Eric B. Springman

1.5k citations

25 papers · 1.1k indexed · 1 hit paper · h-index 15

Impact in

Cancer Research top 5%
- Protease and Inhibitor Mechanisms
Hematology top 5%
- Blood Coagulation and Thrombosis Mechanisms

Papers in ⓘ

Molecular Biology 9
- Melanoma and MAPK Pathways 6
Genetics 7
- Coagulation, Bradykinin, Polyphosphates, and Angioedema 7

Co-authors: Harold E. Van Wart (3 shared papers)Henning Birkedal‐Hansen (2 shared papers)Eddie L. Angleton (1 shared paper)Marina Bukhtiyarova (8 shared papers)Michael Karpusas (5 shared papers)David J. Casper (2 shared papers)W E Serafin (2 shared papers)B.A. Katz (2 shared papers)
Journals: Bioorganic & Medicinal Chemistry Letters (5 papers)Journal of Biological Chemistry (3 papers)Journal of Cystic Fibrosis (3 papers)Biochemistry (3 papers)Contemporary Clinical Trials (2 papers)
Partner nations: United States United Kingdom Switzerland

In The Last Decade

Eric B. Springman

23 papers receiving 1.1k citations

Hit Papers

align trajectories log scale

Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation. 1990 · 577 citations

Peers

Countries citing papers authored by Eric B. Springman

Since Specialization

Citations

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Fields of papers citing papers by Eric B. Springman

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Eric B. Springman. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Eric B. Springman. The network helps show where Eric B. Springman may publish in the future.

Co-authors

The 25 scholars most cited alongside Eric B. Springman, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Eric B. Springman Line = papers co-authored together Eric B. Springman links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

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#	Work
1	Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation. Proceedings of the National Academy of Sciences ·Eric B. Springman, Eddie L. Angleton, Henning Birkedal‐Hansen, Harold E. Van Wart Hit paper breakdown →	1990	577
2	Expression, Crystallization, and Three-dimensional Structure of the Catalytic Domain of Human Plasma Kallikrein Journal of Biological Chemistry ·Jie Tang, Christine Yu, Steven R. Williams, Eric B. Springman, Douglas A. Jeffery, Paul A. Sprengeler, Alberto Estevez, Jun Sampang, William D. Shrader, Jeff Spencer, Wendy B. Young, Mary E. McGrath, B.A. Katz	2005	60
3	Analysis of Imatinib and Sorafenib Binding to p38α Compared with c-Abl and b-Raf Provides Structural Insights for Understanding the Selectivity of Inhibitors Targeting the DFG-Out Form of Protein Kinases Biochemistry ·H.V.M. Namboodiri, Marina Bukhtiyarova, Joseph Ramcharan, Michael Karpusas, Younghee Lee, Eric B. Springman	2010	58
4	A Biacore biosensor method for detailed kinetic binding analysis of small molecule inhibitors of p38α mitogen-activated protein kinase Analytical Biochemistry ·David J. Casper, Marina Bukhtiyarova, Eric B. Springman	2003	50
5	Crystal structure of recombinant human tissue kallikrein at 2.0 Å resolution Protein Science ·B.A. Katz, Beishan Liu, Micael Barnes, Eric B. Springman	1998	43
6	Improved expression, purification, and crystallization of p38α MAP kinase Protein Expression and Purification ·Marina Bukhtiyarova, Katrina Northrop, Xiaomei Chai, David J. Casper, Michael Karpusas, Eric B. Springman	2004	39
7	Processing of procarboxypeptidase A and other zymogens in murine mast cells. Journal of Biological Chemistry ·M.M. Dikov, Eric B. Springman, Suresh Yeola, W E Serafin	1994	37
8	Mutagenesis of p38α MAP Kinase Establishes Key Roles of Phe169 in Function and Structural Dynamics and Reveals a Novel DFG-OUT State Biochemistry ·Marina Bukhtiyarova, Michael Karpusas, Katrina Northrop, H.V.M. Namboodiri, Eric B. Springman	2007	34
9	Two classes of p38α MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes Bioorganic & Medicinal Chemistry Letters ·Enrique L. Michelotti, Kristofer K. Moffett, Duyan Nguyen, Martha J. Kelly, Rupa Shetty, Xiaomei Chai, Katrina Northrop, Variketta Namboodiri, Brandon Campbell, Gary A. Flynn, Ted Fujimoto, Frank P. Hollinger, Marina Bukhtiyarova, Eric B. Springman, Michael Karpusas	2005	29
10	EMPIRE-CF: A phase II randomized placebo-controlled trial of once-daily, oral acebilustat in adult patients with cystic fibrosis – Study design and patient demographics Contemporary Clinical Trials ·J.S. Elborn, Sanjeev Ahuja, Eric B. Springman, John L. Mershon, Ralph Grosswald, Steven M. Rowe	2018	25
11	Discovery of a novel class of non-ATP site DFG-out state p38 inhibitors utilizing computationally assisted virtual fragment-based drug design (vFBDD) Bioorganic & Medicinal Chemistry Letters ·Kristofer K. Moffett, Zenon Konteatis, Duyan Nguyen, Rupa Shetty, Jennifer L. Ludington, Ted Fujimoto, Kyoung‐Jin Lee, Xiaomei Chai, H.V.M. Namboodiri, Michael Karpusas, Bruce D. Dorsey, Frank Guarnieri, Marina Bukhtiyarova, Eric B. Springman, Enrique L. Michelotti	2011	24
12	Mast Cell Procarboxypeptidase A Journal of Biological Chemistry ·Eric B. Springman, M.M. Dikov, W E Serafin	1995	21
13	Discovery and SAR of a series of 4,6-diamino-1,3,5-triazin-2-ol as novel non-nucleoside reverse transcriptase inhibitors of HIV-1 Bioorganic & Medicinal Chemistry Letters ·Bin Liu, Younghee Lee, Jinming Zou, H. Michael Petrassi, Rhoda W. Joseph, Wenchun Chao, Enrique L. Michelotti, Marina Bukhtiyarova, Eric B. Springman, Bruce D. Dorsey	2010	17
14	Zinc Content and Function in Human Fibroblast Collagenase Biochemistry ·Eric B. Springman, Hideaki Nagase, Henning Birkedal‐Hansen, Harold E. Van Wart	1995	16
15	Expression and Characterization of Human Tissue Kallikrein Variants Protein Expression and Purification ·Hedy Chan, Eric B. Springman, James M. Clark	1998	14
16	Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-Proteinase. Part 2: Solid-Phase optimization of side chains Bioorganic & Medicinal Chemistry Letters ·Sharon M. Dankwardt, Sarah C. Abbot, Chris A. Broka, Robert L. Martin, Christine Chan, Eric B. Springman, Harold E. Van Wart, Keith A. M. Walker	2002	12
17	Structure-based design of substituted biphenyl ethylene ethers as ligands binding in the hydrophobic pocket of gp41 and blocking the helical bundle formation Bioorganic & Medicinal Chemistry Letters ·Bin Liu, Rhoda W. Joseph, Bruce D. Dorsey, Robert A. Schiksnis, Katrina Northrop, Marina Bukhtiyarova, Eric B. Springman	2009	12
18	Distinct compartmentalization of immune cells and mediators characterizes bullous pemphigoid disease Experimental Dermatology ·Camilla Margaroli, Bridget Bradley, Cecilia Thompson, Milton R. Brown, Vincent D. Giacalone, L. Bhatt, Benjamin K. Stoff, Sanjeev Ahuja, Eric B. Springman, Rabindra Tirouvanziam, Ron J. Feldman	2020	12
19	Empire-CF study: A phase 2 clinical trial of leukotriene A4 hydrolase inhibitor acebilustat in adult subjects with cystic fibrosis Journal of Cystic Fibrosis ·J.S. Elborn, Michael W. Konstan, Jennifer L. Taylor‐Cousar, Isabelle Fajac, Alex Horsley, Sivagurunathan Sutharsan, Shawn D. Aaron, Cori Daines, Ahmet Uluer, D.G. Downey, V. Lucidi, Sanjeev Ahuja, Eric B. Springman, John L. Mershon, Ralph Grosswald, Steven M. Rowe	2021	11
20	Antiangiogenic and antitumor activity of LP-261, a novel oral tubulin binding agent, alone and in combination with bevacizumab Investigational New Drugs ·Erin R. Gardner, Martha J. Kelly, Eric B. Springman, Lee Kyoung-jin, Haiqing Li, William R. Moore, William D. Figg	2010	4

About Eric B. Springman

Eric B. Springman is a scholar working on Molecular Biology, Genetics, Organic Chemistry, Oncology and Pulmonary and Respiratory Medicine, having authored 25 papers that have together received 1.1k indexed citations. Recurring topics across this work include Coagulation, Bradykinin, Polyphosphates, and Angioedema (7 papers), Melanoma and MAPK Pathways (6 papers), Peptidase Inhibition and Analysis (4 papers), Cystic Fibrosis Research Advances (4 papers), Computational Drug Discovery Methods (4 papers), Oral and gingival health research (2 papers), Urticaria and Related Conditions (2 papers) and Synthesis and biological activity (2 papers). The work is most often cited by research in Cancer Research (434 citations), Hematology (234 citations), Immunology and Allergy (86 citations), Genetics (142 citations) and Oncology (348 citations). Eric B. Springman has collaborated with scholars based in United States, United Kingdom and Switzerland. Frequent co-authors include Harold E. Van Wart, Henning Birkedal‐Hansen, Eddie L. Angleton, Marina Bukhtiyarova, Michael Karpusas, David J. Casper, W E Serafin, B.A. Katz, Younghee Lee and Beishan Liu. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Journal of Biological Chemistry, Journal of Cystic Fibrosis, Biochemistry and Contemporary Clinical Trials.

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