Patrick A. Plé

1.9k citations

30 papers · 1.5k indexed · h-index 17

Impact in

Organic Chemistry top 5%
- Quinazolinone synthesis and applications
- Synthesis and biological activity
Oncology top 10%
- HER2/EGFR in Cancer Research

Papers in ⓘ

Transplantation 2
Toxicology 2

Co-authors: Laurent Hennequin (14 shared papers)Jon Curwen (7 shared papers)Christine Lambert‐van der Brempt (9 shared papers)Gerard Costello (6 shared papers)J M Allen (4 shared papers)Tim P. Green (3 shared papers)Stephen R. Wedge (3 shared papers)Elaine S. E. Stokes (3 shared papers)
Journals: Bioorganic & Medicinal Chemistry Letters (8 papers)Journal of Medicinal Chemistry (6 papers)Tetrahedron (3 papers)Cancer Research (2 papers)Molecular Oncology (1 paper)
Partner nations: United Kingdom France United States

In The Last Decade

Patrick A. Plé

30 papers receiving 1.5k citations

Peers

Countries citing papers authored by Patrick A. Plé

Since Specialization

Citations

This map shows the geographic impact of Patrick A. Plé's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Patrick A. Plé with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Patrick A. Plé more than expected).

Fields of papers citing papers by Patrick A. Plé

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Patrick A. Plé. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Patrick A. Plé. The network helps show where Patrick A. Plé may publish in the future.

Co-authors

The 25 scholars most cited alongside Patrick A. Plé, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Patrick A. Plé Line = papers co-authored together Patrick A. Plé links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 30 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a Novel, Highly Selective, Orally Available, Dual-Specific c-Src/Abl Kinase Inhibitor Journal of Medicinal Chemistry ·Laurent Hennequin, J M Allen, J. Breed, Jon Curwen, Michael Fennell, Tim P. Green, Christine Lambert‐van der Brempt, Rémy Morgentin, Richard A. Norman, Annie Olivier, Ludovic R. Otterbein, Patrick A. Plé, Nicolas Warin, Gerard Costello	2006	283
2	Novel 4-Anilinoquinazolines with C-7 Basic Side Chains: Design and Structure Activity Relationship of a Series of Potent, Orally Active, VEGF Receptor Tyrosine Kinase Inhibitors Journal of Medicinal Chemistry ·Laurent Hennequin, Elaine S. E. Stokes, Andrew P. Thomas, Craig Johnstone, Patrick A. Plé, Donald Ogilvie, Michael Dukes, Stephen R. Wedge, Jane Kendrew, Jon Curwen	2002	254
3	Design and Structure−Activity Relationship of a New Class of Potent VEGF Receptor Tyrosine Kinase Inhibitors Journal of Medicinal Chemistry ·Laurent Hennequin, Andrew P. Thomas, Craig Johnstone, Elaine S. E. Stokes, Patrick A. Plé, Jean-Jacques M. Lohmann, Donald Ogilvie, Mike Dukes, Stephen R. Wedge, Jon Curwen, Jane Kendrew, Christine Lambert‐van der Brempt	1999	195
4	Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530 Molecular Oncology ·Tim P. Green, Mike Fennell, Robin Whittaker, Jon Curwen, Vivien N. Jacobs, J M Allen, Armelle Logié, Judith Hargreaves, D. Mark Hickinson, Robert W. Wilkinson, Paul Elvin, Brigitte Boyer, Neil O. Carragher, Patrick A. Plé, Alun Bermingham, Geoffrey A. Holdgate, Walter H.J. Ward, Laurent Hennequin, Barry R. Davies, Gerard Costello	2009	176
5	Discovery of a New Class of Anilinoquinazoline Inhibitors with High Affinity and Specificity for the Tyrosine Kinase Domain of c-Src Journal of Medicinal Chemistry ·Patrick A. Plé, Tim P. Green, Laurent Hennequin, Jon Curwen, Michael Fennell, J M Allen, Christine Lambert‐van der Brempt, Gerard Costello	2004	139
6	Discovery of (R)-8-(1-(3,5-Difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (AZD8186): A Potent and Selective Inhibitor of PI3Kβ and PI3Kδ for the Treatment of PTEN-Deficient Cancers Journal of Medicinal Chemistry ·Bernard Barlaam, Sabina Cosulich, Sébastien L. Degorce, Martina Fitzek, Stephen Green, Urs J. Hancox, Christine Lambert‐van der Brempt, Jean‐Jacques Lohmann, Mickaël Maudet, Rémy Morgentin, Marie‐Jeanne Pasquet, Aurélien Peru, Patrick A. Plé, Twana Saleh, Michel Vautier, Mike Walker, Lara Ward, Nicolas Warin	2014	66
7	Glucuronidation associated with intrinsic resistance to mycophenolic acid in human colorectal carcinoma cells. PubMed ·T. J. Franklin, Vivien N. Jacobs, Geraint Jones, Patrick A. Plé, P. Bruneau	1996	49
8	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases Bioorganic & Medicinal Chemistry Letters ·Patrick A. Plé, Frédéric Jung, Sue Ashton, Laurent Hennequin, Romuald Lainé, Rémy Morgentin, Georges Pasquet, Sian Taylor	2011	44
9	Investigation of (E)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators Journal of Medicinal Chemistry ·Sébastien L. Degorce, Andrew Bailey, Rowena Callis, Chris De Savi, Richard Ducray, Gillian M. Lamont, Philip A. MacFaul, Mickaël Maudet, Scott Martin, Rémy Morgentin, Richard A. Norman, Aurélien Peru, Jennifer H. Pink, Patrick A. Plé, Bryan Roberts, James S. Scott	2015	37
10	Enantioselective syntheses of (+)- and (–)-conduritol C from benzene via microbial oxidation and enzymatic asymmetrization Journal of the Chemical Society Chemical Communications ·Carl R. Johnson, Patrick A. Plé, Joseph P. Adams	1991	36
11	Enantioselective Syntheses of Conduramines from Benzene by Microbial Oxidation, Enzymatic Asymmetrization and Resolution in Organic Media Synlett ·Carl R. Johnson, Patrick A. Plé, Lin Su, Mary Jane Heeg, Joseph P. Adams	1992	27
12	Inhibitors of the tyrosine kinase EphB4. Part 4: Discovery and optimization of a benzylic alcohol series Bioorganic & Medicinal Chemistry Letters ·Bernard Barlaam, Richard Ducray, Christine Lambert‐van der Brempt, Patrick A. Plé, Catherine Bardelle, Nigel Brooks, Tanya Coleman, Darren A.E. Cross, Jason G. Kettle, Jon Read	2011	26
13	New heterocyclic analogues of 4-(2-chloro-5-methoxyanilino)quinazolines as potent and selective c-Src kinase inhibitors Bioorganic & Medicinal Chemistry Letters ·Bernard Barlaam, Mike Fennell, Hervé Germain, Tim Green, Laurent Hennequin, Rémy Morgentin, Annie Olivier, Patrick A. Plé, Michel Vautier, Gerard Costello	2005	23
14	Human colorectal carcinoma cells in vitro as a means to assess the metabolism of analogs of mycophenolic acid. PubMed ·T. J. Franklin, Vivien N. Jacobs, Geraint Jones, Patrick A. Plé	1997	22
15	A convergent synthesis of Mycophenolic acid Tetrahedron ·Patrick A. Plé, A. Hamon, Geraint Jones	1997	22
16	Discovery of 9-(1-anilinoethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours Bioorganic & Medicinal Chemistry Letters ·Bernard Barlaam, Sabina Cosulich, Sébastien L. Degorce, Martina Fitzek, Fabrizio Giordanetto, Stephen Green, Tord Inghardt, Laurent Hennequin, Urs J. Hancox, Christine Lambert‐van der Brempt, Rémy Morgentin, Sarah L. Pass, Patrick A. Plé, Twana Saleh, Lara Ward	2014	17
17	An efficient large-scale synthesis of alkyl 5-hydroxy-pyridin- and pyrimidin-2-yl acetate Tetrahedron ·Rémy Morgentin, Frédéric Jung, Maryannick Lamorlette, Mickaël Maudet, Morgan Ménard, Patrick A. Plé, Georges Pasquet, Fabrice G. Renaud	2008	17
18	The discovery of AZD0530: a novel, oral, highly selective and dual-specific inhibitor of the Src and Abl family kinases Cancer Research ·Laurent Hennequin, Jeffrey C. Allen, Gerard Costello, Michael Fennell, T. P. Green, V. R. Jacobs, Rémy Morgentin, A. Olivier, Patrick A. Plé	2005	16
19	Strategic studies in the syntheses of novel 6,7-substituted quinolones and 7- or 6-substituted 1,6- and 1,7-naphthyridones Tetrahedron ·Rémy Morgentin, Georges Pasquet, Pascal Boutron, Frédéric Jung, Maryannick Lamorlette, Mickaël Maudet, Patrick A. Plé	2008	15
20	Glucuronidation by human colorectal adenocarcinoma cells as a mechanism of resistance to mycophenolic acid Advances in Enzyme Regulation ·Trevor Franklin, Vivien N. Jacobs, Pierre Bruneau, Patrick A. Plé	1995	13

About Patrick A. Plé

Patrick A. Plé is a scholar working on Transplantation, Toxicology, Hematology, Organic Chemistry and Physiology, having authored 30 papers that have together received 1.5k indexed citations. Recurring topics across this work include PI3K/AKT/mTOR signaling in cancer (9 papers), Quinazolinone synthesis and applications (7 papers), Biochemical and Molecular Research (7 papers), Chronic Myeloid Leukemia Treatments (5 papers), Protein Kinase Regulation and GTPase Signaling (5 papers), HER2/EGFR in Cancer Research (3 papers), Angiogenesis and VEGF in Cancer (3 papers) and Cytokine Signaling Pathways and Interactions (2 papers). The work is most often cited by research in Organic Chemistry (572 citations), Oncology (445 citations), Molecular Biology (877 citations), Toxicology (39 citations) and Hematology (124 citations). Patrick A. Plé has collaborated with scholars based in United Kingdom, France and United States. Frequent co-authors include Laurent Hennequin, Jon Curwen, Christine Lambert‐van der Brempt, Gerard Costello, J M Allen, Tim P. Green, Stephen R. Wedge, Elaine S. E. Stokes, Craig Johnstone and Jane Kendrew. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Journal of Medicinal Chemistry, Tetrahedron, Cancer Research and Molecular Oncology.

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