Standout Papers

The DNA Damage Response: Making It Safe to Play ... 1995 2026 2005 2015 3.2k
  1. The DNA Damage Response: Making It Safe to Play with Knives (2010)
    Alberto Ciccia, Stephen J. Elledge Molecular Cell
  2. The DNA damage response: putting checkpoints in perspective (2000)
    Bin‐Bing S. Zhou, Stephen J. Elledge Nature
  3. ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage (2007)
    Shuhei Matsuoka, Bryan A. Ballif et al. Science
  4. Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes (2003)
    Lee Zou, Stephen J. Elledge Science
  5. Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control (1995)
    Chu‐Xia Deng, Pumin Zhang et al. Cell
  6. Cell Cycle Checkpoints: Preventing an Identity Crisis (1996)
    Stephen J. Elledge Science
  7. Dicer is essential for mouse development (2003)
    Emily Bernstein, Sang Yong Kim et al. Nature Genetics
  8. Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint (2000)
    Qinghua Liu, Shuhei Matsuoka et al. Genes & Development
  9. The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. (1993)
    T. Durfee, Kathleen Becherer et al. Genes & Development
  10. Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction (2009)
    Ji Luo, Nicole L. Solimini et al. Cell
  11. The DNA Damage Response: Ten Years After (2007)
    J. Wade Harper, Stephen J. Elledge Molecular Cell
  12. A quantitative atlas of mitotic phosphorylation (2008)
    Noah Dephoure, Chunshui Zhou et al. Proceedings of the National Academy of Sciences
  13. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest (1994)
    Vjekoslav Dulić, William K. Kaufmann et al. Cell
  14. Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex (2002)
    Ning Zheng, Brenda A. Schulman et al. Nature
  15. SKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery through a Novel Motif, the F-Box (1996)
    Chang Bai, Partha Sen et al. Cell
  16. Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen (2008)
    Abraham L. Brass, Derek M. Dykxhoorn et al. Science
  17. Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis (2022)
    Kjetil Bjørnevik, Marianna Cortese et al. Science
  18. Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25 (1997)
    Yolanda Sánchez, Calvin Wong et al. Science
  19. F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex (1997)
    Dorota Skowyra, Karen Craig et al. Cell
  20. DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2 (2000)
    Atsushi Hirao, Young‐Yun Kong et al. Science
  21. The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus (2009)
    Abraham L. Brass, I‐Chueh Huang et al. Cell
  22. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures (2000)
    Yi Wang, David Cortez et al. Genes & Development
  23. p53-Independent Expression of p21 Cip1 in Muscle and Other Terminally Differentiating Cells (1995)
    Susan B. Parker, Gregor Eichele et al. Science
  24. Formation and Activation of a Cyclin E-cdk2 Complex During the G 1 Phase of the Human Cell Cycle (1992)
    Andrew Koff, Antonio Giordano et al. Science
  25. Cyclin D1 provides a link between development and oncogenesis in the retina and breast (1995)
    Piotr Siciński, Joana Liu Donaher et al. Cell
  26. Inhibition of cyclin-dependent kinases by p21. (1995)
    J. Wade Harper, Stephen J. Elledge et al. Molecular Biology of the Cell
  27. Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy (2017)
    Teresa Davoli, Hajime Uno et al. Science
  28. p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. (1995)
    Satomi Matsuoka, Michael C. Edwards et al. Genes & Development
  29. Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks (1999)
    David Cortez, Yi Wang et al. Science
  30. The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitro (1999)
    Jeffrey Winston, Peter R. Strack et al. Genes & Development
  31. A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene (2009)
    Ji Luo, Michael J. Emanuele et al. Cell
  32. Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1 (1993)
    Xianfeng Zhang, Jeffrey Settleman et al. Nature
  33. ATR and ATRIP: Partners in Checkpoint Signaling (2001)
    David Cortez, Jun Qin et al. Science
  34. Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC (2007)
    Mamie Z. Li, Stephen J. Elledge Nature Methods
  35. The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4 (2015)
    Chanhee Kang, Qikai Xu et al. Science
  36. MDC1 is a mediator of the mammalian DNA damage checkpoint (2003)
    Grant S. Stewart, Bin Wang et al. Nature
  37. Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro (2000)
    Shuhei Matsuoka, Galit Rotman et al. Proceedings of the National Academy of Sciences
  38. Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase (1999)
    Takumi Kamura, Deanna M. Koepp et al. Science
  39. Phosphorylation-Dependent Ubiquitination of Cyclin E by the SCF Fbw7 Ubiquitin Ligase (2001)
    Deanna M. Koepp, Laura Schaefer et al. Science
  40. Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair (2015)
    Raphaël Ceccaldi, Jessie Liu et al. Nature
  41. Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith–Wiedemann syndrome (1997)
    Pumin Zhang, Nanette J. Liégeois et al. Nature
  42. Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis (1996)
    Piotr Siciński, Joana Liu Donaher et al. Nature
  43. Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response (2007)
    Bin Wang, Shuhei Matsuoka et al. Science
  44. Identification of the FANCI Protein, a Monoubiquitinated FANCD2 Paralog Required for DNA Repair (2007)
    Agata Smogorzewska, Shuhei Matsuoka et al. Cell
  45. A resource for large-scale RNA-interference-based screens in mammals (2004)
    Patrick J. Paddison, José M. Silva et al. Nature Cell Biology
  46. Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns and Shape the Cancer Genome (2013)
    Teresa Davoli, Andrew Wei Xu et al. Cell
  47. Regulation of RAD53 by the ATM -Like Kinases MEC1 and TEL1 in Yeast Cell Cycle Checkpoint Pathways (1996)
    Yolanda Sánchez, Brian Desany et al. Science
  48. The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo (2011)
    Kristen L. Meerbrey, Guang Hu et al. Proceedings of the National Academy of Sciences
  49. Distinct Patterns of IFITM-Mediated Restriction of Filoviruses, SARS Coronavirus, and Influenza A Virus (2011)
    I‐Chueh Huang, Charles C. Bailey et al. PLoS Pathogens

Immediate Impact

60 by Nobel laureates 114 from Science/Nature 245 standout
Sub-graph 1 of 14

Citing Papers

The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
Cancer Genome Landscapes
2013 StandoutScience
12 intermediate papers

Works of Stephen J. Elledge being referenced

Recurrent Hemizygous Deletions in Cancers May Optimize Proliferative Potential
2012 Science
The DNA damage response: putting checkpoints in perspective
2000 StandoutNature
and 28 more

Author Peers

Author Last Decade Papers Cites
Stephen J. Elledge 75009 27392 14866 360 91.4k
Tony Hunter 77156 23136 17369 502 103.0k
J. Wade Harper 48175 19357 11582 303 61.5k
Tyler Jacks 58358 33760 6890 336 86.1k
Stephen P. Jackson 55777 20612 5513 346 65.3k
Douglas Hanahan 78402 43041 9385 224 134.4k
John C. Reed 72596 21174 9970 788 106.2k
Roderick T. Bronson 45554 22954 7384 543 76.8k
Paul Tempst 61550 8205 8629 320 79.9k
Steven P. Gygi 87120 12298 17827 689 119.3k
Nahum Sonenberg 75137 6966 7594 664 94.7k

All Works

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