David E. Thurston

7.1k total citations
176 papers, 5.4k citations indexed

About

David E. Thurston is a scholar working on Organic Chemistry, Molecular Biology and Oncology. According to data from OpenAlex, David E. Thurston has authored 176 papers receiving a total of 5.4k indexed citations (citations by other indexed papers that have themselves been cited), including 134 papers in Organic Chemistry, 127 papers in Molecular Biology and 68 papers in Oncology. Recurrent topics in David E. Thurston's work include Synthesis and pharmacology of benzodiazepine derivatives (114 papers), Cancer therapeutics and mechanisms (107 papers) and Cancer Treatment and Pharmacology (44 papers). David E. Thurston is often cited by papers focused on Synthesis and pharmacology of benzodiazepine derivatives (114 papers), Cancer therapeutics and mechanisms (107 papers) and Cancer Treatment and Pharmacology (44 papers). David E. Thurston collaborates with scholars based in United Kingdom, United States and Greece. David E. Thurston's co-authors include Philip W. Howard, Khondaker Miraz Rahman, Terence C. Jenkins, John A. Hartley, Stephen Neidle, Giovanna Zinzalla, Dyeison Antonow, Paul J. Jackson, Laurence H. Hurley and Stephen J. Gregson and has published in prestigious journals such as Chemical Reviews, Journal of the American Chemical Society and Nucleic Acids Research.

In The Last Decade

David E. Thurston

172 papers receiving 5.2k citations

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
David E. Thurston United Kingdom 40 3.4k 3.4k 1.9k 537 467 176 5.4k
Ashraf Brik Israel 57 7.4k 2.2× 4.3k 1.3× 2.1k 1.1× 548 1.0× 542 1.2× 182 9.0k
David M. Perrin Canada 45 4.1k 1.2× 1.8k 0.5× 1.4k 0.7× 111 0.2× 1.2k 2.5× 178 7.0k
Tanaji T. Talele United States 36 1.8k 0.5× 1.8k 0.5× 1.4k 0.7× 589 1.1× 91 0.2× 98 4.5k
Malcolm MacCoss United States 36 2.3k 0.7× 3.4k 1.0× 405 0.2× 820 1.5× 177 0.4× 136 6.4k
George L. Trainor United States 37 2.3k 0.7× 1.6k 0.5× 541 0.3× 413 0.8× 85 0.2× 83 4.5k
Marie Boyd United Kingdom 25 2.0k 0.6× 1.3k 0.4× 722 0.4× 137 0.3× 417 0.9× 73 4.6k
Robert S. McDowell United States 28 2.8k 0.8× 969 0.3× 563 0.3× 166 0.3× 403 0.9× 44 4.3k
Alexander Adibekian United States 39 3.1k 0.9× 1.7k 0.5× 485 0.2× 150 0.3× 247 0.5× 95 4.4k
Kevin T. Chapman United States 30 3.5k 1.0× 2.8k 0.8× 703 0.4× 178 0.3× 159 0.3× 82 6.1k
Tarek S. Mansour United States 43 2.2k 0.6× 2.4k 0.7× 436 0.2× 590 1.1× 111 0.2× 148 5.0k

Countries citing papers authored by David E. Thurston

Since Specialization
Citations

This map shows the geographic impact of David E. Thurston's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David E. Thurston with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David E. Thurston more than expected).

Fields of papers citing papers by David E. Thurston

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David E. Thurston. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David E. Thurston. The network helps show where David E. Thurston may publish in the future.

Co-authorship network of co-authors of David E. Thurston

This figure shows the co-authorship network connecting the top 25 collaborators of David E. Thurston. A scholar is included among the top collaborators of David E. Thurston based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with David E. Thurston. David E. Thurston is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Mantaj, Julia, Paul J. Jackson, Richard B. Parsons, et al.. (2025). Transcription Factor Inhibition as a Potential Additional Mechanism of Action of Pyrrolobenzodiazepine (PBD) Dimers. Research Portal (King's College London). 5(1). 8–8.
2.
3.
Jackson, Paul J., et al.. (2018). Use of pyrrolobenzodiazepines and related covalent-binding DNA-interactive molecules as ADC payloads: Is mechanism related to systemic toxicity?. Drug Discovery Today Technologies. 30. 71–83. 22 indexed citations
4.
Heidelberger, Sibylle, Giovanna Zinzalla, Dyeison Antonow, et al.. (2013). Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry. Bioorganic & Medicinal Chemistry Letters. 23(16). 4719–4722. 44 indexed citations
5.
Rahman, Khondaker Miraz, Keith R. Fox, Philip W. Howard, et al.. (2012). Antistaphylococcal activity of DNA-interactive pyrrolobenzodiazepine (PBD) dimers and PBD-biaryl conjugates. Journal of Antimicrobial Chemotherapy. 67(7). 1683–1696. 21 indexed citations
6.
Rahman, Khondaker Miraz, C. James, & David E. Thurston. (2011). Observation of the reversibility of a covalent pyrrolobenzodiazepine (PBD) DNA adduct by HPLC/MS and CD spectroscopy. Organic & Biomolecular Chemistry. 9(5). 1632–1632. 25 indexed citations
7.
Hartley, John A., Marie Suggitt, Zhizhi Chen, et al.. (2010). SG2285, a Novel C2-Aryl-Substituted Pyrrolobenzodiazepine Dimer Prodrug That Cross-links DNA and Exerts Highly Potent Antitumor Activity. Cancer Research. 70(17). 6849–6858. 43 indexed citations
8.
Kaliszczak, Maciej, Dyeison Antonow, Philip W. Howard, et al.. (2010). Optimization of the Antitumor Activity of Sequence-specific Pyrrolobenzodiazepine Derivatives Based on their Affinity for ABC Transporters. The AAPS Journal. 12(4). 617–627. 9 indexed citations
9.
Howard, Philip W., Zhizhi Chen, Stephen J. Gregson, et al.. (2009). Synthesis of a novel C2/C2′-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate. Bioorganic & Medicinal Chemistry Letters. 19(22). 6463–6466. 24 indexed citations
10.
Fox, Keith R., et al.. (2009). Response of Staphylococcus aureus to subinhibitory concentrations of a sequence-selective, DNA minor groove cross-linking pyrrolobenzodiazepine dimer. Journal of Antimicrobial Chemotherapy. 64(5). 949–959. 14 indexed citations
11.
Tiberghien, Arnaud, David A. Evans, Konstantinos Kiakos, et al.. (2008). An asymmetric C8/C8′-tripyrrole-linked sequence-selective pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs. Bioorganic & Medicinal Chemistry Letters. 18(6). 2073–2077. 15 indexed citations
12.
13.
He, Jingyi, et al.. (2005). Direct liquid chromatography determination of the reactive imine SJG-136 (NSC 694501). Journal of Chromatography B. 822(1-2). 10–20. 11 indexed citations
14.
Tsotinis, Andrew, et al.. (2002). An expeditious synthesis of cytotoxic pyrroloisoquinoline derivatives.. European Journal of Pharmaceutical Sciences. 17(3). 139–143. 9 indexed citations
15.
Gregson, Stephen J., et al.. (2000). Effect of C2-exo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines. Bioorganic & Medicinal Chemistry Letters. 10(16). 1845–1847. 34 indexed citations
16.
Jenkins, Terence C., et al.. (1999). Molecular modelling of a sequence-specific DNA-binding agent based on the pyrrolo[2, 1-c][1,4]benzodiazepines. Pharmacy and Pharmacology Communications. 5(9). 555–560. 5 indexed citations
17.
Guiotto, Andrea, Philip W. Howard, Pier Giovanni Baraldi, & David E. Thurston. (1998). Synthesis of novel C7-aryl substituted pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) via pro-N10-troc protection and Suzuki coupling. Bioorganic & Medicinal Chemistry Letters. 8(21). 3017–3018. 7 indexed citations
18.
Howard, Philip W., et al.. (1996). Interaction of the Pyrrolobenzodiazepine Antitumour Agent Anthramycin with Glutathione: A Possible Role in Metabolism. Pharmacy and Pharmacology Communications. 2(1). 39–42. 1 indexed citations
19.
20.
Morris, Stephen J., David E. Thurston, & Thomas G. Nevell. (1990). Evaluation of the electrophilicity of DNA-binding pyrrolo(2,1-c)(1,4)benzodiazepines by HPLC.. The Journal of Antibiotics. 43(10). 1286–1292. 25 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact

Breakdown of academic impact, for papers by Ashraf Brik Breakdown of academic impact, for papers by David M. Perrin Breakdown of academic impact, for papers by Tanaji T. Talele Breakdown of academic impact, for papers by Malcolm MacCoss Breakdown of academic impact, for papers by George L. Trainor Breakdown of academic impact, for papers by Marie Boyd Breakdown of academic impact, for papers by Robert S. McDowell Breakdown of academic impact, for papers by Alexander Adibekian Breakdown of academic impact, for papers by Kevin T. Chapman Breakdown of academic impact, for papers by Tarek S. Mansour
Rankless by CCL
2026