Hubert Josien

2.5k total citations · 1 hit paper
34 papers, 1.6k citations indexed

About

Hubert Josien is a scholar working on Organic Chemistry, Molecular Biology and Pharmacology. According to data from OpenAlex, Hubert Josien has authored 34 papers receiving a total of 1.6k indexed citations (citations by other indexed papers that have themselves been cited), including 15 papers in Organic Chemistry, 13 papers in Molecular Biology and 11 papers in Pharmacology. Recurrent topics in Hubert Josien's work include Cholinesterase and Neurodegenerative Diseases (10 papers), Alzheimer's disease research and treatments (9 papers) and Computational Drug Discovery Methods (8 papers). Hubert Josien is often cited by papers focused on Cholinesterase and Neurodegenerative Diseases (10 papers), Alzheimer's disease research and treatments (9 papers) and Computational Drug Discovery Methods (8 papers). Hubert Josien collaborates with scholars based in United States, France and United Kingdom. Hubert Josien's co-authors include Dennis P. Curran, Sung‐Bo Ko, Thomas Bara, Eric M. Parker, Qi Zhang, Guy A. Higgins, Denise Manfra, Lili Zhang, Gwendolyn T. Wong and Laura Engstrom and has published in prestigious journals such as Journal of Biological Chemistry, Biochemistry and Annals of the New York Academy of Sciences.

In The Last Decade

Hubert Josien

34 papers receiving 1.6k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation

2004 583 citations Gwendolyn T. Wong, Denise Manfra et al. Journal of Biological Chemistry profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Hubert Josien United States	20	743	704	357	255	210	34	1.6k
John H. Hutchinson United States	26	882 1.2×	654 0.9×	275 0.8×	279 1.1×	70 0.3×	90	1.9k
Daniela Pizzirani Italy	22	717 1.0×	645 0.9×	207 0.6×	340 1.3×	165 0.8×	32	1.6k
Craig A. Coburn United States	20	532 0.7×	679 1.0×	233 0.7×	283 1.1×	247 1.2×	34	1.4k
Heiko Kroth United States	20	931 1.3×	313 0.4×	303 0.8×	116 0.5×	89 0.4×	55	1.5k
Shawn J. Stachel United States	20	548 0.7×	519 0.7×	284 0.8×	357 1.4×	305 1.5×	52	1.3k
Thomas W von Geldern United States	26	617 0.8×	853 1.2×	458 1.3×	76 0.3×	65 0.3×	57	2.1k
George W. Carter United States	26	649 0.9×	525 0.7×	224 0.6×	231 0.9×	40 0.2×	58	1.7k
Roger E. Markwell United Kingdom	18	430 0.6×	439 0.6×	316 0.9×	244 1.0×	164 0.8×	42	1.1k
Youhong Hu China	28	745 1.0×	1.3k 1.9×	130 0.4×	508 2.0×	89 0.4×	92	2.3k
Jennifer J. Bouska United States	23	1.1k 1.4×	851 1.2×	92 0.3×	213 0.8×	197 0.9×	41	2.1k

Countries citing papers authored by Hubert Josien

Since Specialization

Citations

This map shows the geographic impact of Hubert Josien's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hubert Josien with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hubert Josien more than expected).

Fields of papers citing papers by Hubert Josien

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hubert Josien. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hubert Josien. The network helps show where Hubert Josien may publish in the future.

Co-authorship network of co-authors of Hubert Josien

This figure shows the co-authorship network connecting the top 25 collaborators of Hubert Josien. A scholar is included among the top collaborators of Hubert Josien based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hubert Josien. Hubert Josien is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Fawaz, Maria V., Hubert Josien, Kara Pearson, et al.. (2024). Leveraging High-Resolution Ion Mobility-Mass Spectrometry for Cyclic Peptide Soft Spot Identification. Journal of the American Society for Mass Spectrometry. 35(11). 2596–2607. 3 indexed citations

Shang, Jackie, Richard A. Tschirret-Guth, Mark T. Cancilla, et al.. (2019). Bioactivation of GPR40 Agonist MK-8666: Formation of Protein Adducts in Vitro from Reactive Acyl Glucuronide and Acyl CoA Thioester. Chemical Research in Toxicology. 33(1). 191–201. 17 indexed citations

Zhao, Zhiqiang, Dmitri Pissarnitski, Hubert Josien, et al.. (2016). Substituted 4-morpholine N -arylsulfonamides as γ-secretase inhibitors. European Journal of Medicinal Chemistry. 124. 36–48. 12 indexed citations

Zhao, Zhiqiang, Dmitri Pissarnitski, Hubert Josien, et al.. (2015). Discovery of a Novel, Potent Spirocyclic Series of γ-Secretase Inhibitors. Journal of Medicinal Chemistry. 58(22). 8806–8817. 19 indexed citations

Huang, Xianhai, Dmitri Pissarnitski, Hongmei Li, et al.. (2012). Efficient synthesis and reaction pathway studies of novel fused morpholine oxadiazolines for use as gamma secretase modulators. Tetrahedron Letters. 53(47). 6451–6455. 8 indexed citations

Josien, Hubert, Thomas Bara, John W. Clader, et al.. (2009). Novel orally active morpholine N-arylsulfonamides γ-secretase inhibitors with low CYP 3A4 liability. Bioorganic & Medicinal Chemistry Letters. 19(21). 6032–6037. 11 indexed citations

Li, Hongmei, Theodros Asberom, Thomas Bara, et al.. (2007). Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors. Bioorganic & Medicinal Chemistry Letters. 17(22). 6290–6294. 16 indexed citations

Josien, Hubert, Thomas Bara, Theodros Asberom, et al.. (2007). Small conformationally restricted piperidine N-arylsulfonamides as orally active γ-secretase inhibitors. Bioorganic & Medicinal Chemistry Letters. 17(19). 5330–5335. 15 indexed citations

Asberom, Theodros, Zhiqiang Zhao, Thomas Bara, et al.. (2006). Discovery of γ-secretase inhibitors efficacious in a transgenic animal model of Alzheimer’s disease. Bioorganic & Medicinal Chemistry Letters. 17(2). 511–516. 21 indexed citations

10.

Asberom, Theodros, Thomas Bara, John W. Clader, et al.. (2006). Tetrahydroquinoline sulfonamides as γ-secretase inhibitors. Bioorganic & Medicinal Chemistry Letters. 17(1). 205–207. 27 indexed citations

11.

Wong, Gwendolyn T., Denise Manfra, Frederique M. Poulet, et al.. (2004). Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation. Journal of Biological Chemistry. 279(13). 12876–12882. 583 indexed citations breakdown →

12.

Tagat, Jayaram R., Stuart W. McCombie, Dennis V. Nazareno, et al.. (2002). Synthesis of Mono- and Difluoronaphthoic Acids. The Journal of Organic Chemistry. 67(4). 1171–1177. 20 indexed citations

13.

Palani, Anandan, Sherry Shapiro, Hubert Josien, et al.. (2002). Synthesis, SAR, and Biological Evaluation of Oximino-Piperidino-Piperidine Amides. 1. Orally Bioavailable CCR5 Receptor Antagonists with Potent Anti-HIV Activity. Journal of Medicinal Chemistry. 45(14). 3143–3160. 62 indexed citations

14.

Josien, Hubert. (2002). Recent advances in the development of gamma-secretase inhibitors.. PubMed. 5(4). 513–25. 33 indexed citations

15.

Curran, Dennis P., Hubert Josien, David Bom, Ana E. Gabarda, & Wu Du. (2000). The Cascade Radical Annulation Approach to New Analogues of Camptothecins: Combinatorial Synthesis of Silatecans and Homosilatecans. Annals of the New York Academy of Sciences. 922(1). 112–121. 17 indexed citations

16.

Déry, Olivier, Hubert Josien, Jacques Grassi, et al.. (1998). Use of conformationally constrained peptides for a topographical analysis of the combining site of a monoclonal anti-substance P antibody. Biopolymers. 39(1). 67–74. 32 indexed citations

17.

Josien, Hubert, et al.. (1997). 7-Silylcamptothecins (silatecans): A new family of camptothecin antitumor agents. Bioorganic & Medicinal Chemistry Letters. 7(24). 3189–3194. 50 indexed citations

18.

Sagan, Sandrine, Hubert Josien, Philippe Karoyan, et al.. (1996). Tachykinin NK-1 receptor probed with constrained analogues of substance P. Bioorganic & Medicinal Chemistry. 4(12). 2167–2178. 21 indexed citations

19.

Curran, Dennis P., Sung‐Bo Ko, & Hubert Josien. (1996). Cascade Radical Reactions of Isonitriles: A Second‐Generation Synthesis of (20S)‐Camptothecin, Topotecan, Irinotecan, and GI‐147211C. Angewandte Chemie International Edition in English. 34(23-24). 2683–2684. 91 indexed citations

20.

Dauzonne, Daniel, Hubert Josien, & Pierre Demerseman. (1990). (2-chloro-2-nitroethenyl)benzenes as synthons: a general method for the preparation of 2,3-dihydro- 2-nitro-3-phenyl-4H-furo [3,2-c] [1]benzopyran-4-ones and 3-phenyl-4H-furo[3,2-c][1]benzopyran-4-ones. Tetrahedron. 46(21). 7359–7371. 21 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact