Lutgarde Serneels

8.4k total citations · 4 hit papers
72 papers, 6.3k citations indexed

About

Lutgarde Serneels is a scholar working on Molecular Biology, Physiology and Cellular and Molecular Neuroscience. According to data from OpenAlex, Lutgarde Serneels has authored 72 papers receiving a total of 6.3k indexed citations (citations by other indexed papers that have themselves been cited), including 42 papers in Molecular Biology, 36 papers in Physiology and 15 papers in Cellular and Molecular Neuroscience. Recurrent topics in Lutgarde Serneels's work include Alzheimer's disease research and treatments (36 papers), Neuroinflammation and Neurodegeneration Mechanisms (10 papers) and Neuroscience and Neuropharmacology Research (8 papers). Lutgarde Serneels is often cited by papers focused on Alzheimer's disease research and treatments (36 papers), Neuroinflammation and Neurodegeneration Mechanisms (10 papers) and Neuroscience and Neuropharmacology Research (8 papers). Lutgarde Serneels collaborates with scholars based in Belgium, United States and United Kingdom. Lutgarde Serneels's co-authors include Bart De Strooper, Wim Annaert, Katleen Craessaerts, Dieter Hartmann, An Herreman, Paul Säftig, Lieve Umans, Fred Van Leuven, Tim Dejaegere and Désiré Collen and has published in prestigious journals such as Science, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

Lutgarde Serneels

68 papers receiving 6.2k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling

2006 587 citations Sara Cipolat, Dieter Hartmann et al. Cell profile →
Presenilins Form ER Ca2+ Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations

2006 565 citations Lutgarde Serneels, Bart De Strooper et al. Cell profile →
MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease

2023 128 citations Sriram Balusu, Katrien Horré et al. Science profile →
Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology

2024 55 citations Renzo Mancuso, Nicola Fattorelli et al. Nature Neuroscience profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Lutgarde Serneels Belgium	37	3.4k	3.3k	1.2k	1.0k	882	72	6.3k
Michael S. Wolfe United States	34	4.0k 1.2×	4.5k 1.3×	1.4k 1.1×	1.3k 1.2×	708 0.8×	66	8.1k
Katleen Craessaerts Belgium	28	4.7k 1.4×	4.6k 1.4×	1.4k 1.1×	1.3k 1.2×	1.4k 1.6×	39	7.9k
Paolo Paganetti Switzerland	37	4.1k 1.2×	3.1k 0.9×	2.1k 1.7×	761 0.7×	1.3k 1.5×	90	7.1k
Satoshi Tsubuki Japan	28	2.4k 0.7×	2.6k 0.8×	1.0k 0.8×	720 0.7×	923 1.0×	40	4.9k
Xin Yu China	25	2.1k 0.6×	3.0k 0.9×	1.3k 1.0×	816 0.8×	368 0.4×	74	5.1k
Anja Capell Germany	48	3.6k 1.1×	5.0k 1.5×	1.1k 0.9×	1.4k 1.3×	1.4k 1.6×	67	7.6k
Mike Hutton United States	40	3.4k 1.0×	5.8k 1.7×	2.1k 1.7×	1.6k 1.5×	707 0.8×	84	9.1k
Toshiharu Suzuki Japan	41	3.0k 0.9×	2.8k 0.8×	1.0k 0.8×	645 0.6×	1.4k 1.6×	133	5.1k
Mark E. Gurney United States	36	3.9k 1.1×	2.7k 0.8×	1.8k 1.5×	1.3k 1.2×	720 0.8×	89	11.0k
Oksana Berezovska United States	38	2.2k 0.6×	2.5k 0.7×	889 0.7×	653 0.6×	590 0.7×	85	4.1k

Countries citing papers authored by Lutgarde Serneels

Since Specialization

Citations

This map shows the geographic impact of Lutgarde Serneels's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Lutgarde Serneels with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Lutgarde Serneels more than expected).

Fields of papers citing papers by Lutgarde Serneels

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Lutgarde Serneels. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Lutgarde Serneels. The network helps show where Lutgarde Serneels may publish in the future.

Co-authorship network of co-authors of Lutgarde Serneels

This figure shows the co-authorship network connecting the top 25 collaborators of Lutgarde Serneels. A scholar is included among the top collaborators of Lutgarde Serneels based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Lutgarde Serneels. Lutgarde Serneels is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Serneels, Lutgarde, Annerieke Sierksma, Emanuela Pasciuto, et al.. (2025). A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseases. Molecular Neurodegeneration. 20(1). 29–29.

Albertini, Giulia, An Snellinx, Suresh Poovathingal, et al.. (2025). The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia. Nature Neuroscience. 29(1). 100–110.

Mancuso, Renzo, Nicola Fattorelli, Anna Martínez‐Muriana, et al.. (2024). Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology. Nature Neuroscience. 27(5). 886–900. 55 indexed citations breakdown →

Albertini, Giulia, Sarah C. Borrie, Lutgarde Serneels, et al.. (2024). Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease. Nature Communications. 15(1). 10634–10634. 35 indexed citations

Acker, Zoë P. Van, Ragna Sannerud, Zsuzsanna Callaerts‐Vegh, et al.. (2024). Altered expression of Presenilin2 impacts endolysosomal homeostasis and synapse function in Alzheimer’s disease-relevant brain circuits. Nature Communications. 15(1). 10412–10412. 3 indexed citations

Erkert, Lena, Reyes Gámez‐Belmonte, Jay V. Patankar, et al.. (2024). Alzheimer’s disease-related presenilins are key to intestinal epithelial cell function and gut immune homoeostasis. Gut. 73(10). 1618–1631. 8 indexed citations

Preman, Pranav, Emre Fertan, Leen Wolfs, et al.. (2024). APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia. EMBO Molecular Medicine. 16(12). 3113–3141. 8 indexed citations

Serneels, Lutgarde, Rajeshwar Narlawar, Laura Pérez‐Benito, et al.. (2023). Selective inhibitors of the PSEN1–gamma-secretase complex. Journal of Biological Chemistry. 299(6). 104794–104794. 10 indexed citations

Balusu, Sriram, Katrien Horré, Nicola Thrupp, et al.. (2023). MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease. Science. 381(6663). 1176–1182. 128 indexed citations breakdown →

10.

Narlawar, Rajeshwar, et al.. (2023). Discovery of brain permeable 2-Azabicyclo[2.2.2]octane sulfonamides as a novel class of presenilin-1 selective γ-secretase inhibitors. European Journal of Medicinal Chemistry. 260. 115725–115725. 2 indexed citations

11.

Lemmens, Sophie, Xavier Hadoux, Géraldine Gelders, et al.. (2021). The AppNL-G-F mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research. Acta Neuropathologica Communications. 9(1). 6–6. 34 indexed citations

12.

Spinazzi, Marco, Enrico Radaelli, Katrien Horré, et al.. (2018). PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome. Proceedings of the National Academy of Sciences. 116(1). 277–286. 69 indexed citations

13.

Serneels, Lutgarde, Enrico Radaelli, Serge Muyldermans, et al.. (2017). Inactivation of γ‐secretases leads to accumulation of substrates and non‐Alzheimer neurodegeneration. EMBO Molecular Medicine. 9(8). 1088–1099. 36 indexed citations

14.

Chávez‐Gutiérrez, Lucía, Lutgarde Serneels, Sam Lismont, et al.. (2014). Signature Amyloid beta Profiles Are Produced by Different gamma-Secretase Complexes. UCL Discovery (University College London). 19 indexed citations

15.

Chávez‐Gutiérrez, Lucía, Lutgarde Serneels, Sam Lismont, et al.. (2013). Signature Amyloid β Profiles Are Produced by Different γ-Secretase Complexes. Journal of Biological Chemistry. 289(7). 4346–4355. 65 indexed citations

16.

Serneels, Lutgarde, et al.. (2013). The composition of the γ-secretase complex defines its Aβ product profile. Molecular Neurodegeneration. 8(S1). 1 indexed citations

17.

Qi, Xiaoping, Jun Cai, Lutgarde Serneels, et al.. (2012). Inhibition of β-secretase Results in a Retinal Phenotype Involving Both the Vasculature and the RPE. Investigative Ophthalmology & Visual Science. 53(14). 1145–1145. 1 indexed citations

18.

Cipolat, Sara, Dieter Hartmann, Veronica Costa, et al.. (2006). Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling. Cell. 126(1). 163–175. 587 indexed citations breakdown →

19.

Hébert, Sébastien S., Lutgarde Serneels, Tim Dejaegere, et al.. (2004). Coordinated and widespread expression of γ-secretase in vivo: evidence for size and molecular heterogeneity. Neurobiology of Disease. 17(2). 260–272. 128 indexed citations

20.

Komano, Hiroto, Hirohisa Shiraishi, Yuuki Kawamura, et al.. (2002). A New Functional Screening System for Identification of Regulators for the Generation of Amyloid β-Protein. Journal of Biological Chemistry. 277(42). 39627–39633. 20 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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