W. David Holtzclaw

7.0k total citations · 2 hit papers
33 papers, 5.9k citations indexed

About

W. David Holtzclaw is a scholar working on Molecular Biology, Organic Chemistry and Endocrinology, Diabetes and Metabolism. According to data from OpenAlex, W. David Holtzclaw has authored 33 papers receiving a total of 5.9k indexed citations (citations by other indexed papers that have themselves been cited), including 25 papers in Molecular Biology, 10 papers in Organic Chemistry and 4 papers in Endocrinology, Diabetes and Metabolism. Recurrent topics in W. David Holtzclaw's work include Genomics, phytochemicals, and oxidative stress (19 papers), Free Radicals and Antioxidants (9 papers) and Glutathione Transferases and Polymorphisms (6 papers). W. David Holtzclaw is often cited by papers focused on Genomics, phytochemicals, and oxidative stress (19 papers), Free Radicals and Antioxidants (9 papers) and Glutathione Transferases and Polymorphisms (6 papers). W. David Holtzclaw collaborates with scholars based in United States, United Kingdom and Japan. W. David Holtzclaw's co-authors include Paul Talalay, Albena T. Dinkova‐Kostova, Nobunao Wakabayashi, Masayuki Yamamoto, Thomas W. Kensler, Jed W. Fahey, Ken Itoh, Robert N. Cole, Yasutake Katoh and Tory Prestera and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and PLoS ONE.

In The Last Decade

W. David Holtzclaw

33 papers receiving 5.8k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

2002 1.6k citations Albena T. Dinkova‐Kostova, W. David Holtzclaw et al. Proceedings of the National Academy of Sciences profile →
Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

2004 823 citations Nobunao Wakabayashi, Albena T. Dinkova‐Kostova et al. Proceedings of the National Academy of Sciences profile →

Peers

W. David Holtzclaw

BIOCH

Margaret M. Manson United Kingdom

Truyen Nguyen United States

Masao Hirose Japan

Patrizia Hrelia Italy

Cecil B. Pickett United States

Toshihiko Kawamori Japan

Tin Oo Khor United States

Katherine K. Stephenson United States

Jee H. Jung South Korea

Chris Beecher United States

Margaret M. Manson United Kingdom

W. David Holtzclaw

3.7k ×0.8

609 ×0.6

493 ×0.7

553 ×1.1

BIOCH

273 ×0.6

Citations per year, relative to W. David Holtzclaw W. David Holtzclaw (= 1×) peers Margaret M. Manson

Countries citing papers authored by W. David Holtzclaw

Since Specialization

Citations

This map shows the geographic impact of W. David Holtzclaw's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by W. David Holtzclaw with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites W. David Holtzclaw more than expected).

Fields of papers citing papers by W. David Holtzclaw

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by W. David Holtzclaw. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by W. David Holtzclaw. The network helps show where W. David Holtzclaw may publish in the future.

Co-authorship network of co-authors of W. David Holtzclaw

This figure shows the co-authorship network connecting the top 25 collaborators of W. David Holtzclaw. A scholar is included among the top collaborators of W. David Holtzclaw based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with W. David Holtzclaw. W. David Holtzclaw is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Kalin, Jay H., Abdulkerim Eroglu, Hua Liu, et al.. (2019). Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model. PLoS ONE. 14(3). e0213095–e0213095. 12 indexed citations

Fahey, Jed W., Kristina L. Wade, Katherine K. Stephenson, et al.. (2019). Bioavailability of Sulforaphane Following Ingestion of Glucoraphanin-Rich Broccoli Sprout and Seed Extracts with Active Myrosinase: A Pilot Study of the Effects of Proton Pump Inhibitor Administration. Nutrients. 11(7). 1489–1489. 51 indexed citations

Fahey, Jed W., W. David Holtzclaw, Scott L. Wehage, et al.. (2015). Sulforaphane Bioavailability from Glucoraphanin-Rich Broccoli: Control by Active Endogenous Myrosinase. PLoS ONE. 10(11). e0140963–e0140963. 130 indexed citations

Fahey, Jed W., Scott L. Wehage, W. David Holtzclaw, et al.. (2012). Protection of Humans by Plant Glucosinolates: Efficiency of Conversion of Glucosinolates to Isothiocyanates by the Gastrointestinal Microflora. Cancer Prevention Research. 5(4). 603–611. 146 indexed citations

Dinkova‐Kostova, Albena T., Paul Talalay, John Sharkey, et al.. (2010). An Exceptionally Potent Inducer of Cytoprotective Enzymes. Journal of Biological Chemistry. 285(44). 33747–33755. 94 indexed citations

Shapiro, Theresa A., Jed W. Fahey, Albena T. Dinkova‐Kostova, et al.. (2006). Safety, Tolerance, and Metabolism of Broccoli Sprout Glucosinolates and Isothiocyanates: A Clinical Phase I Study. Nutrition and Cancer. 55(1). 53–62. 267 indexed citations

Holtzclaw, W. David, Albena T. Dinkova‐Kostova, & Paul Talalay. (2004). Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers. Advances in Enzyme Regulation. 44(1). 335–367. 122 indexed citations

Wakabayashi, Nobunao, Albena T. Dinkova‐Kostova, W. David Holtzclaw, et al.. (2004). Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers. Proceedings of the National Academy of Sciences. 101(7). 2040–2045. 823 indexed citations breakdown →

Talalay, Paul, Albena T. Dinkova‐Kostova, & W. David Holtzclaw. (2003). Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis. Advances in Enzyme Regulation. 43(1). 121–134. 243 indexed citations

10.

Shikita, Mikio, Jed W. Fahey, Tamara R. Golden, W. David Holtzclaw, & Paul Talalay. (1999). An unusual case of ‘uncompetitive activation’ by ascorbic acid: purification and kinetic properties of a myrosinase from Raphanus sativus seedlings. Biochemical Journal. 341(3). 725–725. 109 indexed citations

11.

Zhao, Qinjian, et al.. (1997). Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase). Proceedings of the National Academy of Sciences. 94(5). 1669–1674. 100 indexed citations

12.

Prestera, Tory, et al.. (1996). Comprehensive Chromatographic and Spectroscopic Methods for the Separation and Identification of Intact Glucosinolates. Analytical Biochemistry. 239(2). 168–179. 121 indexed citations

13.

Talalay, Paul, Jed W. Fahey, W. David Holtzclaw, Tory Prestera, & Yuesheng Zhang. (1995). Chemoprotection against cancer by Phase 2 enzyme induction. Toxicology Letters. 82-83. 173–179. 372 indexed citations

14.

Zhang, Yuesheng, et al.. (1995). Mercurials and Dimercaptans: Synergism in the Induction of Chemoprotective Enzymes. Chemical Research in Toxicology. 8(1). 103–110. 15 indexed citations

15.

Prestera, Tory, W. David Holtzclaw, Yuesheng Zhang, & Paul Talalay. (1993). Chemical and molecular regulation of enzymes that detoxify carcinogens.. Proceedings of the National Academy of Sciences. 90(7). 2965–2969. 367 indexed citations

16.

Holtzclaw, W. David & Gary Gordon. (1989). Measurement of serum levels of dehydroepiandrosterone sulfate: A comparison of radioimmunoassay and enzymatic analysis. Steroids. 54(4). 355–371. 14 indexed citations

17.

Payne, Donna W., W. David Holtzclaw, & Eli Y. Adashi. (1989). A convenient, unified scheme for the differential extraction of conjugated and unconjugated serum C19 steroids on Sep-Pak C18-cartridges. Journal of Steroid Biochemistry. 33(2). 289–295. 15 indexed citations

18.

Hernández, Eleuterio R., Carol E. Resnick, W. David Holtzclaw, Donna W. Payne, & Eli Y. Adashi. (1988). Insulin as a Regulator of Androgen Biosynthesis by Cultured Rat Ovarian Cells: Cellular Mechanism(s) Underlying Physiological and Pharmacological Hormonal Actions*. Endocrinology. 122(5). 2034–2043. 57 indexed citations

19.

Payne, Donna W., W. David Holtzclaw, & Eli Y. Adashi. (1988). The Steroidogenic Characteristics of Primary Testicular Cell Cultures from Adult Hypophysectomized Rats: Enhanced Formation of C21 Steroids1. Biology of Reproduction. 39(3). 581–591. 8 indexed citations

20.

Holtzclaw, W. David, et al.. (1975). Degradative acetolactate synthase of Bacillus subtilis: purification and properties. Journal of Bacteriology. 121(3). 917–922. 61 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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