Darren J. Baker

25.3k citations

81 papers · 17.9k indexed · 12 hit papers · h-index 45

Molecular Biology top 0.5%
Physiology top 0.05%
Immunology top 0.5%
Aging top 0.05%
Cell Biology top 0.5%

Co-authors: Jan M. van Deursen Bennett G. Childs Matej Durik Tobias Wijshake James L. Kirkland Karthik B. Jeganathan Bart van de Sluis Nathan K. LeBrasseur
Topics: Telomeres, Telomerase, and Senescence (33 papers)Microtubule and mitosis dynamics (20 papers)Neuroinflammation and Neurodegeneration Mechanisms (9 papers)
Cited by: Aging Physiology Geriatrics and Gerontology
Journals: Nature Science Proceedings of the National Academy of Sciences
Partner nations: United States Netherlands Germany

In The Last Decade

Darren J. Baker

79 papers receiving 17.7k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

2011 2.7k citations Darren J. Baker, Tobias Wijshake et al. profile →
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

2016 2.0k citations Darren J. Baker, Bennett G. Childs et al. profile →
Cellular senescence in aging and age-related disease: from mechanisms to therapy

2015 1.7k citations Bennett G. Childs, Matej Durik et al. Nature Medicine profile →
Cellular senescence in ageing: from mechanisms to therapeutic opportunities

2020 1.4k citations Darren J. Baker et al. profile →
Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

2017 1.1k citations Darren J. Baker, Jan M. van Deursen et al. Nature Medicine profile →
Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

2018 898 citations Jan M. van Deursen, Darren J. Baker et al. profile →
Senescent cells: an emerging target for diseases of ageing

2017 888 citations Bennett G. Childs, Darren J. Baker et al. profile →
Senescent intimal foam cells are deleterious at all stages of atherosclerosis

2016 857 citations Bennett G. Childs, Darren J. Baker et al. Science profile →
Senescence and apoptosis: dueling or complementary cell fates?

2014 650 citations Bennett G. Childs, Darren J. Baker et al. profile →
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

2004 586 citations Darren J. Baker, Karthik B. Jeganathan et al. profile →
Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives

2018 360 citations Darren J. Baker, Ronald C. Petersen Journal of Clinical Investigation profile →
Senescent alveolar macrophages promote early-stage lung tumorigenesis

2023 109 citations Ines Sturmlechner, Cheng Zhang et al. profile →

Peers

Countries citing papers authored by Darren J. Baker

Since Specialization

Citations

This map shows the geographic impact of Darren J. Baker's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Darren J. Baker with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Darren J. Baker more than expected).

Fields of papers citing papers by Darren J. Baker

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Darren J. Baker. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Darren J. Baker. The network helps show where Darren J. Baker may publish in the future.

Co-authorship network of co-authors of Darren J. Baker

This figure shows the co-authorship network connecting the top 25 collaborators of Darren J. Baker. A scholar is included among the top collaborators of Darren J. Baker based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Darren J. Baker. Darren J. Baker is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	An Unbiased Cell‐Culture Selection Yields DNA Aptamers as Novel Senescent Cell‐Specific Reagents 2025 ·Aging Cell ·(unknown),Sarah K. Jachim,(unknown),(unknown),(unknown),(unknown),Darren J. Baker,Nathan K. LeBrasseur,L. James Maher	0
2	BubR1 Insufficiency Drives Transcriptomic Alterations and Pathology Associated With Cardiac Aging and Heart Failure 2025 ·Aging Cell ·(unknown),Andrew R. Haas,(unknown),S. Takafuji,(unknown),(unknown),Zheng Li,Michelle Waknitz,Michael Kim,Darren J. Baker,Jan M. van Deursen,Paul L. Sorgen,Rebekah L. Gundry,Brian J. North	0
3	Senescent Macrophages Release Inflammatory Cytokines and RNA-Loaded Extracellular Vesicles to Circumvent Fibroblast Senescence 2024 ·Biomedicines ·(unknown),(unknown),Véronique Bourdeau,(unknown),(unknown),(unknown),Sebastian Igelmann,(unknown),Marlene Oeffinger,Darren J. Baker,Luc DesGroseillers,Gerardo Ferbeyre	7
4	Hyperphosphorylated PTEN exerts oncogenic properties 2023 ·Nature Communications ·Janine H. van Ree,Karthik B. Jeganathan,(unknown),Cheng Zhang,İsmail Can,Masakazu Hamada,Hu Li,Darren J. Baker,Jan M. van Deursen	5
5	Senescent cells limit p53 activity via multiple mechanisms to remain viable 2022 ·Nature Communications ·Ines Sturmlechner,(unknown),Karthik B. Jeganathan,Cheng Zhang,(unknown),Darren J. Baker,Hu Li,Jan M. van Deursen	24
6	Current Challenges and Solutions for Clinical Management and Care of People with HIV: Findings from the 12th Annual International HIV and Aging Workshop 2022 ·AIDS Research and Human Retroviruses ·Xiaoying Yu,(unknown),Erin E. Sundermann,Darren J. Baker,Russell P. Tracy,George A. Kuchel,Kathryn E. Stephenson,Scott Letendre,Bruce J. Brew,Lucette A. Cysique,Sannisha K. Dale,(unknown),Ken M. Kunisaki,Giovanni Guaraldi,Jovana Milić,Alan Winston,David J. Moore,Joseph B. Margolick,Kristine M. Erlandson	3
7	Senescent cells suppress innate smooth muscle cell repair functions in atherosclerosis 2021 ·Nature Aging ·Bennett G. Childs,Cheng Zhang,Fahad Shuja,Ines Sturmlechner,(unknown),(unknown),Darren J. Baker,Hu Li,Jan M. van Deursen	52
8	p21 produces a bioactive secretome that places stressed cells under immunosurveillance 2021 ·Science ·Ines Sturmlechner,Cheng Zhang,(unknown),(unknown),Karthik B. Jeganathan,Naomi Hamada,(unknown),David J. Friedman,(unknown),İsmail Can,Masakazu Hamada,Do Young Lim,Jeong‐Heon Lee,Tamás Ördög,Rémi-Martin Laberge,Virginia Smith Shapiro,Darren J. Baker,Hu Li,Jan M. van Deursen	177
9	Therapy-Induced Senescence Drives Bone Loss 2020 ·Cancer Research ·Zhangting Yao,Bhavna Murali,Qihao Ren,Xianmin Luo,Douglas V. Faget,Tom Cole,Biancamaria Ricci,Dinesh Thotala,Joseph B. Monahan,Jan M. van Deursen,Darren J. Baker,Roberta Faccio,Julie K. Schwarz,Sheila A. Stewart	84
10	FoxM1 insufficiency hyperactivates Ect2–RhoA–mDia1 signaling to drive cancer 2020 ·Nature Cancer ·(unknown),Karthik B. Jeganathan,Jake A. Kloeber,Brian A. Davies,Cheng Zhang,Ines Sturmlechner,Jian Zhong,(unknown),Alan P. Fields,Yaxia Yuan,Darren J. Baker,Daohong Zhou,Hu Li,David J. Katzmann,Jan M. van Deursen	4
11	Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectivesbreakdown → 2018 ·Journal of Clinical Investigation ·Darren J. Baker,Ronald C. Petersen	360
12	NF-κB p65 serine 467 phosphorylation sensitizes mice to weight gain and TNFα-or diet-induced inflammation 2017 ·Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ·(unknown),(unknown),Tobias Wijshake,Janine K. Kruit,Nicolette Huijkman,Daphne Dekker,Mirjam H. Koster,Niels Kloosterhuis,Debby P.Y. Koonen,Alain de Bruin,Darren J. Baker,Marten H. Hofker,Jan van Deursen,Johan W. Jonker,M. Lienhard Schmitz,Bart van de Sluis	9
13	Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation 2016 ·Science ·Arun Kanakkanthara,Karthik B. Jeganathan,(unknown),Darren J. Baker,Masakazu Hamada,Hyun-Ja Nam,(unknown),Naomi Hamada,Ryan M. Naylor,Nicole A. Becker,Brian A. Davies,Janine H. van Ree,Georges Mer,Virginia Smith Shapiro,L. James Maher,David J. Katzmann,Jan M. van Deursen	59
14	Senescent intimal foam cells are deleterious at all stages of atherosclerosisbreakdown → 2016 ·Science ·Bennett G. Childs,Darren J. Baker,Tobias Wijshake,Cheryl A. Conover,Judith Campisi,Jan M. van Deursen	857
15	Cellular senescence in aging and age-related disease: from mechanisms to therapybreakdown → 2015 ·Nature Medicine ·Bennett G. Childs,Matej Durik,Darren J. Baker,Jan M. van Deursen	1670
16	Chromosome missegregation causes colon cancer byAPCloss of heterozygosity 2010 ·Cell Cycle ·Darren J. Baker,Jan M. van Deursen	28
17	Securin Associates with APCCdh1 in Prometaphase but its Destruction is Delayed by Rae1 and Nup98 until the Metaphase/Anaphase Transition 2006 ·Cell Cycle ·Karthik B. Jeganathan,Darren J. Baker,Jan M. van Deursen	52
18	Smoothelin-A Is Essential for Functional Intestinal Smooth Muscle Contractility in Mice 2005 ·Gastroenterology ·Petra Niessen,Sander S. Rensen,Jan van Deursen,Joris De Man,(unknown),Jean‐Marie Vanderwinden,Thilo Wedel,Darren J. Baker,Pieter A. Doevendans,Marten H. Hofker,Marion J. Gijbels,Guillaume van Eys	62
19	The mitotic checkpoint in cancer and aging: what have mice taught us? 2005 ·Current Opinion in Cell Biology ·Darren J. Baker,Junjie Chen,(unknown)	73
20	Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation 2003 ·The Journal of Cell Biology ·Jeganathan Ramesh Babu,Karthik B. Jeganathan,Darren J. Baker,Xiaosheng Wu,Ningling Kang‐Decker,Jan M. van Deursen	294

About Darren J. Baker

Darren J. Baker is a scholar working on Aging, Physiology and Cell Biology, having authored 81 papers that have together received 17.9k indexed citations. Recurring topics across this work include Telomeres, Telomerase, and Senescence (33 papers), Microtubule and mitosis dynamics (20 papers) and Neuroinflammation and Neurodegeneration Mechanisms (9 papers). The work is most often cited by research in Aging (2.1k citations), Physiology (8.1k citations) and Geriatrics and Gerontology (696 citations). Darren J. Baker has collaborated with scholars based in United States, Netherlands and Germany. Frequent co-authors include Jan M. van Deursen, Bennett G. Childs, Matej Durik, Tobias Wijshake, James L. Kirkland, Karthik B. Jeganathan, Bart van de Sluis, Nathan K. LeBrasseur, Judith Campisi and Valery Krizhanovsky. Their work appears in journals such as Nature, Science and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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