Edward H. Schuchman

20.9k citations

272 papers · 16.1k indexed · 2 hit papers · h-index 67

Physiology top 0.05%
- Lysosomal Storage Disorders Research 163
- Calcium signaling and nucleotide metabolism 31
- Erythrocyte Function and Pathophysiology 25
Physiology top 0.1%
- Lysosomal Storage Disorders Research 163
- Calcium signaling and nucleotide metabolism 31
- Erythrocyte Function and Pathophysiology 25
Cell Biology top 0.2%
- Cellular transport and secretion 19
Molecular Biology top 0.5%
- Sphingolipid Metabolism and Signaling 82
- Glycosylation and Glycoproteins Research 17
Developmental Neuroscience top 1%
Organic Chemistry
- Carbohydrate Chemistry and Synthesis 50
Hematology
- Autoimmune and Inflammatory Disorders Research 27

Co-authors: Robert J. Desnick Xingxuan He Calogera M. Simonaro Konrad Sandhoff Hee Kyung Jin Ira Tabas Richard Kolesnick Zvi Fuks
Cited by: Physiology Cell Biology
Journals: Cell (1 paper)Proceedings of the National Academy of Sciences (8 papers)Journal of the American Chemical Society (1 paper)
Partner nations: United States Germany South Korea

In The Last Decade

Edward H. Schuchman

268 papers receiving 15.9k citations

Hit Papers

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Peers

Countries citing papers authored by Edward H. Schuchman

Since Specialization

Citations

This map shows the geographic impact of Edward H. Schuchman's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Edward H. Schuchman with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Edward H. Schuchman more than expected).

Fields of papers citing papers by Edward H. Schuchman

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Edward H. Schuchman. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Edward H. Schuchman. The network helps show where Edward H. Schuchman may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Edward H. Schuchman, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Edward H. Schuchman Line = papers co-authored together Edward H. Schuchman links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	HDL-bound S1P affects the subventricular niche and early neuropathological features of Alzheimer’s disease Nature Communications ·Byung Jo Choi,Ju Hong,Min Hee Park,Kang Ho Park,Wan Hui Han,Hee Ji Yoon,Hye Yoon Jung,Kyung Yeol Kim,Speaker Soyoung Lee,E. C. H. Lim,Jung Hur,Im‐Sook Song,So Yeon Jeon,Min‐Koo Choi,Christina Christoffersen,Han Jo Kim,Seung Hyun Kim,Edward H. Schuchman,Jae‐sung Bae,Hee Kyung Jin	2025	0
2	Endocannabinoid receptor 2 is a potential biomarker and therapeutic target for the lysosomal storage disorders Journal of Inherited Metabolic Disease ·Calogera M. Simonaro,Makiko Yasuda,Edward H. Schuchman	2024	1
3	The cholesterol transporter NPC1 is essential for epigenetic regulation and maturation of oligodendrocyte lineage cells Nature Communications ·Thaddeus J. Kunkel,Alice Townsend,Kyle A. Sullivan,Jean Merlet,Edward H. Schuchman,Daniel Jacobson,Andrew P. Lieberman	2023	11
4	Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer’s disease mice Proceedings of the National Academy of Sciences ·Min Hee Park,Kang Ho Park,Byung Jo Choi,Wan Hui Han,Hee Ji Yoon,Hye Yoon Jung,Jihoon Lee,Im‐Sook Song,Dong Yu Lim,Min‐Koo Choi,Yang-Ha Lee,Cheol‐Min Park,Ming Wang,Jihoon Jo,Han Jo Kim,Seung Hyun Kim,Edward H. Schuchman,Hee Kyung Jin,Jae‐sung Bae	2022	19
5	The clinical spectrum of SMA‐PME and in vitro normalization of its cellular ceramide profile Annals of Clinical and Translational Neurology ·Michelle M. Lee,Graeme S. V. McDowell,Darryl C. De Vivo,Daniel Friedman,Samuel F. Berkovic,Maria Spanou,Argirios Dinopoulos,Katheryn Grand,Pedro A. Sanchez‐Lara,Michelle Allen‐Sharpley,Jodi Warman‐Chardon,Alexander Sólyom,Thierry Levade,Edward H. Schuchman,Steffany A. L. Bennett,David A. Dyment,Toni S. Pearson	2022	5
6	A New Fluorescent Method to Detect Sulfamidase Activity in Blood, Tissue Extracts and Dried Blood Spots SHILAP Revista de lepidopterología ·Xingxuan He,Edward H. Schuchman,Calogera M. Simonaro	2021	2
7	Growth Plate Pathology in the Mucopolysaccharidosis Type VI Rat Model—An Experimental and Computational Approach Diagnostics ·Johana Guevara,Michael Frohbergh,Héctor Castro-Abril,Juan Jairo Vaca‐González,Luis A. Barrera,Diego Alexander Garzón–Alvarado,Edward H. Schuchman,Calogera M. Simonaro	2020	4
8	N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer’s disease Nature Communications ·Ju Youn Lee,Seung Hoon Han,Min Hee Park,Im‐Sook Song,Min‐Koo Choi,Eunsoo Yu,Cheol‐Min Park,Han Jo Kim,Seung Hyun Kim,Edward H. Schuchman,Hee Kyung Jin,Jae‐sung Bae	2020	41
9	Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis American Journal of Respiratory and Critical Care Medicine ·Aaron Gardner,Iram Haq,A. John Simpson,Katrin Anne Becker,John T. Gallagher,Vinciane Saint‐Criq,Bernard Verdon,Emily Mavin,Alexandra Trigg,Michael A. Gray,Albert Koulman,Melissa J. McDonnell,Andrew J. Fisher,Elizabeth L. Kramer,John Clancy,Chris Ward,Edward H. Schuchman,Erich Gulbins,Malcolm Brodlie	2020	27
10	Adeno-associated viral vector serotype 9–based gene therapy for Niemann-Pick disease type A Science Translational Medicine ·Lluı́s Samaranch,Azucena Pérez‐Cañamás,Beatriz Soto‐Huelin,Vivek Sudhakar,Jerónimo Jurado‐Arjona,Piotr Hadaczek,Jesús Ávila,John R. Bringas,Josefina Casas,Haifeng Chen,Xingxuan He,Edward H. Schuchman,Seng H. Cheng,John Forsayeth,Krystof S. Bankiewicz,María Dolores Ledesma	2019	34
11	Polyarticular Arthritis and Spinal Muscular Atrophy in Acid Ceramidase Deficiency PEDIATRICS ·Hooi Ling Teoh,Alexander Sólyom,Edward H. Schuchman,David Mowat,Tony Roscioli,Michelle A. Farrar,Hugo Sampaio	2016	12
12	Acid ceramidase and the treatment of ceramide diseases: The expanding role of enzyme replacement therapy Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease ·Edward H. Schuchman	2016	31
13	Acid ceramidase treatment enhances the outcome of autologous chondrocyte implantation in a rat osteochondral defect model Osteoarthritis and Cartilage ·Michael Frohbergh,Johana Guevara,Ronald P. Grelsamer,Mary F. Barbe,Xingxuan He,Calogera M. Simonaro,Edward H. Schuchman	2015	12
14	Alterations of myelin‐specific proteins and sphingolipids characterize the brains of acid sphingomyelinase‐deficient mice, an animal model of Niemann–Pick disease type A Journal of Neurochemistry ·Barbara Buccinnà,Marco Piccinini,Alessandro Prinetti,Federica Scandroglio,Simona Prioni,Manuela Valsecchi,Barbara Votta,Silvia Grifoni,Elisa Lupino,Cristina Ramondetti,Edward H. Schuchman,Maria Teresa Giordana,Sandro Sonnino,M. Rinaudo	2009	27
15	Nitric Oxide Boosts Chemoimmunotherapy via Inhibition of Acid Sphingomyelinase in a Mouse Model of Melanoma Cancer Research ·Cristiana Perrotta,Laura Bizzozero,Sestina Falcone,Patrizia Rovere–Querini,Alessandro Prinetti,Edward H. Schuchman,Sandro Sonnino,Angelo A. Manfredi,Emilio Clementi	2007	46
16	Acid ceramidase and human disease Biochimica et Biophysica Acta (BBA) - Biomembranes ·Jae‐Ho Park,Edward H. Schuchman	2006	141
17	Lysosomal enzyme delivery by ICAM-1-targeted nanocarriers bypassing glycosylation- and clathrin-dependent endocytosis Molecular Therapy ·Silvia Muro,Edward H. Schuchman,Vladimir R. Muzykantov	2005	102
18	Enzyme Replacement Therapy in Feline Mucopolysaccharidosis I Molecular Genetics and Metabolism ·Emil Kakkis,Edward H. Schuchman,Xingxuan He,Qi Wan,Stephen A. Kania,Staci Wiemelt,C Hasson,Thomas O’Malley,Margaret A. Weil,G.A. Aguirre,Diane E. Brown,Mark E. Haskins	2001	74
19	Hematopoietic stem cell gene therapy leads to marked visceral organ improvements and a delayed onset of neurological abnormalities in the acid sphingomyelinase deficient mouse model of Niemann–Pick disease Gene Therapy ·Sílvia R.P. Miranda,Shai Erlich,Victor L. Friedrich,Shimon Gátt,Edward H. Schuchman	2000	38
20	Niemann–Pick Disease: Mutation Update, Genotype/Phenotype Correlations, and Prospects for Genetic Testing Genetic Testing ·Edward H. Schuchman,Sílvia R.P. Miranda	1997	56

About Edward H. Schuchman

Edward H. Schuchman is a scholar working on Physiology, Physiology and Hematology, having authored 272 papers that have together received 16.1k indexed citations. Recurring topics across this work include Lysosomal Storage Disorders Research (163 papers), Sphingolipid Metabolism and Signaling (82 papers), Carbohydrate Chemistry and Synthesis (50 papers), Calcium signaling and nucleotide metabolism (31 papers), Autoimmune and Inflammatory Disorders Research (27 papers), Erythrocyte Function and Pathophysiology (25 papers), Cellular transport and secretion (19 papers) and Glycosylation and Glycoproteins Research (17 papers). The work is most often cited by research in Physiology (1.6k citations), Physiology (7.3k citations) and Cell Biology (2.9k citations). Edward H. Schuchman has collaborated with scholars based in United States, Germany and South Korea. Frequent co-authors include Robert J. Desnick, Xingxuan He, Calogera M. Simonaro, Konrad Sandhoff, Hee Kyung Jin, Ira Tabas, Richard Kolesnick, Zvi Fuks, Mark E. Haskins and Shimon Gátt. Their work appears in journals such as Cell, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

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