Egil Lien

24.1k total citations · 8 hit papers
132 papers, 19.7k citations indexed

About

Egil Lien is a scholar working on Immunology, Molecular Biology and Epidemiology. According to data from OpenAlex, Egil Lien has authored 132 papers receiving a total of 19.7k indexed citations (citations by other indexed papers that have themselves been cited), including 94 papers in Immunology, 41 papers in Molecular Biology and 31 papers in Epidemiology. Recurrent topics in Egil Lien's work include Immune Response and Inflammation (71 papers), Inflammasome and immune disorders (24 papers) and Immune Cell Function and Interaction (22 papers). Egil Lien is often cited by papers focused on Immune Response and Inflammation (71 papers), Inflammasome and immune disorders (24 papers) and Immune Cell Function and Interaction (22 papers). Egil Lien collaborates with scholars based in United States, Norway and Germany. Egil Lien's co-authors include Douglas T. Golenbock, Terje Espevik, Robin R. Ingalls, Katherine A. Fitzgerald, Atsutoshi Yoshimura, Eicke Latz, Brian G. Monks, Gregory I. Vladimer, Matthew J. Fenton and Pål Aukrust and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

Egil Lien

131 papers receiving 19.4k citations

Hit Papers

NLRP3 inflammasomes are required for atherogenesis ... 1999 2026 2008 2017 2010 2004 1999 2018 1999 1000 2.0k 3.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
    2010 3.1k citations Cherilyn M. Sirois, Terje Espevik et al. profile →
  2. TLR9 signals after translocating from the ER to CpG DNA in the lysosome
    2004 1.1k citations Eicke Latz, Alberto Visintin et al. profile →
  3. Cutting Edge: Recognition of Gram-Positive Bacterial Cell Wall Components by the Innate Immune System Occurs Via Toll-Like Receptor 2
    1999 1.0k citations Egil Lien, Robin R. Ingalls et al. The Journal of Immunology profile →
  4. Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death
    2018 800 citations Pontus Ørning, Dan Weng et al. Science profile →
  5. Toll-like Receptor 2 Functions as a Pattern Recognition Receptor for Diverse Bacterial Products
    1999 777 citations Egil Lien, Trude Helen Flo et al. Journal of Biological Chemistry profile →
  6. Human Toll-Like Receptors Mediate Cellular Activation by Mycobacterium tuberculosis
    1999 692 citations Egil Lien, Douglas T. Golenbock et al. The Journal of Immunology profile →
  7. Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
    2000 655 citations Egil Lien, Matthew J. Fenton et al. profile →
  8. The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia–reperfusion injury
    2013 435 citations Katherine A. Fitzgerald, Egil Lien et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Egil Lien United States 63 11.5k 7.1k 4.1k 1.8k 1.7k 132 19.7k
Moshe Arditi United States 70 9.0k 0.8× 6.4k 0.9× 3.6k 0.9× 1.8k 1.0× 2.2k 1.3× 212 18.9k
Evelyn A. Kurt‐Jones United States 68 9.8k 0.8× 6.5k 0.9× 6.2k 1.5× 812 0.5× 2.6k 1.5× 139 20.4k
Stefan Endres Germany 83 16.6k 1.4× 9.0k 1.3× 3.5k 0.8× 746 0.4× 1.7k 1.0× 276 28.6k
Kensuke Miyake Japan 78 15.8k 1.4× 7.2k 1.0× 4.0k 1.0× 2.3k 1.3× 1.3k 0.8× 214 23.8k
Stefanie N. Vogel United States 86 15.6k 1.4× 7.0k 1.0× 4.5k 1.1× 1.4k 0.8× 2.3k 1.4× 328 24.6k
Craig Gérard United States 86 16.2k 1.4× 6.3k 0.9× 3.5k 0.9× 820 0.5× 2.4k 1.4× 223 29.5k
Gunther Hartmann Germany 76 16.9k 1.5× 10.0k 1.4× 3.3k 0.8× 900 0.5× 2.8k 1.6× 251 25.1k
Richard J. Ulevitch United States 70 16.3k 1.4× 6.3k 0.9× 4.2k 1.0× 2.8k 1.6× 1.2k 0.7× 134 24.4k
Niels Borregaard Denmark 88 13.4k 1.2× 10.2k 1.4× 2.8k 0.7× 3.7k 2.1× 1.2k 0.7× 254 30.0k
Marina A. Freudenberg Germany 61 12.9k 1.1× 5.1k 0.7× 3.7k 0.9× 1.7k 0.9× 1.5k 0.9× 170 20.9k

Countries citing papers authored by Egil Lien

Since Specialization
Citations

This map shows the geographic impact of Egil Lien's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Egil Lien with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Egil Lien more than expected).

Fields of papers citing papers by Egil Lien

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Egil Lien. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Egil Lien. The network helps show where Egil Lien may publish in the future.

Co-authorship network of co-authors of Egil Lien

This figure shows the co-authorship network connecting the top 25 collaborators of Egil Lien. A scholar is included among the top collaborators of Egil Lien based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Egil Lien. Egil Lien is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Ørning, Pontus, Roland Elling, Michelle A. Kelliher, et al.. (2025). Raver1 links Ripk1 RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance. Proceedings of the National Academy of Sciences. 122(7). e2420802122–e2420802122. 2 indexed citations
2.
Skjesol, Astrid, Liv Ryan, Pontus Ørning, et al.. (2023). Peptide derived from SLAMF1 prevents TLR4-mediated inflammation in vitro and in vivo. Life Science Alliance. 6(12). e202302164–e202302164. 6 indexed citations
3.
Ørning, Pontus, Dan Weng, Kristian K. Starheim, et al.. (2018). Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death. Science. 362(6418). 1064–1069. 800 indexed citations breakdown →
4.
Husebye, Harald, Marie Aune, Jørgen Stenvik, et al.. (2010). The Rab11a GTPase Controls Toll-like Receptor 4-Induced Activation of Interferon Regulatory Factor-3 on Phagosomes. Immunity. 33(4). 583–596. 169 indexed citations
5.
He, Xianbao, et al.. (2010). Inflammation and Fibrosis during Chlamydia pneumoniae Infection Is Regulated by IL-1 and the NLRP3/ASC Inflammasome. The Journal of Immunology. 184(10). 5743–5754. 135 indexed citations
6.
Zhao, Hang, Shaw‐Woei Leu, Liyun Shi, et al.. (2010). TLR4 Is a Negative Regulator in Noninfectious Lung Inflammation. The Journal of Immunology. 184(9). 5308–5314. 41 indexed citations
7.
Lien, Egil & Danny Zipris. (2009). The Role of Toll-Like Receptor Pathways in the Mechanism of Type 1 Diabetes. Current Molecular Medicine. 9(1). 52–68. 59 indexed citations
8.
Bartholomeu, Daniella Castanheira, Catherine Ropert, Mariane B. Melo, et al.. (2008). Recruitment and Endo-Lysosomal Activation of TLR9 in Dendritic Cells Infected with Trypanosoma cruzi. The Journal of Immunology. 181(2). 1333–1344. 54 indexed citations
9.
Robinson, Richard, Shabaana A. Khader, Richard M. Locksley, et al.. (2008). Yersinia pestis Evades TLR4-dependent Induction of IL-12(p40)2 by Dendritic Cells and Subsequent Cell Migration. The Journal of Immunology. 181(8). 5560–5567. 34 indexed citations
10.
Alugupalli, Kishore R., Shizuo Akira, Egil Lien, & John M. Leong. (2007). MyD88- and Bruton’s Tyrosine Kinase-Mediated Signals Are Essential for T Cell-Independent Pathogen-Specific IgM Responses. The Journal of Immunology. 178(6). 3740–3749. 47 indexed citations
11.
Zipris, Danny, Egil Lien, Anjali Nair, et al.. (2007). TLR9-Signaling Pathways Are Involved in Kilham Rat Virus-Induced Autoimmune Diabetes in the Biobreeding Diabetes-Resistant Rat. The Journal of Immunology. 178(2). 693–701. 84 indexed citations
12.
Lehnardt, Seija, Philipp Henneke, Egil Lien, et al.. (2006). A Mechanism for Neurodegeneration Induced by Group B Streptococci through Activation of the TLR2/MyD88 Pathway in Microglia. The Journal of Immunology. 177(1). 583–592. 141 indexed citations
13.
Ngampasutadol, Jutamas, Sanjay Ram, Anna M. Blom, et al.. (2005). Human C4b-binding protein selectively interacts with Neisseria gonorrhoeae and results in species-specific infection. Proceedings of the National Academy of Sciences. 102(47). 17142–17147. 75 indexed citations
14.
Zipris, Danny, et al.. (2005). TLR Activation Synergizes with Kilham Rat Virus Infection to Induce Diabetes in BBDR Rats. The Journal of Immunology. 174(1). 131–142. 102 indexed citations
15.
Espevik, Terje, Eicke Latz, Egil Lien, Brian G. Monks, & Douglas T. Golenbock. (2003). Cell Distributions and Functions of Toll-like Receptor 4 Studied by Fluorescent Gene Constructs. Scandinavian Journal of Infectious Diseases. 35(9). 660–664. 28 indexed citations
16.
Paterson, Hugh, Thomas J. Murphy, Odhran Shelley, et al.. (2003). Injury Primes the Innate Immune System for Enhanced Toll-Like Receptor Reactivity. The Journal of Immunology. 171(3). 1473–1483. 201 indexed citations
17.
Latz, Eicke, Alberto Visintin, Egil Lien, et al.. (2002). Lipopolysaccharide Rapidly Traffics to and from the Golgi Apparatus with the Toll-like Receptor 4-MD-2-CD14 Complex in a Process That Is Distinct from the Initiation of Signal Transduction. Journal of Biological Chemistry. 277(49). 47834–47843. 384 indexed citations
18.
Henneke, Philipp, Osamu Takeuchi, Richard Malley, et al.. (2002). Cellular Activation, Phagocytosis, and Bactericidal Activity Against Group B Streptococcus Involve Parallel Myeloid Differentiation Factor 88-Dependent and Independent Signaling Pathways. The Journal of Immunology. 169(7). 3970–3977. 120 indexed citations
19.
Medvedev, Andrei E., Philipp Henneke, Andra B. Schromm, et al.. (2001). Induction of Tolerance to Lipopolysaccharide and Mycobacterial Components in Chinese Hamster Ovary/CD14 Cells Is Not Affected by Overexpression of Toll-Like Receptors 2 or 4. The Journal of Immunology. 167(4). 2257–2267. 146 indexed citations
20.
Flo, Trude Helen, Øyvind Halaas, Egil Lien, et al.. (2000). Human Toll-Like Receptor 2 Mediates Monocyte Activation by Listeria monocytogenes , But Not by Group B Streptococci or Lipopolysaccharide. The Journal of Immunology. 164(4). 2064–2069. 255 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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