C. Peter Downes

31.0k total citations · 10 hit papers
196 papers, 26.5k citations indexed

About

C. Peter Downes is a scholar working on Molecular Biology, Cell Biology and Surgery. According to data from OpenAlex, C. Peter Downes has authored 196 papers receiving a total of 26.5k indexed citations (citations by other indexed papers that have themselves been cited), including 152 papers in Molecular Biology, 72 papers in Cell Biology and 30 papers in Surgery. Recurrent topics in C. Peter Downes's work include Protein Kinase Regulation and GTPase Signaling (99 papers), Cellular transport and secretion (60 papers) and PI3K/AKT/mTOR signaling in cancer (53 papers). C. Peter Downes is often cited by papers focused on Protein Kinase Regulation and GTPase Signaling (99 papers), Cellular transport and secretion (60 papers) and PI3K/AKT/mTOR signaling in cancer (53 papers). C. Peter Downes collaborates with scholars based in United Kingdom, United States and Canada. C. Peter Downes's co-authors include Michael J. Berridge, Michael R. Hanley, Nicholas R. Leslie, Dario R. Alessi, Robert H. Michell, Robin F. Irvine, Alexander Gray, Stephen R. James, Ian H. Batty and Piers R. J. Gaffney and has published in prestigious journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

C. Peter Downes

196 papers receiving 25.8k citations

Hit Papers

Characterization of a 3-phosphoinositide-dependent prote... 1981 2026 1996 2011 1997 1982 1983 1998 2004 500 1000 1.5k 2.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
    1997 2.3k citations Dario R. Alessi, Stephen R. James et al. Current Biology profile →
  2. Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands
    1982 1.9k citations C. Peter Downes et al. Biochemical Journal profile →
  3. Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides
    1983 1.8k citations C. Peter Downes et al. profile →
  4. The lipid phosphatase activity of PTEN is critical for its tumor supressor function
    1998 977 citations Ian Pass, Ian H. Batty et al. profile →
  5. The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins
    2004 916 citations Laura Harrington, Greg M. Findlay et al. The Journal of Cell Biology profile →
  6. Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate
    1988 872 citations C. Peter Downes et al. profile →
  7. Neural and developmental actions of lithium: A unifying hypothesis
    1989 831 citations C. Peter Downes et al. profile →
  8. The polyphosphoinositide phosphodiesterase of erythrocyte membranes
    1981 573 citations C. Peter Downes, Robert H. Michell Biochemical Journal profile →
  9. The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane
    1982 489 citations C. Peter Downes, Robert H. Michell et al. Biochemical Journal profile →
  10. Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilizing hormones
    1983 488 citations C. Peter Downes, Phillip T. Hawkins et al. Biochemical Journal profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
C. Peter Downes United Kingdom 77 19.3k 5.5k 3.7k 2.9k 2.8k 196 26.5k
Robin F. Irvine United Kingdom 76 21.2k 1.1× 7.5k 1.4× 5.7k 1.6× 3.7k 1.3× 3.7k 1.3× 223 31.0k
Enrique Rozengurt United Kingdom 99 22.2k 1.2× 5.2k 0.9× 5.2k 1.4× 2.5k 0.8× 3.3k 1.1× 504 32.9k
Peter J. Parker United Kingdom 95 25.3k 1.3× 7.6k 1.4× 3.0k 0.8× 3.0k 1.0× 1.5k 0.5× 406 33.7k
Ushio Kikkawa Japan 74 18.9k 1.0× 3.9k 0.7× 3.7k 1.0× 2.7k 0.9× 1.5k 0.5× 203 24.5k
Brian A. Hemmings Switzerland 102 33.2k 1.7× 7.2k 1.3× 3.0k 0.8× 3.0k 1.0× 2.4k 0.8× 313 42.4k
Jacopo Meldolesi Italy 81 15.6k 0.8× 4.8k 0.9× 6.8k 1.9× 2.6k 0.9× 2.5k 0.9× 323 23.8k
Joseph Avruch United States 95 29.1k 1.5× 8.6k 1.6× 2.0k 0.5× 3.2k 1.1× 2.4k 0.9× 189 38.2k
Michel Chrétien Canada 80 10.7k 0.6× 4.5k 0.8× 5.0k 1.4× 1.9k 0.6× 4.6k 1.6× 483 22.8k
George Thomas Switzerland 83 18.4k 1.0× 2.9k 0.5× 1.5k 0.4× 3.3k 1.1× 1.9k 0.7× 162 24.4k
Melanie H. Cobb United States 93 27.3k 1.4× 5.7k 1.0× 3.0k 0.8× 2.4k 0.8× 2.3k 0.8× 278 37.1k

Countries citing papers authored by C. Peter Downes

Since Specialization
Citations

This map shows the geographic impact of C. Peter Downes's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by C. Peter Downes with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites C. Peter Downes more than expected).

Fields of papers citing papers by C. Peter Downes

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by C. Peter Downes. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by C. Peter Downes. The network helps show where C. Peter Downes may publish in the future.

Co-authorship network of co-authors of C. Peter Downes

This figure shows the co-authorship network connecting the top 25 collaborators of C. Peter Downes. A scholar is included among the top collaborators of C. Peter Downes based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with C. Peter Downes. C. Peter Downes is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Hale, Benjamin G., Ian H. Batty, C. Peter Downes, & Richard E. Randall. (2007). Binding of Influenza A Virus NS1 Protein to the Inter-SH2 Domain of p85β Suggests a Novel Mechanism for Phosphoinositide 3-Kinase Activation. Journal of Biological Chemistry. 283(3). 1372–1380. 60 indexed citations
2.
Leslie, Nicholas R., et al.. (2004). PTEN M-CBR3, a Versatile and Selective Regulator of Inositol 1,3,4,5,6-Pentakisphosphate (Ins(1,3,4,5,6)P5). Journal of Biological Chemistry. 279(2). 1116–1122. 26 indexed citations
3.
Harrington, Laura, Greg M. Findlay, Alexander Gray, et al.. (2004). The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins. The Journal of Cell Biology. 166(2). 213–223. 916 indexed citations breakdown →
4.
Watt, Stephen A., Gursant Kular, Ian N. Fleming, C. Peter Downes, & John M. Lucocq. (2002). Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C δ1. Biochemical Journal. 363(3). 657–657. 302 indexed citations
5.
Patel, Lisa, et al.. (2001). Tumor suppressor and anti-inflammatory actions of PPARγ agonists are mediated via upregulation of PTEN. Current Biology. 11(10). 764–768. 312 indexed citations
6.
DOWLER, Simon, A Currie, Mária Deák, et al.. (2000). Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Biochemical Journal. 351(1). 19–19. 453 indexed citations
7.
8.
9.
Tang, Xiuwen & C. Peter Downes. (1997). Purification and Characterization of Gβγ-responsive Phosphoinositide 3-Kinases from Pig Platelet Cytosol. Journal of Biological Chemistry. 272(22). 14193–14199. 68 indexed citations
10.
Kaay, Jeroen van der, Ian H. Batty, Darren A.E. Cross, P. Watt, & C. Peter Downes. (1997). A Novel, Rapid, and Highly Sensitive Mass Assay for Phosphatidylinositol 3,4,5-Trisphosphate (PtdIns(3,4,5)P3) and Its Application to Measure Insulin-stimulated PtdIns(3,4,5)P3 Production in Rat Skeletal Muscle in Vivo. Journal of Biological Chemistry. 272(9). 5477–5481. 37 indexed citations
11.
Alessi, Dario R., Stephen R. James, C. Peter Downes, et al.. (1997). Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. Current Biology. 7(4). 261–269. 2349 indexed citations breakdown →
12.
Nicholls, David G., et al.. (1996). Characterization of the Effects of Lithium and Inositol on Phosphoinositide Turnover in Cerebellar Granule Cells in Primary Culture. Journal of Neurochemistry. 66(2). 517–524. 12 indexed citations
13.
Baxter, Ruth, Philip Cohen, Axel Obermeier, et al.. (1995). Phosphotyrosine Residues in the Nerve‐Growth‐Factor Receptor (Trk‐A). European Journal of Biochemistry. 234(1). 84–91. 47 indexed citations
14.
Nicholls, David G., et al.. (1994). Involvement of Calcium Influx in Muscarinic Cholinergic Regulation of Phospholipase C in Cerebellar Granule Cells. Journal of Neurochemistry. 63(2). 535–543. 31 indexed citations
15.
Estévez, Francisco, et al.. (1994). Inositol trisphosphate metabolism in Saccharomyces cerevisiae: identification, purification and properties of inositol 1,4,5-trisphosphate 6-kinase. Biochemical Journal. 302(3). 709–716. 25 indexed citations
16.
Downes, C. Peter, et al.. (1991). Phosphoinositide 3-kinase: A new effector in signal transduction?. Cellular Signalling. 3(6). 501–513. 148 indexed citations
17.
Macphee, Colin H., et al.. (1991). Chemotactic Peptides but not Macrophage Colony Stimulating Factor Effect the Synthesis of Inositol Lipids in Macrophages. Growth Factors. 4(3). 175–181. 2 indexed citations
18.
Harden, T. Kendall, Andrew J. Morris, Gary L. Waldo, C. Peter Downes, & José L. Boyer. (1991). Avian G-protein-regulated phospholipase C. Biochemical Society Transactions. 19(2). 342–346. 4 indexed citations
19.
Michell, Robert H., Alan H. Drummond, & C. Peter Downes. (1989). Inositol lipids in cell signalling.. Academic Press eBooks. 182 indexed citations
20.
Stephens, Len, Phillip T. Hawkins, Christopher J. Barker, & C. Peter Downes. (1988). Synthesis of myo-inositol 1,3,4,5,6-pentakisphosphate from inositol phosphates generated by receptor activation. Biochemical Journal. 253(3). 721–733. 106 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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