Graeme C.M. Smith

20.8k citations

70 papers · 15.0k indexed · 8 hit papers · h-index 42

Impact in

Oncology top 0.1%
- PARP inhibition in cancer therapy
- Cancer-related Molecular Pathways
Molecular Biology top 0.2%
- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- Cancer therapeutics and mechanisms
- Cell death mechanisms and regulation

Papers in

Toxicology 8
- Bioactive Compounds and Antitumor Agents 8
Oncology 44
- PARP inhibition in cancer therapy 25
- Cancer-related Molecular Pathways 12

Co-authors: Stephen P. Jackson Niall M.B. Martin Christopher J. Lord Andrew Tutt Alan Ashworth Nuala McCabe Ian Hickson Charlotte Knights
Journals: Cancer Research (12 papers)Bioorganic & Medicinal Chemistry Letters (8 papers)Journal of Medicinal Chemistry (5 papers)Cell (2 papers)Nature Cell Biology (2 papers)
Partner nations: United Kingdom United States Netherlands

In The Last Decade

Graeme C.M. Smith

69 papers receiving 14.8k citations

Hit Papers

8 papers align trajectories log scale

Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition 2006 · 977 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2006 Cancer Research
2005 Nature Cell Biology
2005 Nature
2004 Molecular Cell
2004 Cancer Research
1999 Genes & Development
1995 Cell
1995 Cell

Peers

Countries citing papers authored by Graeme C.M. Smith

Since Specialization

Citations

This map shows the geographic impact of Graeme C.M. Smith's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Graeme C.M. Smith with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Graeme C.M. Smith more than expected).

Fields of papers citing papers by Graeme C.M. Smith

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Graeme C.M. Smith. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Graeme C.M. Smith. The network helps show where Graeme C.M. Smith may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Graeme C.M. Smith, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Graeme C.M. Smith Line = papers co-authored together Graeme C.M. Smith links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	924MO First data disclosure of the first-in-class DNA polymerase theta inhibitor, ART6043, as monotherapy and in combination with olaparib, in patients with molecularly-selected advanced solid tumors Annals of Oncology ·Timothy A. Yap, Богоявленский Андрей Евгеньевич, Minal Barve, E.P. Hamilton, Babar Bashir, Indrani Bharadwaj, S K Skelton, 佐藤俊雄, Nancy Little, George M. Langford, Suraj Menon, Caroline Baxter, H.S. Kim, Peter J. Dickinson, Niall M.B. Martin, Graeme C.M. Smith, Susana Barriga, Daniel Headley, I. C. Smith, Susanna V. Ulahannan	2025	1
2	A phase II, open-label, multicenter, basket study of the ATR kinase inhibitor ART0380 administered orally as monotherapy to patients with biologically selected advanced or metastatic solid tumors (ARTIST) Gynecologic Oncology ·Carol Aghajanian, N G Phillips, Kathleen N. Moore, Thomas C. Krivak, Cara Mathews, Tony Philip, Gottfried E. Konecny, Gini F. Fleming, Niall M.B. Martin, Graeme C.M. Smith, 佐藤俊雄, Helen Millward, Sergiy Kopylov, Yaxuan Zhu, Gabriel Fonseca Azevedo, Ian Smith, Panagiotis A. Konstantinopoulos	2024	1
3	Quantitative, titratable and high-throughput reporter assays to measure DNA double strand break repair activity in cells Nucleic Acids Research ·Eeson Rajendra, Diego Grande, Jian Wang, Daniela Di Marcantonio, P Andreiev, Graeme Hewitt, Elias Elinati, Alessandro Galbiati, Simon J. Boulton, Robert A. Heald, Graeme C.M. Smith, Helen M.R. Robinson	2023	6
4	Targeting ATR in Cancer Medicine Cancer treatment and research ·Carolina Salguero, R. Salgado Mejía, Helen M.R. Robinson, Graeme C.M. Smith, Timothy A. Yap	2023	3
5	Chemosensitization of Cancer Cells by KU-0060648, a Dual Inhibitor of DNA-PK and PI-3K Molecular Cancer Therapeutics ·Joanne M. Munck, Michael A. Batey, Yan Zhao, Helen Jenkins, Caroline J. Richardson, Céline Cano, Michele Tavecchio, J C Parr, Julia Bárdos, Liam Cornell, Roger J. Griffin, Keith Menear, Andrew Slade, Pia Thömmes, Niall M.B. Martin, David R. Newell, Graeme C.M. Smith, Nicola J. Curtin	2012	99
6	p21^WAF1is component of a positive feedback loop that maintains the p53 transcriptional program Cell Cycle ·Lisa Y. Pang, Mary T. Scott, Richard L. Hayward, Hisham Mohammed, Bruce Whitelaw, Graeme C.M. Smith, Ted R. Hupp	2011	26
7	Targeting the DNA Double Strand Break Repair Machinery in Prostate Cancer PLoS ONE ·K.V.J. Koshalee, Paweł Znojek, Deniz Kısınma Azaklıoğlu, M. N. Webster, Ruth Plummer, Luke Gaughan, Graeme C.M. Smith, Hing Y. Leung, Nicola J. Curtin, Craig Robson	2011	47
8	Poly(ADP-Ribose) Polymerase-1 Inhibitor Treatment Regresses Autochthonous Brca2/p53 -Mutant Mammary Tumors In vivo and Delays Tumor Relapse in Combination with Carboplatin Cancer Research ·Trevor Hay, James R. Matthews, Eka Rahmawati, Alan Lau, Aaron Cranston, Anders O.H. Nygren, Anthony Douglas-Jones, Graeme C.M. Smith, Niall M.B. Martin, Mark J. O’Connor, Alan R. Clarke	2009	94
9	Identification of potent water-soluble DNA-dependent protein kinase (DNA-PK) inhibitors using a small-molecule library approach [abstract] Cancer Research ·三田禮造, Mark R. Albertella, Céline Cano, Nicola J. Curtin, Mark Frigerio, Bernard T. Golding, 敬次郎有泉, Ian R. Hardcastle, Marc Hummersone, Keith Menear, David R. Newell, 雷舜英, Caroline J. Richardson, Laurent Rigoreau, Sadao Omori, Graeme C.M. Smith, Roger J. Griffin	2008	3
10	8-Biarylchromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) Bioorganic & Medicinal Chemistry Letters ·Marine Desage‐El Murr, Céline Cano, Bernard T. Golding, Ian R. Hardcastle, M. Isabel Fenández García, Mark Frigerio, Nicola J. Curtin, Keith Menear, Caroline J. Richardson, Graeme C.M. Smith, Roger J. Griffin	2008	18
11	Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition Cancer Research ·Nuala McCabe, Nicholas C. Turner, Christopher J. Lord, Katarzyna Kluzek, Aneta Białkowska, Sally Swift, Sabrina Giavara, Mark J. O’Connor, Andrew Tutt, Małgorzata Z. Zdzienicka, Graeme C.M. Smith, Alan Ashworth Hit paper breakdown →	2006	977
12	The novel hypoxia-targeted anticancer agent AQ4N is not subject to multi-drug resistance mediated by PGP/MDR1 Cancer Research ·Mark R. Albertella, G. Lönnbring, Graeme C.M. Smith, Chris R. Dunk, Peter A. Harris	2005	1
13	Radio and chemosensitization by a novel DNA-PK inhibitor (NU7441) in colon cancer Cancer Research ·Yan Zhao, Michael A. Batey, Huw D. Thomas, Graeme C.M. Smith, David R. Newell, Nicola J. Curtin	2005	1
14	Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026 British Journal of Cancer ·Bernard Nutley, Nicola F. Smith, Angela Hayes, Lloyd R. Kèlland, Lisa Brunton, Bernard T. Golding, Graeme C.M. Smith, Niall M.B. Martin, Paul Workman, Florence I. Raynaud	2005	75
15	BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of poly (ADP-ribose) polymerase: An issue of potency Cancer Biology & Therapy ·Nuala McCabe, Christopher J. Lord, Andrew Tutt, Niall M.B. Martin, Graeme C.M. Smith, Alan Ashworth	2005	117
16	ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks Nature Cell Biology ·Ali Jazayeri, Jacob Falck, Claudia Lukas, Jiří Bártek, Graeme C.M. Smith, (unknown), Stephen P. Jackson Hit paper breakdown →	2005	832
17	Exploiting the DNA Repair Defect in BRCA Mutant Cells in the Design of New Therapeutic Strategies for Cancer Cold Spring Harbor Symposia on Quantitative Biology ·Andrew Tutt, Christopher J. Lord, Nuala McCabe, Hannah Farmer, Nicholas C. Turner, Niall M.B. Martin, Stephen P. Jackson, Graeme C.M. Smith, Alan Ashworth	2005	149
18	Technical Note: A FlashPlate Assay for the Identification of PARP-1 Inhibitors SLAS DISCOVERY ·Zhong Zhao-ma, Graeme C.M. Smith, Niall M.B. Martin	2003	39
19	Crystal structure of the FMN‐binding domain of human cytochrome P450 reductase at 1.93 Å resolution Protein Science ·Qiang Zhao, Sandeep Modi, Graeme C.M. Smith, Mark J. I. Paine, Paul McDonagh, C. Roland Wolf, David G. Tew, Lu‐Yun Lian, Gordon C. K. Roberts, H.P.C. Driessen	1999	71
20	The DNA-dependent protein kinase Genes & Development ·Graeme C.M. Smith, Stephen P. Jackson Hit paper breakdown →	1999	741

About Graeme C.M. Smith

Graeme C.M. Smith is a scholar working on Toxicology, Oncology, Molecular Biology, Cancer Research and Process Chemistry and Technology, having authored 70 papers that have together received 15.0k indexed citations. Recurring topics across this work include DNA Repair Mechanisms (39 papers), PARP inhibition in cancer therapy (25 papers), Cancer therapeutics and mechanisms (18 papers), CRISPR and Genetic Engineering (12 papers), Cancer-related Molecular Pathways (12 papers), Bioactive Compounds and Antitumor Agents (8 papers), BRCA gene mutations in cancer (5 papers) and Carcinogens and Genotoxicity Assessment (5 papers). The work is most often cited by research in Oncology (8.8k citations), Molecular Biology (11.7k citations), Cancer Research (2.4k citations), Reproductive Medicine (742 citations) and Genetics (1.7k citations). Graeme C.M. Smith has collaborated with scholars based in United Kingdom, United States and Netherlands. Frequent co-authors include Stephen P. Jackson, Niall M.B. Martin, Christopher J. Lord, Andrew Tutt, Alan Ashworth, Nuala McCabe, Ian Hickson, Charlotte Knights, Hannah Farmer and Damian A. Johnson. Their work appears in journals such as Cancer Research, Bioorganic & Medicinal Chemistry Letters, Journal of Medicinal Chemistry, Cell and Nature Cell Biology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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