Timothy J. Ley

87.2k total citations · 9 hit papers
227 papers, 22.6k citations indexed

About

Timothy J. Ley is a scholar working on Molecular Biology, Hematology and Cancer Research. According to data from OpenAlex, Timothy J. Ley has authored 227 papers receiving a total of 22.6k indexed citations (citations by other indexed papers that have themselves been cited), including 153 papers in Molecular Biology, 95 papers in Hematology and 49 papers in Cancer Research. Recurrent topics in Timothy J. Ley's work include Acute Myeloid Leukemia Research (84 papers), Retinoids in leukemia and cellular processes (41 papers) and Epigenetics and DNA Methylation (29 papers). Timothy J. Ley is often cited by papers focused on Acute Myeloid Leukemia Research (84 papers), Retinoids in leukemia and cellular processes (41 papers) and Epigenetics and DNA Methylation (29 papers). Timothy J. Ley collaborates with scholars based in United States, United Kingdom and Italy. Timothy J. Ley's co-authors include John H. Russell, Christine T. N. Pham, Richard K. Wilson, Li Ding, Robin L. Wesselschmidt, Christopher A. Miller, Matthew J. Walter, Michael D. McLellan, Michael C. Wendl and William J. Grossman and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Timothy J. Ley

222 papers receiving 22.2k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Mutational landscape and significance across 12 major cancer types

2013 3.1k citations Christopher A. Miller, John S. Welch et al. profile →
Age-related mutations associated with clonal hematopoietic expansion and malignancies

2014 1.2k citations Christopher A. Miller, John S. Welch et al. profile →
BreakDancer: an algorithm for high-resolution mapping of genomic structural variation

2009 997 citations Robert S. Fulton, Timothy J. Ley et al. profile →
Lymphocyte-Mediated Cytotoxicity

2002 808 citations Timothy J. Ley et al. profile →
Human T Regulatory Cells Can Use the Perforin Pathway to Cause Autologous Target Cell Death

2004 765 citations William J. Grossman, James Verbsky et al. profile →
Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance

2007 726 citations Xuefang Cao, Sheng F. Cai et al. profile →
Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

1994 721 citations Timothy J. Ley et al. profile →
Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis

1998 542 citations Timothy J. Ley et al. profile →
5-Azacytidine Selectively Increases γ-Globin Synthesis in a Patient with β⁺Thalassemia

1982 424 citations Timothy J. Ley et al. New England Journal of Medicine profile →

Peers

Countries citing papers authored by Timothy J. Ley

Since Specialization

Citations

This map shows the geographic impact of Timothy J. Ley's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Timothy J. Ley with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Timothy J. Ley more than expected).

Fields of papers citing papers by Timothy J. Ley

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Timothy J. Ley. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Timothy J. Ley. The network helps show where Timothy J. Ley may publish in the future.

Co-authorship network of co-authors of Timothy J. Ley

This figure shows the co-authorship network connecting the top 25 collaborators of Timothy J. Ley. A scholar is included among the top collaborators of Timothy J. Ley based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Timothy J. Ley. Timothy J. Ley is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Overexpression of the signaling coordinator GAB2 can play an important role in acute myeloid leukemia progression 2025 ·Journal of Clinical Investigation ·Michael H. Kramer, (unknown), Yang Li, (unknown), Nichole Helton, Daniel R. George, (unknown), Sai Mukund Ramakrishnan, (unknown), Christopher A. Miller, Timothy J. Ley	0
2	Rapid and accurate remethylation of DNA in Dnmt3a- deficient hematopoietic cells with restoration of DNMT3A activity 2024 ·Science Advances ·(unknown), Haley Abel, (unknown), (unknown), (unknown), Nichole Helton, Amanda M. Smith, Christopher A. Miller, Timothy J. Ley	1
3	Genomic landscape of TP53-mutated myeloid malignancies 2023 ·Blood Advances ·Haley Abel, Karolyn A. Oetjen, Christopher A. Miller, Sai Mukund Ramakrishnan, Ryan B. Day, Nichole Helton, Catrina C. Fronick, Robert S. Fulton, Sharon E. Heath, (unknown), Sridhar Nonavinkere Srivatsan, Eric J. Duncavage, Molly C. Schroeder, Jacqueline E. Payton, David H. Spencer, Matthew J. Walter, Peter Westervelt, John F. DiPersio, Timothy J. Ley, Daniel C. Link	15
4	Melanoma in a patient with DNMT3A overgrowth syndrome 2023 ·Molecular Case Studies ·David Y. Chen, (unknown), Sai Mukund Ramakrishnan, Eric J. Duncavage, Sharon E. Heath, Leigh A. Compton, Christopher A. Miller, Timothy J. Ley	3
5	Failure to Detect Mutations in U2AF1 due to Changes in the GRCh38 Reference Sequence 2022 ·Journal of Molecular Diagnostics ·Christopher A. Miller, Jason Walker, (unknown), (unknown), Robert S. Fulton, Jeffrey S. Painter, Mikkael A. Sekeres, Timothy J. Ley, David H. Spencer, Johannes B. Goll, Matthew J. Walter	14
6	Recurrent transcriptional responses in AML and MDS patients treated with decitabine 2022 ·Experimental Hematology ·Pawan Upadhyay, (unknown), Nakul M. Shah, (unknown), Christopher A. Miller, Allegra A. Petti, Sai Mukund Ramakrishnan, Daniel C. Link, Timothy J. Ley, John S. Welch	10
7	Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype 2021 ·Proceedings of the National Academy of Sciences ·David Y. Chen, (unknown), (unknown), (unknown), Nichole Helton, Sai Mukund Ramakrishnan, Amanda M. Smith, Christopher A. Miller, Timothy J. Ley	8
8	MIR142 Loss-of-Function Mutations Derepress ASH1L to Increase HOXA Gene Expression and Promote Leukemogenesis 2018 ·Cancer Research ·Maria Trissal, Terrence N. Wong, Juo-Chin Yao, (unknown), (unknown), Jack Baty, Yaping Sun, Gloria Jih, Nishi Parikh, Melissa M. Berrien-Elliott, Todd A. Fehniger, Timothy J. Ley, Ivan Maillard, Pavan Reddy, Daniel C. Link	34
9	Subclonal Evolution Characterizes MDS Disease Progression Following Allogeneic Stem Cell Transplant 2017 ·Blood ·Meagan A. Jacoby, Eric J. Duncavage, Gue Su Chang, Christopher A. Miller, Jin Shao, (unknown), Joshua D. Robinson, Robert S. Fulton, Catrina C. Fronick, Michelle D. O’Laughlin, Daniel C. Link, John F. DiPersio, Peter Westervelt, Timothy J. Ley, Timothy A. Graubert, Matthew J. Walter	1
10	Expression of the Tumor Suppressor WT1 Is Induced By PML-Rara in Acute Promyelocytic Leukemia.Â Â 2017 ·Blood ·(unknown), Andrew J. Menssen, Margery Gang, (unknown), Lukas D. Wartman, Timothy J. Ley	3
11	Whole Exome Sequencing Reveals the Order of Genetic Changes during Malignant Transformation and Metastasis in a Single Patient with NF1-plexiform Neurofibroma 2015 ·Clinical Cancer Research ·Angela C. Hirbe, Sonika Dahiya, Christopher A. Miller, Tiandao Li, Robert S. Fulton, Xiaochun Zhang, Sandra McDonald, Katherine DeSchryver, Eric J. Duncavage, Jessica C. Walrath, Karlyne M. Reilly, Haley Abel, Melike Pekmezci, Arie Perry, Timothy J. Ley, David H. Gutmann	37
12	Latent herpesvirus infection arms NK cells 2010 ·Blood ·Douglas W. White, Catherine R. Keppel, Stephanie Schneider, Tiffany A. Reese, (unknown), Jacqueline E. Payton, Timothy J. Ley, Herbert W. Virgin, Todd A. Fehniger	53
13	POU4F1 is associated with t(8;21) acute myeloid leukemia and contributes directly to its unique transcriptional signature 2010 ·Leukemia ·(unknown), Jacqueline E. Payton, Patrick Cahan, Timothy J. Ley, Matthew J. Walter, Timothy A. Graubert	15
14	Interleukin 12 Stimulates IFN-γ–Mediated Inhibition of Tumor-Induced Regulatory T-Cell Proliferation and Enhances Tumor Clearance 2009 ·Cancer Research ·Xuefang Cao, (unknown), Lynne Collins, Sheng F. Cai, (unknown), Jacqueline E. Payton, Michael Walter, David Piwnica‐Worms, Robert D. Schreiber, Timothy J. Ley	70
15	The unique roles of murine granzymes (Gzm) A and B for NK-dependent tumor cell killing and regulatory T cell control of NK cells 2006 ·Cancer Research ·Xuefang Cao, Todd A. Fehniger, Sheng F. Cai, Timothy J. Ley	1
16	Granzyme B and the Downstream Granzymes C and/or F Are Important for Cytotoxic Lymphocyte Functions 2005 ·The Journal of Immunology ·Paula A. Revell, William J. Grossman, Dori A. Thomas, Xuefang Cao, (unknown), (unknown), Zhi Hong Lu, Timothy J. Ley	94
17	Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells 2004 ·Blood ·William J. Grossman, James Verbsky, (unknown), Claudia Kemper, John P. Atkinson, Timothy J. Ley	400
18	Papillon-Lefevre Syndrome: Correlating the Molecular, Cellular, and Clinical Consequences of Cathepsin C/Dipeptidyl Peptidase I Deficiency in Humans 2004 ·The Journal of Immunology ·Christine T. N. Pham, Jennifer Ivanovich, Sofia Z. Raptis, Barbara A. Zehnbauer, Timothy J. Ley	162
19	The orphan granzymes of humans and mice 2003 ·Current Opinion in Immunology ·William J. Grossman, Paula A. Revell, Zhi Hong Lu, Hillary Johnson, Andrew J. Bredemeyer, Timothy J. Ley	129
20	Removing Career Obstacles for Young Physician-Scientists — Loan-Repayment Programs 2002 ·New England Journal of Medicine ·Timothy J. Ley, León E. Rosenberg	94

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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