Joseph P. Vacca

10.2k citations

115 papers · 4.8k indexed · h-index 38

Molecular Biology top 5%
Organic Chemistry top 1%
Infectious Diseases top 1%
Virology top 0.5%
Computational Theory and Mathematics top 0.5%

Co-authors: William A. Schleif Bruce D. Dorsey Rhonda B. Levin Stacey L. McDaniel M. Katharine Holloway S. J. DESOLMS Joel R. Huff James P. Guare
Topics: HIV/AIDS drug development and treatment (41 papers)HIV Research and Treatment (28 papers)Chemical Synthesis and Analysis (18 papers)
Cited by: Virology Infectious Diseases Organic Chemistry
Journals: Proceedings of the National Academy of Sciences Journal of the American Chemical Society Journal of Biological Chemistry
Partner nations: United States China Poland

In The Last Decade

Joseph P. Vacca

114 papers receiving 4.5k citations

Peers

Countries citing papers authored by Joseph P. Vacca

Since Specialization

Citations

This map shows the geographic impact of Joseph P. Vacca's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Joseph P. Vacca with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Joseph P. Vacca more than expected).

Fields of papers citing papers by Joseph P. Vacca

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Joseph P. Vacca. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Joseph P. Vacca. The network helps show where Joseph P. Vacca may publish in the future.

Co-authorship network of co-authors of Joseph P. Vacca

This figure shows the co-authorship network connecting the top 25 collaborators of Joseph P. Vacca. A scholar is included among the top collaborators of Joseph P. Vacca based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Joseph P. Vacca. Joseph P. Vacca is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Characterization of Pyrrolidinyl-hexahydro-pyranopiperazines as a Novel Kappa Opioid Receptor Agonist Scaffold 2022 ·ACS Chemical Neuroscience ·Brian Reed,Michael Miller,Mayako Michino,Eduardo R. Butelman,(unknown),(unknown),(unknown),(unknown),(unknown),Joseph P. Vacca,Mary Jeanne Kreek	2
2	Epsilon substituted lysinol derivatives as HIV-1 protease inhibitors 2010 ·Bioorganic & Medicinal Chemistry Letters ·Kristen L. Jones,M. Katharine Holloway,Hua-Poo Su,Steven S. Carroll,Christine Burlein,Sinoeun Touch,Daniel J. DiStefano,Rosa I. Sánchez,Theresa M. Williams,Joseph P. Vacca,Craig A. Coburn	7
3	Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: Development of novel spiropiperidines 2009 ·Bioorganic & Medicinal Chemistry Letters ·Christopher S. Burgey,(unknown),James Z. Deng,Scott D. Mosser,Christopher Salvatore,Sean Yu,Shane Roller,Stefanie A. Kane,Joseph P. Vacca,Theresa M. Williams	11
4	Discovery of aminoheterocycles as a novel β-secretase inhibitor class: pH dependence on binding activity part 1 2009 ·Bioorganic & Medicinal Chemistry Letters ·Shawn J. Stachel,Craig A. Coburn,(unknown),Kristen L. Jones,Hong Zhu,Hemaka A. Rajapakse,Samuel Graham,Adam Simon,M. Katharine Holloway,(unknown),Sanjeev Munshi,Amy S. Espeseth,Paul Zuck,Dennis Colussi,Abigail Wolfe,Beth Pietrak,Ming‐Tain Lai,Joseph P. Vacca	49
5	Potent benzimidazolone-based CGRP receptor antagonists 2008 ·Bioorganic & Medicinal Chemistry Letters ·Cory R. Theberge,Rodney A. Bednar,Ian M. Bell,(unknown),John F. Fay,James C. Hershey,Victor K. Johnston,Stefanie A. Kane,Scott D. Mosser,Christopher Salvatore,Theresa M. Williams,C. Blair Zartman,(unknown),Samuel Graham,Joseph P. Vacca	8
6	Potent, Orally Bioavailable Calcitonin Gene-Related Peptide Receptor Antagonists for the Treatment of Migraine: Discovery of N -[(3 R ,6 S )-6-(2,3-Difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1 H -imidazo[4,5- b ]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974) 2007 ·Journal of Medicinal Chemistry ·Daniel V. Paone,Anthony W. Shaw,Diem N. Nguyen,Christopher S. Burgey,James Z. Deng,Stefanie A. Kane,Kenneth S. Koblan,Christopher Salvatore,Scott D. Mosser,Victor K. Johnston,Bradley K. Wong,Cynthia Miller‐Stein,James C. Hershey,Samuel Graham,Joseph P. Vacca,Theresa M. Williams	114
7	8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors 2007 ·Bioorganic & Medicinal Chemistry Letters ·Thorsten E. Fisher,Bo-Young Kim,(unknown),Terry A. Lyle,Steven D. Young,Joseph P. Vacca,Matthew M. Zrada,Daria J. Hazuda,Peter J. Felock,William A. Schleif,Lori J. Gabryelski,M. Reza Anari,Christopher J. Kochansky,John Wai	31
8	Pharmacological Characterization of MK-0974 [N-[(3 R,6 S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1 H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine 2007 ·Journal of Pharmacology and Experimental Therapeutics ·Christopher Salvatore,James C. Hershey,(unknown),John F. Fay,Victor K. Johnston,Eric L. Moore,Scott D. Mosser,Christopher S. Burgey,Daniel V. Paone,Anthony W. Shaw,Samuel Graham,Joseph P. Vacca,Theresa M. Williams,Kenneth S. Koblan,Stefanie A. Kane	115
9	Design and synthesis of substituted 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamides, novel HIV-1 integrase inhibitors 2007 ·Bioorganic & Medicinal Chemistry Letters ·(unknown),Peter Williams,Carl F. Homnick,Joseph P. Vacca,Peter J. Felock,Kara A. Stillmock,Marc Witmer,Daria J. Hazuda,Lori J. Gabryelski,William A. Schleif	13
10	The Integration of Medicinal Chemistry, Drug Metabolism, and Pharmaceutical Research and Development in Drug Discovery and Development 2006 ·Kluwer Academic Publishers eBooks ·Jiunn H. Lin,Dražen Ostović,Joseph P. Vacca	10
11	A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors 2006 ·Bioorganic & Medicinal Chemistry Letters ·James P. Guare,John Wai,Robert Gomez,Neville J. Anthony,Samson M. Jolly,(unknown),Joseph P. Vacca,Peter J. Felock,Kara A. Stillmock,William A. Schleif,Gregory Moyer,Lori J. Gabryelski,Lixia Jin,I‐Wu Chen,Daria J. Hazuda,Steven D. Young	37
12	Discovery of potent, selective 4-fluoroproline-based thrombin inhibitors with improved metabolic stability 2006 ·Bioorganic & Medicinal Chemistry ·(unknown),(unknown),(unknown),(unknown),Terry A. Lyle,(unknown),(unknown),Daniel R. McMasters,Philip E.J. Sanderson,(unknown),Bobby J. Lucas,Julie A. Krueger,Sidney D. Lewis,Rebecca B. White,Sean Yu,Bradley K. Wong,Christopher J. Kochansky,M. Reza Anari,Youwei Yan,Joseph P. Vacca	31
13	Conformationally biased P3 amide replacements of β-secretase inhibitors 2005 ·Bioorganic & Medicinal Chemistry Letters ·Shawn J. Stachel,Craig A. Coburn,Thomas G. Steele,(unknown),Beth Pietrak,Ming‐Tain Lai,M. Katharine Holloway,Sanjeev Munshi,Samuel Graham,Joseph P. Vacca	55
14	Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization 2005 ·Bioorganic & Medicinal Chemistry Letters ·James Z. Deng,Daniel R. McMasters,(unknown),Peter Williams,Craig A. Coburn,Youwei Yan,Lawrence C. Kuo,Sidney D. Lewis,Bobby J. Lucas,Julie A. Krueger,Berta Strulovici,Joseph P. Vacca,Terry A. Lyle,Christopher S. Burgey	35
15	Unexpected enhancement of thrombin inhibitor potency with o-aminoalkylbenzylamides in the P1 position 2003 ·Bioorganic & Medicinal Chemistry Letters ·Kenneth E. Rittle,James C. Barrow,(unknown),(unknown),Julie A. Krueger,Lawrence C. Kuo,Sidney D. Lewis,Bobby J. Lucas,Daniel R. McMasters,(unknown),Philippe G. Nantermet,(unknown),William M. Sanders,Youwei Yan,Joseph P. Vacca,Harold G. Selnick	20
16	New advances in the discovery of thrombin and factor Xa inhibitors 2000 ·Current Opinion in Chemical Biology ·Joseph P. Vacca	47
17	A priori prediction of activity for HIV-1 protease inhibitors employing energy minimization in the active site 1995 ·Journal of Medicinal Chemistry ·M. Katharine Holloway,Jenny Wai,Thomas A. Halgren,Paula M.D. Fitzgerald,Joseph P. Vacca,Bruce D. Dorsey,Rhonda B. Levin,Wayne J. Thompson,(unknown)	178
18	L-735,524: The Design of a Potent and Orally Bioavailable HIV Protease Inhibitor 1994 ·Journal of Medicinal Chemistry ·Bruce D. Dorsey,Rhonda B. Levin,Stacey L. McDaniel,Joseph P. Vacca,James P. Guare,(unknown),(unknown),Emilio A. Emini,William A. Schleif	324
19	Interaction of Mutant Forms of the HIV-1 Protease with Substrate and Inhibitors 1991 ·Advances in experimental medicine and biology ·Paul L. Darke,Nancy E. Kohl,(unknown),Chih‐Tai Leu,Joseph P. Vacca,James P. Guare,Jill C. Heimbach,Richard A. F. Dixon	2
20	Pharmacological profile of a new potent and specific ?2-adrenoceptor antagonist, L-657,743 1987 ·Naunyn-Schmiedeberg s Archives of Pharmacology ·Douglas J. Pettibone,Bradley V. Clineschmidt,Victor J. Lotti,John J. Baldwin,Joel R. Huff,William C. Randall,Joseph P. Vacca,Steven D. Young	24

About Joseph P. Vacca

Joseph P. Vacca is a scholar working on Virology, Infectious Diseases and Hematology, having authored 115 papers that have together received 4.8k indexed citations. Recurring topics across this work include HIV/AIDS drug development and treatment (41 papers), HIV Research and Treatment (28 papers) and Chemical Synthesis and Analysis (18 papers). The work is most often cited by research in Virology (1.0k citations), Infectious Diseases (1.4k citations) and Organic Chemistry (1.8k citations). Joseph P. Vacca has collaborated with scholars based in United States, China and Poland. Frequent co-authors include William A. Schleif, Bruce D. Dorsey, Rhonda B. Levin, Stacey L. McDaniel, M. Katharine Holloway, S. J. DESOLMS, Joel R. Huff, James P. Guare, Daria J. Hazuda and Samuel Graham. Their work appears in journals such as Proceedings of the National Academy of Sciences, Journal of the American Chemical Society and Journal of Biological Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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