Graeme Hewitt

5.5k citations

23 papers · 2.9k indexed · 2 hit papers · h-index 20

Impact in

Aging top 0.5%
- Genetics, Aging, and Longevity in Model Organisms
Physiology top 2%
- Telomeres, Telomerase, and Senescence

Papers in

Aging 2
- Genetics, Aging, and Longevity in Model Organisms 2
Molecular Biology 19
- DNA Repair Mechanisms 15
- CRISPR and Genetic Engineering 7
- Genomics and Chromatin Dynamics 3

Co-authors: João F. Passos Clara Correia‐Melo Diana Jurk Viktor I. Korolchuk Jelena Mann Rhys Anderson Timothy Hardy Morgan L. Taschuk
Journals: Molecular Cell (6 papers)Nature Communications (3 papers)The Journal of Cell Biology (2 papers)Cell Reports (2 papers)Trends in cancer (1 paper)
Partner nations: United Kingdom United States Germany

In The Last Decade

Graeme Hewitt

22 papers receiving 2.9k citations

Hit Papers

align trajectories log scale

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice 2014 · 593 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2014 Nature Communications
2012 Nature Communications

Peers

Countries citing papers authored by Graeme Hewitt

Since Specialization

Citations

This map shows the geographic impact of Graeme Hewitt's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Graeme Hewitt with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Graeme Hewitt more than expected).

Fields of papers citing papers by Graeme Hewitt

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Graeme Hewitt. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Graeme Hewitt. The network helps show where Graeme Hewitt may publish in the future.

Co-authors

The 25 scholars most cited alongside Graeme Hewitt, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Graeme Hewitt Line = papers co-authored together Graeme Hewitt links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	EXO1 as a therapeutic target for Fanconi Anaemia, ZRSR2 and BRCA1-A complex deficient cancers Nature Communications ·Manda Magdalena Marić, Sandra Segura‐Bayona, Raviprasad Kuthethur, Tohru Takaki, Valérie Borel, Tyler H. Stanage, Miroslav P Ivanov, Nishita Parnandi, Graeme Hewitt, Rhona Millar, Carmen Fonseca, Harshil Patel, Miriam Llorian, Scott Warchal, Michael Howell, A Chaudhuri, Panagiotis Kotsantis, Simon J. Boulton	2025	0
2	Quantitative, titratable and high-throughput reporter assays to measure DNA double strand break repair activity in cells Nucleic Acids Research ·Eeson Rajendra, Diego Grande, Bethany Mason, Daniela Di Marcantonio, Lucy Armstrong, Graeme Hewitt, Elias Elinati, Alessandro Galbiati, Simon J. Boulton, Robert A. Heald, Graeme C.M. Smith, Helen M.R. Robinson	2023	6
3	RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks Molecular Cell ·Shubo Zhao, Jacqueline Cordes, Karolina M Caban, Maximilian J. Götz, Timur Mackens‐Kiani, Anthony J. Veltri, Niladri K. Sinha, Pedro Weickert, Shunji KAYA, Graeme Hewitt, Danny D. Nedialkova, Thomas Fröhlich, Roland Beckmann, Allen R. Buskirk, Rachel Green, Julian Stingele	2023	22
4	H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ Molecular Cell ·Rachel Bayley, Valérie Borel, Rhiannon J. Moss, Ellie Sweatman, Philip Ruis, Alice Ormrod, Amalia Goula, Rachel M.A. Mottram, Tyler H. Stanage, Graeme Hewitt, Marco Saponaro, Grant S. Stewart, Simon J. Boulton, Martin R. Higgs	2022	23
5	POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells Molecular Cell ·Ondrej Beláň, Marie Sebald, Marek Adamowicz, Roopesh Anand, Aleksandra Vančevska, Joana Neves, Vera Grinkevich, Graeme Hewitt, Sandra Segura‐Bayona, Roberto Bellelli, Helen M.R. Robinson, Geoff S. Higgins, Graeme C.M. Smith, Stephen C. West, David Rueda, Simon J. Boulton	2022	72
6	Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA -deficient cells to PARP inhibitors Science ·Kasper Fugger, Ilirjana Bajrami, Mariana Silva dos Santos, Sarah Jane Young, Simone Kunzelmann, Geoff Kelly, Graeme Hewitt, Harshil Patel, Robert Goldstone, Thomas Carell, Simon J. Boulton, James I. MacRae, Ian A. Taylor, Stephen C. West	2021	91
7	mTORC1 activity is supported by spatial association with focal adhesions The Journal of Cell Biology ·Yoana Rabanal‐Ruiz, Adam Byron, Alexander Wirth, Ralitsa R. Madsen, Lucia Sedlackova, Graeme Hewitt, Glyn Nelson, Julian Stingele, Jimi Wills, Tong Zhang, André Zeug, Reinhard Fässler, Bart Vanhaesebroeck, Oliver D.K. Maddocks, Evgeni Ponimaskin, Bernadette Carroll, Viktor I. Korolchuk	2021	38
8	Tackling PARP inhibitor resistance Trends in cancer ·Kasper Fugger, Graeme Hewitt, Stephen C. West, Simon J. Boulton	2021	37
9	Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome eLife ·Luka Bačić, Guillaume Gaullier, Anton Sabantsev, Laura C. Lehmann, Klaus Brackmann, Despoina Dimakou, Mario Halić, Graeme Hewitt, Simon J. Boulton, Sebastian Deindl	2021	29
10	Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch Cell Reports ·Laura C. Lehmann, Luka Bačić, Graeme Hewitt, Klaus Brackmann, Anton Sabantsev, Guillaume Gaullier, Sofia Pytharopoulou, Gianluca Degliesposti, Hanneke Okkenhaug, Song Tan, Alessandro Costa, Mark Skehel, Simon J. Boulton, Sebastian Deindl	2020	28
11	RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions Cell Reports ·Panagiotis Kotsantis, Sandra Segura‐Bayona, Pol Margalef, Paulina Marzec, Phil Ruis, Graeme Hewitt, Roberto Bellelli, Harshil Patel, Robert Goldstone, Anna R. Poetsch, Simon J. Boulton	2020	43
12	SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance Molecular Cell ·Stephanie Panier, Marija Marić, Graeme Hewitt, Emily Mason‐Osann, Himabindu Gali, Anqi Dai, Adam Labadorf, Jean-Hugues Guervilly, Philip Ruis, Sandra Segura‐Bayona, Ondrej Beláň, Paulina Marzec, Pierre-Henri L. Gaillard, Rachel Litman Flynn, Simon J. Boulton	2019	67
13	Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1 Molecular Cell ·Laura C. Lehmann, Graeme Hewitt, Shintaro Aibara, Alexander Leitner, Emil Marklund, Sarah Maslen, Varun Maturi, Yang Chen, David van der Spoel, Mark Skehel, Aristidis Moustakas, Simon J. Boulton, Sebastian Deindl	2017	50
14	Repair, Reuse, Recycle: The Expanding Role of Autophagy in Genome Maintenance Trends in Cell Biology ·Graeme Hewitt, Viktor I. Korolchuk	2016	114
15	Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN Molecular Cell ·Julian Stingele, Roberto Bellelli, Ferdinand Alte, Graeme Hewitt, Grzegorz Sarek, Sarah Maslen, Susan E. Tsutakawa, Annabel Borg, Susanne K. Kjær, John A. Tainer, Mark Skehel, M. Groll, Simon J. Boulton	2016	189
16	DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease American Journal of Physiology-Lung Cellular and Molecular Physiology ·Jodie Birch, Rhys K. Anderson, Clara Correia‐Melo, Diana Jurk, Graeme Hewitt, Francisco Madeira Marques, Nicola J. Green, Elizabeth Moisey, Mark A. Birrell, Maria G. Belvisi, Fiona Black, John J. Taylor, Andrew J. Fisher, Anthony De Soyza, João F. Passos	2015	117
17	Chronic inflammation induces telomere dysfunction and accelerates ageing in mice Nature Communications ·Diana Jurk, Caroline Wilson, João F. Passos, Fiona Oakley, Clara Correia‐Melo, Laura C. Greaves, Gabriele Saretzki, Chris Fox, Conor Lawless, Rhys Anderson, Graeme Hewitt, Sylvia L. F. Pender, Nicola Fullard, Glyn Nelson, Jelena Mann, Bart van de Sluis, Derek A. Mann, Thomas von Zglinicki Hit paper breakdown →	2014	593
18	Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence? PubMed ·Clara Correia‐Melo, Graeme Hewitt, João F. Passos	2014	147
19	Cell Sorting of Young and Senescent Cells Methods in molecular biology ·Graeme Hewitt, Thomas von Zglinicki, João F. Passos	2013	11
20	Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence Nature Communications ·Graeme Hewitt, Diana Jurk, Francisco Madeira Marques, Clara Correia‐Melo, Timothy Hardy, Agata Gackowska, Rhys Anderson, Morgan L. Taschuk, Jelena Mann, João F. Passos Hit paper breakdown →	2012	651

About Graeme Hewitt

Graeme Hewitt is a scholar working on Aging, Molecular Biology, Physiology, Oncology and Immunology, having authored 23 papers that have together received 2.9k indexed citations. Recurring topics across this work include DNA Repair Mechanisms (15 papers), Telomeres, Telomerase, and Senescence (7 papers), CRISPR and Genetic Engineering (7 papers), PARP inhibition in cancer therapy (6 papers), Genomics and Chromatin Dynamics (3 papers), Autophagy in Disease and Therapy (3 papers), Neutrophil, Myeloperoxidase and Oxidative Mechanisms (2 papers) and Genetics, Aging, and Longevity in Model Organisms (2 papers). The work is most often cited by research in Aging (347 citations), Physiology (1.2k citations), Molecular Biology (1.7k citations), Immunology (434 citations) and Geriatrics and Gerontology (71 citations). Graeme Hewitt has collaborated with scholars based in United Kingdom, United States and Germany. Frequent co-authors include João F. Passos, Clara Correia‐Melo, Diana Jurk, Viktor I. Korolchuk, Jelena Mann, Rhys Anderson, Timothy Hardy, Morgan L. Taschuk, Simon J. Boulton and Thomas von Zglinicki. Their work appears in journals such as Molecular Cell, Nature Communications, The Journal of Cell Biology, Cell Reports and Trends in cancer.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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