Christopher M. Overall

39.1k total citations · 9 hit papers
297 papers, 28.1k citations indexed

About

Christopher M. Overall is a scholar working on Cancer Research, Molecular Biology and Oncology. According to data from OpenAlex, Christopher M. Overall has authored 297 papers receiving a total of 28.1k indexed citations (citations by other indexed papers that have themselves been cited), including 134 papers in Cancer Research, 123 papers in Molecular Biology and 118 papers in Oncology. Recurrent topics in Christopher M. Overall's work include Protease and Inhibitor Mechanisms (127 papers), Peptidase Inhibition and Analysis (99 papers) and Advanced Proteomics Techniques and Applications (56 papers). Christopher M. Overall is often cited by papers focused on Protease and Inhibitor Mechanisms (127 papers), Peptidase Inhibition and Analysis (99 papers) and Advanced Proteomics Techniques and Applications (56 papers). Christopher M. Overall collaborates with scholars based in Canada, United States and Switzerland. Christopher M. Overall's co-authors include Carlos López-Otı́n, Georgina S. Butler, Jaro Sodek, Oded Kleifeld, Charlotte Morrison, Eric M. Tam, Jeffrey L. Wrana, Oliver Schilling, Richard A. Dean and Ian Clark‐Lewis and has published in prestigious journals such as Nature, Science and Chemical Reviews.

In The Last Decade

Christopher M. Overall

296 papers receiving 27.6k citations

Hit Papers

Strategies for MMP inhibition in cancer: innovations for... 1989 2026 2001 2013 2002 2006 2007 2003 2000 250 500 750 1000
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Strategies for MMP inhibition in cancer: innovations for the post-trial era
    2002 1.1k citations Christopher M. Overall et al. profile →
  2. Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy
    2006 989 citations Christopher M. Overall et al. profile →
  3. Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion
    2007 770 citations Yi Wu, Eric M. Tam et al. profile →
  4. Human and mouse proteases: a comparative genomic approach
    2003 730 citations Christopher M. Overall et al. profile →
  5. Inflammation Dampened by Gelatinase A Cleavage of Monocyte Chemoattractant Protein-3
    2000 633 citations Eric M. Tam, Christopher M. Overall et al. profile →
  6. Protease degradomics: A new challenge for proteomics
    2002 584 citations Christopher M. Overall et al. profile →
  7. Independent Regulation of Collagenase, 72-kDa Progelatinase, and Metalloendoproteinase Inhibitor Expression in Human Fibroblasts by Transforming Growth Factor-β
    1989 570 citations Christopher M. Overall et al. Journal of Biological Chemistry profile →
  8. Matrix Metalloproteinase Activity Inactivates the CXC Chemokine Stromal Cell-derived Factor-1
    2001 527 citations Georgina S. Butler, Christopher M. Overall et al. Journal of Biological Chemistry profile →
  9. Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour
    2016 496 citations Anthony J. Filiano, Rachel Marsh et al. profile →

Peers

Christopher M. Overall
Comparison fields: 5 of 180
  • Molecular Biology 11.8k
  • Cancer Research 10.8k
  • Oncology 9.5k
  • Immunology and Allergy 3.2k
  • Hematology 3.0k
Replace Jo Van Damme with:
Jo Van Damme Belgium
Ghislain Opdenakker Belgium
J. Silvio Gutkind United States
Lynn M. Matrisian United States
Jan J. Enghild Denmark
Stephen J. Weiss United States
Yasunori Okada Japan
Lisa M. Coussens United States
Paul Säftig Germany
Jeffrey L. Wrana Canada
Jo Van Damme Belgium View profile →
Citations per field, relative to Christopher M. Overall
Christopher M. Overall · 1×
Citations per year, relative to Christopher M. Overall
Christopher M. Overall · 1×

Countries citing papers authored by Christopher M. Overall

Since Specialization
Citations

This map shows the geographic impact of Christopher M. Overall's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Christopher M. Overall with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Christopher M. Overall more than expected).

Fields of papers citing papers by Christopher M. Overall

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Christopher M. Overall. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Christopher M. Overall. The network helps show where Christopher M. Overall may publish in the future.

Co-authorship network of co-authors of Christopher M. Overall

This figure shows the co-authorship network connecting the top 25 collaborators of Christopher M. Overall. A scholar is included among the top collaborators of Christopher M. Overall based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Christopher M. Overall. Christopher M. Overall is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
# Work Indexed citations
1
The 2023 Report on the Proteome from the HUPO Human Proteome Project
2024 ·Journal of Proteome Research ·Gilbert S. Omenn, Lydie Lane, Christopher M. Overall, Cecilia Lindskog, Charles Pineau, Nicolle H. Packer, Ileana M. Cristea, Susan T. Weintraub, Sandra Orchard, Michael H. A. Roehrl, Edouard C. Nice, Tiannan Guo, Jennifer E. Van Eyk, Siqi Liu, Nuno Bandeira, Ruedi Aebersold, Robert L. Moritz, Eric W. Deutsch
11
2
Hydrolases & Lipases in GtoPdb v.2024.4
2024 ·IUPHAR/BPS Guide to Pharmacology CITE ·S P H Alexander, Patrick Doherty, David P. Fairlie, Christopher J. Fowler, Christopher M. Overall, Neil D. Rawlings, Christopher Southan, Anthony J. Turner
1
3
SARS-CoV-2 3CLpro (main protease) regulates caspase activation of gasdermin-D/E pores leading to secretion and extracellular activity of 3CLpro
2024 ·Cell Reports ·Peter M. Grin, Kaushal Baid, Hugo César Ramos de Jesus, (unknown), Peter A. Bell, (unknown), Reinhild Kappelhoff, Georgina S. Butler, (unknown), (unknown), (unknown), Yoan Machado, John C. Vederas, Hugh Kim, Charaf Benarafa, Arinjay Banerjee, Christopher M. Overall
6
4
The 2024 Report on the Human Proteome from the HUPO Human Proteome Project
2024 ·Journal of Proteome Research ·Gilbert S. Omenn, Sandra Orchard, Lydie Lane, Cecilia Lindskog, Charles Pineau, Christopher M. Overall, Bogdan Budnik, Jonathan M. Mudge, Nicolle H. Packer, Susan T. Weintraub, Michael H. A. Roehrl, Edouard C. Nice, Tiannan Guo, Jennifer E. Van Eyk, Uwe Völker, Gong Zhang, Nuno Bandeira, Ruedi Aebersold, Robert L. Moritz, Eric W. Deutsch
4
5
Cleavage of 14-3-3ε by the enteroviral 3C protease dampens RIG-I-mediated antiviral signaling
2023 ·Journal of Virology ·(unknown), Marli Vlok, (unknown), (unknown), Yasir Mohamud, Leonard J. Foster, Honglin Luo, Christopher M. Overall, Eric Jan
9
6
Research on the Human Proteome Reaches a Major Milestone: >90% of Predicted Human Proteins Now Credibly Detected, According to the HUPO Human Proteome Project
2020 ·Journal of Proteome Research ·Gilbert S. Omenn, Lydie Lane, Christopher M. Overall, Ileana M. Cristea, Fernando J. Corrales, Cecilia Lindskog, Young‐Ki Paik, Jennifer E. Van Eyk, Siqi Liu, Stephen R. Pennington, M Snyder, Mark S. Baker, Nuno Bandeira, Ruedi Aebersold, Robert L. Moritz, Eric W. Deutsch
30
7
Novel Human Aminopeptidase N Inhibitors: Discovery and Optimization of Subsite Binding Interactions
2019 ·Journal of Medicinal Chemistry ·Ji Sook Lee, (unknown), Nyssa Drinkwater, Wei Yang, (unknown), (unknown), Michelle Gazdik, Peter M. Grin, Georgina S. Butler, Christopher M. Overall, Susan A. Charman, Sheena McGowan, Peter J. Scammells
19
8
Hydrolases (version 2019.5) in the IUPHAR/BPS Guide to Pharmacology Database
2019 ·IUPHAR/BPS Guide to Pharmacology CITE ·S P H Alexander, Patrick Doherty, David P. Fairlie, Christopher J. Fowler, Christopher M. Overall, Neil D. Rawlings, Christopher Southan, Anthony J. Turner
1
9
Human Proteome Project Mass Spectrometry Data Interpretation Guidelines 3.0
2019 ·Journal of Proteome Research ·Eric W. Deutsch, Lydie Lane, Christopher M. Overall, Nuno Bandeira, Mark S. Baker, Charles Pineau, Robert L. Moritz, Fernando J. Corrales, Sandra Orchard, Jennifer E. Van Eyk, Young‐Ki Paik, Susan T. Weintraub, Yves Vandenbrouck, Gilbert S. Omenn
85
10
Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases
2018 ·Journal of Medicinal Chemistry ·(unknown), Nyssa Drinkwater, (unknown), Michael Kassiou, Leonardo Lucantoni, Peter M. Grin, Georgina S. Butler, Sandra Duffy, Christopher M. Overall, Vicky M. Avery, Peter J. Scammells, Sheena McGowan
27
11
Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia
2018 ·The Journal of Experimental Medicine ·James C. Cronk, Anthony J. Filiano, Antoine Louveau, Ioana Marin, Rachel Marsh, (unknown), Dylan H. Goldman, Igor Smirnov, Nicholas Geraci, Scott T. Acton, Christopher M. Overall, Jonathan Kipnis
285
12
Neuronal integrity and complement control synaptic material clearance by microglia after CNS injury
2018 ·The Journal of Experimental Medicine ·Geoffrey T. Norris, Igor Smirnov, Anthony J. Filiano, (unknown), (unknown), Jeremy Thompson, Tajie H. Harris, Alban Gaultier, Christopher M. Overall, Jonathan Kipnis
83
13
Discovery of a proteolytic flagellin family in diverse bacterial phyla that assembles enzymatically active flagella
2017 ·Nature Communications ·Ulrich Eckhard, Hina Bandukwala, Michael J. Mansfield, Giada Marino, Jiujun Cheng, (unknown), Todd Holyoak, Trevor C. Charles, John W. Austin, Christopher M. Overall, Andrew C. Doxey
35
14
N‐ and C‐terminal degradomics: new approaches to reveal biological roles for plant proteases from substrate identification
2011 ·Physiologia Plantarum ·Pitter F. Huesgen, Christopher M. Overall
41
15
Biochemical Analysis of Matrix Metalloproteinase Activation of Chemokines CCL15 and CCL23 and Increased Glycosaminoglycan Binding of CCL16
2011 ·Journal of Biological Chemistry ·Amanda E. Starr, Antoine Dufour, (unknown), Christopher M. Overall
57
16
Novel Matrix Metalloproteinase Inhibitor [18F]Marimastat-Aryltrifluoroborate as a Probe for In vivo Positron Emission Tomography Imaging in Cancer
2010 ·Cancer Research ·Ulrich auf dem Keller, Caroline L. Bellac, Ying Li, Yuanmei Lou, Philipp F. Lange, Richard Ting, Curtis Harwig, Reinhild Kappelhoff, Shoukat Dedhar, Michael J. Adam, Thomas J. Ruth, François Bénard, David M. Perrin, Christopher M. Overall
69
17
Dissecting the Role of Matrix Metalloproteinases (MMP) and Integrin αvβ3 in Angiogenesis In vitro : Absence of Hemopexin C Domain Bioactivity, but Membrane-Type 1-MMP and αvβ3 Are Critical
2005 ·Cancer Research ·Riccardo E. Nisato, (unknown), Christian Sirrenberg, Georgina S. Butler, Thomas Crabbe, Andrew Docherty, (unknown), Gillian Murphy, Christopher M. Overall, Simon L. Goodman, Michael S. Pepper
54
18
Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1–matrix metalloproteinase substrates
2004 ·Proceedings of the National Academy of Sciences ·Eric M. Tam, Charlotte Morrison, Yi Wu, M. Sharon Stack, Christopher M. Overall
236
19
Tissue Inhibitor of Metalloproteinase (TIMP)-2 Acts Synergistically with Synthetic Matrix Metalloproteinase (MMP) Inhibitors but Not with TIMP-4 to Enhance the (Membrane Type 1)-MMP-dependent Activation of Pro-MMP-2
2000 ·Journal of Biological Chemistry ·Márta Tóth, M. Margarida Bernardo, David C. Gervasi, Paul D. Soloway, Zhiping Wang, Heather F. Bigg, Christopher M. Overall, Yves A. DeClerck, Harald Tschesche, Michael L. Cher, Stephen H.M. Brown, Shahriar Mobashery, Rafael Fridman
121
20
Oncogenic consequences of down-modulating TIMP expression in 3T3 cells with antisense RNA.
1992 ·PubMed ·(unknown), Rama Khokha, Simcha Yagel, Christopher M. Overall, (unknown)
6

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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