James A. McCubrey

34.5k total citations · 8 hit papers
421 papers, 24.9k citations indexed

About

James A. McCubrey is a scholar working on Molecular Biology, Oncology and Hematology. According to data from OpenAlex, James A. McCubrey has authored 421 papers receiving a total of 24.9k indexed citations (citations by other indexed papers that have themselves been cited), including 296 papers in Molecular Biology, 131 papers in Oncology and 58 papers in Hematology. Recurrent topics in James A. McCubrey's work include PI3K/AKT/mTOR signaling in cancer (106 papers), Melanoma and MAPK Pathways (48 papers) and Cancer-related Molecular Pathways (46 papers). James A. McCubrey is often cited by papers focused on PI3K/AKT/mTOR signaling in cancer (106 papers), Melanoma and MAPK Pathways (48 papers) and Cancer-related Molecular Pathways (46 papers). James A. McCubrey collaborates with scholars based in United States, Italy and Poland. James A. McCubrey's co-authors include Linda S. Steelman, Richard A. Franklin, Alberto M. Martelli, Massimo Libra, Camilla Evangelisti, Patrick M. Navolanic, Stephen L. Abrams, William L. Blalock, Francesca Chiarini and J G Shelton and has published in prestigious journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

James A. McCubrey

420 papers receiving 24.5k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance

2006 1.9k citations James A. McCubrey, Linda S. Steelman et al. profile →
Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy

2003 999 citations Patrick M. Navolanic, Linda S. Steelman et al. Leukemia profile →
Reactive Oxygen Species-Induced Activation of the MAP Kinase Signaling Pathways

2006 672 citations James A. McCubrey, Michelle M. LaHair et al. profile →
Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention

2003 577 citations Linda S. Steelman, Patrick M. Navolanic et al. Leukemia profile →
JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis

2004 555 citations Linda S. Steelman, Richard A. Franklin et al. Leukemia profile →
Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance

2006 550 citations James A. McCubrey, Linda S. Steelman et al. profile →
Transfer of specificity by murine α and β T-cell receptor genes

1986 472 citations James A. McCubrey et al. profile →
Cutaneous melanoma: From pathogenesis to therapy (Review)

2018 428 citations Giulia C. Leonardi, Luca Falzone et al. International Journal of Oncology profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
James A. McCubrey United States	79	16.1k	6.8k	3.9k	3.2k	2.6k	421	24.9k
Steven Grant United States	79	16.7k 1.0×	6.3k 0.9×	2.3k 0.6×	2.2k 0.7×	3.6k 1.4×	451	23.2k
Edward A. Sausville United States	92	19.3k 1.2×	11.7k 1.7×	3.4k 0.9×	2.3k 0.7×	2.1k 0.8×	329	30.9k
Eric W.‐F. Lam United Kingdom	87	15.3k 0.9×	5.4k 0.8×	4.0k 1.0×	3.5k 1.1×	935 0.4×	298	23.1k
Paul Dent United States	81	15.6k 1.0×	7.0k 1.0×	2.4k 0.6×	2.1k 0.7×	1.6k 0.6×	388	23.1k
Scott H. Kaufmann United States	95	25.8k 1.6×	11.9k 1.8×	3.7k 0.9×	4.2k 1.3×	3.2k 1.2×	406	36.2k
Adriana Albini Italy	81	10.2k 0.6×	7.0k 1.0×	4.6k 1.2×	4.0k 1.3×	1.3k 0.5×	396	22.9k
David C.S. Huang Australia	82	20.4k 1.3×	6.2k 0.9×	2.5k 0.7×	6.7k 2.1×	2.8k 1.1×	236	28.2k
Anthony Letai United States	62	12.2k 0.8×	4.5k 0.7×	2.1k 0.5×	2.9k 0.9×	3.7k 1.4×	175	18.2k
Nissim Hay United States	75	20.2k 1.3×	4.9k 0.7×	6.5k 1.7×	3.0k 0.9×	1.1k 0.4×	160	27.9k
David J. McConkey United States	95	15.9k 1.0×	7.2k 1.1×	4.2k 1.1×	3.7k 1.1×	963 0.4×	385	27.3k

Countries citing papers authored by James A. McCubrey

Since Specialization

Citations

This map shows the geographic impact of James A. McCubrey's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by James A. McCubrey with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites James A. McCubrey more than expected).

Fields of papers citing papers by James A. McCubrey

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by James A. McCubrey. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by James A. McCubrey. The network helps show where James A. McCubrey may publish in the future.

Co-authorship network of co-authors of James A. McCubrey

This figure shows the co-authorship network connecting the top 25 collaborators of James A. McCubrey. A scholar is included among the top collaborators of James A. McCubrey based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with James A. McCubrey. James A. McCubrey is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

McCubrey, James A., Matilde Y. Follo, Stefano Ratti, et al.. (2024). TP53 gene status can promote sensitivity and resistance to chemotherapeutic drugs and small molecule signal transduction inhibitors. Advances in Biological Regulation. 95. 101073–101073.

Augello, Giuseppa, Maria Rita Emma, Antonina Azzolina, et al.. (2021). The NUPR1/p73 axis contributes to sorafenib resistance in hepatocellular carcinoma. Cancer Letters. 519. 250–262. 12 indexed citations

Ratti, Stefano, Isabella Rusciano, Sara Mongiorgi, et al.. (2021). Lamin B1 Accumulation’s Effects on Autosomal Dominant Leukodystrophy (ADLD): Induction of Reactivity in the Astrocytes. Cells. 10(10). 2566–2566. 5 indexed citations

Akula, Shaw M., Stephen L. Abrams, Linda S. Steelman, et al.. (2019). RAS/RAF/MEK/ERK, PI3K/PTEN/AKT/mTORC1 and TP53 pathways and regulatory miRs as therapeutic targets in hepatocellular carcinoma. Expert Opinion on Therapeutic Targets. 23(11). 915–929. 71 indexed citations

Leonardi, Giulia C., Luca Falzone, Rossella Salemi, et al.. (2018). Cutaneous melanoma: From pathogenesis to therapy (Review). International Journal of Oncology. 52(4). 1071–1080. 428 indexed citations breakdown →

Ratti, Stefano, Giulia Ramazzotti, Irene Faenza, et al.. (2017). Nuclear inositide signaling and cell cycle. Advances in Biological Regulation. 67. 1–6. 32 indexed citations

Ramazzotti, Giulia, Irene Faenza, Roberta Fiume, et al.. (2016). PLC-β1 and cell differentiation: An insight into myogenesis and osteogenesis. Advances in Biological Regulation. 63. 1–5. 35 indexed citations

McCubrey, James A., Stephen L. Abrams, Timothy L. Fitzgerald, et al.. (2014). Roles of signaling pathways in drug resistance, cancer initiating cells and cancer progression and metastasis. Advances in Biological Regulation. 57. 75–101. 102 indexed citations

Steelman, Linda S., Patrick M. Navolanic, William H. Chappell, et al.. (2011). Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells. Cell Cycle. 10(17). 3003–3015. 70 indexed citations

10.

Chiarini, Francesca, Cecilia Grimaldi, Francesca Ricci, et al.. (2010). Activity of the Novel Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 against T-Cell Acute Lymphoblastic Leukemia. Cancer Research. 70(20). 8097–8107. 133 indexed citations

11.

Chiarini, Francesca, Federica Falà, Pier Luigi Tazzari, et al.. (2009). Dual Inhibition of Class IA Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin as a New Therapeutic Option for T-Cell Acute Lymphoblastic Leukemia. Cancer Research. 69(8). 3520–3528. 98 indexed citations

12.

Maksimović‐Ivanić, Danijela, Sanja Mijatović, Djordje Miljković, et al.. (2009). The antitumor properties of a nontoxic, nitric oxide–modified version of saquinavir are independent of Akt. Molecular Cancer Therapeutics. 8(5). 1169–1178. 37 indexed citations

13.

Tazzari, Pier Luigi, Giovanna Tabellini, Francesca Ricci, et al.. (2008). Synergistic Proapoptotic Activity of Recombinant TRAIL Plus the Akt Inhibitor Perifosine in Acute Myelogenous Leukemia Cells. Cancer Research. 68(22). 9394–9403. 76 indexed citations

14.

Tazzari, Pier Luigi, Francesca Ricci, Camilla Evangelisti, et al.. (2007). Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts. Leukemia. 21(3). 427–438. 158 indexed citations

15.

Libra, Massimo, Grazia Malaponte, Giovanni Ligresti, et al.. (2007). Activation of MAPK and AKT pathways by BRAF, NRAS and PIK3CA mutations in melanoma. Cancer Research. 67. 155–155. 1 indexed citations

16.

Konopleva, Marina, Rooha Contractor, Peter P. Ruvolo, et al.. (2006). Mechanism of apoptosis induction by chemical inhibitors of bcl-2 in acute leukemia cells. Cancer Research. 66. 1142–1143. 2 indexed citations

17.

Wong, Ellis W.T., Shrikanth A.G. Reddy, José Rubén García-Sánchez, & James A. McCubrey. (2006). Role of the PI3K/Akt pathway in promoting drug resistance of human pancreatic cells. Cancer Research. 66. 1001–1001. 1 indexed citations

18.

Howe, Christopher J., et al.. (2003). Models of Anergy in the Human Jurkat T Cell Line. Assay and Drug Development Technologies. 1(4). 537–544. 11 indexed citations

19.

Weinstein‐Oppenheimer, Caroline, Carla Burrows, & James A. McCubrey. (2002). The Effects of Beta-Estradiol on Raf Activity, Cell Cycle Progression and Growth Factor Synthesis in the MCF-7 Breast Cancer Cell Line. Cancer Biology & Therapy. 1(3). 256–262. 24 indexed citations

20.

Buttke, Thomas M., James A. McCubrey, & Terence C. Owen. (1993). Use of an aqueous soluble tetrazolium/formazan assay to measure viability and proliferation of lymphokine-dependent cell lines. Journal of Immunological Methods. 157(1-2). 233–240. 277 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact