Alain de Bruin

13.1k citations

160 papers · 8.1k indexed · 1 hit paper · h-index 47

Co-authors: Sameh A. Youssef Gustavo Leone Harry van Steeg Jan Vijg Judith Campisi Bart Westendorp Jan H.J. Hoeijmakers Martijn E.T. Dollé
Topics: Cancer-related Molecular Pathways (27 papers)Liver Disease Diagnosis and Treatment (19 papers)Epigenetics and DNA Methylation (18 papers)
Cited by: Aging Cancer Research Molecular Biology
Journals: Nature Proceedings of the National Academy of Sciences Nucleic Acids Research
Partner nations: Netherlands United States Germany

In The Last Decade

Alain de Bruin

158 papers receiving 8.0k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

2014 1.4k citations Marco Demaria, Naoko Ohtani et al. Developmental Cell profile →

Peers

Countries citing papers authored by Alain de Bruin

Since Specialization

Citations

This map shows the geographic impact of Alain de Bruin's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alain de Bruin with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alain de Bruin more than expected).

Fields of papers citing papers by Alain de Bruin

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alain de Bruin. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alain de Bruin. The network helps show where Alain de Bruin may publish in the future.

Co-authorship network of co-authors of Alain de Bruin

This figure shows the co-authorship network connecting the top 25 collaborators of Alain de Bruin. A scholar is included among the top collaborators of Alain de Bruin based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Alain de Bruin. Alain de Bruin is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Cell-Free RNA from Plasma in Patients with Neuroblastoma: Exploring the Technical and Clinical Potential 2023 ·Cancers ·(unknown),(unknown),Lieke M. J. van Zogchel,(unknown),(unknown),Lily Zappeij‐Kannegieter,Laura Bongiovanni,(unknown),Janine Stutterheim,C. Ellen van der Schoot,Alain de Bruin,Godelieve A.M. Tytgat	5
2	Crosstalk between androgen receptor and WNT/β-catenin signaling causes sex-specific adrenocortical hyperplasia in mice 2023 ·Disease Models & Mechanisms ·(unknown),(unknown),(unknown),(unknown),Mirko Peitzsch,Nicole Bechmann,Sameh A. Youssef,Alain de Bruin,Elvira R. M. Bakker,Frank Claessens,Marie‐Christine Chaboissier,Andreas Schedl	8
3	Limited Efficacy of Adipose Stromal Cell Secretome-Loaded Skin-Derived Hydrogels to Augment Skin Flap Regeneration in Rats 2022 ·Stem Cells and Development ·(unknown),Joris A. van Dongen,(unknown),Linda A. Brouwer,Henk J. Buikema,Luíz Felipe Pinho Moreira,Rolf Gemperli,Laura Bongiovanni,Alain de Bruin,Berend van der Lei,Cristina Pires Camargo,Martin C. Harmsen	12
4	Impaired Hepatic Vitamin A Metabolism in NAFLD Mice Leading to Vitamin A Accumulation in HepatocytesSummary 2021 ·SHILAP Revista de lepidopterología ·Ali Saeed,Paulina Bartuzi,Janette Heegsma,Daphne Dekker,Niels Kloosterhuis,Alain de Bruin,Johan W. Jonker,Bart van de Sluis,Klaas Nico Faber	57
5	Ablation of liver Fxr results in an increased colonic mucus barrier in mice 2021 ·JHEP Reports ·Noortje Ijssennagger,(unknown),Stefanía Magnúsdóttir,José M. Ramos Pittol,Ellen C.L. Willemsen,Marcel R. de Zoete,(unknown),Paul B. Stege,Carolina Colliva,Roberto Pellicciari,Sameh A. Youssef,Alain de Bruin,Yvonne Vercoulen,Folkert Kuipers,Saskia W. C. van Mil	14
6	DNAJB6b-enriched small extracellular vesicles decrease polyglutamine aggregation in in vitro and in vivo models of Huntington disease 2021 ·iScience ·Bhagyashree S. Joshi,Sameh A. Youssef,Reinier Bron,Alain de Bruin,Harm H. Kampinga,Inge S. Zuhorn	24
7	Hepatic Carbohydrate Response Element Binding Protein Activation Limits Nonalcoholic Fatty Liver Disease Development in a Mouse Model for Glycogen Storage Disease Type 1a 2020 ·Hepatology ·Lei Yu,(unknown),Vincent W. Bloks,Trijnie Bos,Aycha Bleeker,Henk Wolters,Justina C. Wolters,(unknown),Theo H. van Dijk,Rachel Thomas,Michel van Weeghel,Gilles Mithieux,Riekelt H. Houtkooper,Alain de Bruin,Fabienne Rajas,Folkert Kuipers,Maaike H. Oosterveer	31
8	Loss of c‐Jun N‐terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma 2020 ·Hepatology Communications ·Francisco Javier Cubero,(unknown),(unknown),Gang Zhao,Maximilian Hatting,Yulia A. Nevzorova,Chaobo Chen,Johannes Haybaeck,Alain de Bruin,Matías A. Ávila,Mark V. Boekschoten,Roger J. Davis,Christian Trautwein	12
9	C/EBPβ-LIP induces cancer-type metabolic reprogramming by regulating the let-7/LIN28B circuit in mice 2019 ·Communications Biology ·Tobias Ackermann,Götz Hartleben,Christine Müller,Guido Mastrobuoni,Marco Groth,(unknown),(unknown),Sameh A. Youssef,(unknown),(unknown),Gertrud Kortman,Gerald de Haan,Alain de Bruin,Zhao‐Qi Wang,Matthias Platzer,Stefan Kempa,Cornelis F. Calkhoven	14
10	Atypical E2f functions are critical for pancreas polyploidization 2018 ·PLoS ONE ·(unknown),(unknown),M.J.M. Toussaint,Peter C.J. Tooten,(unknown),(unknown),Sameh A. Youssef,Laura Bongiovanni,Alain de Bruin	12
11	Hypoxia negatively affects senescence in osteoclasts and delays osteoclastogenesis 2018 ·Journal of Cellular Physiology ·(unknown),Alain de Bruin,Alberto Miranda Bedate,N.M. Korthagen,Claudia F. Wolschrijn,Teun J. de Vries,P. René van Weeren,Marianna A. Tryfonidou	22
12	DYRK1A Is a Regulator of S-Phase Entry in Hepatic Progenitor Cells 2017 ·Stem Cells and Development ·Hedwig S. Kruitwagen,Bart Westendorp,Cornelia S. Viebahn,(unknown),Monique E. van Wolferen,Loes A. Oosterhoff,David A. Egan,Jean‐Maurice Delabar,(unknown),Baukje A. Schotanus,Alain de Bruin,Jan Rothuizen,Louis C. Penning,Bart Spee	5
13	Atypical E2Fs inhibit tumor angiogenesis 2017 ·Oncogene ·Bart Weijts,Bart Westendorp,(unknown),(unknown),(unknown),(unknown),Rachel Thomas,Stefan Schulte‐Merker,Walbert J. Bakker,Alain de Bruin	18
14	Concise Review: Organoids Are a Powerful Tool for the Study of Liver Disease and Personalized Treatment Design in Humans and Animals 2016 ·Stem Cells Translational Medicine ·Sathidpak Nantasanti,Alain de Bruin,Jan Rothuizen,Louis C. Penning,Baukje A. Schotanus	63
15	GEMC 1 is a critical regulator of multiciliated cell differentiation 2016 ·The EMBO Journal ·Berta Terré,(unknown),Sandra Segura‐Bayona,Gabriel Gil‐Gómez,Sameh A. Youssef,Camille Stephan‐Otto Attolini,Michaela Wilsch‐Bräuninger,Carole Jung,Ana M. Rojas,Marko Marjanović,Philip A. Knobel,Lluís Palenzuela,Teresa López‐Rovira,Stephen Forrow,Wieland Β. Huttner,Miguel A. Valverde,Alain de Bruin,Vincenzo Costanzo,Travis H. Stracker	76
16	The Paracrine Feedback Loop Between Vitamin D₃ (1,25(OH)₂D₃) and PTHrP in Prehypertrophic Chondrocytes 2014 ·Journal of Cellular Physiology ·Frances C. Bach,(unknown),(unknown),Frank M. Riemers,(unknown),Alain de Bruin,Ger J. A. Arkesteijn,Richard Wubbolts,William A. Horton,Louis C. Penning,Marianna A. Tryfonidou	18
17	An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AAbreakdown → 2014 ·Developmental Cell ·Marco Demaria,Naoko Ohtani,Sameh A. Youssef,Françis Rodier,Wendy Toussaint,James R. Mitchell,Rémi-Martin Laberge,Jan Vijg,Harry van Steeg,Martijn E.T. Dollé,Jan H.J. Hoeijmakers,Alain de Bruin,Eiji Hara,Judith Campisi	1413
18	Impaired Shedding of TNF Receptor 1 Aggravates High Fat Diet Induced Non-Alcoholic Fatty Liver Disease But Does Not Cause Insulin Resistance in Mice 2012 ·Hepatology ·Pascal P. H. Hommelberg,Marcela Aparicio-Vergara,Marijke Schreurs,Nanda Gruben,Rinke Stienstra,Ronit Shiri‐Sverdlov,Niels Kloosterhuis,Alain de Bruin,Bart van de Sluis,Debby P.Y. Koonen,Marten H. Hofker	1
19	E2F8 is essential for polyploidization in mammalian cells 2012 ·Nature Cell Biology ·Shusil K. Pandit,Bart Westendorp,Sathidpak Nantasanti,(unknown),Peter C.J. Tooten,(unknown),M.J.M. Toussaint,Wouter H. Lamers,Alain de Bruin	124
20	Direct Evidence for Epithelial-Mesenchymal Transitions in Breast Cancer 2008 ·Cancer Research ·Anthony J. Trimboli,Koichi Fukino,Alain de Bruin,Wei Guo,Lei Shen,Stephan M. Tanner,Nicholas Creasap,Thomas J. Rosol,Michael L. Robinson,Charis Eng,Michael C. Ostrowski,Gustavo Leone	275

About Alain de Bruin

Alain de Bruin is a scholar working on Aging, Cancer Research and Oncology, having authored 160 papers that have together received 8.1k indexed citations. Recurring topics across this work include Cancer-related Molecular Pathways (27 papers), Liver Disease Diagnosis and Treatment (19 papers) and Epigenetics and DNA Methylation (18 papers). The work is most often cited by research in Aging (319 citations), Cancer Research (1.1k citations) and Molecular Biology (4.3k citations). Alain de Bruin has collaborated with scholars based in Netherlands, United States and Germany. Frequent co-authors include Sameh A. Youssef, Gustavo Leone, Harry van Steeg, Jan Vijg, Judith Campisi, Bart Westendorp, Jan H.J. Hoeijmakers, Martijn E.T. Dollé, Naoko Ohtani and Françis Rodier. Their work appears in journals such as Nature, Proceedings of the National Academy of Sciences and Nucleic Acids Research.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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