Keith Menear

2.9k citations

32 papers · 1.6k indexed · h-index 17

Co-authors: Niall M.B. Martin Xiaoling Cockcroft Graeme C.M. Smith Sylvie Gomez Mark J. O’Connor Marc Hummersone Frank Kerrigan Mark Frigerio
Topics: Cancer therapeutics and mechanisms (9 papers)DNA Repair Mechanisms (6 papers)Bioactive Compounds and Antitumor Agents (5 papers)
Cited by: Oncology Molecular Biology Organic Chemistry
Journals: Blood Cancer Research Journal of Medicinal Chemistry
Partner nations: United Kingdom Switzerland United States

In The Last Decade

Keith Menear

32 papers receiving 1.6k citations

Peers

Countries citing papers authored by Keith Menear

Since Specialization

Citations

This map shows the geographic impact of Keith Menear's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Keith Menear with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Keith Menear more than expected).

Fields of papers citing papers by Keith Menear

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Keith Menear. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Keith Menear. The network helps show where Keith Menear may publish in the future.

Co-authorship network of co-authors of Keith Menear

This figure shows the co-authorship network connecting the top 25 collaborators of Keith Menear. A scholar is included among the top collaborators of Keith Menear based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Keith Menear. Keith Menear is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014 2013 ·Bioorganic & Medicinal Chemistry Letters ·Kurt G. Pike,Karine Malagu,Marc Hummersone,Keith Menear,(unknown),Sylvie Gomez,Niall M.B. Martin,Linette Ruston,(unknown),Martin Pass	166
2	Chemosensitization of Cancer Cells by KU-0060648, a Dual Inhibitor of DNA-PK and PI-3K 2012 ·Molecular Cancer Therapeutics ·Joanne M. Munck,Michael A. Batey,Yan Zhao,Helen Jenkins,Caroline J. Richardson,Céline Cano,Michele Tavecchio,(unknown),Julia Bárdos,Liam Cornell,Roger J. Griffin,Keith Menear,Andrew Slade,Pia Thömmes,Niall M.B. Martin,David R. Newell,Graeme C.M. Smith,Nicola J. Curtin	99
3	DNA-dependent protein kinase (DNA-PK) inhibitors: Structure–activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain 2010 ·Bioorganic & Medicinal Chemistry Letters ·(unknown),Julia Bárdos,M. Raymond V. Finlay,Bernard T. Golding,(unknown),Roger J. Griffin,Ian R. Hardcastle,Keith Menear,Attilla Ting,Paul Turner,(unknown),Céline Cano	18
4	Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion 2009 ·Molecular Cancer Therapeutics ·Sarah E. Golding,Elizabeth Rosenberg,Nicholas C.K. Valerie,Isa M. Hussaini,Mark Frigerio,Xiaoling Cockcroft,(unknown),Marc Hummersone,Laurent Rigoreau,Keith Menear,Mark J. O’Connor,Lawrence F. Povirk,Timothy Van Meter,Kristoffer Valerie	285
5	The P1 N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin 2009 ·Bioorganic & Medicinal Chemistry Letters ·Yasuchika Yamaguchi,Keith Menear,(unknown),Robert Mah,Frédéric Cumin,Christian Schnell,Jeanette M. Wood,Jürgen Maibaum	16
6	Identification and optimisation of novel and selective small molecular weight kinase inhibitors of mTOR 2009 ·Bioorganic & Medicinal Chemistry Letters ·Keith Menear,Sylvie Gomez,Karine Malagu,C. L. Bailey,(unknown),Xiaoling Cockcroft,(unknown),(unknown),Armelle Le Gall,(unknown),(unknown),(unknown),(unknown),(unknown),Ian Hickson,Niall M.B. Martin,Graeme C.M. Smith,Kurt G. Pike	51
7	Identification of potent water-soluble DNA-dependent protein kinase (DNA-PK) inhibitors using a small-molecule library approach [abstract] 2008 ·Cancer Research ·(unknown),Mark R. Albertella,Céline Cano,Nicola J. Curtin,Mark Frigerio,Bernard T. Golding,(unknown),Ian R. Hardcastle,Marc Hummersone,Keith Menear,David R. Newell,(unknown),Caroline J. Richardson,Laurent Rigoreau,(unknown),Graeme C.M. Smith,Roger J. Griffin	3
8	8-Biarylchromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) 2008 ·Bioorganic & Medicinal Chemistry Letters ·Marine Desage‐El Murr,Céline Cano,Bernard T. Golding,Ian R. Hardcastle,(unknown),Mark Frigerio,Nicola J. Curtin,Keith Menear,Caroline J. Richardson,Graeme C.M. Smith,Roger J. Griffin	18
9	Novel alkoxybenzamide inhibitors of poly(ADP-ribose) polymerase 2008 ·Bioorganic & Medicinal Chemistry Letters ·Keith Menear,(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),Armelle Le Gall,Sylvie Gomez,(unknown),(unknown),Niall M.B. Martin,(unknown),Graeme C.M. Smith	34
10	Phthalazinones. Part 1: The design and synthesis of a novel series of potent inhibitors of poly(ADP-ribose)polymerase 2005 ·Bioorganic & Medicinal Chemistry Letters ·(unknown),Xiaoling Cockcroft,(unknown),(unknown),(unknown),(unknown),Sylvie Gomez,(unknown),Frank Kerrigan,Ian T.W. Matthews,Keith Menear,Niall M.B. Martin,Roger F. Newton,(unknown),Graeme C.M. Smith,(unknown),Alan J. Whittle	79
11	Phthalazinones 2: Optimisation and synthesis of novel potent inhibitors of poly(ADP-ribose)polymerase 2005 ·Bioorganic & Medicinal Chemistry Letters ·Xiaoling Cockcroft,(unknown),(unknown),(unknown),Frank Kerrigan,(unknown),Niall M.B. Martin,Keith Menear,Graeme C.M. Smith	70
12	the design and synthesis of thrombin inhibitors: the introduction of in vivo efficacy and oral bioavailability into benzthiazolylalanine inhibitors 2000 ·Bioorganic & Medicinal Chemistry Letters ·(unknown),Peter D. Kane,(unknown),(unknown),Keith Menear,Ric N. Price,Mark C. Allen,Xiaoling Cockcroft,John Ambler,Keith Butler,(unknown),(unknown),(unknown),Morris Tweed,(unknown)	9
13	Purification and Characterization of Human Syk Produced Using a Baculovirus Expression System 2000 ·Protein Expression and Purification ·(unknown),Brent Graham,Mohammed Shahid Akhlaq,Patrick Graff,Carol E. Jones,Keith Menear	9
14	The discovery of orally available thrombin inhibitors: Optimisation of the P1 pharmacophore 1999 ·Bioorganic & Medicinal Chemistry Letters ·John Ambler,David J. Bentley,(unknown),(unknown),(unknown),(unknown),(unknown),Keith Menear,(unknown),(unknown),Morris Tweed,Bernard Wathey	6
15	Studies towards the identification of potent, selective and bioavailable thrombin inhibitors 1999 ·Bioorganic & Medicinal Chemistry Letters ·John Ambler,Emma L. Baker,(unknown),(unknown),Keith Butler,Peter C. Butler,(unknown),(unknown),(unknown),(unknown),(unknown),Darryl Jones,Keith Menear,(unknown),(unknown),(unknown),Morris Tweed	6
16	Optimisation of the P2 pharmacophore in a series of thrombin inhibitors: Ion-dipole interactions with lysine 60G 1999 ·Bioorganic & Medicinal Chemistry Letters ·John Ambler,(unknown),Xiaoling Cockcroft,Markus G. Grütter,(unknown),(unknown),Darryl Jones,Peter D. Kane,Keith Menear,John P. Priestle,(unknown),(unknown),(unknown),Bernard Wathey	5
17	ChemInform Abstract: Progress Towards the Discovery of Orally Active Thrombin Inhibitors 1999 ·ChemInform ·Keith Menear	1
18	The Discovery of orally available thrombin inhibitors : Studies towards the optimisation of CGH1668 1998 ·Bioorganic & Medicinal Chemistry Letters ·John Ambler,Emma L. Baker,(unknown),Peter C. Butler,(unknown),(unknown),(unknown),(unknown),Darryl Jones,Keith Menear,(unknown),(unknown),(unknown),Morris Tweed	8
19	Studies on the uptake of low molecular weight monomeric tris-galactosyl conjugates by the rat liver 1992 ·Biochemical Pharmacology ·Hans‐Georg Eichler,Keith Menear,(unknown),J G Hastewell,Peter W. Taylor	3
20	An intramolecular Diels–Alder approach to forskolin 1984 ·Journal of the Chemical Society Chemical Communications ·Paul R. Jenkins,Keith Menear,Paul Barraclough,M. S. NOBBS	36

About Keith Menear

Keith Menear is a scholar working on Toxicology, Oncology and Hematology, having authored 32 papers that have together received 1.6k indexed citations. Recurring topics across this work include Cancer therapeutics and mechanisms (9 papers), DNA Repair Mechanisms (6 papers) and Bioactive Compounds and Antitumor Agents (5 papers). The work is most often cited by research in Oncology (778 citations), Molecular Biology (1.1k citations) and Organic Chemistry (393 citations). Keith Menear has collaborated with scholars based in United Kingdom, Switzerland and United States. Frequent co-authors include Niall M.B. Martin, Xiaoling Cockcroft, Graeme C.M. Smith, Sylvie Gomez, Mark J. O’Connor, Marc Hummersone, Frank Kerrigan, Mark Frigerio, Ian T.W. Matthews and Charlotte Knights. Their work appears in journals such as Blood, Cancer Research and Journal of Medicinal Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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