David H. Perlmutter

15.4k citations

96 papers · 5.8k indexed · 1 hit paper · h-index 43

Impact in

Aging top 1%
- Genetics, Aging, and Longevity in Model Organisms
Cell Biology top 0.5%
- Endoplasmic Reticulum Stress and Disease
- Cellular transport and secretion

Papers in

Aging 11
- Genetics, Aging, and Longevity in Model Organisms 11
Cell Biology 28
- Endoplasmic Reticulum Stress and Disease 24

Co-authors: Jeffrey Teckman Harvey R. Colten Charles A. Dinarello Ernesto P. Molmenti Béla Z. Schmidt Dongfeng Qu Pamela Hale Gary A. Silverman
Journals: Journal of Biological Chemistry (24 papers)Journal of Clinical Investigation (12 papers)American Journal of Physiology-Gastrointestinal and Liver Physiology (7 papers)Journal of Pediatric Gastroenterology and Nutrition (5 papers)Hepatology (5 papers)
Partner nations: United States Japan Denmark

In The Last Decade

David H. Perlmutter

95 papers receiving 5.6k citations

Hit Papers

align trajectories log scale

Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression. 1986 · 495 citations

Peers

Countries citing papers authored by David H. Perlmutter

Since Specialization

Citations

This map shows the geographic impact of David H. Perlmutter's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David H. Perlmutter with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David H. Perlmutter more than expected).

Fields of papers citing papers by David H. Perlmutter

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David H. Perlmutter. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David H. Perlmutter. The network helps show where David H. Perlmutter may publish in the future.

Co-authors

The 25 scholars most cited alongside David H. Perlmutter, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with David H. Perlmutter Line = papers co-authored together David H. Perlmutter links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Detecting lithium plating dynamics in a solid-state battery with operando X-ray computed tomography using machine learning npj Computational Materials ·Ying Huang, David H. Perlmutter, Noris Santamaría, 川上ゆり, Pavel Shevchenko, Dilworth Y. Parkinson, Iryna V. Zenyuk, Daniela Ushizima	2023	32
2	An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z PLoS ONE ·Yan Wang, Murat Can Çobanoğlu, Jie Li, Tunda Hidvegi, Pamela Hale, Michael Ewing, Andrew S. Chu, Zhenwei Gong, Radhika Muzumdar, Stephen C. Pak, Gary A. Silverman, İvet Bahar, David H. Perlmutter	2019	15
3	Induced pluripotent stem cells model personalized variations in liver disease resulting from α1‐antitrypsin deficiency Hepatology ·Edgar N. Tafaleng, Souvik Chakraborty, Bing Han, Pamela Hale, Anuradha Vasant. Gujar, Alejandro Soto–Gutiérrez, Carol Feghali‐Bostwick, Andrew A. Wilson, Darrell N. Kotton, Masaki Nagaya, Stephen C. Strom, Jayanta Roy‐Chowdhury, Donna B. Stolz, David H. Perlmutter, Ira J. Fox	2015	62
4	The Aggregation-Prone Intracellular Serpin SRP-2 Fails to Transit the ER inCaenorhabditis elegans Genetics ·弘篠田, Erin E. Cummings, Linda P. O’Reilly, Mark T. Miedel, Gary A. Silverman, Cliff J. Luke, David H. Perlmutter, Stephen C. Pak	2015	1
5	C. elegans in high-throughput drug discovery Advanced Drug Delivery Reviews ·Linda P. O’Reilly, Cliff J. Luke, David H. Perlmutter, Gary A. Silverman, Stephen C. Pak	2013	192
6	α1-Antitrypsin deficiency and the hepatocytes – An elegans solution to drug discovery The International Journal of Biochemistry & Cell Biology ·Linda P. O’Reilly, David H. Perlmutter, Gary A. Silverman, Stephen C. Pak	2013	4
7	Spontaneous hepatic repopulation in transgenic mice expressing mutant human α1-antitrypsin by wild-type donor hepatocytes Journal of Clinical Investigation ·Jianqiang Ding, Govardhana Rao Yannam, Namita Roy‐Chowdhury, Tunda Hidvegi, Hesham Basma, Stephen I. Rennard, Ronald J. Wong, Xingpeng Xie, Chandan Guha, David H. Perlmutter, Ira J. Fox, Jayanta Roy‐Chowdhury	2011	61
8	Hepatic Fibrosis and Carcinogenesis in 1-Antitrypsin Deficiency: A Prototype for Chronic Tissue Damage in Gain-of-Function Disorders Cold Spring Harbor Perspectives in Biology ·David H. Perlmutter, Gary A. Silverman	2011	27
9	The Role of Autophagy in Alpha-1-Antitrypsin Deficiency: A Specific Cellular Response in Genetic Diseases Associated with Aggregation-Prone Proteins Autophagy ·David H. Perlmutter	2006	68
10	Analyses of hepatocellular proliferation in a mouse model of α-1-antitrypsin deficiency Hepatology ·David A. Rudnick, Yunjun Liao, Ashokeshwer Godara, Louis J. Muglia, David H. Perlmutter, Jeffrey Teckman	2004	98
11	Chemical Chaperones: A Pharmacological Strategy for Disorders of Protein Folding and Trafficking Pediatric Research ·David H. Perlmutter	2002	210
12	??1-Antitrypsin Deficiency???Associated Liver Disease Progresses Slowly in Some Children Journal of Pediatric Gastroenterology and Nutrition ·Eniola Tawakalitu, Jean P. Molleston, David H. Perlmutter	2000	25
13	α1‐Antitrypsin Deficiency–Associated Liver Disease Progresses Slowly in Some Children Journal of Pediatric Gastroenterology and Nutrition ·Eniola Tawakalitu, Jean P. Molleston, David H. Perlmutter	2000	1
14	Chain Length of the Polylysine in Receptor-targeted Gene Transfer Complexes Affects Duration of Reporter Gene Expression Both in Vitro and in Vivo Journal of Biological Chemistry ·Assem Ziady, Thomas W. Ferkol, Deborah V. Dawson, David H. Perlmutter, Pamela B. Davis	1999	52
15	Disruption of Disulfide Bonds Is Responsible for Impaired Secretion in Human Complement Factor H Deficiency Journal of Biological Chemistry ·Béla Z. Schmidt, Silvina Pezzetta, Tünde Hidvégi, David H. Perlmutter, Harvey R. Colten	1999	34
16	REVIEW: α₁‐Antitrypsin deficiency associated liver disease Journal of Gastroenterology and Hepatology ·Dongfeng Qu, Jeffrey Teckman, David H. Perlmutter	1997	32
17	The Endoplasmic Reticulum Degradation Pathway for Mutant Secretory Proteins α1-Antitrypsin Z and S Is Distinct from That for an Unassembled Membrane Protein Journal of Biological Chemistry ·Jeffrey Teckman, David H. Perlmutter	1996	72
18	Alpha-1-antitrypsin Deficiency: Biochemistry and Clinical Manifestations Annals of Medicine ·David H. Perlmutter	1996	29
19	The serpin-enzyme complex (SEC) receptor mediates the neutrophil chemotactic effect of alpha-1 antitrypsin-elastase complexes and amyloid-beta peptide. Journal of Clinical Investigation ·Zsolt Osváth, Gail L. Griffin, Anna August, S P Adams, Robert J. Fallon, Rashaud Senior, David H. Perlmutter	1992	55
20	The Use of Nifedipine for the Treatment of Achalasia in Children Journal of Pediatric Gastroenterology and Nutrition ·金晓英, David H. Perlmutter, Harland S. Winter	1986	4

About David H. Perlmutter

David H. Perlmutter is a scholar working on Aging, Cell Biology, Cancer Research, Hematology and Gastroenterology, having authored 96 papers that have together received 5.8k indexed citations. Recurring topics across this work include Endoplasmic Reticulum Stress and Disease (24 papers), Protease and Inhibitor Mechanisms (20 papers), Peptidase Inhibition and Analysis (12 papers), Genetics, Aging, and Longevity in Model Organisms (11 papers), Complement system in diseases (10 papers), Autophagy in Disease and Therapy (9 papers), Signaling Pathways in Disease (7 papers) and Ubiquitin and proteasome pathways (6 papers). The work is most often cited by research in Aging (264 citations), Cell Biology (1.5k citations), Cancer Research (1.2k citations), Hematology (670 citations) and Immunology (891 citations). David H. Perlmutter has collaborated with scholars based in United States, Japan and Denmark. Frequent co-authors include Jeffrey Teckman, Harvey R. Colten, Charles A. Dinarello, Ernesto P. Molmenti, Béla Z. Schmidt, Dongfeng Qu, Pamela Hale, Gary A. Silverman, Satoshi Ōmura and Robert J. Fallon. Their work appears in journals such as Journal of Biological Chemistry, Journal of Clinical Investigation, American Journal of Physiology-Gastrointestinal and Liver Physiology, Journal of Pediatric Gastroenterology and Nutrition and Hepatology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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