Edward H. Schuchman

20.9k citations

272 papers · 16.1k indexed · 2 hit papers · h-index 67

Molecular Biology top 0.5%
Physiology top 0.1%
Cell Biology top 0.2%
Epidemiology top 1%
Physiology top 0.05%

Co-authors: Robert J. Desnick Xingxuan He Calogera M. Simonaro Konrad Sandhoff Hee Kyung Jin Ira Tabas Richard Kolesnick Zvi Fuks
Topics: Lysosomal Storage Disorders Research (163 papers)Sphingolipid Metabolism and Signaling (82 papers)Carbohydrate Chemistry and Synthesis (50 papers)
Cited by: Physiology Cell Biology
Journals: Cell Proceedings of the National Academy of Sciences Journal of the American Chemical Society
Partner nations: United States Germany South Korea

In The Last Decade

Edward H. Schuchman

268 papers receiving 15.9k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis

1996 691 citations Edward H. Schuchman et al. profile →
Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

2008 669 citations Xingxuan He, Edward H. Schuchman et al. profile →

Peers

Countries citing papers authored by Edward H. Schuchman

Since Specialization

Citations

This map shows the geographic impact of Edward H. Schuchman's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Edward H. Schuchman with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Edward H. Schuchman more than expected).

Fields of papers citing papers by Edward H. Schuchman

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Edward H. Schuchman. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Edward H. Schuchman. The network helps show where Edward H. Schuchman may publish in the future.

Co-authorship network of co-authors of Edward H. Schuchman

This figure shows the co-authorship network connecting the top 25 collaborators of Edward H. Schuchman. A scholar is included among the top collaborators of Edward H. Schuchman based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Edward H. Schuchman. Edward H. Schuchman is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	HDL-bound S1P affects the subventricular niche and early neuropathological features of Alzheimer’s disease 2025 ·Nature Communications ·(unknown),Ju Hong,Min Hee Park,(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),Jung Hur,Im‐Sook Song,So Yeon Jeon,Min‐Koo Choi,Christina Christoffersen,Han Jo Kim,Seung Hyun Kim,Edward H. Schuchman,Jae‐sung Bae,Hee Kyung Jin	0
2	Endocannabinoid receptor 2 is a potential biomarker and therapeutic target for the lysosomal storage disorders 2024 ·Journal of Inherited Metabolic Disease ·Calogera M. Simonaro,Makiko Yasuda,Edward H. Schuchman	1
3	The cholesterol transporter NPC1 is essential for epigenetic regulation and maturation of oligodendrocyte lineage cells 2023 ·Nature Communications ·(unknown),(unknown),Kyle A. Sullivan,(unknown),Edward H. Schuchman,Daniel Jacobson,Andrew P. Lieberman	11
4	Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer’s disease mice 2022 ·Proceedings of the National Academy of Sciences ·Min Hee Park,(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),Im‐Sook Song,(unknown),Min‐Koo Choi,(unknown),Cheol‐Min Park,Ming Wang,Jihoon Jo,Han Jo Kim,Seung Hyun Kim,Edward H. Schuchman,Hee Kyung Jin,Jae‐sung Bae	19
5	The clinical spectrum of SMA‐PME and in vitro normalization of its cellular ceramide profile 2022 ·Annals of Clinical and Translational Neurology ·Michelle M. Lee,(unknown),Darryl C. De Vivo,Daniel Friedman,Samuel F. Berkovic,(unknown),Argirios Dinopoulos,Katheryn Grand,Pedro A. Sanchez‐Lara,(unknown),Jodi Warman‐Chardon,(unknown),Thierry Levade,Edward H. Schuchman,Steffany A. L. Bennett,David A. Dyment,Toni S. Pearson	5
6	A New Fluorescent Method to Detect Sulfamidase Activity in Blood, Tissue Extracts and Dried Blood Spots 2021 ·SHILAP Revista de lepidopterología ·Xingxuan He,Edward H. Schuchman,Calogera M. Simonaro	2
7	Growth Plate Pathology in the Mucopolysaccharidosis Type VI Rat Model—An Experimental and Computational Approach 2020 ·Diagnostics ·Johana Guevara,Michael Frohbergh,(unknown),(unknown),Luis A. Barrera,Diego Alexander Garzón–Alvarado,Edward H. Schuchman,Calogera M. Simonaro	4
8	N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer’s disease 2020 ·Nature Communications ·Ju Youn Lee,(unknown),Min Hee Park,Im‐Sook Song,Min‐Koo Choi,(unknown),Cheol‐Min Park,Han Jo Kim,Seung Hyun Kim,Edward H. Schuchman,Hee Kyung Jin,Jae‐sung Bae	41
9	Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis 2020 ·American Journal of Respiratory and Critical Care Medicine ·Aaron Gardner,Iram Haq,A. John Simpson,Katrin Anne Becker,John T. Gallagher,Vinciane Saint‐Criq,Bernard Verdon,(unknown),(unknown),Michael A. Gray,Albert Koulman,Melissa J. McDonnell,Andrew J. Fisher,Elizabeth L. Kramer,John Clancy,Chris Ward,Edward H. Schuchman,Erich Gulbins,Malcolm Brodlie	27
10	Adeno-associated viral vector serotype 9–based gene therapy for Niemann-Pick disease type A 2019 ·Science Translational Medicine ·Lluı́s Samaranch,(unknown),(unknown),Vivek Sudhakar,Jerónimo Jurado‐Arjona,Piotr Hadaczek,Jesús Ávila,John R. Bringas,Josefina Casas,Haifeng Chen,Xingxuan He,Edward H. Schuchman,Seng H. Cheng,John Forsayeth,Krystof S. Bankiewicz,María Dolores Ledesma	34
11	Polyarticular Arthritis and Spinal Muscular Atrophy in Acid Ceramidase Deficiency 2016 ·PEDIATRICS ·(unknown),(unknown),Edward H. Schuchman,(unknown),Tony Roscioli,Michelle A. Farrar,Hugo Sampaio	12
12	Acid ceramidase and the treatment of ceramide diseases: The expanding role of enzyme replacement therapy 2016 ·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease ·Edward H. Schuchman	31
13	Acid ceramidase treatment enhances the outcome of autologous chondrocyte implantation in a rat osteochondral defect model 2015 ·Osteoarthritis and Cartilage ·Michael Frohbergh,Johana Guevara,Ronald P. Grelsamer,Mary F. Barbe,Xingxuan He,Calogera M. Simonaro,Edward H. Schuchman	12
14	Alterations of myelin‐specific proteins and sphingolipids characterize the brains of acid sphingomyelinase‐deficient mice, an animal model of Niemann–Pick disease type A 2009 ·Journal of Neurochemistry ·Barbara Buccinnà,Marco Piccinini,Alessandro Prinetti,(unknown),Simona Prioni,Manuela Valsecchi,Barbara Votta,Silvia Grifoni,Elisa Lupino,Cristina Ramondetti,Edward H. Schuchman,Maria Teresa Giordana,Sandro Sonnino,M. Rinaudo	27
15	Nitric Oxide Boosts Chemoimmunotherapy via Inhibition of Acid Sphingomyelinase in a Mouse Model of Melanoma 2007 ·Cancer Research ·Cristiana Perrotta,Laura Bizzozero,Sestina Falcone,Patrizia Rovere–Querini,Alessandro Prinetti,Edward H. Schuchman,Sandro Sonnino,Angelo A. Manfredi,Emilio Clementi	46
16	Acid ceramidase and human disease 2006 ·Biochimica et Biophysica Acta (BBA) - Biomembranes ·Jae‐Ho Park,Edward H. Schuchman	141
17	Lysosomal enzyme delivery by ICAM-1-targeted nanocarriers bypassing glycosylation- and clathrin-dependent endocytosis 2005 ·Molecular Therapy ·Silvia Muro,Edward H. Schuchman,Vladimir R. Muzykantov	102
18	Enzyme Replacement Therapy in Feline Mucopolysaccharidosis I 2001 ·Molecular Genetics and Metabolism ·Emil Kakkis,Edward H. Schuchman,Xingxuan He,Qi Wan,Stephen A. Kania,(unknown),(unknown),Thomas O’Malley,Margaret A. Weil,(unknown),Diane E. Brown,Mark E. Haskins	74
19	Hematopoietic stem cell gene therapy leads to marked visceral organ improvements and a delayed onset of neurological abnormalities in the acid sphingomyelinase deficient mouse model of Niemann–Pick disease 2000 ·Gene Therapy ·Sílvia R.P. Miranda,Shai Erlich,Victor L. Friedrich,Shimon Gátt,Edward H. Schuchman	38
20	Niemann–Pick Disease: Mutation Update, Genotype/Phenotype Correlations, and Prospects for Genetic Testing 1997 ·Genetic Testing ·Edward H. Schuchman,Sílvia R.P. Miranda	56

About Edward H. Schuchman

Edward H. Schuchman is a scholar working on Physiology, Physiology and Hematology, having authored 272 papers that have together received 16.1k indexed citations. Recurring topics across this work include Lysosomal Storage Disorders Research (163 papers), Sphingolipid Metabolism and Signaling (82 papers) and Carbohydrate Chemistry and Synthesis (50 papers). The work is most often cited by research in Physiology (1.6k citations), Physiology (7.3k citations) and Cell Biology (2.9k citations). Edward H. Schuchman has collaborated with scholars based in United States, Germany and South Korea. Frequent co-authors include Robert J. Desnick, Xingxuan He, Calogera M. Simonaro, Konrad Sandhoff, Hee Kyung Jin, Ira Tabas, Richard Kolesnick, Zvi Fuks, Mark E. Haskins and Shimon Gátt. Their work appears in journals such as Cell, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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