John W. Clader

4.4k citations

72 papers · 3.1k indexed · h-index 28

Impact in

Virology top 1%
- HIV Research and Treatment
Organic Chemistry top 1%
- Synthesis of β-Lactam Compounds
- Synthesis and Catalytic Reactions
- Asymmetric Synthesis and Catalysis

Papers in

Virology 6
Endocrine and Autonomic Systems 8
- Regulation of Appetite and Obesity 8

Co-authors: Harry R. Davis Duane A. Burnett William J. Greenlee Anandan Palani Mary Ann Caplen Robert E. Burrier Bahige M. Baroudy Yuguang Wang
Journals: Bioorganic & Medicinal Chemistry Letters (29 papers)Journal of Medicinal Chemistry (17 papers)Bioorganic & Medicinal Chemistry (4 papers)Current Topics in Medicinal Chemistry (2 papers)Tetrahedron Letters (2 papers)
Partner nations: United States United Kingdom Switzerland

In The Last Decade

John W. Clader

72 papers receiving 2.8k citations

Peers

Countries citing papers authored by John W. Clader

Since Specialization

Citations

This map shows the geographic impact of John W. Clader's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John W. Clader with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John W. Clader more than expected).

Fields of papers citing papers by John W. Clader

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John W. Clader. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John W. Clader. The network helps show where John W. Clader may publish in the future.

Co-authorship network

The 25 scholars most cited alongside John W. Clader, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with John W. Clader Line = papers co-authored together John W. Clader links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors Bioorganic & Medicinal Chemistry ·Dmitri Pissarnitski, Zhiqiang Zhao, David Cole, Wen‐Lian Wu, Martin S. Domalski, John W. Clader, Giovanna Scapin, Johannes Voigt, Aileen Soriano, Theresa M. Kelly, Mary Ann Powles, B Stefanowska, Duane A. Burnett	2016	13
2	Substituted 4-morpholine N -arylsulfonamides as γ-secretase inhibitors European Journal of Medicinal Chemistry ·Zhiqiang Zhao, Dmitri Pissarnitski, Hubert Josien, Thomas Bara, John W. Clader, Hongmei Li, Mark D. McBriar, Randy Ki-Kwan Chiu, Ruo Xu, Giuseppe Terracina, Lynn A. Hyde, Lixin Song, Lili Zhang, Eric M. Parker, Yicong Liao, Alexei V. Buevich	2016	12
3	Tetracyclic sulfones as potent γ-secretase inhibitors: Synthesis and structure–activity relationship studies Bioorganic & Medicinal Chemistry Letters ·Philipp Benzinger, Duane A. Burnett, Theodros Asberom, Wen‐Lian Wu, Enrique Valencia Lopez, David Cole, Ruo Xu, William J. Greenlee, John W. Clader, Lili Zhang, Lynn A. Hyde	2010	6
4	Design, synthesis, and structure–activity relationship studies of N-arylsulfonyl morpholines as γ-secretase inhibitors Bioorganic & Medicinal Chemistry Letters ·Hongmei Li, Ruo Xu, David Cole, John W. Clader, William J. Greenlee, Amin A. Nomeir, Lixin Song, Lili Zhang	2010	12
5	Tricyclic sulfones as orally active γ-secretase inhibitors: Synthesis and structure–activity relationship studies Bioorganic & Medicinal Chemistry Letters ·Philipp Benzinger, Qiang Li, Duane A. Burnett, David Cole, Harun Bodur, Hongmei Li, William J. Greenlee, John W. Clader, Lili Zhang, Lynn A. Hyde	2010	25
6	Novel orally active morpholine N-arylsulfonamides γ-secretase inhibitors with low CYP 3A4 liability Bioorganic & Medicinal Chemistry Letters ·Hubert Josien, Thomas Bara, Randy Ki-Kwan Chiu, John W. Clader, William J. Greenlee, Leonard Favreau, Lynn A. Hyde, Amin A. Nomeir, Eric M. Parker, Lixin Song, محمد داود طالب زاده, Qi Zhang	2009	11
7	Synthesis of novel bicyclo[4.1.0]heptane and bicyclo[3.1.0]hexane derivatives as melanin-concentrating hormone receptor R1 antagonists Bioorganic & Medicinal Chemistry Letters ·Jing Su, 杨居礼, Brian A. McKittrick, Nick Brekke, Tao Guo, Gang Qian, Duane A. Burnett, John W. Clader, William J. Greenlee, Brian E. Hawes, Kim O’Neill, Brian D. Spar, Blair Weig, Timothy J. Kowalski, Steve Sorota	2007	5
8	Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active γ-secretase inhibitors Bioorganic & Medicinal Chemistry Letters ·Mark D. McBriar, John W. Clader, Inhou Chu, Robert A. Del Vecchio, Leonard Favreau, William J. Greenlee, Lynn A. Hyde, Amin A. Nomeir, Eric M. Parker, Dmitri Pissarnitski, Lixin Song, Lili Zhang, Zhiqiang Zhao	2007	37
9	Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors Bioorganic & Medicinal Chemistry Letters ·Hongmei Li, Theodros Asberom, Thomas Bara, John W. Clader, William J. Greenlee, Hubert Josien, Mark D. McBriar, Amin A. Nomeir, Dmitri Pissarnitski, Randy Ki-Kwan Chiu, Ruo Xu, Zhiqiang Zhao, Lixin Song, Lili Zhang	2007	16
10	Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as γ-secretase inhibitors Bioorganic & Medicinal Chemistry Letters ·Tao Guo, Nick Brekke, Doug W. Hobbs, Laura L. Rokosz, Tara M. Stauffer, 正裕日野, John W. Clader	2007	32
11	Bicyclic[4.1.0]heptanes as phenyl replacements for melanin concentrating hormone receptor antagonists Bioorganic & Medicinal Chemistry ·Ruo Xu, Shengjian Li, Rakesh Kundu, Mark D. McBriar, Henry Guzik, Anandan Palani, John W. Clader, Kathleen Cox, William J. Greenlee, Brian E. Hawes, Timothy J. Kowalski, Kim O’Neill, Brian D. Spar, Blair Weig, Daniel J. Weston	2006	22
12	Interaction of small molecule inhibitors of HIV-1 entry with CCR5 Virology ·Christoph Seibert, Weiwen Ying, Svetlana Gavrilov, esraa el nadoury, Shawn E. Kuhmann, Anandan Palani, Jayaram R. Tagat, John W. Clader, Stuart W. McCombie, Bahige M. Baroudy, Steven O. Smith, Tatjana Dragic, John P. Moore, Thomas P. Sakmar	2006	99
13	Bicyclo[3.1.0]hexyl urea melanin concentrating hormone (MCH) receptor-1 antagonists: Impacting hERG liability via aryl modifications Bioorganic & Medicinal Chemistry Letters ·Mark D. McBriar, Henry Guzik, Sherry Shapiro, Ruo Xu, Rakesh Kundu, John W. Clader, Kim O’Neill, Brian E. Hawes, Steve Sorota, Michael Margulis, Kristal R. Tucker, Daniel J. Weston, Kathleen Cox	2006	11
14	Ezetimibe and other Azetidinone Cholesterol Absorption Inhibitors Current Topics in Medicinal Chemistry ·John W. Clader	2005	24
15	Oximino-piperidino-piperidine-based CCR5 antagonists. Part 2: synthesis, SAR and biological evaluation of symmetrical heteroaryl carboxamides Bioorganic & Medicinal Chemistry Letters ·Anandan Palani, Sherry Shapiro, John W. Clader, William J. Greenlee, Susan F. Vice, Stuart W. McCombie, Kathleen Cox, Julie Strizki, Bahige M. Baroudy	2003	27
16	Synthesis of iodinated biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors Bioorganic & Medicinal Chemistry Letters ·Duane A. Burnett, Mary Ann Caplen, Martin S. Domalski, Margaret Browne, Harry R. Davis, John W. Clader	2002	20
17	Diphenylsulfone muscarinic antagonists: piperidine derivatives with high m2 selectivity and improved potency Bioorganic & Medicinal Chemistry Letters ·William Billard, Herbert Binch, Wangqiang Huang, Jian Xu, Gordon Crosby, Ruth A. Duffy, Sundeep Dugar, Jean E. Lachowicz, Xie Kele, G. B. Shobha, Vilma Ruperto, Lisa A. Taylor, John W. Clader	2000	13
18	SCH 57790: A novel M2 receptor selective antagonist Life Sciences ·Jean E. Lachowicz, Derek Lowe, Ruth A. Duffy, Vilma Ruperto, Lisa A. Taylor, Henry Guzik, Eleonora Troiani, Joel G. Berger, 황명현, Xie Kele, Joseph A. Kozlowski, John W. Clader, Catherine D. Strader, Nicholas Murgolo	1999	19
19	2-Azetidinones as Inhibitors of Cholesterol Absorption Journal of Medicinal Chemistry ·Duane A. Burnett, Mary Ann Caplen, Harry R. Davis, Robert E. Burrier, John W. Clader	1994	182
20	Synthesis and receptor affinities of some conformationally restricted analogs of the dopamine D1 selective ligand (5R)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol Journal of Medicinal Chemistry ·Joel G. Berger, 노대균, John W. Clader, Luca Lucia Feichter, Richard E. Chipkin, Andrew T. McPhail	1989	59

About John W. Clader

John W. Clader is a scholar working on Virology, Endocrine and Autonomic Systems, Pharmacology, Computational Theory and Mathematics and Organic Chemistry, having authored 72 papers that have together received 3.1k indexed citations. Recurring topics across this work include Synthesis of β-Lactam Compounds (15 papers), Computational Drug Discovery Methods (14 papers), Alzheimer's disease research and treatments (13 papers), Cholinesterase and Neurodegenerative Diseases (13 papers), Receptor Mechanisms and Signaling (11 papers), Regulation of Appetite and Obesity (8 papers), Synthesis and Catalytic Reactions (7 papers) and Biochemical Analysis and Sensing Techniques (7 papers). The work is most often cited by research in Virology (533 citations), Organic Chemistry (1.4k citations), Endocrine and Autonomic Systems (154 citations), Infectious Diseases (397 citations) and Pharmaceutical Science (109 citations). John W. Clader has collaborated with scholars based in United States, United Kingdom and Switzerland. Frequent co-authors include Harry R. Davis, Duane A. Burnett, William J. Greenlee, Anandan Palani, Mary Ann Caplen, Robert E. Burrier, Bahige M. Baroudy, Yuguang Wang, Nathan Yumibe and Sherry Shapiro. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry, Current Topics in Medicinal Chemistry and Tetrahedron Letters.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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