Xi Chen

39.6k total citations · 10 hit papers
346 papers, 20.2k citations indexed

About

Xi Chen is a scholar working on Molecular Biology, Cancer Research and Immunology. According to data from OpenAlex, Xi Chen has authored 346 papers receiving a total of 20.2k indexed citations (citations by other indexed papers that have themselves been cited), including 232 papers in Molecular Biology, 137 papers in Cancer Research and 35 papers in Immunology. Recurrent topics in Xi Chen's work include Cancer-related molecular mechanisms research (79 papers), RNA modifications and cancer (78 papers) and MicroRNA in disease regulation (45 papers). Xi Chen is often cited by papers focused on Cancer-related molecular mechanisms research (79 papers), RNA modifications and cancer (78 papers) and MicroRNA in disease regulation (45 papers). Xi Chen collaborates with scholars based in China, United States and Singapore. Xi Chen's co-authors include Yu Shyr, Brian D. Lehmann, Jennifer A. Pietenpol, Melinda E. Sanders, Ron Prywes, Joshua A. Bauer, A. Bapsi Chakravarthy, Juan R. Cubillos‐Ruiz, Jingshi Shen and Linda M. Hendershot and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Nucleic Acids Research and Journal of Biological Chemistry.

In The Last Decade

Xi Chen

325 papers receiving 19.9k citations

Hit Papers

Identification of human triple-negative breast can... 2000 2026 2008 2017 2011 2000 2002 2016 2020 1000 2.0k 3.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
    2011 3.9k citations Xi Chen et al. Journal of Clinical Investigation profile →
  2. ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs
    2000 1.5k citations Xi Chen et al. profile →
  3. ER Stress Regulation of ATF6 Localization by Dissociation of BiP/GRP78 Binding and Unmasking of Golgi Localization Signals
    2002 1.1k citations Xi Chen et al. profile →
  4. Refinement of Triple-Negative Breast Cancer Molecular Subtypes: Implications for Neoadjuvant Chemotherapy Selection
    2016 946 citations Xi Chen et al. profile →
  5. Endoplasmic reticulum stress signals in the tumour and its microenvironment
    2020 848 citations Xi Chen et al. profile →
  6. TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages
    2010 787 citations Xi Chen et al. profile →
  7. Serum MicroRNA Signatures Identified in a Genome-Wide Serum MicroRNA Expression Profiling Predict Survival of Non–Small-Cell Lung Cancer
    2010 660 citations Xi Chen et al. profile →
  8. Reciprocal Transcriptional Regulation of Pou5f1 and Sox2 via the Oct4/Sox2 Complex in Embryonic Stem Cells
    2005 534 citations Xi Chen et al. profile →
  9. An Overview: The Diversified Role of Mitochondria in Cancer Metabolism
    2023 137 citations Xi Chen et al. profile →
  10. METTL5 stabilizes c‐Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression
    2023 99 citations Peng Xia, Hao Zhang et al. Cancer Communications profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Xi Chen China 53 11.7k 5.8k 4.5k 4.3k 2.5k 346 20.2k
J. Alan Diehl United States 73 13.6k 1.2× 3.4k 0.6× 5.6k 1.3× 6.0k 1.4× 3.5k 1.4× 175 20.9k
Federica Sotgia United States 84 14.8k 1.3× 9.9k 1.7× 4.7k 1.1× 4.0k 0.9× 2.2k 0.9× 210 21.6k
Brendan D. Manning United States 62 22.0k 1.9× 4.9k 0.9× 3.9k 0.9× 3.5k 0.8× 3.6k 1.4× 118 30.9k
Jian Yu United States 69 13.5k 1.2× 3.6k 0.6× 6.4k 1.4× 2.3k 0.5× 1.5k 0.6× 262 20.4k
Ze’ev A. Ronai United States 83 16.0k 1.4× 4.4k 0.8× 5.9k 1.3× 2.7k 0.6× 1.8k 0.7× 299 21.1k
Owen J. Sansom United Kingdom 80 14.4k 1.2× 4.9k 0.8× 8.8k 2.0× 3.5k 0.8× 1.6k 0.6× 311 23.8k
Jan M. van Deursen United States 60 13.3k 1.1× 2.8k 0.5× 4.1k 0.9× 3.5k 0.8× 2.0k 0.8× 116 26.1k
Gerhard Christofori Switzerland 71 12.4k 1.1× 4.5k 0.8× 7.1k 1.6× 2.9k 0.7× 961 0.4× 163 19.6k
Vassilis G. Gorgoulis Greece 63 11.6k 1.0× 3.2k 0.6× 5.4k 1.2× 1.7k 0.4× 1.5k 0.6× 331 18.5k
Nissim Hay United States 75 20.2k 1.7× 6.5k 1.1× 4.9k 1.1× 2.1k 0.5× 2.2k 0.9× 160 27.9k

Countries citing papers authored by Xi Chen

Since Specialization
Citations

This map shows the geographic impact of Xi Chen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Xi Chen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Xi Chen more than expected).

Fields of papers citing papers by Xi Chen

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Xi Chen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Xi Chen. The network helps show where Xi Chen may publish in the future.

Co-authorship network of co-authors of Xi Chen

This figure shows the co-authorship network connecting the top 25 collaborators of Xi Chen. A scholar is included among the top collaborators of Xi Chen based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Xi Chen. Xi Chen is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Jaehnig, Eric J., Meenakshi Anurag, Jonathan T. Lei, et al.. (2025). NF1-depleted ER + breast cancers are differentially sensitive to CDK4/6 inhibitors. Science Translational Medicine. 17(813). eadq5492–eadq5492.
2.
Zhang, Ligang, Chunyan Liu, Xi Chen, et al.. (2024). Targeting ONECUT2 inhibits tumor angiogenesis via down-regulating ZKSCAN3/VEGFA. Biochemical Pharmacology. 225. 116315–116315. 3 indexed citations
3.
Chen, Junhao, Yi Pan, Fang Xue, et al.. (2024). The Function and Mechanism of Long Noncoding RNAs in Adipogenic Differentiation. Genes. 15(7). 875–875. 2 indexed citations
4.
Jiang, Fahui, Mahbub Ul Islam, Xinfeng Jiang, et al.. (2024). Selenium levels in soil and tea as affected by soil properties in Jiangxi Province, China. BMC Plant Biology. 24(1). 3 indexed citations
5.
Li, Xiaoyu, Jianwei Huang, Xi Chen, et al.. (2024). Lnc00113 promotes triple‐negative breast cancer progression via the NOB‐1/MAPK signaling axis. The Journal of Gene Medicine. 26(2). 1 indexed citations
6.
7.
Wang, Xiaofeng, Tao Yang, Xi Chen, et al.. (2023). Patterns and causes of forest gap disturbance in a semi-humid evergreen broadleaved forest in the Jizu Mountains, Yunnan. Biodiversity Science. 31(11). 23219–23219. 1 indexed citations
8.
Xia, Peng, Hao Zhang, Haofeng Lu, et al.. (2023). METTL5 stabilizes c‐Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression. Cancer Communications. 43(3). 338–364. 99 indexed citations breakdown →
9.
Zheng, Caishang, Yanjun Wei, Peng Zhang, et al.. (2023). CRISPR/Cas9 screen uncovers functional translation of cryptic lncRNA-encoded open reading frames in human cancer. Journal of Clinical Investigation. 133(5). 25 indexed citations
10.
Zhu, Tingting, Han Liu, Li Su, et al.. (2021). Identification of Unique Key miRNAs, TFs, and mRNAs in Virulent MTB Infection Macrophages by Network Analysis. International Journal of Molecular Sciences. 23(1). 382–382. 11 indexed citations
11.
Yan, Yuanliang, Qiuju Liang, Xinxin Ren, et al.. (2021). Dynamic m6A-ncRNAs association and their impact on cancer pathogenesis, immune regulation and therapeutic response. Genes & Diseases. 10(1). 135–150. 12 indexed citations
12.
Tsika, Elpida, Kaela Kelly, Nathan Levine, et al.. (2020). Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity. Proceedings of the National Academy of Sciences. 117(29). 17296–17307. 43 indexed citations
13.
Shen, Yao, Jiaxin Hong, Shiho Asaka, et al.. (2020). Inhibition of the MYC-Regulated Glutaminase Metabolic Axis Is an Effective Synthetic Lethal Approach for Treating Chemoresistant Ovarian Cancers. Cancer Research. 80(20). 4514–4526. 60 indexed citations
14.
Gomez, Lissette, Gabriel Odom, Juan I. Young, et al.. (2019). coMethDMR: accurate identification of co-methylated and differentially methylated regions in epigenome-wide association studies with continuous phenotypes. Nucleic Acids Research. 47(17). e98–e98. 22 indexed citations
15.
Yu, Aixin, Yuguang Ban, Xi Chen, et al.. (2018). IL-2/CD25: A Long-Acting Fusion Protein That Promotes Immune Tolerance by Selectively Targeting the IL-2 Receptor on Regulatory T Cells. The Journal of Immunology. 201(9). 2579–2592. 68 indexed citations
16.
Chen, Zheng, Zheng Li, Mohammed Soutto, et al.. (2018). Integrated Analysis of Mouse and Human Gastric Neoplasms Identifies Conserved microRNA Networks in Gastric Carcinogenesis. Gastroenterology. 156(4). 1127–1139.e8. 36 indexed citations
17.
Du, Shangce, Kai Yin, Shichao Ai, et al.. (2018). Knockdown long noncoding RNA nuclear paraspeckle assembly transcript 1 suppresses colorectal cancer through modulating miR‐193a‐3p/KRAS. Cancer Medicine. 8(1). 261–275. 25 indexed citations
18.
Chen, Xi, et al.. (2018). Correlation of TET2 SNP rs2454206 with improved survival in children with acute myeloid leukemia featuring intermediate‐risk cytogenetics. Genes Chromosomes and Cancer. 57(8). 379–386. 7 indexed citations
19.
Chen, Bo, Hailin Tang, Xi Chen, et al.. (2018). Transcriptomic analyses identify key differentially expressed genes and clinical outcomes between triple-negative and non-triple-negative breast cancer. Cancer Management and Research. Volume 11. 179–190. 38 indexed citations
20.
Chen, Chao, Lianrong Wang, Si Chen, et al.. (2017). Convergence of DNA methylation and phosphorothioation epigenetics in bacterial genomes. Proceedings of the National Academy of Sciences. 114(17). 4501–4506. 59 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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