Thomas Bara

1.3k citations

12 papers · 854 indexed · 1 hit paper · h-index 12

Impact in

Physiology top 10%
- Alzheimer's disease research and treatments
Pharmacology top 5%
- Cholinesterase and Neurodegenerative Diseases

Papers in ⓘ

Computational Theory and Mathematics 9
- Computational Drug Discovery Methods 9
Physiology 8
- Alzheimer's disease research and treatments 8

Co-authors: Hubert Josien (11 shared papers)Eric M. Parker (9 shared papers)Qi Zhang (4 shared papers)Denise Manfra (2 shared papers)Guy A. Higgins (2 shared papers)Lili Zhang (3 shared papers)Gwendolyn T. Wong (3 shared papers)Maria Pinzon-Ortiz (1 shared paper)
Journals: Bioorganic & Medicinal Chemistry Letters (6 papers)European Journal of Medicinal Chemistry (1 paper)Journal of Pharmacology and Experimental Therapeutics (1 paper)Biochemistry (1 paper)Journal of Medicinal Chemistry (1 paper)
Partner nations: United States United Kingdom

In The Last Decade

Thomas Bara

12 papers receiving 827 citations

Hit Papers

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Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation 2004 · 583 citations

Peers

Countries citing papers authored by Thomas Bara

Since Specialization

Citations

This map shows the geographic impact of Thomas Bara's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Thomas Bara with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Thomas Bara more than expected).

Fields of papers citing papers by Thomas Bara

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Thomas Bara. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Thomas Bara. The network helps show where Thomas Bara may publish in the future.

Co-authors

The 25 scholars most cited alongside Thomas Bara, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Thomas Bara Line = papers co-authored together Thomas Bara links everyone, so they are left out of the graph.

All Works

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12 of 12 papers shown

#	Work
1	Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation Journal of Biological Chemistry ·Gwendolyn T. Wong, Denise Manfra, Frederique M. Poulet, Qi Zhang, Hubert Josien, Thomas Bara, Laura Engstrom, Maria Pinzon-Ortiz, Jay S. Fine, Hu-Jung J. Lee, Lili Zhang, Guy A. Higgins, Eric M. Parker Hit paper breakdown →	2004	583
2	Synthesis, SAR, and Biological Evaluation of Oximino-Piperidino-Piperidine Amides. 1. Orally Bioavailable CCR5 Receptor Antagonists with Potent Anti-HIV Activity Journal of Medicinal Chemistry ·Anandan Palani, Sherry Shapiro, Hubert Josien, Thomas Bara, John W. Clader, William J. Greenlee, Kathleen Cox, Julie Strizki, Bahige M. Baroudy	2002	62
3	Studies to Investigate the in Vivo Therapeutic Window of the γ-Secretase Inhibitor N2-[(2 S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7 S)-5-methyl-6-oxo-6,7-dihydro-5 H-dibenzo[b,d]azepin-7-yl]-l-alaninamide (LY411,575) in the CRND8 Mouse Journal of Pharmacology and Experimental Therapeutics ·Lynn A. Hyde, Nansie A. McHugh, Joseph Chen, Qi Zhang, Denise Manfra, Amin A. Nomeir, Hubert Josien, Thomas Bara, John W. Clader, Lili Zhang, Eric M. Parker, Guy A. Higgins	2006	50
4	Tetrahydroquinoline sulfonamides as γ-secretase inhibitors Bioorganic & Medicinal Chemistry Letters ·Theodros Asberom, Thomas Bara, John W. Clader, William J. Greenlee, Henry Guzik, Hubert Josien, Wěi Li, Eric M. Parker, Dmitri Pissarnitski, Lixin Song, Lili Zhang, Zhiqiang Zhao	2006	27
5	Identification of Presenilin 1-Selective γ-Secretase Inhibitors with Reconstituted γ-Secretase Complexes Biochemistry ·Julie Lee, Lixin Song, Giuseppe Terracina, Thomas Bara, Hubert Josien, Theodros Asberom, Thavalakulamgar Sasikumar, Duane A. Burnett, John W. Clader, Eric M. Parker, Lili Zhang	2011	26
6	Discovery of γ-secretase inhibitors efficacious in a transgenic animal model of Alzheimer’s disease Bioorganic & Medicinal Chemistry Letters ·Theodros Asberom, Zhiqiang Zhao, Thomas Bara, John W. Clader, William J. Greenlee, Lynn A. Hyde, Hubert Josien, Wěi Li, Andrew T. McPhail, Amin A. Nomeir, Eric M. Parker, Murali Rajagopalan, Lixin Song, Gwendolyn T. Wong, Lili Zhang, Qi Zhang, Dmitri Pissarnitski	2006	21
7	Iminoheterocycles as γ-secretase modulators Bioorganic & Medicinal Chemistry Letters ·John P. Caldwell, Chad Bennett, Troy McCracken, Robert Mazzola, Thomas Bara, Alexei V. Buevich, Duane A. Burnett, Inhou Chu, Mary Cohen-Williams, Hubert Josein, Lynn A. Hyde, Julie Lee, Brian McKittrick, Lixin Song, Giuseppe Terracina, Johannes Voigt, Lili Zhang, Zhaoning Zhu	2010	19
8	Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors Bioorganic & Medicinal Chemistry Letters ·Hongmei Li, Theodros Asberom, Thomas Bara, John W. Clader, William J. Greenlee, Hubert Josien, Mark D. McBriar, Amin A. Nomeir, Dmitri Pissarnitski, Murali Rajagopalan, Ruo Xu, Zhiqiang Zhao, Lixin Song, Lili Zhang	2007	16
9	Small conformationally restricted piperidine N-arylsulfonamides as orally active γ-secretase inhibitors Bioorganic & Medicinal Chemistry Letters ·Hubert Josien, Thomas Bara, Murali Rajagopalan, Theodros Asberom, John W. Clader, Leonard Favreau, William J. Greenlee, Lynn A. Hyde, Amin A. Nomeir, Eric M. Parker, Dmitri Pissarnitski, Lixin Song, Gwendolyn T. Wong, Lili Zhang, Qi Zhang, Zhiqiang Zhao	2007	15
10	Substituted 4-morpholine N -arylsulfonamides as γ-secretase inhibitors European Journal of Medicinal Chemistry ·Zhiqiang Zhao, Dmitri Pissarnitski, Hubert Josien, Thomas Bara, John W. Clader, Hongmei Li, Mark D. McBriar, Murali Rajagopalan, Ruo Xu, Giuseppe Terracina, Lynn A. Hyde, Lixin Song, Lili Zhang, Eric M. Parker, Rebecca Osterman, Alexei V. Buevich	2016	12
11	Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease ACS Medicinal Chemistry Letters ·Wen‐Lian Wu, Martin S. Domalski, Duane A. Burnett, Hubert Josien, Thomas Bara, Murali Rajagopalan, Ruo Xu, John W. Clader, William J. Greenlee, Andrew P. J. Brunskill, Lynn A. Hyde, Robert A. Del Vecchio, Mary Cohen-Williams, Lixin Song, Julie Lee, Giuseppe Terracina, Qi Zhang, Amin A. Nomeir, Eric M. Parker, Lili Zhang	2012	12
12	Novel orally active morpholine N-arylsulfonamides γ-secretase inhibitors with low CYP 3A4 liability Bioorganic & Medicinal Chemistry Letters ·Hubert Josien, Thomas Bara, Murali Rajagopalan, John W. Clader, William J. Greenlee, Leonard Favreau, Lynn A. Hyde, Amin A. Nomeir, Eric M. Parker, Lixin Song, Lili Zhang, Qi Zhang	2009	11

About Thomas Bara

Thomas Bara is a scholar working on Computational Theory and Mathematics, Physiology, Pharmacology, Molecular Biology and Oncology, having authored 12 papers that have together received 854 indexed citations. Recurring topics across this work include Computational Drug Discovery Methods (9 papers), Alzheimer's disease research and treatments (8 papers), Cholinesterase and Neurodegenerative Diseases (7 papers), Drug Transport and Resistance Mechanisms (2 papers), Receptor Mechanisms and Signaling (2 papers), Chemical Synthesis and Analysis (2 papers), HIV Research and Treatment (1 paper) and Retinoids in leukemia and cellular processes (1 paper). The work is most often cited by research in Physiology (337 citations), Pharmacology (217 citations), Computational Theory and Mathematics (190 citations), Molecular Biology (388 citations) and Biological Psychiatry (13 citations). Thomas Bara has collaborated with scholars based in United States and United Kingdom. Frequent co-authors include Hubert Josien, Eric M. Parker, Qi Zhang, Denise Manfra, Guy A. Higgins, Lili Zhang, Gwendolyn T. Wong, Maria Pinzon-Ortiz, Jay S. Fine and Laura Engstrom. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, European Journal of Medicinal Chemistry, Journal of Pharmacology and Experimental Therapeutics, Biochemistry and Journal of Medicinal Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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