius B. Lucks	24
9	Engineering Acinetobacter baylyi ADP1 for mevalonate production from lignin-derived aromatic compounds 2021 ·Metabolic Engineering Communications ·(unknown), Bradley W. Biggs, Laura Guerrero, (unknown), Keith E. J. Tyo	20
10	Development of a genetic toolset for the highly engineerable and metabolically versatile Acinetobacter baylyi ADP1 2020 ·Nucleic Acids Research ·Bradley W. Biggs, (unknown), (unknown), Shu Huang, (unknown), Emily McIntyre, (unknown), Ellen L. Neidle, Keith E. J. Tyo	34
11	Kinetic ensemble model of gas fermenting Clostridium autoethanogenum for improved ethanol production 2019 ·Biochemical Engineering Journal ·Jennifer L. Greene, James Daniell, Michael Köpke, Linda J. Broadbelt, Keith E. J. Tyo	27
12	Metabolic kinetic modeling provides insight into complex biological questions, but hurdles remain 2019 ·Current Opinion in Biotechnology ·Jonathan Strutz, (unknown), Jennifer L. Greene, Linda J. Broadbelt, Keith E. J. Tyo	41
13	Modulating and evaluating receptor promiscuity through directed evolution and modeling 2017 ·Protein Engineering Design and Selection ·(unknown), (unknown), (unknown), Neda Bagheri, Keith E. J. Tyo	5
14	Draft Genome Sequence of a Multidrug-Resistant Klebsiella quasipneumoniae subsp. similipneumoniae Isolate from a Clinical Source 2016 ·Genome Announcements ·Egon A. Ozer, Andrew R. Morris, Fiorella Krapp, Christopher S. Henry, Keith E. J. Tyo, Wyndham W. Lathem, Alan R. Hauser	4
15	N-Terminal-Based Targeted, Inducible Protein Degradation in Escherichia coli 2016 ·PLoS ONE ·Karthik Sekar, (unknown), John W. Bostick, Keith E. J. Tyo	25
16	Regulatory effects on central carbon metabolism from poly-3-hydroxybutryate synthesis 2015 ·Metabolic Engineering ·Karthik Sekar, Keith E. J. Tyo	14
17	Computational Tools for Guided Discovery and Engineering of Metabolic Pathways 2013 ·Methods in molecular biology ·(unknown), Linda J. Broadbelt, Keith E. J. Tyo	13
18	Metabolic engineering of recombinant protein secretion by Saccharomyces cerevisiae 2012 ·FEMS Yeast Research ·Jin Hou, Keith E. J. Tyo, Zihe Liu, Dina Petranović, Jens Nielsen	154
19	Directed Evolution of Promoters and Tandem Gene Arrays for Customizing RNA Synthesis Rates and Regulation 2011 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Keith E. J. Tyo, Elke Nevoigt, Gregory Stephanopoulos	16
20	Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli breakdown → 2010 ·Science ·Parayil Kumaran Ajikumar, Wenhai Xiao, Keith E. J. Tyo, Yong Wang, Fritz Simeon, Effendi Leonard, (unknown), (unknown), Blaine A. Pfeifer, Gregory Stephanopoulos	1266

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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