Thomas D. Meek

7.0k total citations · 2 hit papers
70 papers, 5.3k citations indexed

About

Thomas D. Meek is a scholar working on Molecular Biology, Infectious Diseases and Virology. According to data from OpenAlex, Thomas D. Meek has authored 70 papers receiving a total of 5.3k indexed citations (citations by other indexed papers that have themselves been cited), including 40 papers in Molecular Biology, 32 papers in Infectious Diseases and 22 papers in Virology. Recurrent topics in Thomas D. Meek's work include HIV/AIDS drug development and treatment (26 papers), HIV Research and Treatment (22 papers) and Biochemical and Molecular Research (18 papers). Thomas D. Meek is often cited by papers focused on HIV/AIDS drug development and treatment (26 papers), HIV Research and Treatment (22 papers) and Biochemical and Molecular Research (18 papers). Thomas D. Meek collaborates with scholars based in United States, New Zealand and United Kingdom. Thomas D. Meek's co-authors include David L. Pompliano, Robert A. Copeland, Thaddeus A. Tomaszek, Christine Debouck, Geoffrey A. Holdgate, Rachel L. Grimley, Brian W. Metcalf, James E. Strickler, Geoffrey B. Dreyer and David G. Tew and has published in prestigious journals such as Nature, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

In The Last Decade

Thomas D. Meek

69 papers receiving 5.2k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Drug–target residence time and its implications for lead optimization

2006 1.1k citations Robert A. Copeland, David L. Pompliano et al. Nature Reviews Drug Discovery profile →
Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1999 887 citations Ishrut Hussain, David J. Powell et al. Molecular and Cellular Neuroscience profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Thomas D. Meek United States	33	2.9k	1.4k	1.1k	1.1k	854	70	5.3k
Joseph P. Vacca United States	38	2.0k 0.7×	1.4k 1.0×	1.0k 0.9×	387 0.4×	1.8k 2.1×	115	4.8k
Alfredo G. Tomasselli United States	32	2.3k 0.8×	610 0.4×	554 0.5×	1.2k 1.1×	368 0.4×	72	4.1k
James E. Strickler United States	31	3.4k 1.2×	823 0.6×	766 0.7×	256 0.2×	798 0.9×	47	6.1k
Kiaran Kirk Australia	51	3.2k 1.1×	884 0.6×	245 0.2×	751 0.7×	549 0.6×	196	9.0k
Jordan Tang United States	53	4.8k 1.7×	591 0.4×	377 0.3×	2.9k 2.7×	757 0.9×	173	9.1k
Manuel A. Navia United States	26	3.0k 1.1×	729 0.5×	615 0.5×	205 0.2×	645 0.8×	49	4.8k
Edward P. Garvey United States	39	1.5k 0.5×	1.9k 1.3×	655 0.6×	1.3k 1.2×	727 0.9×	82	5.1k
U. Helena Danielson Sweden	39	4.7k 1.6×	763 0.5×	401 0.4×	130 0.1×	984 1.2×	158	6.6k
Federico Gago Spain	42	3.3k 1.2×	739 0.5×	499 0.4×	98 0.1×	1.9k 2.2×	247	6.1k
Eric S. Furfine United States	33	1.4k 0.5×	1.2k 0.9×	1.1k 1.0×	1.2k 1.1×	595 0.7×	73	4.3k

Countries citing papers authored by Thomas D. Meek

Since Specialization

Citations

This map shows the geographic impact of Thomas D. Meek's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Thomas D. Meek with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Thomas D. Meek more than expected).

Fields of papers citing papers by Thomas D. Meek

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Thomas D. Meek. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Thomas D. Meek. The network helps show where Thomas D. Meek may publish in the future.

Co-authorship network of co-authors of Thomas D. Meek

This figure shows the co-authorship network connecting the top 25 collaborators of Thomas D. Meek. A scholar is included among the top collaborators of Thomas D. Meek based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Thomas D. Meek. Thomas D. Meek is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Meneely, Kathleen M., et al.. (2023). Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine–Guanine–Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors. Biochemistry. 62(14). 2182–2201. 2 indexed citations

Meek, Thomas D., et al.. (2022). Characterization of adenine phosphoribosyltransferase (APRT) activity in Trypanosoma brucei brucei: Only one of the two isoforms is kinetically active. PLoS neglected tropical diseases. 16(2). e0009926–e0009926. 5 indexed citations

Clinch, Keith, et al.. (2022). Kinetic Characterization and Inhibition of Trypanosoma cruzi Hypoxanthine–Guanine Phosphoribosyltransferases. Biochemistry. 61(19). 2088–2105. 9 indexed citations

Shaffer, Karl J., et al.. (2022). The design of protozoan phosphoribosyltransferase inhibitors containing non-charged phosphate mimic residues. Bioorganic & Medicinal Chemistry. 74. 117038–117038. 1 indexed citations

Murkin, Andrew S., et al.. (2017). Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences. 114(29). 7617–7622. 32 indexed citations

Holdgate, Geoffrey A., Thomas D. Meek, & Rachel L. Grimley. (2017). Mechanistic enzymology in drug discovery: a fresh perspective. Nature Reviews Drug Discovery. 17(2). 115–132. 153 indexed citations

Copeland, Robert A., David L. Pompliano, & Thomas D. Meek. (2006). Drug–target residence time and its implications for lead optimization. Nature Reviews Drug Discovery. 5(9). 730–739. 1098 indexed citations breakdown →

Hussain, Ishrut, David J. Powell, David Howlett, et al.. (2000). ASP1 (BACE2) Cleaves the Amyloid Precursor Protein at the β-Secretase Site. Molecular and Cellular Neuroscience. 16(5). 609–619. 131 indexed citations

Meek, Thomas D., et al.. (1994). [9] Use of steady state kinetic methods to elucidate the kinetic and chemical mechanisms of retroviral proteases. Methods in enzymology on CD-ROM/Methods in enzymology. 241. 127–156. 19 indexed citations

10.

Debouck, Christine, et al.. (1993). Inhibitor binding to the Phe53Trp mutant of HIV-1 protease promotes conformational changes detectable by spectrofluorometry. Biochemistry. 32(14). 3557–3563. 35 indexed citations

11.

Angeles, Thelma S., et al.. (1993). Use of nitrogen-15 kinetic isotope effects to elucidate details of the chemical mechanism of human immunodeficiency virus 1 protease. Biochemistry. 32(46). 12380–12385. 45 indexed citations

12.

Dreyer, Geoffrey B., Dennis M. Lambert, Thomas D. Meek, et al.. (1992). Hydroxyethylene isostere inhibitors of human immunodeficiency virus-1 protease: structure-activity analysis using enzyme kinetics, x-ray crystallography, and infected T-cell assays. Biochemistry. 31(29). 6646–6659. 110 indexed citations

13.

Deckman, Ingrid C., Jeffrey S. Culp, Michael D. Minnich, et al.. (1992). Use of protein unfolding studies to determine the conformational and dimeric stabilities of HIV-1 and SIV proteases. Biochemistry. 31(39). 9491–9501. 78 indexed citations

14.

Angeles, Thelma S., Gordon C. K. Roberts, Steven A. Carr, & Thomas D. Meek. (1992). Solvent isotope partitioning: a new kinetic tool for the determination of desorption rates of reactant water from enzyme-substrate complexes in proteases. Biochemistry. 31(47). 11778–11784. 3 indexed citations

15.

Deckman, Ingrid C., Michael D. Minnich, Jeffrey S. Culp, et al.. (1991). Purification and biochemical characterization of recombinant simian immunodeficiency virus protease and comparison to human immunodeficiency virus type 1 protease. Biochemistry. 30(34). 8424–8434. 42 indexed citations

16.

Tomaszek, Thaddeus A., et al.. (1991). Human immunodeficiency virus-1 protease. 2. Use of pH rate studies and solvent kinetic isotope effects to elucidate details of chemical mechanism. Biochemistry. 30(34). 8454–8463. 199 indexed citations

17.

Meek, Thomas D. & Geoffrey B. Dreyer. (1990). HIV‐1 Protease as a Potential Target for Anti‐AIDS Therapy. Annals of the New York Academy of Sciences. 616(1). 41–53. 14 indexed citations

18.

Dayton, Brian D., et al.. (1990). A radiometric assay for HIV-1 protease. Analytical Biochemistry. 188(2). 408–415. 22 indexed citations

19.

Strickler, James E., Joselina Gorniak, Brian D. Dayton, et al.. (1989). Characterization and autoprocessing of precursor and mature forms of human immunodeficiency virus type 1 (HIV 1) protease purified from Escherichia coli. Proteins Structure Function and Bioinformatics. 6(2). 139–154. 57 indexed citations

20.

Adams, Jerry L., Thomas D. Meek, Shau Ming Mong, Randall K. Johnson, & Brian W. Metcalf. (1988). cis-4-Carboxy-6-(mercaptomethyl)-3,4,5,6-tetrahydropyrimidin-2(1H)-one, a potent inhibitor of mammalian dihydroorotase. Journal of Medicinal Chemistry. 31(7). 1355–1359. 34 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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