Brian W. Metcalf

5.8k citations

81 papers · 4.9k indexed · 3 hit papers · h-index 34

Molecular Biology top 5%
Organic Chemistry top 2%
Infectious Diseases top 2%
Cellular and Molecular Neuroscience top 2%
Virology top 0.5%

Co-authors: Patrick Casara Michael J. Jung Bruce Lippert Charles Danzin Michel J. Jung Philippe Bey Jean‐Paul Vevert Christine Debouck
Topics: HIV/AIDS drug development and treatment (14 papers)HIV Research and Treatment (14 papers)Amino Acid Enzymes and Metabolism (12 papers)
Cited by: Virology Biochemistry Infectious Diseases
Journals: Nature Proceedings of the National Academy of Sciences Journal of the American Chemical Society
Partner nations: United States France United Kingdom

In The Last Decade

Brian W. Metcalf

79 papers receiving 4.5k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogs

1978 880 citations Brian W. Metcalf et al. profile →
γ‐VINYL GABA (4‐amino‐hex‐5‐enoic acid), A NEW SELECTIVE IRREVERSIBLE INHIBITOR OF GABA‐T: EFFECTS ON BRAIN GABA METABOLISM IN MICE¹

1977 417 citations Brian W. Metcalf et al. profile →
4‐Amino‐hex‐5‐enoic Acid, a Selective Catalytic Inhibitor of 4‐Aminobutyric‐Acid Aminotransferase in Mammalian Brain

1977 325 citations Brian W. Metcalf, Michel J. Jung et al. profile →

Peers

Countries citing papers authored by Brian W. Metcalf

Since Specialization

Citations

This map shows the geographic impact of Brian W. Metcalf's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Brian W. Metcalf with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Brian W. Metcalf more than expected).

Fields of papers citing papers by Brian W. Metcalf

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Brian W. Metcalf. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Brian W. Metcalf. The network helps show where Brian W. Metcalf may publish in the future.

Co-authorship network of co-authors of Brian W. Metcalf

This figure shows the co-authorship network connecting the top 25 collaborators of Brian W. Metcalf. A scholar is included among the top collaborators of Brian W. Metcalf based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Brian W. Metcalf. Brian W. Metcalf is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	An Orally Bioavailable HIV-1 Protease Inhibitor Containing an Imidazole-Derived Peptide Bond Replacement: Crystallographic and Pharmacokinetic Analysis 1994 ·Biochemistry ·Sherin S. Abdel‐Meguid,Brian W. Metcalf,Thomas J. Carr,(unknown),Renée L. DesJarlais,(unknown),David W. Green,Lucinda A. Ivanoff,Dennis M. Lambert	52
2	Epristeride is a selective and specific uncompetitive inhibitor of human steroid 5α-reductase isoform 2 1994 ·The Journal of Steroid Biochemistry and Molecular Biology ·Mark A. Levy,Martín Brandt,(unknown),(unknown),Dennis A. Holt,(unknown),Derk J. Bergsma,Brian W. Metcalf	49
3	Proteolysis of an active site peptide of lactate dehydrogenase by human immunodeficiency virus type 1 protease 1992 ·Biochemistry ·Thaddeus A. Tomaszek,Michael L. Moore,James E. Strickler,(unknown),(unknown),Brian W. Metcalf,Anne M. Hassell,Geoffrey B. Dreyer,(unknown)	35
4	Synthesis of a steroidal A ring aromatic sulfonic acid as an inhibitor of steroid Sa-reductase 1991 ·Steroids ·Dennis A. Holt,Hye-Ja Oh,Mark A. Levy,Brian W. Metcalf	9
5	The chronically infected cell as a target for the treatment of HIV infection and AIDS 1991 ·Trends in Pharmacological Sciences ·Stephen R. Petteway,Dennis M. Lambert,Brian W. Metcalf	11
6	Steroidal A ring aryl carboxylic acids: a new class of steroid 5.alpha.-reductase inhibitors 1990 ·Journal of Medicinal Chemistry ·Dennis A. Holt,Mark A. Levy,David L. Ladd,(unknown),Jill M. Erb,(unknown),Martín Brandt,Brian W. Metcalf	59
7	Studies on the mechanism of steroid 5α-reductase inhibition by 3-carboxy A-ring aryl steroids 1990 ·The Journal of Steroid Biochemistry and Molecular Biology ·Martín Brandt,(unknown),Dennis A. Holt,Brian W. Metcalf,Mark A. Levy	10
8	Inhibition of rat liver steroid 5.alpha.-reductase by 3-androstene-3-carboxylic acids: mechanism of enzyme-inhibitor interaction 1990 ·Biochemistry ·Mark A. Levy,Martín Brandt,J. Richard Heys,Dennis A. Holt,Brian W. Metcalf	33
9	Slow binding inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1990 ·Biochemistry ·Pearl Louis-Flamberg,Catherine E. Peishoff,Deborah Bryan,Jack D. Leber,John D. Elliott,Brian W. Metcalf,Ruth J. Mayer	11
10	Inhibition of steroid 5.alpha.-reductase by unsaturated 3-carboxy steroids 1990 ·Journal of Medicinal Chemistry ·Dennis A. Holt,Mark A. Levy,(unknown),Jill M. Erb,(unknown),Martín Brandt,(unknown),Brian W. Metcalf	82
11	Inhibition of HIV-1 protease in infected T-lymphocytes by synthetic peptide analogues 1990 ·Nature ·Thomas D. Meek,Dennis M. Lambert,Geoffrey B. Dreyer,Thomas J. Carr,Thaddeus A. Tomaszek,Michael L. Moore,James E. Strickler,Christine Debouck,(unknown),Thomas J. Matthews,Brian W. Metcalf,Stephen R. Petteway	201
12	Interaction between rat prostatic steroid 5α-reductase and 3-Carboxy-17β-substituted steroids: Novel mechanism of enzyme inhibition 1989 ·Journal of Steroid Biochemistry ·Mark A. Levy,Martín Brandt,Dennis A. Holt,Brian W. Metcalf	17
13	Human immunodeficiency virus 1 protease expressed in Escherichia coli behaves as a dimeric aspartic protease. 1989 ·Proceedings of the National Academy of Sciences ·Thomas D. Meek,Brian D. Dayton,Brian W. Metcalf,Geoffrey B. Dreyer,James E. Strickler,Joselina Gorniak,Martin Rosenberg,Michael L. Moore,Victoria W. Magaard,Christine Debouck	155
14	Purification and properties of the catalytic domain of human 3-hydroxy-3-methylglutaryl-CoA reductase expressed in Escherichia coli 1988 ·Archives of Biochemistry and Biophysics ·Ruth J. Mayer,Christine Debouck,Brian W. Metcalf	21
15	cis-4-Carboxy-6-(mercaptomethyl)-3,4,5,6-tetrahydropyrimidin-2(1H)-one, a potent inhibitor of mammalian dihydroorotase 1988 ·Journal of Medicinal Chemistry ·Jerry L. Adams,Thomas D. Meek,Shau Ming Mong,Randall K. Johnson,Brian W. Metcalf	34
16	Inhibition of pyridine-nucleotide-dependent enzymes by pyrazoles. Synthesis and enzymology of A novel A-ring pyrazole steroid 1986 ·Steroids ·Dennis A. Holt,Mark A. Levy,Martín Brandt,Brian W. Metcalf	2
17	4-Amino-4,5-dihydrothiophene-2-carboxylic acid 1985 ·The Journal of Organic Chemistry ·Jerry L. Adams,(unknown),Brian W. Metcalf	14
18	Molecular Basis for the Irreversible Inhibition of 4-Aminobutyric Acid:2-Oxoglutarate and L-Ornithine:2-Oxoacid Aminotransferases by 3-Amino-1,5-Cyclohexadienyl Carboxylic Acid (Isogabaculine) 1979 ·Molecular Pharmacology ·Brian W. Metcalf,Michel J. Jung	3
19	Catalytic inhibition of γ-aminobutyric acid-α-ketoglutarate transaminase of bacterial origin by 4-aminohex-5-ynoic acid, a substrate analog 1975 ·Biochemical and Biophysical Research Communications ·Michel J. Jung,Brian W. Metcalf	123
20	Structural revision and synthesis of a novel fungal diaryl ether 1971 ·Journal of the Chemical Society D Chemical Communications ·J. R. CANNON,(unknown),Brian W. Metcalf,Melvyn V. Sargent,John A. Elix	2

About Brian W. Metcalf

Brian W. Metcalf is a scholar working on Virology, Biochemistry and Biological Psychiatry, having authored 81 papers that have together received 4.9k indexed citations. Recurring topics across this work include HIV/AIDS drug development and treatment (14 papers), HIV Research and Treatment (14 papers) and Amino Acid Enzymes and Metabolism (12 papers). The work is most often cited by research in Virology (830 citations), Biochemistry (742 citations) and Infectious Diseases (881 citations). Brian W. Metcalf has collaborated with scholars based in United States, France and United Kingdom. Frequent co-authors include Patrick Casara, Michael J. Jung, Bruce Lippert, Charles Danzin, Michel J. Jung, Philippe Bey, Jean‐Paul Vevert, Christine Debouck, Peter Böhlen and Paul J. Schechter. Their work appears in journals such as Nature, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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