William E. Mitch

51.9k total citations · 17 hit papers
312 papers, 37.4k citations indexed

About

William E. Mitch is a scholar working on Molecular Biology, Cell Biology and Physiology. According to data from OpenAlex, William E. Mitch has authored 312 papers receiving a total of 37.4k indexed citations (citations by other indexed papers that have themselves been cited), including 107 papers in Molecular Biology, 102 papers in Cell Biology and 102 papers in Physiology. Recurrent topics in William E. Mitch's work include Muscle metabolism and nutrition (93 papers), Dialysis and Renal Disease Management (63 papers) and Metabolism and Genetic Disorders (58 papers). William E. Mitch is often cited by papers focused on Muscle metabolism and nutrition (93 papers), Dialysis and Renal Disease Management (63 papers) and Metabolism and Genetic Disorders (58 papers). William E. Mitch collaborates with scholars based in United States, China and Italy. William E. Mitch's co-authors include S. Russ Price, Alfred L. Goldberg, Giuseppe Remuzzi, William F. Keane, Dick de Zeeuw, Barry M. Brenner, Shahnaz Shahinfar, Mark E. Cooper, Hans‐Henrik Parving and Stewart H. Lecker and has published in prestigious journals such as New England Journal of Medicine, Proceedings of the National Academy of Sciences and The Lancet.

In The Last Decade

William E. Mitch

308 papers receiving 36.0k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy

2001 5.4k citations William E. Mitch et al. profile →
Diabetes and Cardiovascular Disease

1999 2.1k citations Scott M. Grundy, Ivor J. Benjamin et al. Circulation profile →
A proposed nomenclature and diagnostic criteria for protein–energy wasting in acute and chronic kidney disease

2007 1.4k citations Joel D. Kopple, William E. Mitch et al. Kidney International profile →
Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression

2004 1.3k citations James L. Bailey, S. Russ Price et al. profile →
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

2003 1.2k citations Ulf Landmesser, Sergey Dikalov et al. Journal of Clinical Investigation profile →
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

2003 1.2k citations Ulf Landmesser, Sergey Dikalov et al. Journal of Clinical Investigation profile →
AHA Dietary Guidelines

2000 1.2k citations Robert H. Eckel, Barbara V. Howard et al. Circulation profile →
Protein Degradation by the Ubiquitin–Proteasome Pathway in Normal and Disease States

2006 959 citations William E. Mitch et al. Journal of the American Society of Nephrology profile →
Mechanisms of Muscle Wasting — The Role of the Ubiquitin–Proteasome Pathway

1996 917 citations William E. Mitch et al. profile →
Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: Lessons from RENAAL

2004 731 citations William E. Mitch et al. Kidney International profile →
A method for estimating nitrogen intake of patients with chronic renal failure

1985 633 citations William E. Mitch et al. Kidney International profile →
Etiology of the Protein-Energy Wasting Syndrome in Chronic Kidney Disease: A Consensus Statement From the International Society of Renal Nutrition and Metabolism (ISRNM)

2013 629 citations William E. Mitch, S. Russ Price et al. profile →
Muscle Protein Breakdown and the Critical Role of the Ubiquitin-Proteasome Pathway in Normal and Disease States

1999 592 citations William E. Mitch et al. profile →
Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions

2004 575 citations Jie Du, Xiaonan Wang et al. Journal of Clinical Investigation profile →
Albuminuria, a Therapeutic Target for Cardiovascular Protection in Type 2 Diabetic Patients With Nephropathy

2004 567 citations William E. Mitch et al. Circulation profile →
Mechanisms of muscle wasting in chronic kidney disease

2014 447 citations William E. Mitch et al. profile →
A SIMPLE METHOD OF ESTIMATING PROGRESSION OF CHRONIC RENAL FAILURE

1976 356 citations William E. Mitch et al. profile →

Peers

Countries citing papers authored by William E. Mitch

Since Specialization

Citations

This map shows the geographic impact of William E. Mitch's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William E. Mitch with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William E. Mitch more than expected).

Fields of papers citing papers by William E. Mitch

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William E. Mitch. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William E. Mitch. The network helps show where William E. Mitch may publish in the future.

Co-authorship network of co-authors of William E. Mitch

This figure shows the co-authorship network connecting the top 25 collaborators of William E. Mitch. A scholar is included among the top collaborators of William E. Mitch based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with William E. Mitch. William E. Mitch is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Interplay between Skeletal Muscle Catabolism and Remodeling of Arteriovenous Fistula by Yes-Associated Protein 1 (YAP1) Signaling 2025 ·Journal of the American Society of Nephrology ·(unknown), Tae Hoon Lee, (unknown), Eric K. Peden, Qingtian Li, Jun Wang, (unknown), Marites P. Melancon, David Sheikh‐Hamad, Tao Wang, Luan D. Truong, William E. Mitch, Ming Liang, Jizhong Cheng	1
2	Chronic kidney disease promotes atrial fibrillation via inflammasome pathway activation 2023 ·Journal of Clinical Investigation ·Jia Song, José Alberto Navarro‐García, Jiao Wu, Arnela Saljic, Issam Abu-Taha, Luge Li, Satadru K. Lahiri, Joshua A. Keefe, (unknown), (unknown), Yue Yuan, (unknown), Markus Kamler, William E. Mitch, Gema Ruiz‐Hurtado, Zhaoyong Hu, Sandhya S. Thomas, Dobromir Dobrev, Xander H.T. Wehrens, Na Li	38
3	Stat3 activation induces insulin resistance via a muscle-specific E3 ubiquitin ligase Fbxo40 2020 ·American Journal of Physiology-Endocrinology and Metabolism ·Ping Zhang, (unknown), Ying Wang, David J. Tweardy, William E. Mitch	33
4	Proton Pump Inhibitors, Histamine-2 Receptor Antagonists, and Hip Fracture Risk among Patients on Hemodialysis 2018 ·Clinical Journal of the American Society of Nephrology ·Chandan Vangala, Jingbo Niu, Colin R. Lenihan, William E. Mitch, Sankar D. Navaneethan, Wolfgang C. Winkelmayer	14
5	AMP-activated protein kinase/myocardin-related transcription factor-A signaling regulates fibroblast activation and renal fibrosis 2017 ·Kidney International ·Yuguo Wang, Jia Li, Zhaoyong Hu, Mark L. Entman, William E. Mitch, Yanlin Wang	36
6	The pathway to muscle fibrosis depends on myostatin stimulating the differentiation of fibro/adipogenic progenitor cells in chronic kidney disease 2016 ·Kidney International ·Jiangling Dong, Yanjun Dong, (unknown), William E. Mitch, Ping Zhang	62
7	Loss of glutathione S‐transferase A4 accelerates obstruction‐induced tubule damage and renal fibrosis 2012 ·The Journal of Pathology ·Anlin Liang, Yun Wang, Lauren E. Woodard, Matthew H. Wilson, Rajendra Sharma, Sanjay Awasthi, Jie Du, William E. Mitch, Jizhong Cheng	25
8	Development of a Diagnostic Method for Detecting Increased Muscle Protein Degradation in Patients with Catabolic Conditions 2006 ·Journal of the American Society of Nephrology ·Biruh Workeneh, Helbert Rondon‐Berrios, Ping Zhang, Zhaoyong Hu, (unknown), Arny A. Ferrando, Joel D. Kopple, Hui‐Yun Wang, Thomas W. Storer, Mario Fournier, Seoung Woo Lee, Jie Du, William E. Mitch	96
9	Beneficial responses to modified diets in treating patients with chronic kidney disease 2005 ·Kidney International ·William E. Mitch	30
10	Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions 2004 ·Journal of Clinical Investigation ·Jie Du, Xiaonan Wang, (unknown), James L. Bailey, Richard Debigaré, Bin Zheng, S. Russ Price, William E. Mitch	45
11	Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions breakdown → 2004 ·Journal of Clinical Investigation ·Jie Du, Xiaonan Wang, (unknown), James L. Bailey, Richard Debigaré, Bin Zheng, S. Russ Price, William E. Mitch	575
12	Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension breakdown → 2003 ·Journal of Clinical Investigation ·Ulf Landmesser, Sergey Dikalov, S. Russ Price, Louise McCann, Tohru Fukai, Steven M. Holland, William E. Mitch, David G. Harrison	1176
13	Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension breakdown → 2003 ·Journal of Clinical Investigation ·Ulf Landmesser, Sergey Dikalov, S. Russ Price, Louise McCann, Tohru Fukai, Steven M. Holland, William E. Mitch, David G. Harrison	1224
14	Malnutrition: a frequent misdiagnosis for hemodialysis patients 2002 ·Journal of Clinical Investigation ·William E. Mitch	6
15	Malnutrition: a frequent misdiagnosis for hemodialysis patients 2002 ·Journal of Clinical Investigation ·William E. Mitch	83
16	Diabetes and Cardiovascular Disease breakdown → 1999 ·Circulation ·Scott M. Grundy, Ivor J. Benjamin, Gregory L. Burke, Alan Chait, Robert H. Eckel, Barbara V. Howard, William E. Mitch, Sidney C. Smith, James R. Sowers	2118
17	Report from the Treasurer 1999 ·Kidney International ·William E. Mitch	2
18	Glomerular function in Pima Indians with noninsulin-dependent diabetes mellitus of recent onset. 1991 ·Journal of Clinical Investigation ·Bryan D. Myers, Robert G. Nelson, George W. Williams, Paul Bennett, Sheila Hardy, (unknown), Nicholas R. Loon, William C. Knowler, William E. Mitch	101
19	The Progressive nature of renal disease 1986 ·Churchill Livingstone eBooks ·William E. Mitch	102
20	Creatinine, Uric Acid, and Other Nitrogenous Waste Products: Clinical Implication of the Imbalance Between Their Production and Elimination in Uremia 1983 ·Seminars in Nephrology ·Ralph A. Kelly, William E. Mitch	5

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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