Stephen J. Gregson

1.4k citations

25 papers · 828 indexed · h-index 16

Molecular Biology
Organic Chemistry top 5%
Oncology top 10%
Radiology, Nuclear Medicine and Imaging top 10%
Infectious Diseases

Co-authors: Philip W. Howard David E. Thurston John A. Hartley Terence C. Jenkins Lloyd R. Kèlland Natalie Brooks Melinda G. Hollingshead Michael C. Alley
Topics: Synthesis and pharmacology of benzodiazepine derivatives (21 papers)Cancer therapeutics and mechanisms (16 papers)Cancer Treatment and Pharmacology (14 papers)
Cited by: Organic Chemistry Oncology Molecular Biology
Journals: Cancer Research Chemical Communications Clinical Cancer Research
Partner nations: United Kingdom United States India

In The Last Decade

Stephen J. Gregson

25 papers receiving 785 citations

Peers

Countries citing papers authored by Stephen J. Gregson

Since Specialization

Citations

This map shows the geographic impact of Stephen J. Gregson's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Stephen J. Gregson with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Stephen J. Gregson more than expected).

Fields of papers citing papers by Stephen J. Gregson

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Stephen J. Gregson. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Stephen J. Gregson. The network helps show where Stephen J. Gregson may publish in the future.

Co-authorship network of co-authors of Stephen J. Gregson

This figure shows the co-authorship network connecting the top 25 collaborators of Stephen J. Gregson. A scholar is included among the top collaborators of Stephen J. Gregson based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Stephen J. Gregson. Stephen J. Gregson is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Efficacy, Tolerability, and Pharmacokinetic Studies of Antibody–Drug Conjugates Containing a Low-Potency Pyrrolobenzodiazepine Dimer 2022 ·Molecular Cancer Therapeutics ·Stephen J. Gregson,(unknown),Neki V. Patel,(unknown),Balakumar Vijayakrishnan,(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),Lauren Adams,Conor S. Barry,Kathryn Ball,Luke A. Masterson,Mary McFarlane,John A. Hartley,Philip W. Howard	4
2	Synthesis and evaluation of pyrrolobenzodiazepine dimer antibody-drug conjugates with dual β-glucuronide and dipeptide triggers 2019 ·European Journal of Medicinal Chemistry ·Stephen J. Gregson,Allison Barrett,Neki V. Patel,(unknown),Davide Schiavone,Erin Sult,Conor S. Barry,Balakumar Vijayakrishnan,Lauren Adams,Luke A. Masterson,François D’Hooge,M. L. Snaith,Jay Harper,John A. Hartley,Philip W. Howard	16
3	SLC46A3 as a Potential Predictive Biomarker for Antibody–Drug Conjugates Bearing Noncleavable Linked Maytansinoid and Pyrrolobenzodiazepine Warheads 2018 ·Clinical Cancer Research ·Krista Kinneer,John Meekin,Arnaud Tiberghien,Yu‐Tzu Tai,Sandrina Phipps,Christine Mione Kiefer,Marlon C. Rebelatto,Nazzareno Dimasi,Alyssa Moriarty,Kyriakos P. Papadopoulos,Sriram Sridhar,Stephen J. Gregson,Michael J. Wick,Luke A. Masterson,Kenneth C. Anderson,Ronald Herbst,Philip W. Howard,David A. Tice	58
4	Pyrrolobenzodiazepine Dimer Antibody–Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers 2017 ·Journal of Medicinal Chemistry ·Stephen J. Gregson,Luke A. Masterson,BinQing Wei,Thomas H. Pillow,Susan D. Spencer,(unknown),Shang‐Fan Yu,Helga Raab,Jeffrey Lau,Guangmin Li,Gail D. Lewis Phillips,Janet Gunzner-Toste,Brian S. Safina,Rachana Ohri,Martine Darwish,Katherine R. Kozak,Josefa dela Cruz-Chuh,Andrew G. Polson,John A. Flygare,Philip W. Howard	27
5	An optimised synthesis of SG3376, a non-cleavable antibody-drug conjugate pyrrolobenzodiazepine drug-linker 2017 ·Tetrahedron Letters ·Arnaud Tiberghien,Stephen J. Gregson,Luke A. Masterson,(unknown),(unknown),Lauren Adams,Neki V. Patel,Philip W. Howard	6
6	Antistaphylococcal activity of DNA-interactive pyrrolobenzodiazepine (PBD) dimers and PBD-biaryl conjugates 2012 ·Journal of Antimicrobial Chemotherapy ·Khondaker Miraz Rahman,(unknown),(unknown),(unknown),Keith R. Fox,(unknown),Philip W. Howard,Stephen J. Gregson,C. James,María de la Fuente,(unknown),David E. Thurston,Peter W. Taylor	21
7	DNA interstrand cross-linking and in vivo antitumor activity of the extended pyrrolo[2,1-c][1,4]benzodiazepine dimer SG2057 2011 ·Investigational New Drugs ·John A. Hartley,(unknown),Marie Suggitt,Stephen J. Gregson,David E. Thurston,Philip W. Howard	23
8	SG2285, a Novel C2-Aryl-Substituted Pyrrolobenzodiazepine Dimer Prodrug That Cross-links DNA and Exerts Highly Potent Antitumor Activity 2010 ·Cancer Research ·John A. Hartley,(unknown),(unknown),(unknown),Marie Suggitt,Zhizhi Chen,Stephen J. Gregson,Luke A. Masterson,Arnaud Tiberghien,Janet M. Hartley,Chris Pepper,Thet Thet Lin,Chris Fegan,David E. Thurston,Philip W. Howard	43
9	Synthesis of a novel C2/C2′-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate 2009 ·Bioorganic & Medicinal Chemistry Letters ·Philip W. Howard,Zhizhi Chen,Stephen J. Gregson,Luke A. Masterson,Arnaud Tiberghien,(unknown),Min Fang,(unknown),(unknown),John A. Hartley,David E. Thurston	24
10	New applications of sporopollenin as a solid phase support for peptide synthesis and the use of sonic agitation 2009 ·International journal of peptide & protein research ·(unknown),Stephen J. Gregson,G. Shaw	11
11	A novel approach to the synthesis of cytotoxic C2–C3 unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) with conjugated acrylyl C2-substituents 2004 ·Bioorganic & Medicinal Chemistry Letters ·Zhizhi Chen,Stephen J. Gregson,Philip W. Howard,David E. Thurston	14
12	SJG-136 (NSC 694501), a Novel Rationally Designed DNA Minor Groove Interstrand Cross-Linking Agent with Potent and Broad Spectrum Antitumor Activity 2004 ·Cancer Research ·John A. Hartley,Victoria J. Spanswick,Natalie Brooks,Peter H. Clingen,Peter J. McHugh,Daniel Hochhauser,RB Pedley,Lloyd R. Kèlland,Michael C. Alley,Robert Schultz,Melinda G. Hollingshead,Karen Schweikart,Joseph E. Tomaszewski,Edward A. Sausville,Stephen J. Gregson,Philip W. Howard,David E. Thurston	111
13	SJG-136 (NSC 694501), A Novel Rationally Designed DNA Minor Groove Interstrand Cross-Linking Agent with Potent and Broad Spectrum Antitumor Activity 2004 ·Cancer Research ·Michael C. Alley,Melinda G. Hollingshead,(unknown),William R. Waud,John A. Hartley,Philip W. Howard,Stephen J. Gregson,David E. Thurston,Edward A. Sausville	69
14	Synthesis of the first examples of A-C8/C-C2 amide-Linked pyrrolo[2,1-c][1,4]benzodiazepine dimers 2003 ·Bioorganic & Medicinal Chemistry Letters ·Stephen J. Gregson,Philip W. Howard,David E. Thurston	15
15	Synthesis of the first example of a c2-C3/C2′-C3′-endo unsaturated pyrrolo[2,1-c][1,4]benzodiazepine dimer 2001 ·Bioorganic & Medicinal Chemistry Letters ·Stephen J. Gregson,Philip W. Howard,(unknown),Terence C. Jenkins,Lloyd R. Kèlland,David E. Thurston	19
16	Effect of C2-exo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines 2000 ·Bioorganic & Medicinal Chemistry Letters ·Stephen J. Gregson,Philip W. Howard,(unknown),(unknown),(unknown),(unknown),Terence C. Jenkins,Lloyd R. Kèlland,David E. Thurston	34
17	Effect of C2/C3-endo unsaturation on the cytotoxicity and dna-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines 2000 ·Bioorganic & Medicinal Chemistry Letters ·Stephen J. Gregson,Philip W. Howard,(unknown),(unknown),Terence C. Jenkins,Lloyd R. Kèlland,David E. Thurston	13
18	Design and synthesis of novel pyrrolobenzodiazepine (PBD) prodrugs for ADEPT and GDEPT 2000 ·Bioorganic & Medicinal Chemistry Letters ·Marina Sagnou,Philip W. Howard,Stephen J. Gregson,Ebun Eno‐Amooquaye,Philip J. Burke,David E. Thurston	23
19	Purines, pyrimidines, and imidazoles. Part 61. Reaction of 6-alkylamino-4-chloro-5-nitropyrimidines with diethyl malonate, ethyl cyanoacetate, and ethyl acetoacetate and some derived pyrrolo[3,2-d]pyrimidines related to the cytokinins 1985 ·Journal of the Chemical Society Perkin Transactions 1 ·Stephen J. Gregson,Gordon Shaw	4
20	Cytokinin activities of thiozeatin and related compounds in Phaseolus callus culture bioassays 1985 ·Plant Science ·Stephen J. Gregson,Gordon Shaw,Machteld C. Mok,David W. S. Mok	1

About Stephen J. Gregson

Stephen J. Gregson is a scholar working on Organic Chemistry, Oncology and Molecular Biology, having authored 25 papers that have together received 828 indexed citations. Recurring topics across this work include Synthesis and pharmacology of benzodiazepine derivatives (21 papers), Cancer therapeutics and mechanisms (16 papers) and Cancer Treatment and Pharmacology (14 papers). The work is most often cited by research in Organic Chemistry (553 citations), Oncology (434 citations) and Molecular Biology (579 citations). Stephen J. Gregson has collaborated with scholars based in United Kingdom, United States and India. Frequent co-authors include Philip W. Howard, David E. Thurston, John A. Hartley, Terence C. Jenkins, Lloyd R. Kèlland, Natalie Brooks, Melinda G. Hollingshead, Michael C. Alley, Edward A. Sausville and Luke A. Masterson. Their work appears in journals such as Cancer Research, Chemical Communications and Clinical Cancer Research.

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