Che‐Kun James Shen

1.8k citations

16 papers · 1.5k indexed · 1 hit paper · h-index 11

Co-authors: Tom Maniatis John E. Hearst Kuen‐Jer Tsai I‐Fang Wang Henry Rapoport Stephen T. Isaacs Carl V. Hanson Cheng‐Chun Wu
Topics: Hemoglobinopathies and Related Disorders (4 papers)Epigenetics and DNA Methylation (3 papers)Amyotrophic Lateral Sclerosis Research (3 papers)
Cited by: Genetics Neurology Hematology
Journals: Nature Science Cell
Partner nations: Taiwan United States Spain

In The Last Decade

Che‐Kun James Shen

16 papers receiving 1.3k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The chromosomal arrangement of human α-like globin genes: Sequence homology and α-globin gene deletions

1980 470 citations Che‐Kun James Shen, Tom Maniatis et al. Cell profile →

Peers

Countries citing papers authored by Che‐Kun James Shen

Since Specialization

Citations

This map shows the geographic impact of Che‐Kun James Shen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Che‐Kun James Shen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Che‐Kun James Shen more than expected).

Fields of papers citing papers by Che‐Kun James Shen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Che‐Kun James Shen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Che‐Kun James Shen. The network helps show where Che‐Kun James Shen may publish in the future.

Co-authorship network of co-authors of Che‐Kun James Shen

This figure shows the co-authorship network connecting the top 25 collaborators of Che‐Kun James Shen. A scholar is included among the top collaborators of Che‐Kun James Shen based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Che‐Kun James Shen. Che‐Kun James Shen is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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16 of 16 papers shown

#	Work	Indexed citations
1	Hypoxia-induced genome-wide DNA demethylation by DNMT3A and EMT of cancer cells 2025 ·Cellular & Molecular Biology Letters ·(unknown),Pritha Majumder,Sean Chun-Chang Chen,(unknown),Po‐Hsuan Su,Hung-Cheng Lai,(unknown),Hsin-Nan Lin,Chen-Hsin Albert Yu,Hanna S. Yuan,Che‐Kun James Shen	1
2	Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice 2023 ·Journal of Neuroinflammation ·(unknown),Carmen Rodríguez‐Cueto,(unknown),Fabiana Piscitelli,Anna Lauritano,Che‐Kun James Shen,Vincenzo Di Marzo,Javier Fernández‐Ruíz,Eva de Lago	7
3	Activation of a hippocampal CREB-pCREB-miRNA-MEF2 axis modulates individual variation of spatial learning and memory capability 2021 ·Cell Reports ·I‐Fang Wang,Yihan Wang,Yihua Yang,Guo‐Jen Huang,Kuen‐Jer Tsai,Che‐Kun James Shen	14
4	RNA Modifications and RNA Metabolism in Neurological Disease Pathogenesis 2021 ·International Journal of Molecular Sciences ·(unknown),Che‐Kun James Shen,Pritha Majumder	43
5	A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL Sustaining the Erythropoiesis 2021 ·International Journal of Molecular Sciences ·(unknown),Tung‐Liang Lee,(unknown),Kang‐Chung Yang,Yu‐Chiau Shyu,(unknown),Mu‐Jie Lu,Shinsheng Yuan,Che‐Kun James Shen	4
6	Potent and orally active purine-based fetal hemoglobin inducers for treating β-thalassemia and sickle cell disease 2020 ·European Journal of Medicinal Chemistry ·(unknown),Teng‐Kuang Yeh,Yu‐Chi Chou,Tsu Hsu,(unknown),(unknown),(unknown),Chun‐Hung Lin,Chiung‐Tong Chen,Che‐Kun James Shen,Weir‐Torn Jiaang	5
7	G-CSF-mobilized Bone Marrow Mesenchymal Stem Cells Replenish Neural Lineages in Alzheimer’s Disease Mice via CXCR4/SDF-1 Chemotaxis 2016 ·Molecular Neurobiology ·Cheng‐Chun Wu,I‐Fang Wang,Po‐Min Chiang,(unknown),Che‐Kun James Shen,Kuen‐Jer Tsai	43
8	Autophagy Activators Rescue and Alleviate the Pathogenesis of a FTLD-TDP model with TDP-43 Proteinopathies (S8.005) 2015 ·Neurology ·I‐Fang Wang,Kuen‐Jer Tsai,Che‐Kun James Shen	1
9	Autophagy activation ameliorates neuronal pathogenesis of FTLD-U mice 2012 ·Autophagy ·I‐Fang Wang,Kuen‐Jer Tsai,Che‐Kun James Shen	51
10	Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43 2012 ·Proceedings of the National Academy of Sciences ·I‐Fang Wang,(unknown),Yu‐Chih Liu,Cheng‐Chun Wu,Chun‐Hung Yang,Kuen‐Jer Tsai,Che‐Kun James Shen	314
11	Structure and expression of the human θl globin gene 1988 ·Nature ·Shih‐Lan Hsu,Jon Marks,(unknown),Ming F. Tam,Douglas R. Higgs,(unknown),Che‐Kun James Shen	47
12	Competitive and Cooperative Functioning of the Anterior and Posterior Promoter Elements of an Alu Family Repeat 1986 ·Molecular and Cellular Biology ·Carlos Perez‐Stable,Che‐Kun James Shen	18
13	The chromosomal arrangement of human α-like globin genes: Sequence homology and α-globin gene deletionsbreakdown → 1980 ·Cell ·(unknown),Che‐Kun James Shen,Tom Maniatis	470
14	Synthesis and characterization of new psoralen derivatives with superior photoreactivity with DNA and RNA 1977 ·Biochemistry ·Stephen T. Isaacs,Che‐Kun James Shen,John E. Hearst,Henry Rapoport	281
15	Photochemical cross-linking of DNA-RNA helices by psoralen derivatives 1977 ·Journal of Molecular Biology ·Che‐Kun James Shen,Tao‐shih Hsieh,James C. Wang,John E. Hearst	19
16	Cross-Linking of DNA in Situ as a Probe for Chromatin Structure 1976 ·Science ·Carl V. Hanson,Che‐Kun James Shen,John E. Hearst	157

About Che‐Kun James Shen

Che‐Kun James Shen is a scholar working on Aging, Genetics and Toxicology, having authored 16 papers that have together received 1.5k indexed citations. Recurring topics across this work include Hemoglobinopathies and Related Disorders (4 papers), Epigenetics and DNA Methylation (3 papers) and Amyotrophic Lateral Sclerosis Research (3 papers). The work is most often cited by research in Genetics (380 citations), Neurology (264 citations) and Hematology (160 citations). Che‐Kun James Shen has collaborated with scholars based in Taiwan, United States and Spain. Frequent co-authors include Tom Maniatis, John E. Hearst, Kuen‐Jer Tsai, I‐Fang Wang, Henry Rapoport, Stephen T. Isaacs, Carl V. Hanson, Cheng‐Chun Wu, Yu‐Chih Liu and Chun‐Hung Yang. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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