Joseph P. Vacca

10.2k citations

115 papers · 4.8k indexed · h-index 38

Virology top 0.5%
- HIV Research and Treatment 28
Infectious Diseases top 1%
- HIV/AIDS drug development and treatment 41
Organic Chemistry top 1%
Hepatology top 2%
Computational Theory and Mathematics top 0.5%
Molecular Biology
- Chemical Synthesis and Analysis 18
- Biochemical and Molecular Research 10
Psychiatry and Mental health
- Migraine and Headache Studies 15
Cellular and Molecular Neuroscience
- Neuropeptides and Animal Physiology 13
Hematology
- Blood Coagulation and Thrombosis Mechanisms 11
Oncology
- Peptidase Inhibition and Analysis 10

Co-authors: William A. Schleif Bruce D. Dorsey Rhonda B. Levin Stacey L. McDaniel M. Katharine Holloway S. J. DESOLMS Joel R. Huff James P. Guare
Cited by: Virology Infectious Diseases Organic Chemistry
Journals: Proceedings of the National Academy of Sciences (2 papers)Journal of the American Chemical Society (4 papers)Journal of Biological Chemistry (1 paper)
Partner nations: United States China Poland

In The Last Decade

Joseph P. Vacca

114 papers receiving 4.5k citations

Peers

Countries citing papers authored by Joseph P. Vacca

Since Specialization

Citations

This map shows the geographic impact of Joseph P. Vacca's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Joseph P. Vacca with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Joseph P. Vacca more than expected).

Fields of papers citing papers by Joseph P. Vacca

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Joseph P. Vacca. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Joseph P. Vacca. The network helps show where Joseph P. Vacca may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Joseph P. Vacca, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Joseph P. Vacca Line = papers co-authored together Joseph P. Vacca links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Characterization of Pyrrolidinyl-hexahydro-pyranopiperazines as a Novel Kappa Opioid Receptor Agonist Scaffold ACS Chemical Neuroscience ·Brian Reed,Michael Miller,Mayako Michino,Eduardo R. Butelman,Ariel Ben-Ezra,Philip Pikus,Michelle Morochnik,Yuli Kim,Amy Ripka,Joseph P. Vacca,Mary Jeanne Kreek	2022	2
2	Epsilon substituted lysinol derivatives as HIV-1 protease inhibitors Bioorganic & Medicinal Chemistry Letters ·Kristen L. Jones,M. Katharine Holloway,Hua-Poo Su,Steven S. Carroll,Christine Burlein,Sinoeun Touch,Daniel J. DiStefano,Rosa I. Sánchez,Theresa M. Williams,Joseph P. Vacca,Craig A. Coburn	2010	7
3	Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: Development of novel spiropiperidines Bioorganic & Medicinal Chemistry Letters ·Christopher S. Burgey,Craig M. Potteiger,James Z. Deng,Scott D. Mosser,Christopher Salvatore,Sean Yu,Shane Roller,Stefanie A. Kane,Joseph P. Vacca,Theresa M. Williams	2009	11
4	Discovery of aminoheterocycles as a novel β-secretase inhibitor class: pH dependence on binding activity part 1 Bioorganic & Medicinal Chemistry Letters ·Shawn J. Stachel,Craig A. Coburn,Diane M. Rush,Kristen L. Jones,Hong Zhu,Hemaka A. Rajapakse,Samuel Graham,Adam Simon,M. Katharine Holloway,Tim J. Allison,Sanjeev Munshi,Amy S. Espeseth,Paul Zuck,Dennis Colussi,Abigail Wolfe,Beth Pietrak,Ming‐Tain Lai,Joseph P. Vacca	2009	49
5	Potent benzimidazolone-based CGRP receptor antagonists Bioorganic & Medicinal Chemistry Letters ·Cory R. Theberge,Rodney A. Bednar,Ian M. Bell,Halea A. Corcoran,John F. Fay,James C. Hershey,Victor K. Johnston,Stefanie A. Kane,Scott D. Mosser,Christopher Salvatore,Theresa M. Williams,C. Blair Zartman,Xu-Fang Zhang,Samuel Graham,Joseph P. Vacca	2008	8
6	Potent, Orally Bioavailable Calcitonin Gene-Related Peptide Receptor Antagonists for the Treatment of Migraine: Discovery of N -[(3 R ,6 S )-6-(2,3-Difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1 H -imidazo[4,5- b ]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974) Journal of Medicinal Chemistry ·Daniel V. Paone,Anthony W. Shaw,Diem N. Nguyen,Christopher S. Burgey,James Z. Deng,Stefanie A. Kane,Kenneth S. Koblan,Christopher Salvatore,Scott D. Mosser,Victor K. Johnston,Bradley K. Wong,Cynthia Miller‐Stein,James C. Hershey,Samuel Graham,Joseph P. Vacca,Theresa M. Williams	2007	114
7	8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors Bioorganic & Medicinal Chemistry Letters ·Thorsten E. Fisher,Bo-Young Kim,Donnette D. Staas,Terry A. Lyle,Steven D. Young,Joseph P. Vacca,Matthew M. Zrada,Daria J. Hazuda,Peter J. Felock,William A. Schleif,Lori J. Gabryelski,M. Reza Anari,Christopher J. Kochansky,John Wai	2007	31
8	Pharmacological Characterization of MK-0974 [N-[(3 R,6 S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1 H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine Journal of Pharmacology and Experimental Therapeutics ·Christopher Salvatore,James C. Hershey,Halea A. Corcoran,John F. Fay,Victor K. Johnston,Eric L. Moore,Scott D. Mosser,Christopher S. Burgey,Daniel V. Paone,Anthony W. Shaw,Samuel Graham,Joseph P. Vacca,Theresa M. Williams,Kenneth S. Koblan,Stefanie A. Kane	2007	115
9	Design and synthesis of substituted 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamides, novel HIV-1 integrase inhibitors Bioorganic & Medicinal Chemistry Letters ·H. Marie Langford,Peter Williams,Carl F. Homnick,Joseph P. Vacca,Peter J. Felock,Kara A. Stillmock,Marc Witmer,Daria J. Hazuda,Lori J. Gabryelski,William A. Schleif	2007	13
10	The Integration of Medicinal Chemistry, Drug Metabolism, and Pharmaceutical Research and Development in Drug Discovery and Development Kluwer Academic Publishers eBooks ·Jiunn H. Lin,Dražen Ostović,Joseph P. Vacca	2006	10
11	A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors Bioorganic & Medicinal Chemistry Letters ·James P. Guare,John Wai,Robert Gomez,Neville J. Anthony,Samson M. Jolly,Amanda R. Cortes,Joseph P. Vacca,Peter J. Felock,Kara A. Stillmock,William A. Schleif,Gregory Moyer,Lori J. Gabryelski,Lixia Jin,I‐Wu Chen,Daria J. Hazuda,Steven D. Young	2006	37
12	Discovery of potent, selective 4-fluoroproline-based thrombin inhibitors with improved metabolic stability Bioorganic & Medicinal Chemistry ·Donnette D. Staas,Kelly L. Savage,Vanessa Sherman,Heidi L. Shimp,Terry A. Lyle,Lekhanh O. Tran,Catherine M. Wiscount,Daniel R. McMasters,Philip E.J. Sanderson,Peter D. Williams,Bobby J. Lucas,Julie A. Krueger,Sidney D. Lewis,Rebecca B. White,Sean Yu,Bradley K. Wong,Christopher J. Kochansky,M. Reza Anari,Youwei Yan,Joseph P. Vacca	2006	31
13	Conformationally biased P3 amide replacements of β-secretase inhibitors Bioorganic & Medicinal Chemistry Letters ·Shawn J. Stachel,Craig A. Coburn,Thomas G. Steele,Min-Chi Crouthamel,Beth Pietrak,Ming‐Tain Lai,M. Katharine Holloway,Sanjeev Munshi,Samuel Graham,Joseph P. Vacca	2005	55
14	Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization Bioorganic & Medicinal Chemistry Letters ·James Z. Deng,Daniel R. McMasters,Philippe M. A. Rabbat,Peter Williams,Craig A. Coburn,Youwei Yan,Lawrence C. Kuo,Sidney D. Lewis,Bobby J. Lucas,Julie A. Krueger,Berta Strulovici,Joseph P. Vacca,Terry A. Lyle,Christopher S. Burgey	2005	35
15	Unexpected enhancement of thrombin inhibitor potency with o-aminoalkylbenzylamides in the P1 position Bioorganic & Medicinal Chemistry Letters ·Kenneth E. Rittle,James C. Barrow,Kellie J. Cutrona,Kristen L. Glass,Julie A. Krueger,Lawrence C. Kuo,Sidney D. Lewis,Bobby J. Lucas,Daniel R. McMasters,Matthew M. Morrissette,Philippe G. Nantermet,Christina L. Newton,William M. Sanders,Youwei Yan,Joseph P. Vacca,Harold G. Selnick	2003	20
16	New advances in the discovery of thrombin and factor Xa inhibitors Current Opinion in Chemical Biology ·Joseph P. Vacca	2000	47
17	A priori prediction of activity for HIV-1 protease inhibitors employing energy minimization in the active site Journal of Medicinal Chemistry ·M. Katharine Holloway,Jenny Wai,Thomas A. Halgren,Paula M.D. Fitzgerald,Joseph P. Vacca,Bruce D. Dorsey,Rhonda B. Levin,Wayne J. Thompson,L. Jenny Chen	1995	178
18	L-735,524: The Design of a Potent and Orally Bioavailable HIV Protease Inhibitor Journal of Medicinal Chemistry ·Bruce D. Dorsey,Rhonda B. Levin,Stacey L. McDaniel,Joseph P. Vacca,James P. Guare,Paul L. Darke,Joan A. Zugay,Emilio A. Emini,William A. Schleif	1994	324
19	Interaction of Mutant Forms of the HIV-1 Protease with Substrate and Inhibitors Advances in experimental medicine and biology ·Paul L. Darke,Nancy E. Kohl,Michelle G. Hanobik,Chih‐Tai Leu,Joseph P. Vacca,James P. Guare,Jill C. Heimbach,Richard A. F. Dixon	1991	2
20	Pharmacological profile of a new potent and specific ?2-adrenoceptor antagonist, L-657,743 Naunyn-Schmiedeberg s Archives of Pharmacology ·Douglas J. Pettibone,Bradley V. Clineschmidt,Victor J. Lotti,John J. Baldwin,Joel R. Huff,William C. Randall,Joseph P. Vacca,Steven D. Young	1987	24

About Joseph P. Vacca

Joseph P. Vacca is a scholar working on Virology, Infectious Diseases and Hematology, having authored 115 papers that have together received 4.8k indexed citations. Recurring topics across this work include HIV/AIDS drug development and treatment (41 papers), HIV Research and Treatment (28 papers), Chemical Synthesis and Analysis (18 papers), Migraine and Headache Studies (15 papers), Neuropeptides and Animal Physiology (13 papers), Blood Coagulation and Thrombosis Mechanisms (11 papers), Biochemical and Molecular Research (10 papers) and Peptidase Inhibition and Analysis (10 papers). The work is most often cited by research in Virology (1.0k citations), Infectious Diseases (1.4k citations) and Organic Chemistry (1.8k citations). Joseph P. Vacca has collaborated with scholars based in United States, China and Poland. Frequent co-authors include William A. Schleif, Bruce D. Dorsey, Rhonda B. Levin, Stacey L. McDaniel, M. Katharine Holloway, S. J. DESOLMS, Joel R. Huff, James P. Guare, Daria J. Hazuda and Samuel Graham. Their work appears in journals such as Proceedings of the National Academy of Sciences, Journal of the American Chemical Society and Journal of Biological Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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