D. Grahame Hardie

87.7k total citations · 40 hit papers
450 papers, 71.0k citations indexed

About

D. Grahame Hardie is a scholar working on Molecular Biology, Surgery and Materials Chemistry. According to data from OpenAlex, D. Grahame Hardie has authored 450 papers receiving a total of 71.0k indexed citations (citations by other indexed papers that have themselves been cited), including 328 papers in Molecular Biology, 146 papers in Surgery and 77 papers in Materials Chemistry. Recurrent topics in D. Grahame Hardie's work include Metabolism, Diabetes, and Cancer (251 papers), Pancreatic function and diabetes (142 papers) and Adipose Tissue and Metabolism (60 papers). D. Grahame Hardie is often cited by papers focused on Metabolism, Diabetes, and Cancer (251 papers), Pancreatic function and diabetes (142 papers) and Adipose Tissue and Metabolism (60 papers). D. Grahame Hardie collaborates with scholars based in United Kingdom, United States and Denmark. D. Grahame Hardie's co-authors include Simon A. Hawley, David Carling, Fiona A. Ross, W. W. Winder, Stephen Davies, David Pan, Ian P. Salt, John G. Gillespie, Julia M. Corton and Mhairi C. Towler and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

D. Grahame Hardie

444 papers receiving 69.5k citations

Hit Papers

AMPK: a nutrient and energy sen... 1989 2026 2001 2013 2012 2005 2007 2017 2003 1000 2.0k 3.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. AMPK: a nutrient and energy sensor that maintains energy homeostasis
    2012 3.5k citations D. Grahame Hardie, Fiona A. Ross et al. profile →
  2. AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
    2005 2.3k citations David Carling, D. Grahame Hardie et al. Cell Metabolism profile →
  3. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
    2007 1.8k citations D. Grahame Hardie profile →
  4. The mechanisms of action of metformin
    2017 1.6k citations D. Grahame Hardie et al. profile →
  5. Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade
    2003 1.4k citations Simon A. Hawley, Kirsty J. Mustard et al. profile →
  6. Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase
    2005 1.3k citations Simon A. Hawley, David Pan et al. Cell Metabolism profile →
  7. AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function
    2011 1.3k citations D. Grahame Hardie profile →
  8. THE AMP-ACTIVATED/SNF1 PROTEIN KINASE SUBFAMILY: Metabolic Sensors of the Eukaryotic Cell?
    1998 1.2k citations D. Grahame Hardie, David Carling et al. profile →
  9. The AMP‐Activated Protein Kinase
    1997 1.1k citations D. Grahame Hardie, David Carling European Journal of Biochemistry profile →
  10. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1
    2004 1.1k citations Simon A. Hawley, D. Grahame Hardie et al. profile →
  11. 5-Aminoimidazole-4-Carboxamide Ribonucleoside. A Specific Method for Activating AMP-Activated Protein Kinase in Intact Cells?
    1995 1.1k citations Simon A. Hawley, D. Grahame Hardie et al. European Journal of Biochemistry profile →
  12. AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling
    2007 1.0k citations Mhairi C. Towler, D. Grahame Hardie profile →
  13. Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase
    1996 1.0k citations Simon A. Hawley, David Carling et al. profile →
  14. The AMP-activated protein kinase pathway – new players upstream and downstream
    2004 961 citations D. Grahame Hardie Journal of Cell Science profile →
  15. Metabolism of inflammation limited by AMPK and pseudo-starvation
    2013 926 citations D. Grahame Hardie et al. profile →
  16. AMPK: Sensing Glucose as well as Cellular Energy Status
    2017 878 citations D. Grahame Hardie et al. Cell Metabolism profile →
  17. AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle
    1997 844 citations D. Grahame Hardie et al. profile →
  18. AMP-activated protein kinase, a metabolic master switch: possible roles in Type 2 diabetes
    1999 842 citations D. Grahame Hardie et al. profile →
  19. Minireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status
    2003 842 citations D. Grahame Hardie profile →
  20. 5-Aminoimidazole-4-Carboxamide Ribonucleoside. A Specific Method for Activating AMP-Activated Protein Kinase in Intact Cells?
    1995 838 citations Simon A. Hawley, D. Grahame Hardie et al. European Journal of Biochemistry profile →
  21. Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism
    1989 763 citations David Carling, D. Grahame Hardie et al. profile →
  22. Management of cellular energy by the AMP‐activated protein kinase system
    2003 702 citations D. Grahame Hardie, David Pan et al. FEBS Letters profile →
  23. AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs
    2015 699 citations D. Grahame Hardie et al. profile →
  24. Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin
    2013 671 citations Morgan D. Fullerton, D. Grahame Hardie et al. profile →
  25. Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise
    1996 662 citations D. Grahame Hardie et al. profile →
  26. AMP‐activated protein kinase – development of the energy sensor concept
    2006 655 citations D. Grahame Hardie, Simon A. Hawley et al. profile →
  27. AMP‐activated protein kinase: the energy charge hypothesis revisited
    2001 642 citations D. Grahame Hardie, Simon A. Hawley profile →
  28. Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation
    2010 634 citations Simon A. Hawley, Fiona A. Ross et al. Cell Metabolism profile →
  29. CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations
    2004 606 citations Simon A. Hawley, Kevin A. Green et al. Journal of Clinical Investigation profile →
  30. The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase
    2012 590 citations Simon A. Hawley, Morgan D. Fullerton et al. Science profile →
  31. The Antidiabetic Drug Metformin Activates the AMP-Activated Protein Kinase Cascade via an Adenine Nucleotide-Independent Mechanism
    2002 566 citations Simon A. Hawley, D. Grahame Hardie et al. profile →
  32. AMPK: a key regulator of energy balance in the single cell and the whole organism
    2008 562 citations D. Grahame Hardie profile →
  33. AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control
    2020 545 citations D. Grahame Hardie et al. Cell Metabolism profile →
  34. New insights into activation and function of the AMPK
    2022 537 citations Gregory R. Steinberg, D. Grahame Hardie profile →
  35. Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding
    2000 512 citations Ian P. Salt, D. Grahame Hardie et al. profile →
  36. Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK
    2017 508 citations Simon A. Hawley, Alexander Gray et al. profile →
  37. AMPK—Sensing Energy while Talking to Other Signaling Pathways
    2014 465 citations D. Grahame Hardie Cell Metabolism profile →
  38. AMPK: positive and negative regulation, and its role in whole-body energy homeostasis
    2014 397 citations D. Grahame Hardie profile →
  39. AMPK: A Target for Drugs and Natural Products With Effects on Both Diabetes and Cancer
    2013 372 citations D. Grahame Hardie profile →
  40. The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels
    2016 314 citations Simon A. Hawley, Graeme J. Gowans et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
D. Grahame Hardie United Kingdom 128 50.5k 19.4k 15.9k 10.2k 8.4k 450 71.0k
Johan Auwerx Switzerland 157 51.3k 1.0× 12.8k 0.7× 29.9k 1.9× 19.7k 1.9× 8.0k 1.0× 638 96.6k
Christopher K. Glass United States 149 61.4k 1.2× 8.8k 0.5× 10.0k 0.6× 8.8k 0.9× 7.0k 0.8× 375 96.6k
David Carling United Kingdom 85 28.9k 0.6× 11.9k 0.6× 11.6k 0.7× 8.2k 0.8× 5.3k 0.6× 183 40.7k
Ronald M. Evans United States 187 96.0k 1.9× 13.3k 0.7× 20.1k 1.3× 11.6k 1.1× 19.8k 2.4× 629 148.1k
Bruce E. Kemp Australia 112 31.0k 0.6× 8.7k 0.4× 11.1k 0.7× 5.2k 0.5× 4.7k 0.6× 451 44.8k
C. Ronald Kahn United States 143 36.9k 0.7× 14.4k 0.7× 26.6k 1.7× 13.6k 1.3× 13.9k 1.7× 515 74.9k
Bart Staels France 147 41.5k 0.8× 17.1k 0.9× 18.2k 1.1× 18.4k 1.8× 13.1k 1.6× 789 78.9k
Aldons J. Lusis United States 116 30.8k 0.6× 11.3k 0.6× 12.1k 0.8× 6.8k 0.7× 6.5k 0.8× 617 63.9k
Benoı̂t Viollet France 98 27.2k 0.5× 9.7k 0.5× 9.5k 0.6× 10.8k 1.1× 5.3k 0.6× 344 42.4k
Jerrold M. Olefsky United States 136 34.7k 0.7× 12.4k 0.6× 24.9k 1.6× 19.1k 1.9× 15.5k 1.9× 592 72.0k

Countries citing papers authored by D. Grahame Hardie

Since Specialization
Citations

This map shows the geographic impact of D. Grahame Hardie's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by D. Grahame Hardie with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites D. Grahame Hardie more than expected).

Fields of papers citing papers by D. Grahame Hardie

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by D. Grahame Hardie. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by D. Grahame Hardie. The network helps show where D. Grahame Hardie may publish in the future.

Co-authorship network of co-authors of D. Grahame Hardie

This figure shows the co-authorship network connecting the top 25 collaborators of D. Grahame Hardie. A scholar is included among the top collaborators of D. Grahame Hardie based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with D. Grahame Hardie. D. Grahame Hardie is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Hewitt, Victoria L., David Zhang, Kevin C. Gonzalez, et al.. (2024). Activity-dependent compartmentalization of dendritic mitochondria morphology through local regulation of fusion-fission balance in neurons in vivo. Nature Communications. 15(1). 2142–2142. 24 indexed citations
2.
Towler, Mhairi C., Emma Hudson, Thomas Macartney, et al.. (2024). AMPK associates with and causes fragmentation of the Golgi by phosphorylating the guanine nucleotide exchange factor GBF1. Journal of Cell Science. 137(24). 2 indexed citations
3.
Hawley, Simon A., Fiona M. Russell, Fiona A. Ross, & D. Grahame Hardie. (2023). BAY-3827 and SBI-0206965: Potent AMPK Inhibitors That Paradoxically Increase Thr172 Phosphorylation. International Journal of Molecular Sciences. 25(1). 453–453. 11 indexed citations
4.
Vara‐Ciruelos, Diana, et al.. (2017). Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca2+/CaMKK2 Signaling to Enhance Tumor Cell Survival. Molecular Cancer Research. 16(2). 345–357. 45 indexed citations
5.
Fogarty, Sarah, Fiona A. Ross, Diana Vara‐Ciruelos, et al.. (2016). AMPK Causes Cell Cycle Arrest in LKB1-Deficient Cells via Activation of CAMKK2. Molecular Cancer Research. 14(8). 683–695. 65 indexed citations
6.
Gowans, Graeme J., Simon A. Hawley, Fiona A. Ross, & D. Grahame Hardie. (2013). AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation. Cell Metabolism. 18(4). 556–566. 403 indexed citations
7.
Lee, Chi Wai, Leo Lap-Yan Wong, Veronica Yee-Law Leong, et al.. (2012). AMPK Promotes p53 Acetylation via Phosphorylation and Inactivation of SIRT1 in Liver Cancer Cells. Cancer Research. 72(17). 4394–4404. 180 indexed citations
8.
Hawley, Simon A., Morgan D. Fullerton, Fiona A. Ross, et al.. (2012). The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase. Science. 336(6083). 918–922. 590 indexed citations breakdown →
9.
Evans, Anthony M., et al.. (2006). Does AMP-activated Protein Kinase Couple Inhibition of Mitochondrial Oxidative Phosphorylation by Hypoxia to Pulmonary Artery Constriction?. Advances in experimental medicine and biology. 580. 147–154. 11 indexed citations
10.
Hardie, D. Grahame. (2004). AMP-activated protein kinase: the guardian of cardiac energy status. Journal of Clinical Investigation. 114(4). 465–468. 80 indexed citations
11.
Hardie, D. Grahame. (2004). AMP-activated protein kinase: the guardian of cardiac energy status. Journal of Clinical Investigation. 114(4). 465–468. 71 indexed citations
12.
Downs, Stephen M., Emma Hudson, & D. Grahame Hardie. (2002). A Potential Role for AMP-Activated Protein Kinase in Meiotic Induction in Mouse Oocytes. Developmental Biology. 245(1). 200–212. 96 indexed citations
13.
14.
Wei, Kexiang, et al.. (1996). Notch severity effect on hydrogen embrittlement of type 4340 steel. Journal of Material Science and Technology. 12(1). 51–56. 10 indexed citations
15.
Hardie, D. Grahame & Steven K. Hanks. (1995). Protein-tyrosine kinases. Academic Press eBooks. 1 indexed citations
16.
Hardie, D. Grahame, David Carling, & Nigel G. Halford. (1994). Roles of the Snf1/Rkin1/AMP-activated protein kinase family in the response to environmental and nutritional stress. PubMed. 5(6). 409–416. 77 indexed citations
17.
Hardie, D. Grahame. (1991). Reactin' with activin. Current Biology. 1(5). 321–322. 1 indexed citations
18.
Hardie, D. Grahame, et al.. (1990). Yeast carbamoyl‐phosphate‐synthetase – aspartate‐transcarbamylase multidomain protein is phosphorylated in vitro by cAMP‐dependent protein kinase. European Journal of Biochemistry. 193(2). 581–587. 12 indexed citations
19.
Hardie, D. Grahame & J.R. Coggins. (1986). Multidomain proteins : structure and evolution. Elsevier eBooks. 28 indexed citations
20.
Hardie, D. Grahame, et al.. (1965). THE ROLE OF HYDRIDE PRECIPITATE IN THE FRACTURE OF ZIRCONIUM AND ITS ALLOYS. 1 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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