Tamar Tchkonia

48.4k total citations · 26 hit papers
187 papers, 26.4k citations indexed

About

Tamar Tchkonia is a scholar working on Physiology, Molecular Biology and Epidemiology. According to data from OpenAlex, Tamar Tchkonia has authored 187 papers receiving a total of 26.4k indexed citations (citations by other indexed papers that have themselves been cited), including 126 papers in Physiology, 54 papers in Molecular Biology and 46 papers in Epidemiology. Recurrent topics in Tamar Tchkonia's work include Telomeres, Telomerase, and Senescence (90 papers), Adipokines, Inflammation, and Metabolic Diseases (38 papers) and Adipose Tissue and Metabolism (31 papers). Tamar Tchkonia is often cited by papers focused on Telomeres, Telomerase, and Senescence (90 papers), Adipokines, Inflammation, and Metabolic Diseases (38 papers) and Adipose Tissue and Metabolism (31 papers). Tamar Tchkonia collaborates with scholars based in United States, China and United Kingdom. Tamar Tchkonia's co-authors include James L. Kirkland, Nathan K. LeBrasseur, Yi Zhu, Tamar Pirtskhalava, Michael D. Jensen, Nino Giorgadze, Sundeep Khosla, Jan van Deursen, Jan M. van Deursen and Darren J. Baker and has published in prestigious journals such as Nature, Proceedings of the National Academy of Sciences and JAMA.

In The Last Decade

Tamar Tchkonia

181 papers receiving 26.1k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

2011 2.7k citations Tamar Tchkonia, Nathan K. LeBrasseur et al. profile →
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

2013 1.3k citations Tamar Tchkonia, Yi Zhu et al. profile →
Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

2019 837 citations Jamie N. Justice, Anoop M. Nambiar et al. EBioMedicine profile →
Targeting cellular senescence prevents age-related bone loss in mice

2017 819 citations Ming Xu, Megan Weivoda et al. profile →
Fat tissue, aging, and cellular senescence

2010 814 citations Tamar Tchkonia, Sundeep Khosla et al. Aging Cell profile →
Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors

2015 803 citations Yi Zhu, Tamar Tchkonia et al. Aging Cell profile →
Cellular senescence drives age-dependent hepatic steatosis

2017 732 citations Tamar Tchkonia, James L. Kirkland et al. profile →
Cellular Senescence: A Translational Perspective

2017 722 citations James L. Kirkland, Tamar Tchkonia EBioMedicine profile →
Senolytic drugs: from discovery to translation

2020 721 citations James L. Kirkland, Tamar Tchkonia profile →
Cellular senescence and senolytics: the path to the clinic

2022 636 citations Tamar Tchkonia, James L. Kirkland et al. profile →
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

2015 631 citations Ming Xu, Tamar Tchkonia et al. Proceedings of the National Academy of Sciences profile →
Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

2016 564 citations Tamar Pirtskhalava, Yi Zhu et al. Aging Cell profile →
New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

2017 531 citations Yi Zhu, Tamar Pirtskhalava et al. profile →
Identification of HSP90 inhibitors as a novel class of senolytics

2017 506 citations Yi Zhu, Tamar Tchkonia et al. profile →
Mechanisms and Metabolic Implications of Regional Differences among Fat Depots

2013 501 citations Tamar Tchkonia, Yi Zhu et al. profile →
Targeting senescent cells enhances adipogenesis and metabolic function in old age

2015 460 citations Ming Xu, Megan Weivoda et al. profile →
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

2022 453 citations Nathan K. LeBrasseur, Paul D. Robbins et al. profile →
Identification of Senescent Cells in the Bone Microenvironment

2016 403 citations Megan Weivoda, Matthew T. Drake et al. profile →
The Clinical Potential of Senolytic Drugs

2017 394 citations James L. Kirkland, Tamar Tchkonia et al. profile →
The role of cellular senescence in ageing and endocrine disease

2020 366 citations Sundeep Khosla, Tamar Tchkonia et al. profile →
Senescent cell clearance by the immune system: Emerging therapeutic opportunities

2018 353 citations Larissa Prata, Tamar Tchkonia et al. profile →
Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice

2021 180 citations Tatiana D. Saccon, Ravinder Nagpal et al. The Journals of Gerontology Series A profile →
Senolytic therapy in mild Alzheimer’s disease: a phase 1 feasibility trial

2023 149 citations Tamar Tchkonia, James L. Kirkland et al. profile →
Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability

2023 140 citations Anoop M. Nambiar, Rodolfo M. Pascual et al. EBioMedicine profile →
Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial

2024 46 citations Matthew T. Drake, Tamar Tchkonia et al. profile →
A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer’s disease

2025 16 citations Tamar Tchkonia, Tamar Pirtskhalava et al. EBioMedicine profile →

Peers

Countries citing papers authored by Tamar Tchkonia

Since Specialization

Citations

This map shows the geographic impact of Tamar Tchkonia's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Tamar Tchkonia with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Tamar Tchkonia more than expected).

Fields of papers citing papers by Tamar Tchkonia

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Tamar Tchkonia. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Tamar Tchkonia. The network helps show where Tamar Tchkonia may publish in the future.

Co-authorship network of co-authors of Tamar Tchkonia

This figure shows the co-authorship network connecting the top 25 collaborators of Tamar Tchkonia. A scholar is included among the top collaborators of Tamar Tchkonia based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Tamar Tchkonia. Tamar Tchkonia is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Activin A Antagonism with Follistatin Reduces Kidney Fibrosis, Injury, and Cellular Senescence-Associated Inflammation in Murine Diabetic Kidney Disease 2025 ·Kidney360 ·Xiaohui Bian, (unknown), (unknown), (unknown), Sabena M. Conley, (unknown), Khaled Elhusseiny, Jordan D. Miller, Tamar Tchkonia, James L. Kirkland, Lilach O. Lerman, LaTonya J. Hickson	3
2	Effects of inhibition of Janus kinase signalling during controlled mechanical ventilation on the rate of skeletal muscle protein synthesis 2025 ·The Journal of Physiology ·William J. Evans, Mahalakshmi Shankaran, Lars Larsson, Nicola Cacciani, Yvette Hedström, James L. Kirkland, Tamar Tchkonia, (unknown), Tyler Field, Marc K. Hellerstein	0
3	Senescence profiling of monoclonal gammopathies reveals paracrine senescence as a crucial defense against disease progression 2025 ·Leukemia ·Gabriel Álvares Borges, Marta Diaz‐delCastillo, (unknown), (unknown), (unknown), (unknown), Maja Hinge, Thomas Lund, Nadine Abdallah, Linda B. Baughn, Ming Xu, Anne Gingery, Tamar Tchkonia, James L. Kirkland, Taxiarchis Kourelis, Matthew T. Drake, Thomas Levin Andersen, Megan Weivoda	1
4	Long COVID as a disease of accelerated biological aging: An opportunity to translate geroscience interventions 2024 ·Ageing Research Reviews ·Areez Shafqat, Mary Clare Masters, Utkarsh Tripathi, Tamar Tchkonia, James L. Kirkland, Shahrukh K. Hashmi	6
5	Mapping epidermal and dermal cellular senescence in human skin aging 2024 ·Aging Cell ·(unknown), Clarisse Gânier, David B. Allison, Tamar Tchkonia, Sundeep Khosla, James L. Kirkland, (unknown), Saranya P. Wyles	12
6	Clearance of p21 highly expressing senescent cells accelerates cutaneous wound healing 2024 ·Nature Aging ·Nathan Gasek, Pengyi Yan, (unknown), K‐Raman Purushothaman, (unknown), Lichao Wang, Binsheng Wang, William F. Flynn, (unknown), Chun Guo, (unknown), (unknown), Yueying Zhou, (unknown), Tamar Tchkonia, James L. Kirkland, Saranya P. Wyles, Ming Xu	9
7	Circulating monocytes expressing senescence‐associated features are enriched in COVID‐19 patients with severe disease 2023 ·Aging Cell ·(unknown), Douwe F. Postma, (unknown), (unknown), James L. Kirkland, Jair Machado Espíndola‐Netto, Tamar Tchkonia, Michela Borghesan, Hjalmar R. Bouma, Marco Demaria	12
8	Transplanting old organs promotes senescence in young recipients 2023 ·American Journal of Transplantation ·Jasper Iske, (unknown), (unknown), Andreas Schroeter, Tomohisa Matsunaga, Ryoichi Maenosono, Utkarsh Tripathi, Yao Xiao, Yeqi Nian, Barbara J. Caldarone, Florian W. R. Vondran, Peter T. Sage, Haruhito Azuma, Reza Abdi, Abdallah Elkhal, Tamar Pirtskhalava, Tamar Tchkonia, James L. Kirkland, Hao Zhou, Stefan G. Tullius	15
9	Past and Future Directions for Research on Cellular Senescence 2023 ·Cold Spring Harbor Perspectives in Medicine ·Yi Zhu, (unknown), Jair Machado Espindola Netto, Tamara S. Evans, Tamar Tchkonia, James L. Kirkland	14
10	Cellular senescence in skin‐related research: Targeted signaling pathways and naturally occurring therapeutic agents 2023 ·Aging Cell ·Aleksandra Dańczak‐Pazdrowska, Justyna Gornowicz‐Porowska, Adriana Polańska, Violetta Krajka‐Kuźniak, Maciej Stawny, Aleksandra Gostyńska, Błażej Rubiś, (unknown), (unknown), Augusto Schneider, Tamar Tchkonia, Saranya P. Wyles, James L. Kirkland, Michał M. Masternak	36
11	TNF‐α/IFN‐γ synergy amplifies senescence‐associated inflammation and SARS‐CoV‐2 receptor expression via hyper‐activated JAK/STAT1 2022 ·Aging Cell ·Renuka Kandhaya‐Pillai, Xiaomeng Yang, Tamar Tchkonia, George M. Martin, James L. Kirkland, Junko Oshima	68
12	Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice breakdown → 2021 ·The Journals of Gerontology Series A ·Tatiana D. Saccon, Ravinder Nagpal, Hariom Yadav, Marcelo Borges Cavalcante, (unknown), Augusto Schneider, Adam Gesing, Brian M. Hughes, Matthew J. Yousefzadeh, Tamar Tchkonia, James L. Kirkland, Laura J. Niedernhofer, Paul D. Robbins, Michał M. Masternak	180
13	An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo 2021 ·Nature Aging ·Binsheng Wang, Lichao Wang, Nathan Gasek, Yueying Zhou, (unknown), Chun Guo, Evan R. Jellison, Laura Haynes, Sumit Yadav, Tamar Tchkonia, George A. Kuchel, James L. Kirkland, Ming Xu	96
14	JAK/STAT inhibition augments soleus muscle function in a rat model of critical illness myopathy via regulation of complement C3/3R 2021 ·The Journal of Physiology ·(unknown), Nicola Cacciani, (unknown), Heba Salah, Tamar Tchkonia, James L. Kirkland, Lars Larsson	15
15	A toolbox for the longitudinal assessment of healthspan in aging mice 2020 ·Nature Protocols ·Ilaria Bellantuono, Rafael de Cabo, Dan Ehninger, Clara Di Germanio, Allan Lawrie, Jordan D. Miller, Sarah J. Mitchell, Ignacio Navas‐Enamorado, Paul Potter, Tamar Tchkonia, José Luís Trejo, Dudley W. Lamming	88
16	Transplanting cells from old but not young donors causes physical dysfunction in older recipients 2020 ·Aging Cell ·Binsheng Wang, (unknown), (unknown), Lichao Wang, Christina L. Inman, Yueying Zhou, Chun Guo, Tamar Tchkonia, David W. Rowe, George A. Kuchel, Paul Robson, James L. Kirkland, Ming Xu	53
17	Aged‐senescent cells contribute to impaired heart regeneration 2019 ·Aging Cell ·Fiona Lewis, Prashant J. Ruchaya, (unknown), (unknown), Larissa Prata, (unknown), Jane Clark, Prakash P Punjabi, Wael I. Awad, Daniele Torella, Tamar Tchkonia, James L. Kirkland, Georgina M. Ellison	236
18	Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study breakdown → 2019 ·EBioMedicine ·Jamie N. Justice, Anoop M. Nambiar, Tamar Tchkonia, Nathan K. LeBrasseur, Rodolfo M. Pascual, (unknown), Larissa Prata, Michał M. Masternak, Stephen B. Kritchevsky, Nicolas Musi, James L. Kirkland	837
19	Vamorolone treatment improves skeletal muscle outcome in a critical illness myopathy rat model 2018 ·Acta Physiologica ·(unknown), Nicola Cacciani, Monica Llano‐Diez, (unknown), Tamar Tchkonia, James L. Kirkland, Lars Larsson	17
20	Regional differences in cellular mechanisms of adipose tissue gain with overfeeding 2010 ·Proceedings of the National Academy of Sciences ·Yourka D. Tchoukalova, Susanne B. Votruba, Tamar Tchkonia, Nino Giorgadze, James L. Kirkland, Michael D. Jensen	301

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