Lea Guo

1.7k citations

21 papers · 1.4k indexed · h-index 16

Impact in

Cell Biology top 5%
- Cellular transport and secretion
- Microtubule and mitosis dynamics
Molecular Biology top 10%
- PI3K/AKT/mTOR signaling in cancer
- Protein Kinase Regulation and GTPase Signaling
- Fungal and yeast genetics research
- Ubiquitin and proteasome pathways
- Polyamine Metabolism and Applications

Papers in ⓘ

Genetics 3
- Glioma Diagnosis and Treatment 3
Cell Biology 4

Co-authors: Fuyuhiko Tamanoi (13 shared papers)Akio Nakashima (2 shared papers)Tatsuhiro Sato (2 shared papers)Chia‐Ling Gau (4 shared papers)Akio Toh‐e (1 shared paper)Yasushi Matsui (1 shared paper)Jun Imai (1 shared paper)Hironori Edamatsu (2 shared papers)
Journals: Journal of Biological Chemistry (4 papers)Neuro-Oncology (2 papers)Oncogene (2 papers)Electrophoresis (1 paper)Molecular Microbiology (1 paper)
Partner nations: United States Japan Germany

In The Last Decade

Lea Guo

20 papers receiving 1.3k citations

Peers

Countries citing papers authored by Lea Guo

Since Specialization

Citations

This map shows the geographic impact of Lea Guo's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Lea Guo with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Lea Guo more than expected).

Fields of papers citing papers by Lea Guo

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Lea Guo. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Lea Guo. The network helps show where Lea Guo may publish in the future.

Co-authors

The 25 scholars most cited alongside Lea Guo, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Lea Guo Line = papers co-authored together Lea Guo links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 21 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Rho3 ofSaccharomyces cerevisiae, Which Regulates the Actin Cytoskeleton and Exocytosis, Is a GTPase Which Interacts with Myo2 and Exo70 Molecular and Cellular Biology ·Nicole Robinson, Lea Guo, Jun Imai, Akio Toh‐e, Yasushi Matsui, Fuyuhiko Tamanoi	1999	165
2	Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer Oncogene ·Tatsuhiro Sato, Akio Nakashima, Lea Guo, Kimberly Coffman, Fuyuhiko Tamanoi	2010	163
3	Specific Activation of mTORC1 by Rheb G-protein in Vitro Involves Enhanced Recruitment of Its Substrate Protein Journal of Biological Chemistry ·Tatsuhiro Sato, Akio Nakashima, Lea Guo, Fuyuhiko Tamanoi	2009	153
4	DrosophilaRheb GTPase is required for cell cycle progression and cell growth Journal of Cell Science ·Parthive H. Patel, Nitika Thapar, Lea Guo, Mónica Martínez, John M. Maris, Chia‐Ling Gau, Judith A. Lengyel, Fuyuhiko Tamanoi	2003	126
5	Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells Proceedings of the National Academy of Sciences ·Juran Kato‐Stankiewicz, Irina Hakimi, Gang Zhi, Jie Zhang, Ilya G. Serebriiskii, Lea Guo, Hironori Edamatsu, Hiroshi Koide, Sanjay Menon, Robert Eckl, Sukumar Sakamuri, Yingchun Lu, Quin‐Zene Chen, Seema Agarwal, W R Baumbach, Erica A. Golemis, Fuyuhiko Tamanoi, Vladimir Khazak	2002	116
6	Identification of Dominant Negative Mutants of Rheb GTPase and Their Use to Implicate the Involvement of Human Rheb in the Activation of p70S6K Journal of Biological Chemistry ·Angel P. Tabancay, Chia‐Ling Gau, Iara M.P. Machado, Erik J. Uhlmann, David H. Gutmann, Lea Guo, Fuyuhiko Tamanoi	2003	90
7	Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines Oncogene ·Hironori Edamatsu, Chia‐Ling Gau, Tetsuo Nemoto, Lea Guo, Fuyuhiko Tamanoi	2000	90
8	Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast Molecular Microbiology ·Jun Urano, Melissa J. Comiso, Lea Guo, Paul‐Joseph Aspuria, Roman Deniskin, Angel P. Tabancay, Juran Kato‐Stankiewicz, Fuyuhiko Tamanoi	2005	73
9	Inhibitors of Protein Geranylgeranyltransferase I and Rab Geranylgeranyltransferase Identified from a Library of Allenoate-derived Compounds Journal of Biological Chemistry ·Masaru Watanabe, Hannah D.G. Fiji, Lea Guo, Lai N. Chan, Sape S. Kinderman, Dennis J. Slamon, Ohyun Kwon, Fuyuhiko Tamanoi	2008	67
10	Glioblastoma Utilizes Fatty Acids and Ketone Bodies for Growth Allowing Progression during Ketogenic Diet Therapy iScience ·Jantzen Sperry, Michael Condro, Lea Guo, Daniel Braas, Nathan VanderVeer-Harris, Kristen K.O. Kim, Whitney B. Pope, Ajit S. Divakaruni, Albert Lai, Heather R. Christofk, María G. Castro, Pedro R. Löwenstein, Janel E. Le Belle, Harley I. Kornblum	2020	63
11	A novel approach to tag and identify geranylgeranylated proteins Electrophoresis ·Lai N. Chan, Courtenay Hart, Lea Guo, Tamara Nyberg, Brandon S.J. Davies, Loren G. Fong, Stephen G. Young, Brian Agnew, Fuyuhiko Tamanoi	2009	50
12	Nitroxoline induces apoptosis and slows glioma growth in vivo Neuro-Oncology ·Jelena Lazović, Lea Guo, Jonathan Nakashima, Leili Mirsadraei, William H. Yong, Han Jo Kim, Benjamin M. Ellingson, Hong Wu, Whitney B. Pope	2014	45
13	Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to SARS-CoV-2 Infection Stroke ·Naoki Kaneko, Sandro Satta, Yutaro Komuro, Sree Deepthi Muthukrishnan, Visesha Kakarla, Lea Guo, Jennifer An, Fanny M. Elahi, Harley I. Kornblum, David S. Liebeskind, Tzung K. Hsiai, Jason D. Hinman	2020	43
14	Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments inTsc-deficient cells via inhibition of both rapamycin-sensitive and -insensitive pathways Molecular Cancer Therapeutics ·Chia‐Ling Gau, Juran Kato‐Stankiewicz, Jiang Chen, Susie Miyamoto, Lea Guo, Fuyuhiko Tamanoi	2005	43
15	A Mutant Form of Human Protein Farnesyltransferase Exhibits Increased Resistance to Farnesyltransferase Inhibitors Journal of Biological Chemistry ·Keith Del Villar, Jun Urano, Lea Guo, Fuyuhiko Tamanoi	1999	35
16	A new aspiration device equipped with a hydro-separator for acute ischemic stroke due to challenging soft and stiff clots Interventional Neuroradiology ·Naoki Kaneko, Mahsa Ghovvati, Yutaro Komuro, Lea Guo, Kasra Khatibi, Lucido Luciano Ponce Mejia, Hamidreza Saber, Nasim Annabi, Satoshi Tateshima	2021	15
17	C-terminally truncated form of αB-crystallin is associated with IDH1 R132H mutation in anaplastic astrocytoma Journal of Neuro-Oncology ·Nuraly K. Avliyakulov, Kavitha S. Rajavel, Khanh Le, Lea Guo, Leili Mirsadraei, William H. Yong, Linda M. Liau, Sichen Li, Albert Lai, Phioanh L. Nghiemphu, Timothy F. Cloughesy, Michael Linetsky, Michael J. Haykinson, Whitney B. Pope	2014	8
18	Evaluation of Magnetonanoparticles Conjugated with New Angiogenesis Peptides in Intracranial Glioma Tumors by MRI Applied Biochemistry and Biotechnology ·Érica A. Oliveira, Jelena Lazović, Lea Guo, Horacio Soto, Bluma Linkowski Faintuch, Massoud Akhtari, Whitney B. Pope	2017	6
19	CBMT-31. HDAC INHIBITION DIMINISHES THE GROWTH OF ENDOGENOUS IDH MUTANT GLIOMAS Neuro-Oncology ·Lubayna Elahi, Matthew C. Garrett, Lea Guo, Michael Condro, Riki Kawaguchi, Shwetal Mehta, Albert Lai, Whitney B. Pope, Harley I. Kornblum	2019	2
20	A novel intracranial exchange guidewire improves the navigation of various endovascular devices: An in vitro study of challenging situations Interventional Neuroradiology ·Naoki Kaneko, Ariel Takayanagi, Hamidreza Saber, Lea Guo, Satoshi Tateshima	2021	2

About Lea Guo

Lea Guo is a scholar working on Genetics, Cell Biology, Molecular Biology, Neurology and Oncology, having authored 21 papers that have together received 1.4k indexed citations. Recurring topics across this work include Cancer-related Molecular Pathways (5 papers), Protein Kinase Regulation and GTPase Signaling (5 papers), PI3K/AKT/mTOR signaling in cancer (5 papers), Glioma Diagnosis and Treatment (3 papers), Mast cells and histamine (2 papers), Nanoplatforms for cancer theranostics (2 papers), Fungal and yeast genetics research (2 papers) and Cell death mechanisms and regulation (2 papers). The work is most often cited by research in Cell Biology (289 citations), Molecular Biology (1.1k citations), Cancer Research (119 citations), Aging (13 citations) and Oncology (198 citations). Lea Guo has collaborated with scholars based in United States, Japan and Germany. Frequent co-authors include Fuyuhiko Tamanoi, Akio Nakashima, Tatsuhiro Sato, Chia‐Ling Gau, Akio Toh‐e, Yasushi Matsui, Jun Imai, Hironori Edamatsu, Juran Kato‐Stankiewicz and Tetsuo Nemoto. Their work appears in journals such as Journal of Biological Chemistry, Neuro-Oncology, Oncogene, Electrophoresis and Molecular Microbiology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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