Ellen M. Dobrusin

1.9k citations

24 papers · 1.5k indexed · h-index 16

Oncology top 5%
- Cancer-related Molecular Pathways 7
- HER2/EGFR in Cancer Research 4
Organic Chemistry top 5%
- Quinazolinone synthesis and applications 5
- Synthesis and biological activity 4
Molecular Biology top 10%
- Protein Kinase Regulation and GTPase Signaling 5
- Protein Tyrosine Phosphatases 4
- Cancer therapeutics and mechanisms 4
Toxicology top 10%
Immunology
Pathology and Forensic Medicine
- Cancer Mechanisms and Therapy 3

Co-authors: Dennis J. McNamara David W. Fry William A. Denny Paul R. Keller Wilbur R. Leopold Jeff B. Smaill Z.Y. Zhang Derek Maclean
Cited by: Oncology Organic Chemistry Molecular Biology
Journals: Proceedings of the National Academy of Sciences (2 papers)Journal of Biological Chemistry (3 papers)Biochemistry (1 paper)
Partner nations: United States New Zealand United Kingdom

In The Last Decade

Ellen M. Dobrusin

24 papers receiving 1.5k citations

Peers

Countries citing papers authored by Ellen M. Dobrusin

Since Specialization

Citations

This map shows the geographic impact of Ellen M. Dobrusin's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ellen M. Dobrusin with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ellen M. Dobrusin more than expected).

Fields of papers citing papers by Ellen M. Dobrusin

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ellen M. Dobrusin. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ellen M. Dobrusin. The network helps show where Ellen M. Dobrusin may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Ellen M. Dobrusin, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Ellen M. Dobrusin Line = papers co-authored together Ellen M. Dobrusin links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Inhibition of binding of phospholipase Cγ1 SH2 domains to phosphorylated epidermal growth factor receptor by phosphorylated peptides International journal of peptide & protein research ·Dennis J. McNamara,Ellen M. Dobrusin,Guochang Zhu,Stuart J. Decker,Alan R. Saltiel	2009	1
2	Synthesis and structure–activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases European Journal of Medicinal Chemistry ·Jeff B. Smaill,Edward N. Baker,R J Booth,Alexander J. Bridges,James M. Dickson,Ellen M. Dobrusin,Ivan Ivanović,Alan J. Kraker,Ho H. Lee,Elizabeth A. Lunney,Daniel F. Ortwine,Brian D. Palmer,John Quin,C.J. Squire,Andrew M. Thompson,William A. Denny	2007	28
3	Structure–activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1 Bioorganic & Medicinal Chemistry Letters ·Brian D. Palmer,Jeff B. Smaill,Gordon W. Rewcastle,Ellen M. Dobrusin,Alan J. Kraker,Charles Watson Moore,Randall W. Steinkampf,William A. Denny	2005	54
4	2-Aminoquinazoline inhibitors of cyclin-dependent kinases Bioorganic & Medicinal Chemistry Letters ·Yadagiri Bathini,Inderjit Singh,Patricia J. Harvey,Paul R. Keller,Rajeshwar Singh,Ronald G. Micetich,David W. Fry,Ellen M. Dobrusin,Peter L. Toogood	2005	20
5	Pyrido[2,3-d]pyrimidin-7-ones as Specific Inhibitors of Cyclin-Dependent Kinase 4 Journal of Medicinal Chemistry ·Scott N. VanderWel,Patricia J. Harvey,Dennis J. McNamara,Joseph T. Repine,Paul R. Keller,John Quin,R J Booth,William L. Elliott,Ellen M. Dobrusin,David W. Fry,Peter L. Toogood	2005	121
6	Synthesis and SAR development of PD 0325901, a potent and highly bioavailable MEK inhibitor. Cancer Research ·Michael D. Kaufman,Stephen D. Barrett,Cathlin Flamme,Joseph S. Warmus,Yvonne Smith,Manoj Cheriyan,Luyan Zhang,Haile Tecle,Judith S. Sebolt–Leopold,Heather Valik,Richard Gowan,Keri Van Becelaere,Ronald L. Merriman,Sally Przybranowski,Jeffrey F. Ohren,Christopher E. Whitehead,Wilbur R. Leopold,Ellen M. Dobrusin,Alexander J. Bridges	2004	1
7	Cell Cycle and Biochemical Effects of PD 0183812 Journal of Biological Chemistry ·David W. Fry,David C. Bedford,Patricia H. Harvey,Alexandra Fritsch,Paul R. Keller,Zhipei Wu,Ellen M. Dobrusin,Wilbur R. Leopold,Ali Fattaey,Michelle D. Garrett	2001	90
8	Pyrido[2,3-d]pyrimidin-7-one Inhi-bitors of Cyclin-Dependent Kinases. Journal of Medicinal Chemistry ·Mark R. Barvian,Diane H. Boschelli,Jennifer Cossrow,Ellen M. Dobrusin,Ali Fattaey,Alex Fritsch,David W. Fry,Patricia J. Harvey,Paul R. Keller,Michelle D. Garrett,Frances La,Wilbur R. Leopold,Dennis J. McNamara,Maire Quin,Susanne Trumpp-Kallmeyer,Peter L. Toogood,Zhipei Wu,Erli Zhang	2001	2
9	Pyrido[2,3-d]pyrimidin-7-one Inhibitors of Cyclin-Dependent Kinases Journal of Medicinal Chemistry ·Mark R. Barvian,Diane H. Boschelli,Jennifer Cossrow,Ellen M. Dobrusin,Ali Fattaey,Alex Fritsch,David W. Fry,Patricia J. Harvey,Paul R. Keller,Michelle D. Garrett,Frances La,Wilbur R. Leopold,Dennis J. McNamara,Maire Quin,Susanne Trumpp-Kallmeyer,Peter L. Toogood,Zhipei Wu,Erli Zhang	2000	130
10	Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor Proceedings of the National Academy of Sciences ·David W. Fry,Alexander J. Bridges,William A. Denny,Annette M. Doherty,Kenneth D. Greis,James L. Hicks,Kenneth E. Hook,Paul R. Keller,Wilbur R. Leopold,Joseph A. Loo,Dennis J. McNamara,James M. Nelson,Veronika Sherwood,Jeff B. Smaill,Susanne Trumpp-Kallmeyer,Ellen M. Dobrusin	1998	344
11	Structure-Based Design of a Potent, Selective, and Irreversible Inhibitor of the Catalytic Domain of the erbB Receptor Subfamily of Protein Tyrosine Kinases Journal of Medicinal Chemistry ·Juswinder Singh,Ellen M. Dobrusin,David W. Fry,Taraneh Haske,Adrian Whitty,Dennis J. McNamara	1997	89
12	C-Terminal Modifications of Histidyl-N-benzylglycinamides To Give Improved Inhibition of Ras Farnesyltransferase, Cellular Activity, and Anticancer Activity in Mice Journal of Medicinal Chemistry ·Dennis J. McNamara,Ellen M. Dobrusin,Daniele M. Leonard,Kevon R. Shuler,James S. Kaltenbronn,John Quin,Scott K. Bur,C. Thomas,Annette M. Doherty,Jeffrey D. Scholten,Karen K. Zimmerman,Barbara S. Gibbs,Richard Gowan,Michael P. Latash,Wilbur R. Leopold,Sally Przybranowski,Judith S. Sebolt–Leopold	1997	20
13	Determinants of Substrate Recognition in the Protein-tyrosine Phosphatase, PTP1 Journal of Biological Chemistry ·Zhong-Yin Zhang,Amy B. Walsh,Li Wu,Dennis J. McNamara,Ellen M. Dobrusin,W. Todd Miller	1996	26
14	Differentiation of peptide molecular recognition by phospholipase Cγ‐1 Src homology‐2 domain and a mutant Tyr phosphatase PTP1b^C215S Protein Science ·Derek Maclean,Andrea M. Sefler,Guochang Zhu,Stuart J. Decker,Alan R. Saltiel,Juswinder Singh,Dennis J. McNamara,Ellen M. Dobrusin,Tomi K. Sawyer	1995	2
15	Design of a potent peptide inhibitor of the epidermal growth factor receptor tyrosine kinase utilizing sequences based on the natural phosphorylation sites of phospholipase C-γ1 Peptides ·David W. Fry,Amy McMichael,Juswinder Singh,Ellen M. Dobrusin,Dennis J. McNamara	1994	14
16	Tyrosine Kinase Inhibitors. 3. Structure-Activity Relationships for Inhibition of Protein Tyrosine Kinases by Nuclear-Substituted Derivatives of 2,2'-Dithiobis(1-methyl-N-phenyl-1H-indole-3-carboxamide) Journal of Medicinal Chemistry ·Gordon W. Rewcastle,Brian D. Palmer,Ellen M. Dobrusin,David W. Fry,A J Kraker,William A. Denny	1994	28
17	ChemInform Abstract: Tyrosine Kinase Inhibitors. Part 3. Structure‐Activity Relationships for Inhibition of Protein Tyrosine Kinases by Nuclear‐Substituted Derivatives of 2,2′‐Dithiobis(1‐methyl‐N‐phenyl‐1H‐indole‐3‐ carboxamide). ChemInform ·Gordon W. Rewcastle,Brian D. Palmer,Ellen M. Dobrusin,David W. Fry,A. J. Kraker,William A. Denny	1994	3
18	Identification of Amino Acids in the N-Terminal SH2 Domain of Phospholipase C.gamma.1 Important in the Interaction with Epidermal Growth Factor Receptor Biochemistry ·James R. Gergel,Dennis J. McNamara,Ellen M. Dobrusin,Guochang Zhu,Alan R. Saltiel,W. Todd Miller	1994	15
19	Tyrosine kinase inhibitors. 1. Structure-activity relationships for inhibition of epidermal growth factor receptor tyrosine kinase activity by 2,3-dihydro-2-thioxo-1H-indole-3-alkanoic acids and 2,2'-dithiobis(1H-indole-3-alkanoic acids) Journal of Medicinal Chemistry ·Andrew M. Thompson,Gordon W. Rewcastle,Moana Tercel,Ellen M. Dobrusin,David W. Fry,Alan J. Kraker,William A. Denny	1993	30
20	Sequence specificity in recognition of the epidermal growth factor receptor by protein tyrosine phosphatase 1B. Journal of Biological Chemistry ·Kim Milarski,Guodong Zhu,Carson Pearl,Dennis J. McNamara,Ellen M. Dobrusin,Derek Maclean,Andrea M. Thieme-Sefler,Z.Y. Zhang,Tomi K. Sawyer,Stuart J. Decker	1993	89

About Ellen M. Dobrusin

Ellen M. Dobrusin is a scholar working on Oncology, Organic Chemistry and Immunology and Allergy, having authored 24 papers that have together received 1.5k indexed citations. Recurring topics across this work include Cancer-related Molecular Pathways (7 papers), Quinazolinone synthesis and applications (5 papers), Protein Kinase Regulation and GTPase Signaling (5 papers), Synthesis and biological activity (4 papers), Protein Tyrosine Phosphatases (4 papers), Cancer therapeutics and mechanisms (4 papers), HER2/EGFR in Cancer Research (4 papers) and Cancer Mechanisms and Therapy (3 papers). The work is most often cited by research in Oncology (608 citations), Organic Chemistry (513 citations) and Molecular Biology (893 citations). Ellen M. Dobrusin has collaborated with scholars based in United States, New Zealand and United Kingdom. Frequent co-authors include Dennis J. McNamara, David W. Fry, William A. Denny, Paul R. Keller, Wilbur R. Leopold, Jeff B. Smaill, Z.Y. Zhang, Derek Maclean, Tomi K. Sawyer and Alexander J. Bridges. Their work appears in journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Biochemistry.

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