Alain de Bruin

13.1k citations

160 papers · 8.1k indexed · 1 hit paper · h-index 47

Aging top 0.5%
Cancer Research top 1%
- Cancer, Hypoxia, and Metabolism 9
Molecular Biology top 1%
- Epigenetics and DNA Methylation 18
- Ubiquitin and proteasome pathways 12
- DNA Repair Mechanisms 9
- RNA modifications and cancer 9
Physiology top 1%
Oncology top 2%
- Cancer-related Molecular Pathways 27
Epidemiology
- Liver Disease Diagnosis and Treatment 19
Hepatology
- Liver physiology and pathology 9

Co-authors: Sameh A. Youssef Gustavo Leone Harry van Steeg Jan Vijg Judith Campisi Bart Westendorp Jan H.J. Hoeijmakers Martijn E.T. Dollé
Cited by: Aging Cancer Research Molecular Biology
Journals: Nature (2 papers)Proceedings of the National Academy of Sciences (2 papers)Nucleic Acids Research (2 papers)
Partner nations: Netherlands United States Germany

In The Last Decade

Alain de Bruin

158 papers receiving 8.0k citations

Hit Papers

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Peers

Countries citing papers authored by Alain de Bruin

Since Specialization

Citations

This map shows the geographic impact of Alain de Bruin's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alain de Bruin with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alain de Bruin more than expected).

Fields of papers citing papers by Alain de Bruin

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alain de Bruin. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alain de Bruin. The network helps show where Alain de Bruin may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Alain de Bruin, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Alain de Bruin Line = papers co-authored together Alain de Bruin links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Cell-Free RNA from Plasma in Patients with Neuroblastoma: Exploring the Technical and Clinical Potential Cancers ·Nathalie S.M. Lak,Anne Seijger,Lieke M. J. van Zogchel,Nina U. Gelineau,Ahmad Javadi,Lily Zappeij‐Kannegieter,Laura Bongiovanni,Anneloes Andriessen,Janine Stutterheim,C. Ellen van der Schoot,Alain de Bruin,Godelieve A.M. Tytgat	2023	5
2	Crosstalk between androgen receptor and WNT/β-catenin signaling causes sex-specific adrenocortical hyperplasia in mice Disease Models & Mechanisms ·Rodanthi Lyraki,Anaëlle Grabek,Amélie Tison,Lahiru Chamara Weerasinghe Arachchige,Mirko Peitzsch,Nicole Bechmann,Sameh A. Youssef,Alain de Bruin,Elvira R. M. Bakker,Frank Claessens,Marie‐Christine Chaboissier,Andreas Schedl	2023	8
3	Limited Efficacy of Adipose Stromal Cell Secretome-Loaded Skin-Derived Hydrogels to Augment Skin Flap Regeneration in Rats Stem Cells and Development ·Linda Vriend,Joris A. van Dongen,Viktor Sinkunas,Linda A. Brouwer,Henk J. Buikema,Luíz Felipe Pinho Moreira,Rolf Gemperli,Laura Bongiovanni,Alain de Bruin,Berend van der Lei,Cristina Pires Camargo,Martin C. Harmsen	2022	12
4	Impaired Hepatic Vitamin A Metabolism in NAFLD Mice Leading to Vitamin A Accumulation in HepatocytesSummary SHILAP Revista de lepidopterología ·Ali Saeed,Paulina Bartuzi,Janette Heegsma,Daphne Dekker,Niels Kloosterhuis,Alain de Bruin,Johan W. Jonker,Bart van de Sluis,Klaas Nico Faber	2021	57
5	Ablation of liver Fxr results in an increased colonic mucus barrier in mice JHEP Reports ·Noortje Ijssennagger,Kristel S. van Rooijen,Stefanía Magnúsdóttir,José M. Ramos Pittol,Ellen C.L. Willemsen,Marcel R. de Zoete,Matthijs J.D. Baars,Paul B. Stege,Carolina Colliva,Roberto Pellicciari,Sameh A. Youssef,Alain de Bruin,Yvonne Vercoulen,Folkert Kuipers,Saskia W. C. van Mil	2021	14
6	DNAJB6b-enriched small extracellular vesicles decrease polyglutamine aggregation in in vitro and in vivo models of Huntington disease iScience ·Bhagyashree S. Joshi,Sameh A. Youssef,Reinier Bron,Alain de Bruin,Harm H. Kampinga,Inge S. Zuhorn	2021	24
7	Hepatic Carbohydrate Response Element Binding Protein Activation Limits Nonalcoholic Fatty Liver Disease Development in a Mouse Model for Glycogen Storage Disease Type 1a Hepatology ·Lei Yu,Joanne A. Hoogerland,Vincent W. Bloks,Trijnie Bos,Aycha Bleeker,Henk Wolters,Justina C. Wolters,Brenda S. Hijmans,Theo H. van Dijk,Rachel Thomas,Michel van Weeghel,Gilles Mithieux,Riekelt H. Houtkooper,Alain de Bruin,Fabienne Rajas,Folkert Kuipers,Maaike H. Oosterveer	2020	31
8	Loss of c‐Jun N‐terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma Hepatology Communications ·Francisco Javier Cubero,Mohamed Ramadan Mohamed,Marius Maximilian Woitok,Gang Zhao,Maximilian Hatting,Yulia A. Nevzorova,Chaobo Chen,Johannes Haybaeck,Alain de Bruin,Matías A. Ávila,Mark V. Boekschoten,Roger J. Davis,Christian Trautwein	2020	12
9	C/EBPβ-LIP induces cancer-type metabolic reprogramming by regulating the let-7/LIN28B circuit in mice Communications Biology ·Tobias Ackermann,Götz Hartleben,Christine Müller,Guido Mastrobuoni,Marco Groth,Britt Amber Sterken,Mohamad Amr Zaini,Sameh A. Youssef,Hidde R. Zuidhof,Sara Russo Krauss,Gertrud Kortman,Gerald de Haan,Alain de Bruin,Zhao‐Qi Wang,Matthias Platzer,Stefan Kempa,Cornelis F. Calkhoven	2019	14
10	Atypical E2f functions are critical for pancreas polyploidization PLoS ONE ·A.B. Matondo,Eva Venegas Moreno,M.J.M. Toussaint,Peter C.J. Tooten,Saskia C. van Essen,Elsbeth A. van Liere,Sameh A. Youssef,Laura Bongiovanni,Alain de Bruin	2018	12
11	Hypoxia negatively affects senescence in osteoclasts and delays osteoclastogenesis Journal of Cellular Physiology ·B. M. C. Gorissen,Alain de Bruin,Alberto Miranda Bedate,N.M. Korthagen,Claudia F. Wolschrijn,Teun J. de Vries,P. René van Weeren,Marianna A. Tryfonidou	2018	22
12	DYRK1A Is a Regulator of S-Phase Entry in Hepatic Progenitor Cells Stem Cells and Development ·Hedwig S. Kruitwagen,Bart Westendorp,Cornelia S. Viebahn,Krista Post,Monique E. van Wolferen,Loes A. Oosterhoff,David A. Egan,Jean‐Maurice Delabar,M.J.M. Toussaint,Baukje A. Schotanus,Alain de Bruin,Jan Rothuizen,Louis C. Penning,Bart Spee	2017	5
13	Atypical E2Fs inhibit tumor angiogenesis Oncogene ·Bart Weijts,Bart Westendorp,B T Hien,L M Martínez-López,M Zijp,Ingrid Thurlings,Rachel Thomas,Stefan Schulte‐Merker,Walbert J. Bakker,Alain de Bruin	2017	18
14	Concise Review: Organoids Are a Powerful Tool for the Study of Liver Disease and Personalized Treatment Design in Humans and Animals Stem Cells Translational Medicine ·Sathidpak Nantasanti,Alain de Bruin,Jan Rothuizen,Louis C. Penning,Baukje A. Schotanus	2016	63
15	GEMC 1 is a critical regulator of multiciliated cell differentiation The EMBO Journal ·Berta Terré,Gabriele Piergiovanni,Sandra Segura‐Bayona,Gabriel Gil‐Gómez,Sameh A. Youssef,Camille Stephan‐Otto Attolini,Michaela Wilsch‐Bräuninger,Carole Jung,Ana M. Rojas,Marko Marjanović,Philip A. Knobel,Lluís Palenzuela,Teresa López‐Rovira,Stephen Forrow,Wieland Β. Huttner,Miguel A. Valverde,Alain de Bruin,Vincenzo Costanzo,Travis H. Stracker	2016	76
16	The Paracrine Feedback Loop Between Vitamin D₃ (1,25(OH)₂D₃) and PTHrP in Prehypertrophic Chondrocytes Journal of Cellular Physiology ·Frances C. Bach,Kirsten Rutten,Kristyanne Hendriks,Frank M. Riemers,Peter W. A. Cornelissen,Alain de Bruin,Ger J. A. Arkesteijn,Richard Wubbolts,William A. Horton,Louis C. Penning,Marianna A. Tryfonidou	2014	18
17	An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AAbreakdown → Developmental Cell ·Marco Demaria,Naoko Ohtani,Sameh A. Youssef,Françis Rodier,Wendy Toussaint,James R. Mitchell,Rémi-Martin Laberge,Jan Vijg,Harry van Steeg,Martijn E.T. Dollé,Jan H.J. Hoeijmakers,Alain de Bruin,Eiji Hara,Judith Campisi	2014	1413
18	Impaired Shedding of TNF Receptor 1 Aggravates High Fat Diet Induced Non-Alcoholic Fatty Liver Disease But Does Not Cause Insulin Resistance in Mice Hepatology ·Pascal P. H. Hommelberg,Marcela Aparicio-Vergara,Marijke Schreurs,Nanda Gruben,Rinke Stienstra,Ronit Shiri‐Sverdlov,Niels Kloosterhuis,Alain de Bruin,Bart van de Sluis,Debby P.Y. Koonen,Marten H. Hofker	2012	1
19	E2F8 is essential for polyploidization in mammalian cells Nature Cell Biology ·Shusil K. Pandit,Bart Westendorp,Sathidpak Nantasanti,Elsbeth van Liere,Peter C.J. Tooten,Peter W. A. Cornelissen,M.J.M. Toussaint,Wouter H. Lamers,Alain de Bruin	2012	124
20	Direct Evidence for Epithelial-Mesenchymal Transitions in Breast Cancer Cancer Research ·Anthony J. Trimboli,Koichi Fukino,Alain de Bruin,Wei Guo,Lei Shen,Stephan M. Tanner,Nicholas Creasap,Thomas J. Rosol,Michael L. Robinson,Charis Eng,Michael C. Ostrowski,Gustavo Leone	2008	275

About Alain de Bruin

Alain de Bruin is a scholar working on Aging, Cancer Research and Oncology, having authored 160 papers that have together received 8.1k indexed citations. Recurring topics across this work include Cancer-related Molecular Pathways (27 papers), Liver Disease Diagnosis and Treatment (19 papers), Epigenetics and DNA Methylation (18 papers), Ubiquitin and proteasome pathways (12 papers), DNA Repair Mechanisms (9 papers), Liver physiology and pathology (9 papers), RNA modifications and cancer (9 papers) and Cancer, Hypoxia, and Metabolism (9 papers). The work is most often cited by research in Aging (319 citations), Cancer Research (1.1k citations) and Molecular Biology (4.3k citations). Alain de Bruin has collaborated with scholars based in Netherlands, United States and Germany. Frequent co-authors include Sameh A. Youssef, Gustavo Leone, Harry van Steeg, Jan Vijg, Judith Campisi, Bart Westendorp, Jan H.J. Hoeijmakers, Martijn E.T. Dollé, Naoko Ohtani and Françis Rodier. Their work appears in journals such as Nature, Proceedings of the National Academy of Sciences and Nucleic Acids Research.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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