William B. Guggino

28.1k citations

248 papers · 22.4k indexed · 9 hit papers · h-index 75

Molecular Biology top 0.2%
Pulmonary and Respiratory Medicine top 0.1%
Genetics top 0.1%
Cellular and Molecular Neuroscience top 0.5%
Physiology top 1%

Co-authors: Peter Agre Gregory M. Preston Erik M. Schwiebert Tiziana Piazza Carroll Garry R. Cutting Pamela L. Zeitlin Terence R. Flotte Bruce A. Stanton
Topics: Cystic Fibrosis Research Advances (107 papers)Neonatal Respiratory Health Research (68 papers)Ion Transport and Channel Regulation (54 papers)
Cited by: Pulmonary and Respiratory Medicine Molecular Biology Physiology
Journals: Nature Science Cell
Partner nations: United States Brazil Czechia

In The Last Decade

William B. Guggino

245 papers receiving 21.9k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Appearance of Water Channels in Xenopus Oocytes Expressing Red Cell CHIP28 Protein

1992 1.6k citations William B. Guggino et al. profile →
In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium

1992 774 citations William B. Guggino et al. Cell profile →
Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

2000 661 citations William B. Guggino et al. profile →
Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance.

1994 585 citations William B. Guggino et al. Proceedings of the National Academy of Sciences profile →
CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP

1995 548 citations Garry R. Cutting, William B. Guggino et al. Cell profile →
Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout

2009 497 citations Owen M. Woodward, Anna Köttgen et al. Proceedings of the National Academy of Sciences profile →
Molecular structure of the water channel through aquaporin CHIP. The hourglass model.

1994 494 citations William B. Guggino et al. profile →
From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations

2016 422 citations Harvey B. Pollard, William B. Guggino et al. profile →
Molecular Cloning and Characterization of an Aquaporin cDNA from Salivary, Lacrimal, and Respiratory Tissues

1995 360 citations William B. Guggino et al. profile →

Peers

Countries citing papers authored by William B. Guggino

Since Specialization

Citations

This map shows the geographic impact of William B. Guggino's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William B. Guggino with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William B. Guggino more than expected).

Fields of papers citing papers by William B. Guggino

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William B. Guggino. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William B. Guggino. The network helps show where William B. Guggino may publish in the future.

Co-authorship network of co-authors of William B. Guggino

This figure shows the co-authorship network connecting the top 25 collaborators of William B. Guggino. A scholar is included among the top collaborators of William B. Guggino based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with William B. Guggino. William B. Guggino is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Amelioration of airway and GI disease in G551D-CF ferrets by AAV1 and AAV6 2024 ·Gene Therapy ·(unknown),(unknown),(unknown),Jessica Izzi,William B. Guggino,Liudmila Cebotaru	0
2	Transduction of Ferret Surface and Basal Cells of Airways, Lung, Liver, and Pancreas via Intratracheal or Intravenous Delivery of Adeno-Associated Virus 1 or 6 2023 ·Human Gene Therapy ·(unknown),(unknown),(unknown),Jessica Izzi,William B. Guggino,Liudmila Cebotaru	3
3	CFTR and PC2, partners in the primary cilia in autosomal dominant polycystic kidney disease 2023 ·American Journal of Physiology-Cell Physiology ·(unknown),(unknown),William B. Guggino,Liudmila Cebotaru	2
4	Short-Term Steroid Treatment of Rhesus Macaque Increases Transduction 2021 ·Human Gene Therapy ·(unknown),Vartika Tomar,(unknown),William B. Guggino,Liudmila Cebotaru	5
5	Gene Therapy for Cystic Fibrosis Paved the Way for the Use of Adeno-Associated Virus in Gene Therapy 2020 ·Human Gene Therapy ·William B. Guggino,Liudmila Cebotaru	13
6	A new role for heat shock factor 27 in the pathophysiology of Clostridium difficile toxin B 2019 ·American Journal of Physiology-Gastrointestinal and Liver Physiology ·(unknown),William B. Guggino,Liudmila Cebotaru	6
7	Restoration of F508-del Function by Transcomplementation: The Partners Meet in the Endoplasmic Reticulum 2019 ·Cellular Physiology and Biochemistry ·Emily Anne Smith Bergbower,(unknown),(unknown),William B. Guggino,Liudmila Cebotaru	2
8	The CFTR corrector, VX-809 (Lumacaftor) and Hsp27 rescues ABCA4 trafficking mutants: a potential treatment for Stargardt disease 2018 ·Investigative Ophthalmology & Visual Science ·Liudmila Cebotaru,(unknown),(unknown),Emily Anne Smith Bergbower,(unknown),William B. Guggino	1
9	A Preclinical Study in Rhesus Macaques for Cystic Fibrosis to Assess Gene Transfer and Transduction by AAV1 and AAV5 with a Dual-Luciferase Reporter System 2017 ·PubMed ·William B. Guggino,Janet M. Benson,JeanClare Seagrave,Ziying Yan,John F. Engelhardt,Guangping Gao,Thomas J. Conlon,Liudmila Cebotaru	18
10	Generation and Genetic Engineering of Human Induced Pluripotent Stem Cells Using Designed Zinc Finger Nucleases 2012 ·Stem Cells and Development ·Sivaprakash Ramalingam,(unknown),Karthikeyan Kandavelou,Liudmila Cebotaru,William B. Guggino,Curt I. Civin,Srinivasan Chandrasegaran	36
11	Future Directions in Early Cystic Fibrosis Lung Disease Research: An NHLBI Workshop Report 2012 ·American Journal of Respiratory and Critical Care Medicine ·Bonnie W. Ramsey,Susan Banks‐Schlegel,Frank J. Accurso,Richard C. Boucher,Garry R. Cutting,John F. Engelhardt,William B. Guggino,Christopher L. Karp,Michael R. Knowles,Jay K. Kolls,John J. LiPuma,Susan V. Lynch,Paul B. McCray,Ronald C. Rubenstein,Pradeep K. Singh,Eric J. Sorscher,Michael J. Welsh	52
12	Identification of a urate transporter, ABCG2, with a common functional polymorphism causing goutbreakdown → 2009 ·Proceedings of the National Academy of Sciences ·Owen M. Woodward,Anna Köttgen,Josef Coresh,Eric Boerwinkle,William B. Guggino,Michael Köttgen	497
13	PKB and megalin determine the survival or death of renal proximal tubule cells 2006 ·Proceedings of the National Academy of Sciences ·Celso Caruso‐Neves,Ana Acácia S. Pinheiro,Hui Cai,Jackson Souza‐Menezes,William B. Guggino	97
14	De Novo Biosynthetic Profiling of High Abundance Proteins in Cystic Fibrosis Lung Epithelial Cells 2006 ·Molecular & Cellular Proteomics ·Harvey B. Pollard,Ofer Eidelman,Catherine Jozwik,Wei Huang,Meera Srivastava,(unknown),(unknown),(unknown),Tsuyoshi Todo,Thomas N. Darling,Peter J. Mogayzel,Pamela L. Zeitlin,Jerry Wright,William B. Guggino,(unknown),William J. Driscoll,(unknown),Cloud P. Paweletz,David M. Jacobowitz	38
15	Macromolecular Interactions and Ion Transport in Cystic Fibrosis 2004 ·American Journal of Respiratory and Critical Care Medicine ·William B. Guggino,Susan Banks‐Schlegel	52
16	Do polycystins function as cation channels? 2002 ·Current Opinion in Nephrology & Hypertension ·Masahiro Ikeda,William B. Guggino	21
17	Accessory Protein Facilitated CFTR-CFTR Interaction, a Molecular Mechanism to Potentiate the Chloride Channel Activity 2000 ·Cell ·Shusheng Wang,Hongwen Yue,(unknown),William B. Guggino,Min Li	253
18	Resistance properties of the diluting segment ofAmphiuma kidney: Influence of potassium adaptation 1985 ·The Journal of Membrane Biology ·Hans Oberleithner,William B. Guggino,Gerhard Giebisch	13
19	Cell heterogeneity in the diluting segment of the Amphiuma kidney: Evidence for two modes of Cl- ad K+ transport across the basolateral membrane 1984 ·Federation Proceedings ·William B. Guggino	2
20	The effect of furosemide on luminal sodium, chloride and potassium transport in the early distal tubule ofAmphiuma kidney 1983 ·Pflügers Archiv - European Journal of Physiology ·Hans Oberleithner,William B. Guggino,Gerhard Giebisch	45

About William B. Guggino

William B. Guggino is a scholar working on Pulmonary and Respiratory Medicine, Molecular Biology and Genetics, having authored 248 papers that have together received 22.4k indexed citations. Recurring topics across this work include Cystic Fibrosis Research Advances (107 papers), Neonatal Respiratory Health Research (68 papers) and Ion Transport and Channel Regulation (54 papers). The work is most often cited by research in Pulmonary and Respiratory Medicine (7.5k citations), Molecular Biology (13.5k citations) and Physiology (813 citations). William B. Guggino has collaborated with scholars based in United States, Brazil and Czechia. Frequent co-authors include Peter Agre, Gregory M. Preston, Erik M. Schwiebert, Tiziana Piazza Carroll, Garry R. Cutting, Pamela L. Zeitlin, Terence R. Flotte, Bruce A. Stanton, Marie E. Egan and Jin Sup Jung. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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