William H. Prusoff

19.2k citations

191 papers · 16.6k indexed · 1 hit paper · h-index 40

Impact in

Cellular and Molecular Neuroscience top 0.2%
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
Physiology top 0.2%

Papers in

Virology 15
- HIV Research and Treatment 14
Infectious Diseases 45
- HIV/AIDS drug development and treatment 43

Co-authors: Yung-Chi Cheng Tai‐Shun Lin Raymond F. Schinazi Ming S. Chen Yung‐Chi Cheng David C. Ward Arnold D. Welch Tai Shun Lin
Journals: Biochemical Pharmacology (30 papers)Journal of Medicinal Chemistry (22 papers)Journal of Biological Chemistry (21 papers)Antimicrobial Agents and Chemotherapy (8 papers)Antiviral Research (7 papers)
Partner nations: United States United Kingdom Belgium

In The Last Decade

William H. Prusoff

188 papers receiving 15.7k citations

Hit Papers

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Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction 1973 · 11.7k citations

Peers

Countries citing papers authored by William H. Prusoff

Since Specialization

Citations

This map shows the geographic impact of William H. Prusoff's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William H. Prusoff with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William H. Prusoff more than expected).

Fields of papers citing papers by William H. Prusoff

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William H. Prusoff. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William H. Prusoff. The network helps show where William H. Prusoff may publish in the future.

Co-authors

The 25 scholars most cited alongside William H. Prusoff, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with William H. Prusoff Line = papers co-authored together William H. Prusoff links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Inhibition of HIV-1 protease by a boron-modified polypeptide Biochemical Pharmacology ·MPawenimana Innocent, Donald S. Matteson, Suárez Matarrita, Rajendra Prasad Singh, Pin‐Fang Lin, Wade Blair, Mabrook Aidah Bin Mohanna, Brett S. Robinson, William H. Prusoff	2000	17
2	Metabolism and mode of selective inhibition of human immunodeficiency virus replication by 3'-azido-2',3'-dideoxy-5-iodouridine and 3'-azido-2',3'-dideoxy-5-bromouridine Biochemical Pharmacology ·Elias August, Heying Qian, Rajan Madhav V., Deny Tresnapriady, Tai‐Shun Lin, William H. Prusoff	1993	7
3	Empirical and rational approaches for development of inhibitors of the human immunodeficiency virus — HIV-1 Pharmacology & Therapeutics ·William H. Prusoff, Lázaro Emílio Makili, MPawenimana Innocent, An–Qiang Sun, Rajan Madhav V.	1993	10
4	Effect of ultraviolet light on DNA structure in 5-iodo-2′-deoxyuridine-substituted HSV-1 DNA Biochemical Pharmacology ·Thomas G. Wood, Maria Elena Marongiu, William H. Prusoff	1991	3
5	Synthesis and anticancer and antiviral activities of various 2'- and 3'-methylidene-substituted nucleoside analogs and crystal structure of 2'-deoxy-2'-methylidenecytidine hydrochloride Journal of Medicinal Chemistry ·T.‐S. LIN, Weiyu Luo, Stanley K. Liu, Grewal Ds, Yi-Ting Cheng, William H. Prusoff, U Hilber, George I. Birnbaum, E. J. Gabe, Jerzy Giziewicz	1991	29
6	Synthesis and anticancer activity of various 3'-deoxy pyrimidine nucleoside analogs, and crystal structure of 1-(3-deoxy-.beta.-D-threo-pentofuranosyl)cytosine Journal of Medicinal Chemistry ·T.‐S. LIN, Jian Yang, Stanley K. Liu, Miguel Mandujano Estrada, Yi-Ting Cheng, William H. Prusoff, George I. Birnbaum, Jerzy Giziewicz, Ismail Ghazzouli	1991	30
7	The pc12 cell as a model for studies of the mechanism of induction of peripheral neuropathy by anti-HIV-1 dideoxynucleoside analogs Biochemical Pharmacology ·Sue A. Keilbaugh, William H. Prusoff, Melvin V. Simpson	1991	78
8	1-(2,3-Dideoxy-.beta.-D-glycero-pent-2-enofuranosyl)thymine. A highly potent and selective anti-HIV agent Journal of Medicinal Chemistry ·Muzammil M. Mansuri, John E. Starrett, Ismail Ghazzouli, Michael J. M. Hitchcock, Roman Sterzycki, V Brankovan, Tai Shun Lin, Elias August, William H. Prusoff	1989	183
9	Studies on the inhibition of mitochondrial DNA replication by 3′-azido-3′-dhoxythymidine and other dideoxynucleoside analogs which inhibit HIV-1 replication Biochemical Pharmacology ·Melvin V. Simpson, Somnath Bhattacharyyaa, Sue A. Keilbaugh, Tai‐Shun Lin, William H. Prusoff	1989	150
10	Unusual structural features of 2′,3′-dideoxycytidine, an inhibitor of the HIV (AIDS) virus Biochemical and Biophysical Research Communications ·George I. Birnbaum, A.M. Shcherbakova, William H. Prusoff	1988	31
11	Initial studies on the cellular pharmacology of 3'-deoxythymidin-2'-ene (d4t): A potent and selective inhibitor of human immunodeficiency virus Biochemical Pharmacology ·Elias August, Maria Elena Marongiu, Huisu, William H. Prusoff	1988	33
12	Synthesis and antiviral evaluation of carbocyclic analogs of 2'-azido- and 2'-amino-2'-deoxycytidine Journal of Medicinal Chemistry ·Tai Shun Lin, 辛建平, J. Wang, William H. Prusoff	1988	11
13	Structure and conformation of 3′-azido-3′-deoxythymidine (AZT), an inhibitor of the HIV (AIDS) virus Canadian Journal of Chemistry ·George I. Birnbaum, Jerzy Giziewicz, Eric J. Gabe, Tai‐Shun Lin, William H. Prusoff	1987	59
14	Effect of incorporation of 5-iodo-2′-deoxyuridine into HSV-1 DNA on virion sensitivity to ultraviolet light Biochemical Pharmacology ·Márcia L. Zucker, William H. Prusoff	1987	5
15	Molecular basis of the antineoplastic activity of 3'-amino-3'-deoxythymidine. Molecular Pharmacology ·Eok-Bong Kim, Jin Yi Yoo, William H. Prusoff	1984	16
16	[45] Thymidine kinase from Escherichia coli Methods in enzymology on CD-ROM/Methods in enzymology ·Ming S. Chen, William H. Prusoff	1978	17
17	THE COMPARATIVE UPTAKE OF I-125-LABELED 5-IODO-2'-DEOXYURIDINE AND THYMIDINE-H3 INTO TISSUES OF MICE BEARING HEPATOMA-129. PubMed ·Brian W. Fox, William H. Prusoff	1965	48
18	Photochemistry of Proteins and Nucleic Acids The Yale Journal of Biology and Medicine ·William H. Prusoff	1964	4
19	Biological investigations of 6-azathymine, a thymine analog. PubMed ·William H. Prusoff, William L. Holmes, Arnold D. Welch	1954	15
20	Effect of 5-Bromouracil on Utilization of Thymidine by Streptococcus faecalis. Experimental Biology and Medicine ·William H. Prusoff	1954	6

About William H. Prusoff

William H. Prusoff is a scholar working on Virology, Infectious Diseases, Organic Chemistry, Pharmaceutical Science and Molecular Biology, having authored 191 papers that have together received 16.6k indexed citations. Recurring topics across this work include Biochemical and Molecular Research (43 papers), HIV/AIDS drug development and treatment (43 papers), Cancer therapeutics and mechanisms (29 papers), DNA and Nucleic Acid Chemistry (26 papers), Herpesvirus Infections and Treatments (24 papers), Synthesis and Characterization of Heterocyclic Compounds (18 papers), HIV Research and Treatment (14 papers) and Enzyme function and inhibition (13 papers). The work is most often cited by research in Cellular and Molecular Neuroscience (5.0k citations), Physiology (893 citations), Virology (849 citations), Molecular Biology (10.8k citations) and Infectious Diseases (1.8k citations). William H. Prusoff has collaborated with scholars based in United States, United Kingdom and Belgium. Frequent co-authors include Yung-Chi Cheng, Tai‐Shun Lin, Raymond F. Schinazi, Tai‐Shun Lin, Ming S. Chen, Yung‐Chi Cheng, David C. Ward, Arnold D. Welch, Tai Shun Lin and Elias August. Their work appears in journals such as Biochemical Pharmacology, Journal of Medicinal Chemistry, Journal of Biological Chemistry, Antimicrobial Agents and Chemotherapy and Antiviral Research.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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