Thomas K. H. Chang

14.8k total citations · 2 hit papers
222 papers, 12.1k citations indexed

About

Thomas K. H. Chang is a scholar working on Pharmacology, Molecular Biology and Oncology. According to data from OpenAlex, Thomas K. H. Chang has authored 222 papers receiving a total of 12.1k indexed citations (citations by other indexed papers that have themselves been cited), including 124 papers in Pharmacology, 67 papers in Molecular Biology and 49 papers in Oncology. Recurrent topics in Thomas K. H. Chang's work include Pharmacogenetics and Drug Metabolism (117 papers), Drug Transport and Resistance Mechanisms (37 papers) and Eicosanoids and Hypertension Pharmacology (21 papers). Thomas K. H. Chang is often cited by papers focused on Pharmacogenetics and Drug Metabolism (117 papers), Drug Transport and Resistance Mechanisms (37 papers) and Eicosanoids and Hypertension Pharmacology (21 papers). Thomas K. H. Chang collaborates with scholars based in United States, Canada and India. Thomas K. H. Chang's co-authors include Wayne Levin, Dene E. Ryan, David J. Waxman, Linda M. Reik, Charles L. Crespi, Frank S. Abbott, Alexander W. Wood, Georg F. Weber, Frank J. Gonzalez and Vincent Tong and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of the American Chemical Society and Journal of Biological Chemistry.

In The Last Decade

Thomas K. H. Chang

222 papers receiving 11.5k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Separation and characterization of highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, and 3-methylcholanthrene.

1979 516 citations Dene E. Ryan, Thomas K. H. Chang et al. Journal of Biological Chemistry profile →
Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes.

1993 457 citations Thomas K. H. Chang, Charles L. Crespi et al. PubMed profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Thomas K. H. Chang United States	59	6.4k	3.9k	3.0k	1.3k	1.3k	222	12.1k
Tetsuya Kamataki Japan	56	7.9k 1.2×	5.5k 1.4×	4.0k 1.3×	1.2k 0.9×	1.4k 1.1×	364	13.7k
Patrick Maurel France	63	6.6k 1.0×	3.3k 0.9×	3.9k 1.3×	1.7k 1.2×	857 0.6×	205	12.8k
Jeffrey R. Idle United Kingdom	70	6.4k 1.0×	6.4k 1.6×	3.3k 1.1×	922 0.7×	995 0.8×	270	15.7k
Yasushi Yamazoe Japan	53	5.0k 0.8×	3.7k 0.9×	2.4k 0.8×	1.3k 1.0×	913 0.7×	313	9.7k
Philip S. Guzelian United States	56	5.9k 0.9×	2.4k 0.6×	3.5k 1.1×	1.7k 1.2×	786 0.6×	120	10.1k
Ryo Sato Japan	33	11.8k 1.8×	6.9k 1.8×	4.7k 1.6×	1.6k 1.2×	2.3k 1.7×	125	17.3k
Olavi Pelkonen Finland	61	6.4k 1.0×	3.9k 1.0×	2.8k 0.9×	608 0.5×	1.0k 0.8×	291	13.2k
Tsuyoshi Yokoi Japan	67	7.2k 1.1×	6.2k 1.6×	4.8k 1.6×	853 0.6×	935 0.7×	369	16.2k
Joyce A. Goldstein United States	58	6.8k 1.1×	2.0k 0.5×	3.4k 1.1×	1.6k 1.2×	1.6k 1.2×	125	10.3k
Laurence S. Kaminsky United States	51	5.6k 0.9×	3.0k 0.8×	2.6k 0.9×	933 0.7×	1.1k 0.9×	157	9.6k

Countries citing papers authored by Thomas K. H. Chang

Since Specialization

Citations

This map shows the geographic impact of Thomas K. H. Chang's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Thomas K. H. Chang with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Thomas K. H. Chang more than expected).

Fields of papers citing papers by Thomas K. H. Chang

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Thomas K. H. Chang. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Thomas K. H. Chang. The network helps show where Thomas K. H. Chang may publish in the future.

Co-authorship network of co-authors of Thomas K. H. Chang

This figure shows the co-authorship network connecting the top 25 collaborators of Thomas K. H. Chang. A scholar is included among the top collaborators of Thomas K. H. Chang based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Thomas K. H. Chang. Thomas K. H. Chang is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Lau, Aik Jiang, Regina Politi, Guixiang Yang, & Thomas K. H. Chang. (2016). Cell-based and in silico evidence against quercetin and structurally-related flavonols as activators of vitamin D receptor. The Journal of Steroid Biochemistry and Molecular Biology. 163. 59–67. 6 indexed citations

Chang, Thomas K. H., et al.. (2007). In Vitro Inhibition of Rat CYP1A1 and CYP1A2 by Piceatannol, a Hydroxylated Metabolite of trans-Resveratrol. Drug Metabolism Letters. 1(1). 13–16. 7 indexed citations

Kiang, Tony K. L., et al.. (2006). Contribution of CYP2C9, CYP2A6, and CYP2B6 to Valproic Acid Metabolism in Hepatic Microsomes from Individuals with the CYP2C9*1/*1 Genotype. Toxicological Sciences. 94(2). 261–271. 123 indexed citations

Chang, Thomas K. H., Ni Bai, Nada A. Sallam, et al.. (2006). Increased vascular contractility in isolated vessels from cigarette smoking rats is mediated by basal endothelin release. Vascular Pharmacology. 46(1). 35–42. 24 indexed citations

Rajaraman, Ganesh, Jie Chen, & Thomas K. H. Chang. (2006). Ginkgolide A contributes to the potentiation of acetaminophen toxicity by Ginkgo biloba extract in primary cultures of rat hepatocytes. Toxicology and Applied Pharmacology. 217(2). 225–233. 28 indexed citations

Waxman, David J. & Thomas K. H. Chang. (2006). Use of 7-Ethoxycoumarin to Monitor Multiple Enzymes in the Human CYP1, CYP2, and CYP3 Families. Humana Press eBooks. 320. 153–156. 31 indexed citations

Chang, Thomas K. H., Charles L. Crespi, & David J. Waxman. (2006). Determination of CYP2B6 Component of 7-Ethoxy-4-Trifluoromethylcoumarin <i>O</i>-Deethylation Activity in Human Liver Microsomes. Humana Press eBooks. 320. 97–102. 6 indexed citations

Reuhl, Kenneth R., Thomas K. H. Chang, Allan H. Conney, et al.. (2004). The effects of steroidal estrogens in ACI rat mammary carcinogenesis: 17β-estradiol, 2-hydroxyestradiol, 4-hydroxyestradiol, 16α-hydroxyestradiol, and 4-hydroxyestrone. Journal of Endocrinology. 183(1). 91–99. 53 indexed citations

Chen, Jie, et al.. (2004). LACK OF EVIDENCE FOR INDUCTION OF CYP2B1, CYP3A23, AND CYP1A2 GENE EXPRESSION BY Panax ginseng AND Panax quinquefolius EXTRACTS IN ADULT RATS AND PRIMARY CULTURES OF RAT HEPATOCYTES. Drug Metabolism and Disposition. 33(1). 19–22. 17 indexed citations

10.

Crespi, Charles L., Thomas K. H. Chang, & David J. Waxman. (2003). High-Performance Liquid Chromatographic Analysis of CYP2CSCatalyzed Paclitaxel 6α-Hydroxylation. Humana Press eBooks. 107. 123–128. 2 indexed citations

11.

Chang, Thomas K. H., Charles L. Crespi, & David J. Waxman. (2003). Spectrophotometric Analysis of Human CY P2El -Catalyzed pNitrophenol Hydroxylation. Humana Press eBooks. 107. 147–152. 56 indexed citations

12.

Ensom, Mary H. H., Thomas K. H. Chang, & Payal Patel. (2001). Pharmacogenetics. Clinical Pharmacokinetics. 40(11). 783–802. 80 indexed citations

13.

O’Reilly, Barry, Alan Kosaka, Thomas K. H. Chang, et al.. (2001). A quantitative analysis of purinoceptor expression in the bladders of patients with symptomatic outlet obstruction. British Journal of Urology. 87(7). 617–622. 85 indexed citations

14.

Chang, Thomas K. H., et al.. (2001). Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2.. PubMed. 299(3). 874–82. 116 indexed citations

15.

Kawai, Masahiko, Stelvio M. Bandiera, Thomas K. H. Chang, & Gail D. Bellward. (2000). Growth hormone regulation and developmental expression of rat hepatic CYP3A18, CYP3A9, and CYP3A2. Biochemical Pharmacology. 59(10). 1277–1287. 31 indexed citations

16.

Chen, Laishun, et al.. (1996). CAFFEINE INDUCES CYTOCHROME P4501A2: INDUCTION OF CYP1A2 BY TEA IN RATS. Drug Metabolism and Disposition. 24(5). 529–533. 58 indexed citations

17.

Ryan, Dene E., Thomas K. H. Chang, Wayne Levin, et al.. (1993). Monoclonal Antibodies of Differentiating Specificities as Probes of Cytochrome P450h (2C11). Archives of Biochemistry and Biophysics. 301(2). 282–293. 12 indexed citations

18.

Chang, Thomas K. H., Stelvio M. Bandiera, S L Maines, Dene E. Ryan, & Wayne Levin. (1987). Regulation of rat liver cytochrome P450j, a high affinity N-nitrosodimethylamine demethylase (NDMAD). Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States). 2 indexed citations

19.

Wood, Alexander W., Dene E. Ryan, Thomas K. H. Chang, & Wayne Levin. (1983). Regio- and stereoselective metabolism of two C19 steroids by five highly purified and reconstituted rat hepatic cytochrome P-450 isozymes.. Journal of Biological Chemistry. 258(14). 8839–8847. 314 indexed citations

20.

Chang, Thomas K. H., et al.. (1975). Studies on sprout inhibition of onions by gamma irradiation—I. influence of time interval between harvest and irradiation, radiation dose and environmental conditions on sprouting. Radiation Botany. 15(3). 215–222. 11 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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