Timothy L. Macdonald

12.0k total citations
199 papers, 9.6k citations indexed

About

Timothy L. Macdonald is a scholar working on Molecular Biology, Organic Chemistry and Pharmacology. According to data from OpenAlex, Timothy L. Macdonald has authored 199 papers receiving a total of 9.6k indexed citations (citations by other indexed papers that have themselves been cited), including 110 papers in Molecular Biology, 66 papers in Organic Chemistry and 29 papers in Pharmacology. Recurrent topics in Timothy L. Macdonald's work include Sphingolipid Metabolism and Signaling (43 papers), Pharmacogenetics and Drug Metabolism (24 papers) and Cancer therapeutics and mechanisms (17 papers). Timothy L. Macdonald is often cited by papers focused on Sphingolipid Metabolism and Signaling (43 papers), Pharmacogenetics and Drug Metabolism (24 papers) and Cancer therapeutics and mechanisms (17 papers). Timothy L. Macdonald collaborates with scholars based in United States, United Kingdom and Japan. Timothy L. Macdonald's co-authors include F. Peter Guengerich, Kevin R. Lynch, Joel Linden, R. Bruce Martin, Jayson Rieger, Michael D. Davis, Mark D. Okusa, Jeremy J. Clemens, Benjamin Gaston and Liping Huang and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

Timothy L. Macdonald

198 papers receiving 9.3k citations

Peers

Timothy L. Macdonald
David Ross United States
Barry V. L. Potter United Kingdom
Angelika M. Vollmar Germany
Emanuele Albano Italy
Richard B. Silverman United States
Andrea Mattevi Italy
Duane D. Miller United States
Paul Hochstein United States
Angelo Azzi Switzerland
Fulvio Ursini Italy
David Ross United States
Timothy L. Macdonald
Citations per year, relative to Timothy L. Macdonald Timothy L. Macdonald (= 1×) peers David Ross

Countries citing papers authored by Timothy L. Macdonald

Since Specialization
Citations

This map shows the geographic impact of Timothy L. Macdonald's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Timothy L. Macdonald with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Timothy L. Macdonald more than expected).

Fields of papers citing papers by Timothy L. Macdonald

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Timothy L. Macdonald. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Timothy L. Macdonald. The network helps show where Timothy L. Macdonald may publish in the future.

Co-authorship network of co-authors of Timothy L. Macdonald

This figure shows the co-authorship network connecting the top 25 collaborators of Timothy L. Macdonald. A scholar is included among the top collaborators of Timothy L. Macdonald based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Timothy L. Macdonald. Timothy L. Macdonald is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Macdonald, Timothy L., et al.. (2015). Repurposing and Rescuing of Mibefradil, an Antihypertensive, for Cancer: A Case Study. Assay and Drug Development Technologies. 13(10). 650–653. 24 indexed citations
2.
Gray, Lloyd S., et al.. (2015). Repurposing and Rescuing of Mibefradil, an Antihypertensive, for Cancer: A Case Study. 1(1). 36–39. 1 indexed citations
3.
Gray, Lloyd S., David Schiff, & Timothy L. Macdonald. (2013). A model for the regulation of T-type Ca2+channels in proliferation: roles in stem cells and cancer. Expert Review of Anticancer Therapy. 13(5). 589–595. 12 indexed citations
4.
Kennedy, Perry, Ran Zhu, Tao Huang, et al.. (2011). Characterization of a Sphingosine 1-Phosphate Receptor Antagonist Prodrug. Journal of Pharmacology and Experimental Therapeutics. 338(3). 879–889. 29 indexed citations
5.
Aronin, Caren E. Petrie, Lauren S. Sefcik, Sunil S. Tholpady, et al.. (2009). FTY720 Promotes Local Microvascular Network Formation and Regeneration of Cranial Bone Defects. Tissue Engineering Part A. 16(6). 1801–1809. 48 indexed citations
6.
Wamhoff, Brian R., Kevin R. Lynch, Timothy L. Macdonald, & Gary K. Owens. (2008). Sphingosine-1-Phosphate Receptor Subtypes Differentially Regulate Smooth Muscle Cell Phenotype. Arteriosclerosis Thrombosis and Vascular Biology. 28(8). 1454–1461. 82 indexed citations
7.
Foss, Frank W., Jeremy J. Clemens, Michael D. Davis, et al.. (2005). Synthesis, stability, and implications of phosphothioate agonists of sphingosine-1-phosphate receptors. Bioorganic & Medicinal Chemistry Letters. 15(20). 4470–4474. 21 indexed citations
8.
Riou, Laurent, Mirta Ruiz, Jayson Rieger, et al.. (2002). Influence of propranolol, enalaprilat, verapamil, and caffeine on adenosine A2A-receptor–mediated coronary vasodilation. Journal of the American College of Cardiology. 40(9). 1687–1694. 18 indexed citations
9.
Dieckhaus, Christine M., Charles D. Thompson, Shane Roller, & Timothy L. Macdonald. (2002). Mechanisms of idiosyncratic drug reactions: the case of felbamate. Chemico-Biological Interactions. 142(1-2). 99–117. 57 indexed citations
10.
Sullivan, Gail W., Jayson Rieger, W. Michael Scheld, Timothy L. Macdonald, & Joel Linden. (2001). Cyclic AMP‐dependent inhibition of human neutrophil oxidative activity by substituted 2‐propynylcyclohexyl adenosine A2A receptor agonists. British Journal of Pharmacology. 132(5). 1017–1026. 145 indexed citations
11.
Brown, Milton L., Jayson Rieger, & Timothy L. Macdonald. (2000). Comparative molecular field analysis of colchicine inhibition and tubulin polymerization for combretastatins binding to the colchicine binding site on β-tubulin. Bioorganic & Medicinal Chemistry. 8(6). 1433–1441. 25 indexed citations
12.
Thompson, Charles D., et al.. (1997). Mechanisms of Adrenergic Agonist Induced Allergy Bioactivation and Antigen Formation. Experimental Eye Research. 64(5). 767–773. 18 indexed citations
13.
Lynch, Kevin R., et al.. (1997). Structure/Activity Relationships in Lysophosphatidic Acid: The 2-Hydroxyl Moiety. Molecular Pharmacology. 52(1). 75–81. 30 indexed citations
14.
Guengerich, F. Peter, Chul‐Ho Yun, & Timothy L. Macdonald. (1996). Evidence for a 1-Electron Oxidation Mechanism in N-Dealkylation of N,N-Dialkylanilines by Cytochrome P450 2B1. Journal of Biological Chemistry. 271(44). 27321–27329. 139 indexed citations
15.
Leteurtre, François, Dan L. Sackett, José S. Madalengoitia, et al.. (1995). Azatoxin derivatives with potent and selective action on topoisomerase II. Biochemical Pharmacology. 49(9). 1283–1290. 30 indexed citations
16.
Guengerich, F. Peter, Tsutomu Shimada, Arnaud Bondon, & Timothy L. Macdonald. (1991). Cytochrome P-450 Oxidations and the Generation of Biologically Reactive Intermediates. Advances in experimental medicine and biology. 283. 1–11. 10 indexed citations
17.
Macdonald, Timothy L., et al.. (1989). Oxidation of substituted N,N-dimethylanilines by cytochrome P-450: estimation of the effective oxidation-reduction potential of cytochrome P-450. Biochemistry. 28(5). 2071–2077. 96 indexed citations
18.
Latham, Michael D., et al.. (1989). Inhibition of topoisomerases by fredericamycin A. Cancer Chemotherapy and Pharmacology. 24(3). 167–171. 26 indexed citations
19.
Humphreys, W. Griffith & Timothy L. Macdonald. (1988). The effects on tubulin polymerization and associated guanosine triphosphate hydrolysis of aluminum ion, fluoride and fluoroaluminate species. Biochemical and Biophysical Research Communications. 151(3). 1025–1032. 12 indexed citations
20.
Macdonald, Timothy L. & J. L. Brewbaker. (1975). Isoenzyme polymorphism in flowering plants : V, The isoesterases of maize:tissue and substrate specificities, and responses to chemical inhibitors. ScholarSpace (University of Hawaii at Manoa). 8 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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