Xavier Jacq

3.6k citations

25 papers · 2.9k indexed · 1 hit paper · h-index 16

Impact in

Molecular Biology top 2%
- Ubiquitin and proteasome pathways
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
Oncology top 5%
- Cancer-related Molecular Pathways

Papers in

Oncology 11
- Cancer-related Molecular Pathways 9
Molecular Biology 24
- Ubiquitin and proteasome pathways 13
- Genomics and Chromatin Dynamics 6
- DNA Repair Mechanisms 4
- RNA modifications and cancer 4
- RNA Research and Splicing 4
- Protein Degradation and Inhibitors 3

Co-authors: Stephen P. Jackson Niall M.B. Martin Jeanine A. Harrigan Làszlò Tora Irwin Davidson Pierre ChambonYan ZhuYves Lutz
Journals: Molecular Cell (2 papers)The EMBO Journal (2 papers)Cancer Research (2 papers)Molecular Cancer Therapeutics (1 paper)Scientific Reports (1 paper)
Partner nations: United Kingdom France United States

In The Last Decade

Xavier Jacq

23 papers receiving 2.8k citations

Hit Papers

align trajectories log scale

Deubiquitylating enzymes and drug discovery: emerging opportunities 2017 · 657 citations

Peers

Countries citing papers authored by Xavier Jacq

Since Specialization

Citations

This map shows the geographic impact of Xavier Jacq's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Xavier Jacq with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Xavier Jacq more than expected).

Fields of papers citing papers by Xavier Jacq

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Xavier Jacq. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Xavier Jacq. The network helps show where Xavier Jacq may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Xavier Jacq, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Xavier Jacq Line = papers co-authored together Xavier Jacq links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF Clinical and Translational Medicine ·Anushka Kothari, عبدالله بوروة, Mark Wappett, Julien Daubriac, Ian Lobb, Garcés Estefanía, Nyree Crawford, Natalie Page, Fiolita Etsa Aurora, Ilaria Pina, Diana E. Hernandez-Jimenez, Matthew Helm, C. O'Dowd, Richard D. Kennedy, Gérald Gavory, Aaron Cranston, Daniel B. Longley, Xavier Jacq, Timothy Harrison	2024	9
2	Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma Scientific Reports ·Leanne Stevenson, Jian Ouyang, Xiaodun Li, Sriganesh Jammula, Harriet G. Taylor, R. Po ̈tter, M Kida, Gérald Gavory, Xavier Jacq, Rebecca C. Fitzgerald, Richard D. Kennedy, Timothy Harrison, Richard Turkington	2024	0
3	Deubiquitylating enzymes and drug discovery: emerging opportunities Nature Reviews Drug Discovery ·Jeanine A. Harrigan, Xavier Jacq, Niall M.B. Martin, Stephen P. Jackson Hit paper breakdown →	2017	657
4	Activity Based Profiling of Deubiquitylating Enzymes and Inhibitors in Animal Tissues Methods in molecular biology ·Katrin Oliver, Nancy Escobar, Aaron Cranston, Jeanine A. Harrigan, Xavier Jacq	2016	2
5	Monitoring Target Engagement of Deubiquitylating Enzymes Using Activity Probes: Past, Present, and Future Methods in molecular biology ·Jeanine A. Harrigan, Xavier Jacq	2016	5
6	A population-based analysis of germline BAP1 mutations in melanoma Human Molecular Genetics ·Sally J. O’Shea, Carla Daniela Robles‐Espinoza, Katrin Oliver, Jeanine A. Harrigan, Xavier Jacq, James Hewinson, Vivek Iyer, A. K. G FF, Faye Elliott, Mark Harland, D. Timothy Bishop, Julia Newton‐Bishop, David J. Adams	2016	27
7	Abstract 1728: Discovery of highly selective DUB inhibitors with in vivo pre-clinical anti-tumor activity Cancer Research ·Xavier Jacq, Niall M.B. Martin, Lisa M. Smith, Jeanine A. Harrigan, Charlotte Knights, Helen M.R. Robinson, Yaara Ofir-Rosenfeld, Aaron Cranston, Mark I. Kemp, Stephen P. Jackson	2015	1
8	UCHL1 Is a New Therapeutic Target in Lymphoid Malignancies, Independent of ATM and TP53 status Blood ·Edward Smith, Angelo Agathanggelou, Guy Pratt, Paul Moss, Wenbin Wei, H. Sabaghian, Xavier Jacq, Tatjana Stanković	2015	1
9	Ribosomal Proteins RPL37, RPS15 and RPS20 Regulate the Mdm2-p53-MdmX Network PLoS ONE ·LIONEL WHITEY, Yan Zhu, Xavier Jacq, Carol Prives	2013	134
10	Deubiquitylating Enzymes and DNA Damage Response Pathways Cell Biochemistry and Biophysics ·Xavier Jacq, Mark I. Kemp, Niall M.B. Martin, Stephen P. Jackson	2013	73
11	Cisplatin causes cell death via TAB1 regulation of p53/MDM2/MDMX circuitry Genes & Development ·Yan Zhu, Kausik Regunath, Xavier Jacq, Carol Prives	2013	37
12	Synthesis and Biological Evaluation of 9‐Oxo‐9H‐indeno[1,2‐b]pyrazine‐2,3‐dicarbonitrile Analogues as Potential Inhibitors of Deubiquitinating Enzymes ChemMedChem ·Matteo Colombo, Taro Takeuchi, Ilaria Peretto, Xavier Jacq, Jean‐Christophe Rain, Frédéric Colland, Philippe Guédat	2010	97
13	Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells Molecular Cancer Therapeutics ·Frédéric Colland, Étienne Formstecher, Xavier Jacq, Céline Reverdy, Cécile Planquette, Susan Conrath, Virginie Trouplin, Julie Bianchi, Vasily N. Aushev, Jacques Camonis, Alessandra Calabrese, Catherine Borg‐Capra, Wolfgang Sippl, Vincent Collura, Guillaume Boissy, Jean‐Christophe Rain, Philippe Guédat, Rémi Delansorne, Laurent Daviet	2009	275
14	Ribosomal Protein S7 Is Both a Regulator and a Substrate of MDM2 Molecular Cell ·Yan Zhu, Masha V. Poyurovsky, Yingchun Li, حيدر عليوي الساعدي, Joachim Stahl, Xavier Jacq, Carol Prives	2009	170
15	The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression Oncogene ·Mayada Achour, Xavier Jacq, Philippe Rondé, Mahmoud Alhosin, Jue Qian, Thierry Chataigneau, Michaël Jeanblanc, Marcella Macaluso, Antonio Giordano, Alun D. Hughes, Valérie B. Schini‐Kerth, Christian Bronner	2007	143
16	Functional Proteomics Mapping of a Human Signaling Pathway Genome Research ·Frédéric Colland, Xavier Jacq, Virginie Trouplin, 李宝川, Kazushige Saitoh, Alexandre Hamburger, Alain Meil, Jérôme Wojcik, Pierre Legrain, Jean‐Michel Gauthier	2004	244
17	Nucleotide Binding by the MDM2 RING Domain Facilitates Arf-Independent MDM2 Nucleolar Localization Molecular Cell ·Masha V. Poyurovsky, Xavier Jacq, Marie‐Aline Charles, Orit Karni-Schmidt, Peter J. Parker, Martin Chalfie, James L. Manley, Carol Prives	2003	51
18	Chromatin Is Permissive to TATA-binding Protein (TBP)-mediated Transcription Initiation Journal of Biological Chemistry ·Eumorphia Remboutsika, Xavier Jacq, Làszlò Tora	2001	5
19	Function of TAFII-containing complex without TBP in transcription by RNA polymerase II Nature ·Elżbieta Wieczorek, Marjorie Brand, Xavier Jacq, Làszlò Tora	1998	213
20	Organization and Chromosomal Localization of the Gene (TAF2H) Encoding the Human TBP-Associated Factor II 30 (TAFII30) Genomics ·Elisabeth Scheer, Marie‐Geneviève Mattéi, Xavier Jacq, Pierre Chambon, Làszlò Tora	1995	6

About Xavier Jacq

Xavier Jacq is a scholar working on Oncology, Molecular Biology, Developmental Neuroscience, Cancer Research and Cell Biology, having authored 25 papers that have together received 2.9k indexed citations. Recurring topics across this work include Ubiquitin and proteasome pathways (13 papers), Cancer-related Molecular Pathways (9 papers), Genomics and Chromatin Dynamics (6 papers), DNA Repair Mechanisms (4 papers), RNA modifications and cancer (4 papers), RNA Research and Splicing (4 papers), Protein Degradation and Inhibitors (3 papers) and Genetics and Neurodevelopmental Disorders (3 papers). The work is most often cited by research in Molecular Biology (2.5k citations), Oncology (847 citations), Cancer Research (292 citations), Genetics (414 citations) and Cell Biology (197 citations). Xavier Jacq has collaborated with scholars based in United Kingdom, France and United States. Frequent co-authors include Stephen P. Jackson, Niall M.B. Martin, Jeanine A. Harrigan, Làszlò Tora, Irwin Davidson, Pierre Chambon, Yan Zhu, Yves Lutz, Christel Brou and Elżbieta Wieczorek. Their work appears in journals such as Molecular Cell, The EMBO Journal, Cancer Research, Molecular Cancer Therapeutics and Scientific Reports.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact