Jeffrey S. Flier

100.9k total citations · 42 hit papers
314 papers, 80.7k citations indexed

About

Jeffrey S. Flier is a scholar working on Molecular Biology, Physiology and Endocrine and Autonomic Systems. According to data from OpenAlex, Jeffrey S. Flier has authored 314 papers receiving a total of 80.7k indexed citations (citations by other indexed papers that have themselves been cited), including 121 papers in Molecular Biology, 102 papers in Physiology and 100 papers in Endocrine and Autonomic Systems. Recurrent topics in Jeffrey S. Flier's work include Regulation of Appetite and Obesity (99 papers), Adipose Tissue and Metabolism (79 papers) and Biochemical Analysis and Sensing Techniques (63 papers). Jeffrey S. Flier is often cited by papers focused on Regulation of Appetite and Obesity (99 papers), Adipose Tissue and Metabolism (79 papers) and Biochemical Analysis and Sensing Techniques (63 papers). Jeffrey S. Flier collaborates with scholars based in United States, United Kingdom and Canada. Jeffrey S. Flier's co-authors include Lisa H. Underhill, Erin E. Kershaw, Rexford S. Ahima, Eleftheria Maratos–Flier, Barbara B. Kahn, Christian Bjørbæk, Bradford B. Lowell, Bruce M. Spiegelman, Harold F. Dvorak and Joel K. Elmquist and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Jeffrey S. Flier

312 papers receiving 77.8k citations

Hit Papers

Adipose Tissue as an Endocrine Organ 1976 2026 1992 2009 2004 1986 2006 1996 2000 1000 2.0k 3.0k 4.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Adipose Tissue as an Endocrine Organ
    2004 4.1k citations Jeffrey S. Flier et al. The Journal of Clinical Endocrinology & Metabolism profile →
  2. Tumors: Wounds That Do Not Heal
    1986 3.4k citations Jeffrey S. Flier et al. profile →
  3. TLR4 links innate immunity and fatty acid–induced insulin resistance
    2006 2.9k citations Hang Shi, Maia V. Kokoeva et al. Journal of Clinical Investigation profile →
  4. Role of leptin in the neuroendocrine response to fasting
    1996 2.6k citations Rexford S. Ahima, Bradford B. Lowell et al. Nature profile →
  5. Obesity and insulin resistance
    2000 2.5k citations Barbara B. Kahn, Jeffrey S. Flier Journal of Clinical Investigation profile →
  6. Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications
    1988 2.1k citations Jeffrey S. Flier et al. profile →
  7. Obesity and the Regulation of Energy Balance
    2001 2.0k citations Jeffrey S. Flier et al. profile →
  8. A Transgenic Model of Visceral Obesity and the Metabolic Syndrome
    2001 1.4k citations Hiroaki Masuzaki, J. Paterson et al. Science profile →
  9. Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
    1995 1.4k citations Bradford B. Lowell, Jeffrey S. Flier et al. profile →
  10. Type I Diabetes Mellitus
    1986 1.3k citations Jeffrey S. Flier et al. profile →
  11. Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States
    2007 1.3k citations Jeffrey S. Flier, Eleftheria Maratos–Flier et al. Cell Metabolism profile →
  12. FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
    2012 1.2k citations Jeffrey S. Flier, Eleftheria Maratos–Flier et al. profile →
  13. Leptin
    2000 1.2k citations Rexford S. Ahima, Jeffrey S. Flier Annual Review of Physiology profile →
  14. Adipogenesis and Obesity: Rounding Out the Big Picture
    1996 1.1k citations Jeffrey S. Flier et al. profile →
  15. The Organization, Promoter Analysis, and Expression of the Human PPARγ Gene
    1997 1.0k citations Jeffrey S. Flier, Bart Staels et al. Journal of Biological Chemistry profile →
  16. Mice lacking melanin-concentrating hormone are hypophagic and lean
    1998 910 citations Nicholas A. Tritos, Bradford B. Lowell et al. Nature profile →
  17. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue
    1993 881 citations Bradford B. Lowell, Jeffrey S. Flier et al. Nature profile →
  18. Obesity Wars
    2004 877 citations Jeffrey S. Flier profile →
  19. Distributions of leptin receptor mRNA isoforms in the rat brain
    1998 862 citations Joel K. Elmquist, Rexford S. Ahima et al. profile →
  20. Lipoprotein Lipase
    1989 846 citations Jeffrey S. Flier et al. profile →
  21. Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance
    1998 835 citations Christian Bjørbæk, Joel K. Elmquist et al. profile →
  22. New Concepts about the Mast Cell
    1993 832 citations Jeffrey S. Flier et al. profile →
  23. The Syndromes of Insulin Resistance and Acanthosis Nigricans
    1976 810 citations Jeffrey S. Flier et al. profile →
  24. Sorbitol, Phosphoinositides, and Sodium-Potassium-ATPase in the Pathogenesis of Diabetic Complications
    1987 758 citations Jeffrey S. Flier et al. profile →
  25. Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor
    1997 756 citations Christian Bjørbæk, Shigeo Uotani et al. Journal of Biological Chemistry profile →
  26. Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area
    1999 734 citations Rexford S. Ahima, Christian Bjørbæk et al. profile →
  27. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
    2000 707 citations Dominique D. Pierroz, Stanley M. Hileman et al. Journal of Clinical Investigation profile →
  28. Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State
    2010 666 citations Jeffrey S. Flier, Eleftheria Maratos–Flier et al. profile →
  29. Elevated Levels of Glucose Transport and Transporter Messenger RNA Are Induced by ras or src Oncogenes
    1987 664 citations Jeffrey S. Flier, Harvey F. Lodish et al. Science profile →
  30. Multiple Cytokines and Acute Inflammation Raise Mouse Leptin Levels: Potential Role in Inflammatory Anorexia
    1997 657 citations Jeffrey S. Flier, Bradford B. Lowell et al. profile →
  31. Insulin Resistance — Mechanisms, Syndromes, and Implications
    1991 640 citations Jeffrey S. Flier et al. profile →
  32. Multiple-Drug Resistance in Human Cancer
    1987 605 citations Jeffrey S. Flier et al. profile →
  33. Leptin Regulation of Neuroendocrine Systems
    2000 588 citations Rexford S. Ahima, Clifford B. Saper et al. profile →
  34. Region-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice
    2004 587 citations Jeffrey S. Flier, Christian Bjørbæk et al. Endocrinology profile →
  35. Regulation of PPAR gamma gene expression by nutrition and obesity in rodents.
    1996 558 citations Bradford B. Lowell, Jeffrey S. Flier et al. Journal of Clinical Investigation profile →
  36. Neurogenesis in the Hypothalamus of Adult Mice: Potential Role in Energy Balance
    2005 547 citations Maia V. Kokoeva, Huali Yin et al. Science profile →
  37. Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function.
    1998 528 citations Rexford S. Ahima, Jeffrey S. Flier et al. Journal of Clinical Investigation profile →
  38. The Immunobiology of Eosinophils
    1991 522 citations Jeffrey S. Flier et al. profile →
  39. The Role of SOCS-3 in Leptin Signaling and Leptin Resistance
    1999 519 citations Christian Bjørbæk, Jeffrey S. Flier et al. Journal of Biological Chemistry profile →
  40. Leptin Regulation of the Mesoaccumbens Dopamine Pathway
    2006 511 citations Eleftheria Maratos–Flier, Jeffrey S. Flier et al. profile →
  41. Human leptin levels are pulsatile and inversely related to pituitary–ardenal function
    1997 507 citations Jeffrey S. Flier et al. profile →
  42. New Concepts in the Biology and Biochemistry of Ascorbic Acid
    1986 494 citations Jeffrey S. Flier et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Jeffrey S. Flier United States 137 28.4k 25.4k 22.6k 19.8k 14.6k 314 80.7k
Stephen R. Bloom United Kingdom 137 23.5k 0.8× 28.8k 1.1× 19.6k 0.9× 7.6k 0.4× 15.1k 1.0× 1.1k 79.9k
Kenji Kangawa Japan 133 24.6k 0.9× 34.8k 1.4× 26.1k 1.2× 6.8k 0.3× 21.8k 1.5× 992 84.3k
Christos S. Mantzoros United States 123 21.3k 0.7× 15.7k 0.6× 10.1k 0.4× 20.1k 1.0× 7.8k 0.5× 642 56.4k
Stephen O’Rahilly United Kingdom 108 16.2k 0.6× 14.4k 0.6× 16.7k 0.7× 9.8k 0.5× 7.8k 0.5× 429 46.8k
Yūji Matsuzawa Japan 123 25.2k 0.9× 8.8k 0.3× 16.7k 0.7× 36.8k 1.9× 4.5k 0.3× 700 80.5k
Jeffrey M. Friedman United States 87 21.1k 0.7× 28.4k 1.1× 11.5k 0.5× 15.8k 0.8× 16.0k 1.1× 209 53.0k
Gökhan S. Hotamışlıgil United States 105 24.3k 0.9× 5.6k 0.2× 26.3k 1.2× 29.9k 1.5× 4.4k 0.3× 178 71.9k
Jerrold M. Olefsky United States 136 24.9k 0.9× 4.6k 0.2× 34.7k 1.5× 19.1k 1.0× 4.3k 0.3× 592 72.0k
Johan Auwerx Switzerland 157 29.9k 1.1× 5.3k 0.2× 51.3k 2.3× 19.7k 1.0× 4.9k 0.3× 638 96.6k
Gerald I. Shulman United States 162 44.9k 1.6× 6.9k 0.3× 49.7k 2.2× 29.1k 1.5× 5.0k 0.3× 619 106.8k

Countries citing papers authored by Jeffrey S. Flier

Since Specialization
Citations

This map shows the geographic impact of Jeffrey S. Flier's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Jeffrey S. Flier with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Jeffrey S. Flier more than expected).

Fields of papers citing papers by Jeffrey S. Flier

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Jeffrey S. Flier. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Jeffrey S. Flier. The network helps show where Jeffrey S. Flier may publish in the future.

Co-authorship network of co-authors of Jeffrey S. Flier

This figure shows the co-authorship network connecting the top 25 collaborators of Jeffrey S. Flier. A scholar is included among the top collaborators of Jeffrey S. Flier based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Jeffrey S. Flier. Jeffrey S. Flier is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Ahima, Rexford S. & Jeffrey S. Flier. (2025). Leptin: 30 Years Later. Annual Review of Physiology. 88(1). 229–250.
2.
Flier, Jeffrey S.. (2023). Moderating “the great debate”: The carbohydrate-insulin vs. the energy balance models of obesity. Cell Metabolism. 35(5). 737–741. 14 indexed citations
3.
Flier, Jeffrey S.. (2017). Faculty promotion must assess reproducibility. Nature. 549(7671). 133–133. 14 indexed citations
4.
Glass, David J. & Jeffrey S. Flier. (2017). Dealing with Consequences of Irreproducibility and Modifying the Published Literature: Retractions versus Revisions. Cell Metabolism. 26(5). 695–696. 2 indexed citations
5.
Flier, Jeffrey S.. (2009). Health care reform: without a correct diagnosis, there is no cure. Journal of Clinical Investigation. 119(10). 2850–2852. 1 indexed citations
6.
Koulmanda, Maria, Manoj Bhasin, Lauren Hoffman, et al.. (2008). Curative and β cell regenerative effects of α1-antitrypsin treatment in autoimmune diabetic NOD mice. Proceedings of the National Academy of Sciences. 105(42). 16242–16247. 134 indexed citations
7.
Shi, Hang, Maia V. Kokoeva, Karen Inouye, et al.. (2006). TLR4 links innate immunity and fatty acid–induced insulin resistance. Journal of Clinical Investigation. 116(11). 3015–3025. 2863 indexed citations breakdown →
8.
Kokoeva, Maia V., Huali Yin, & Jeffrey S. Flier. (2005). Neurogenesis in the Hypothalamus of Adult Mice: Potential Role in Energy Balance. Science. 310(5748). 679–683. 547 indexed citations breakdown →
9.
Drukarch, Benjamin, Jeffrey S. Flier, Cornelis A.M. Jongenelen, Gerda Andringa, & Anton N. M. Schoffelmeer. (2005). The antioxidant anethole dithiolethione inhibits monoamine oxidase-B but not monoamine oxidase A activity in extracts of cultured astrocytes. Journal of Neural Transmission. 113(5). 593–598. 23 indexed citations
10.
Shi, Hang, Iphigenia Tzameli, Christian Bjørbæk, & Jeffrey S. Flier. (2004). Suppressor of Cytokine Signaling 3 Is a Physiological Regulator of Adipocyte Insulin Signaling. Journal of Biological Chemistry. 279(33). 34733–34740. 187 indexed citations
11.
Masuzaki, Hiroaki, Hiroshi Yamamoto, Christopher J. Kenyon, et al.. (2003). Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. Journal of Clinical Investigation. 112(1). 83–90. 34 indexed citations
12.
Masuzaki, Hiroaki, Hiroshi Yamamoto, Christopher J. Kenyon, et al.. (2003). Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. Journal of Clinical Investigation. 112(1). 83–90. 345 indexed citations
13.
Morton, Nicholas M., J. Paterson, Hiroaki Masuzaki, et al.. (2003). Reduced intra-adipose glucocorticoid regeneration: A novel adaptive response to, and therapy for, the metabolic syndrome. 2 indexed citations
14.
Ludwig, David S., Nicholas A. Tritos, Jason Mastaitis, et al.. (2001). Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. Journal of Clinical Investigation. 107(3). 379–386. 486 indexed citations
15.
Hileman, Stanley M., Dominique D. Pierroz, & Jeffrey S. Flier. (2000). Leptin, Nutrition, and Reproduction: Timing Is Everything. The Journal of Clinical Endocrinology & Metabolism. 85(2). 804–807. 69 indexed citations
16.
Bjørbæk, Christian, Joel K. Elmquist, Patrick Michl, et al.. (1998). Expression of Leptin Receptor Isoforms in Rat Brain Microvessels. Endocrinology. 139(8). 3485–3491. 270 indexed citations
17.
Silva, Barbara A. da, Christian Bjørbæk, Shigeo Uotani, & Jeffrey S. Flier. (1998). Functional Properties of Leptin Receptor Isoforms Containing the Gln→Pro Extracellular Domain Mutation of the Fatty Rat*. Endocrinology. 139(9). 3681–3690. 61 indexed citations
18.
Elmquist, Joel K., Rexford S. Ahima, Eleftheria Maratos–Flier, Jeffrey S. Flier, & Clifford B. Saper. (1997). Leptin Activates Neurons in Ventrobasal Hypothalamus and Brainstem. Endocrinology. 138(2). 839–842. 357 indexed citations
19.
Kahn, Barbara B., Samuel W. Cushman, & Jeffrey S. Flier. (1989). Regulation of glucose transporter-specific mRNA levels in rat adipose cells with fasting and refeeding. Implications for in vivo control of glucose transporter number.. Journal of Clinical Investigation. 83(1). 199–204. 59 indexed citations
20.
Flier, Jeffrey S., Mike Mueckler, Anthony L. McCall, & Harvey F. Lodish. (1987). Distribution of glucose transporter messenger RNA transcripts in tissues of rat and man.. Journal of Clinical Investigation. 79(2). 657–661. 177 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact

Breakdown of academic impact, for papers by Stephen R. Bloom Breakdown of academic impact, for papers by Kenji Kangawa Breakdown of academic impact, for papers by Christos S. Mantzoros Breakdown of academic impact, for papers by Stephen O’Rahilly Breakdown of academic impact, for papers by Yūji Matsuzawa Breakdown of academic impact, for papers by Jeffrey M. Friedman Breakdown of academic impact, for papers by Gökhan S. Hotamışlıgil Breakdown of academic impact, for papers by Jerrold M. Olefsky Breakdown of academic impact, for papers by Johan Auwerx Breakdown of academic impact, for papers by Gerald I. Shulman
Rankless by CCL
2026