Ellen I. Closs

11.8k citations

95 papers · 9.6k indexed · 4 hit papers · h-index 45

Impact in

Biochemistry top 0.05%
- Amino Acid Enzymes and Metabolism
Physiology top 0.5%
- Nitric Oxide and Endothelin Effects

Papers in

Biochemistry 48
- Amino Acid Enzymes and Metabolism 44
Clinical Biochemistry 9
- Metabolism and Genetic Disorders 9

Co-authors: Ulrich Förstermann James M. Cunningham Alice Habermeier Ursula Martiné Ingolf Gath Petra Schwarz Hartmut Kleinert Suvendra N. Bhattacharyya
Journals: Journal of Biological Chemistry (8 papers)Amino Acids (5 papers)British Journal of Pharmacology (4 papers)Biochemical Journal (4 papers)Frontiers in Immunology (3 papers)
Partner nations: Germany United States Switzerland

In The Last Decade

Ellen I. Closs

95 papers receiving 9.4k citations

Hit Papers

align trajectories log scale

Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages 2014 · 947 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2014 Frontiers in Immunology
2006 Cell
2004 Pflügers Archiv - European Journal of Physiology
1994 Hypertension

Peers

Countries citing papers authored by Ellen I. Closs

Since Specialization

Citations

This map shows the geographic impact of Ellen I. Closs's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ellen I. Closs with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ellen I. Closs more than expected).

Fields of papers citing papers by Ellen I. Closs

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ellen I. Closs. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ellen I. Closs. The network helps show where Ellen I. Closs may publish in the future.

Co-authors

The 25 scholars most cited alongside Ellen I. Closs, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Ellen I. Closs Line = papers co-authored together Ellen I. Closs links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	B Lymphocyte-Deficiency in Mice Causes Vascular Dysfunction by Inducing Neutrophilia Biomedicines ·Ning Xia, Solveig Hasselwander, Gisela Reifenberg, Alice Habermeier, Ellen I. Closs, Hai‐Yun Fan, 吉則小澤, Susanne Karbach, Jérémy Lagrange, Philip Wenzel, Andreas Daiber, Thomas Münzel, Nadine Hövelmeyer, Ari Waisman, Huige Li	2021	7
2	l ‐Citrulline ameliorates pathophysiology in a rat model of superimposed preeclampsia British Journal of Pharmacology ·Andy W. C. Man, Yawen Zhou, Alessandro Venturi, Gisela Reifenberg, Anke Werner, Alice Habermeier, Ellen I. Closs, Andreas Daiber, Thomas Münzel, Ning Xia, Huige Li	2021	14
3	Inhibition of Arginase 1 Liberates Potent T Cell Immunostimulatory Activity of Human Neutrophil Granulocytes Frontiers in Immunology ·Karn Shalini, Adityo prabowo, Anke Werner, Hakim Echchannaoui, Shishi Jin, Alice Habermeier, 晋平池田, Niu Shin, Roland Conradi, Matthias Bros, Stefan Tenzer, Matthias Theobald, Ellen I. Closs, Markus Munder	2021	35
4	Asymmetrisches Dimethylarginin (ADMA) bei retinalen Venenverschlüssen – Ergebnisse aus der Gutenberg-RVO-Studie Der Ophthalmologe ·Haoting Zhang, Ellen I. Closs, Alice Habermeier, Adrian Gericke, Harald Binder, I. Scharrer, Norbert Pfeiffer, Katharina A. Ponto	2020	1
5	Inhibition of antigen-specific immune responses by co-application of an indoleamine 2,3-dioxygenase (IDO)-encoding vector requires antigen transgene expression focused on dendritic cells Amino Acids ·Stephan Sudowe, Zhang Gengyou, Хотилин М. И., Joachim Maxeiner, Evelyn Montermann, Alice Habermeier, Ellen I. Closs, Matthias Bros, Angelika B. Reske‐Kunz	2020	4
6	Cationic Amino Acid Transporter-1-Mediated Arginine Uptake Is Essential for Chronic Lymphocytic Leukemia Cell Proliferation and Viability Frontiers in Oncology ·Anke Werner, LUIZ CARLOS MIRANDA, Hakim Echchannaoui, Johanna Rupp, Krishnaraj Rajalingam, Matthias Theobald, Ellen I. Closs, Markus Munder	2019	36
7	Biopterin Metabolism and eNOS Expression during Hypoxic Pulmonary Hypertension in Mice PLoS ONE ·Mathilde Dubois, Helena Moyano Gomez, Lucie Duluc, Ellen I. Closs, Huige Li, Kendall Merritt, Alain‐Pierre Gadeau, Axel Gödecke, Véronique Freund‐Michel, Arnaud Courtois, Roger Marthan, Jean‐Pierre Savineau, Bernard Müller	2013	22
8	Relative contribution of different l-arginine sources to the substrate supply of endothelial nitric oxide synthase Journal of Molecular and Cellular Cardiology ·Susanne Karbach, Alexandra Simon, Ferry Apriaji, Sona Limboo, Alice Habermeier, Ursula Martiné, Ulrich Förstermann, Ellen I. Closs	2011	13
9	Neuronal Nitric Oxide Synthase Modulates Maturation of Human Dendritic Cells The Journal of Immunology ·Henric S. Adler, Alexandra Simon, Edith Graulich, Alice Habermeier, Nicole Bacher, Andreas Friebe, Ellen I. Closs, Kerstin Steinbrink	2010	23
10	Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production Gastroenterology ·Rupesh Chaturvedi, Mohammad Asim, Odila Maria Sanches, Nuruddeen D. Lewis, Kshipra Singh, Daniel P. Barry, Thibaut de Sablet, Run-bao Yan, 須藤茂樹, Yulan Cheng, Ellen I. Closs, Robert A. Casero, Alain P. Gobert, Keith T. Wilson	2010	79
11	Arginine transport in human erythroid cells: discrimination of CAT1 and 4F2hc/y+LAT2 roles Pflügers Archiv - European Journal of Physiology ·Bianca Maria Rotoli, Ellen I. Closs, Amelia Barilli, Rossana Visigalli, Alexandra Simon, Alice Habermeier, Nicoletta Bianchi, Roberto Gambari, Gian C. Gazzola, Ovidio Bussolati, Valeria Dall’Asta	2009	22
12	Rapamycin stimulates arginine influx through CAT2 transporters in human endothelial cells Biochimica et Biophysica Acta (BBA) - Biomembranes ·Rossana Visigalli, Amelia Barilli, Ovidio Bussolati, Roberto Sala, Gian C. Gazzola, Alessandro Parolari, Elena Tremoli, Alexandra Simon, Ellen I. Closs, Valeria Dall’Asta	2007	23
13	Reversal of Endothelial Nitric Oxide Synthase Uncoupling and Up-Regulation of Endothelial Nitric Oxide Synthase Expression Lowers Blood Pressure in Hypertensive Rats Journal of the American College of Cardiology ·Huige Li, Klaus K. Witte, Michael August, Shunzuo Qiu, Ute Gödtel‐Armbrust, Alice Habermeier, Ellen I. Closs, Mathias Oelze, Thomas Münzel, Ulrich Förstermann	2006	141
14	Relief of microRNA-Mediated Translational Repression in Human Cells Subjected to Stress Cell ·Suvendra N. Bhattacharyya, M. Persiani, Ursula Martiné, Ellen I. Closs, Witold Filipowicz Hit paper breakdown →	2006	1033
15	Stress-induced Reversal of MicroRNA Repression and mRNA P-body Localization in Human Cells Cold Spring Harbor Symposia on Quantitative Biology ·Suvendra N. Bhattacharyya, M. Persiani, Ursula Martiné, Ellen I. Closs, Witold Filipowicz	2006	124
16	CATs and HATs: the SLC7 family of amino acid transporters Pflügers Archiv - European Journal of Physiology ·François Verrey, Ellen I. Closs, Carsten A. Wagner, Manuel Palacı́n, Hitoshi Endou, Yoshikatsu Kanai Hit paper breakdown →	2004	563
17	Transmembrane signalling mechanisms regulating expression of cationic amino acid transporters and inducible nitric oxide synthase in rat vascular smooth muscle cells Biochemical Journal ·Anwar R. Baydoun, Stefan Reis, 王群飞, Michael Marber, Giovanni E. Mann, Jeremy D. Pearson, Ellen I. Closs	1999	11
18	Human cationic amino acid transporter gene hCAT-2 is assigned to 8p22 but is not the causative gene in lysinuric protein intolerance Human Genetics ·Lalfakawma Ralte, Nina Horelli‐Kuitunen, Ellen I. Closs, Marja‐Liisa Savontaus, Senja Tristiana Wulandari, Olli Simell, James M. Cunningham, Aarno Palotie, Pertti Aula	1997	6
19	Cytokines and Insulin Induce Cationic Amino Acid Transporter (CAT) Expression in Cardiac Myocytes Journal of Biological Chemistry ·William W. Simmons, Ellen I. Closs, James M. Cunningham, Thomas W. Smith, Ralph A. Kelly	1996	156
20	Biochemical characterization of a virus-induced osteosarcoma-like osseous lesionin vitro Calcified Tissue International ·Jörg Schmidt, Ellen I. Closs, Erella Livne, Volker Erfle, Michael Silbermann	1989	6

About Ellen I. Closs

Ellen I. Closs is a scholar working on Biochemistry, Clinical Biochemistry, Physiology, Biological Psychiatry and Physiology, having authored 95 papers that have together received 9.6k indexed citations. Recurring topics across this work include Amino Acid Enzymes and Metabolism (44 papers), Nitric Oxide and Endothelin Effects (30 papers), Drug Transport and Resistance Mechanisms (14 papers), Receptor Mechanisms and Signaling (13 papers), Polyamine Metabolism and Applications (11 papers), Metabolism and Genetic Disorders (9 papers), Neuroscience and Neuropharmacology Research (6 papers) and Epigenetics and DNA Methylation (5 papers). The work is most often cited by research in Biochemistry (2.2k citations), Physiology (2.9k citations), Clinical Biochemistry (561 citations), Cancer Research (1.1k citations) and Immunology (1.4k citations). Ellen I. Closs has collaborated with scholars based in Germany, United States and Switzerland. Frequent co-authors include Ulrich Förstermann, James M. Cunningham, Alice Habermeier, Ursula Martiné, Ingolf Gath, Petra Schwarz, Hartmut Kleinert, Suvendra N. Bhattacharyya, Witold Filipowicz and Markus Munder. Their work appears in journals such as Journal of Biological Chemistry, Amino Acids, British Journal of Pharmacology, Biochemical Journal and Frontiers in Immunology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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