Thomas Crabbe

2.5k citations

20 papers · 2.1k indexed · 1 hit paper · h-index 17

Cancer Research top 1%
- Protease and Inhibitor Mechanisms 15
Hematology top 1%
- Blood Coagulation and Thrombosis Mechanisms 8
Immunology and Allergy top 2%
Oncology top 5%
- Peptidase Inhibition and Analysis 12
Biotechnology top 5%
- Enzyme Production and Characterization 4
Molecular Biology
- PI3K/AKT/mTOR signaling in cancer 2
- Enzyme Catalysis and Immobilization 1
- Protein Kinase Regulation and GTPase Signaling 1
Ophthalmology
- Intraocular Surgery and Lenses 1

Co-authors: Gillian Murphy Andrew Docherty Susan J. Atkinson Michael J. Butler James P. O’Connell Frances Willenbrock Georgina S. Butler Tatsuya Tamura
Cited by: Cancer Research Hematology Immunology and Allergy
Journals: Biochemistry (4 papers)FEBS Letters (3 papers)Journal of Biological Chemistry (2 papers)
Partner nations: United Kingdom Canada Germany

In The Last Decade

Thomas Crabbe

20 papers receiving 2.1k citations

Hit Papers

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Peers

Countries citing papers authored by Thomas Crabbe

Since Specialization

Citations

This map shows the geographic impact of Thomas Crabbe's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Thomas Crabbe with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Thomas Crabbe more than expected).

Fields of papers citing papers by Thomas Crabbe

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Thomas Crabbe. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Thomas Crabbe. The network helps show where Thomas Crabbe may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Thomas Crabbe, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Thomas Crabbe Line = papers co-authored together Thomas Crabbe links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR Oncogene ·Václav Veverka,Thomas Crabbe,Ian M. Bird,Vitoria Carvalho Junqueira,Frederick W. Muskett,Richard J. Taylor,Mark D. Carr	2007	122
2	Exploring the potential of PI3K inhibitors for inflammation and cancer Biochemical Society Transactions ·Thomas Crabbe	2007	11
3	Dissecting the Role of Matrix Metalloproteinases (MMP) and Integrin αvβ3 in Angiogenesis In vitro : Absence of Hemopexin C Domain Bioactivity, but Membrane-Type 1-MMP and αvβ3 Are Critical Cancer Research ·Riccardo E. Nisato,宮口文宏,Christian Sirrenberg,Georgina S. Butler,Thomas Crabbe,Andrew Docherty,E. E. SOGLAEVA,Gillian Murphy,Christopher M. Overall,Simon L. Goodman,Michael S. Pepper	2005	54
4	PRIMARY HUMAN HEPATOCYTES ARE PROTECTED AGAINST PROLONGED AND REPEATED EXPOSURE TO ETHANOL BY SILIBININ-DIHEMISUCCINATE Alcohol and Alcoholism ·Jos van Pelt,Chris Verslype,Thomas Crabbe,Z. Zaman,Johan Fevery	2003	23
5	The TIMP2 Membrane Type 1 Metalloproteinase “Receptor” Regulates the Concentration and Efficient Activation of Progelatinase Abreakdown → Journal of Biological Chemistry ·Georgina S. Butler,Michael J. Butler,Susan J. Atkinson,Horst Will,Tatsuya Tamura,T. G. B.,Thomas Crabbe,John M. Clements,Marie‐Pia d’Ortho,Gillian Murphy	1998	510
6	CDP840 Cell Biochemistry and Biophysics ·Maria de Jesus Perry,James P. O’Connell,Christoph Walker,Thomas Crabbe,Chao-jue Huang,Annette Russell,Simon Lumb,Zheng Huang,D. Howat,Rodger A. Allen,Costas Filios,徹夫古倉,T M Daniel,B. Hughes,France Laliberté,G.A. Higgs,Raymond J. Owens	1998	23
7	Matrix metalloproteinases and metastatic cancer. PubMed ·義一宮崎,Gillian Murphy,Hafiz Muhammad Wasif Rasheed,Jan Loffeld,Thomas Crabbe,Edith Rivera,知子種部,Rodrigo Jose Jaimovich Fernandez	1998	108
8	The C‐terminal (haemopexin‐like) domain structure of human gelatinase A (MMP2): structural implications for its function FEBS Letters ·U. Gohlke,F. Xavier Gomis‐Rüth,Thomas Crabbe,Gillian Murphy,Andrew Docherty,Wolfram Bode	1996	75
9	The Secretion of Active Recombinant Human Gastric Lipase bySaccharomyces cerevisiae Protein Expression and Purification ·Thomas Crabbe,A. Neil C. Weir,Ahmad Fu’adin,Michael E. Brown,Chris W. Sutton,将史山内,J. Bonnerjea,Peter A. Lowe,Geoffrey Yarranton	1996	18
10	An analysis of the conformational changes that accompany the activation and inhibition of gelatinase A FEBS Letters ·Thomas Crabbe,Sharon M. Kelly,Nicholas C. Price	1996	6
11	An in Vivo Model for Screening Peptidomimetic Inhibitors of Gelatinase A Journal of Pharmaceutical Sciences ·Surinder K. Chander,Pari Antoniw,Nigel R. A. Beeley,Byron A. Boyce,Thomas Crabbe,Andrew Docherty,J. C. Leonard,Barbara Mason,Kenneth Millar,Andrew T. Millican,Richard Morphy,Andrew Mountain,James P. O’Connell,John Porter,N. Willmott	1995	10
12	Intermolecular Autolytic Cleavage Can Contribute to the Activation of Progelatinase A by Cell Membranes Journal of Biological Chemistry ·Susan J. Atkinson,Thomas Crabbe,Shengyang Jin,Robin V. Ward,Michael J. Butler,Hiroshi Sato,Motoharu Seiki,John J. Reynolds,Gillian Murphy	1995	217
13	[28] Gelatinases A and B Methods in enzymology on CD-ROM/Methods in enzymology ·Gillian Murphy,Thomas Crabbe	1995	162
14	Reciprocated matrix metalloproteinase activation: A process performed by interstitial collagenase and progelatinase A Biochemistry ·Thomas Crabbe,James P. O’Connell,Bryan John Smith,Andrew Docherty	1994	82
15	Mutation of the Active Site Glutamic Acid of Human Gelatinase A: Effects on Latency, Catalysis, and the Binding of Tissue Inhibitor of Metalloproteinases-1 Biochemistry ·Thomas Crabbe,Stanley Zucker,Mark I. Cockett,Frances Willenbrock,Simon Tickle,James P. O’Connell,Hélène Garneau,Gillian Murphy,Andrew Docherty	1994	59
16	Human progelatinase A can be activated by matrilysin FEBS Letters ·Thomas Crabbe,Bryan Ronain Smith,James P. O’Connell,Andrew Docherty	1994	82
17	Regulation of Matrix Metalloproteinase Activity^a Annals of the New York Academy of Sciences ·Gillian Murphy,Frances Willenbrock,Thomas Crabbe,Mark O’Shea,Robyn L. Ward,Susan J. Atkinson,James P. O’Connell,Andrew Docherty	1994	183
18	The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions: A kinetic analysis of the inhibition of gelatinase A Biochemistry ·Frances Willenbrock,Thomas Crabbe,Patrick M. Slocombe,Chris W. Sutton,Andrew Docherty,Mark I. Cockett,Mark O'Shea,K Brocklehurst,Ian Phillips,Gillian Murphy	1993	206
19	Human progelatinase A can be activated by autolysis at a rate that is concentration‐dependent and enhanced by heparin bound to the C‐terminal domain European Journal of Biochemistry ·Thomas Crabbe,Christos V. Ioannou,Andrew Docherty	1993	90
20	Biochemical characterization of matrilysin. Activation conforms to the stepwise mechanisms proposed for other matrix metalloproteinases Biochemistry ·Thomas Crabbe,Frances Willenbrock,Maheshwari Bombale,Peter J. Hynds,Alexander F. Carne,Gillian Murphy,Andrew Docherty	1992	75

About Thomas Crabbe

Thomas Crabbe is a scholar working on Cancer Research, Hematology, Biotechnology, Oncology and Orthodontics, having authored 20 papers that have together received 2.1k indexed citations. Recurring topics across this work include Protease and Inhibitor Mechanisms (15 papers), Peptidase Inhibition and Analysis (12 papers), Blood Coagulation and Thrombosis Mechanisms (8 papers), Enzyme Production and Characterization (4 papers), PI3K/AKT/mTOR signaling in cancer (2 papers), Enzyme Catalysis and Immobilization (1 paper), Protein Kinase Regulation and GTPase Signaling (1 paper) and Intraocular Surgery and Lenses (1 paper). The work is most often cited by research in Cancer Research (1.5k citations), Hematology (669 citations), Immunology and Allergy (332 citations), Oncology (961 citations) and Biotechnology (113 citations). Thomas Crabbe has collaborated with scholars based in United Kingdom, Canada and Germany. Frequent co-authors include Gillian Murphy, Andrew Docherty, Susan J. Atkinson, Michael J. Butler, James P. O’Connell, Frances Willenbrock, Georgina S. Butler, Tatsuya Tamura, Horst Will and Marie‐Pia d’Ortho. Their work appears in journals such as Biochemistry, FEBS Letters, Journal of Biological Chemistry, Journal of Pharmaceutical Sciences and Alcohol and Alcoholism.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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