Philip W. Howard

4.4k citations

88 papers · 2.8k indexed · h-index 29

Organic Chemistry top 1%
Molecular Biology top 5%
Oncology top 2%
Radiology, Nuclear Medicine and Imaging top 2%
Infectious Diseases top 10%

Co-authors: David E. Thurston John A. Hartley Stephen J. Gregson Terence C. Jenkins Arnaud Tiberghien Lloyd R. Kèlland Luke A. Masterson G. R. Stephenson
Topics: Synthesis and pharmacology of benzodiazepine derivatives (62 papers)Cancer therapeutics and mechanisms (52 papers)Cancer Treatment and Pharmacology (33 papers)
Cited by: Organic Chemistry Oncology Radiology, Nuclear Medicine and Imaging
Journals: Blood Biochemistry Cancer Research
Partner nations: United Kingdom United States Italy

In The Last Decade

Philip W. Howard

88 papers receiving 2.6k citations

Peers

Countries citing papers authored by Philip W. Howard

Since Specialization

Citations

This map shows the geographic impact of Philip W. Howard's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Philip W. Howard with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Philip W. Howard more than expected).

Fields of papers citing papers by Philip W. Howard

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Philip W. Howard. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Philip W. Howard. The network helps show where Philip W. Howard may publish in the future.

Co-authorship network of co-authors of Philip W. Howard

This figure shows the co-authorship network connecting the top 25 collaborators of Philip W. Howard. A scholar is included among the top collaborators of Philip W. Howard based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Philip W. Howard. Philip W. Howard is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Integrin-αvβ6 targeted peptide-toxin therapy in a novel αvβ6-expressing immunocompetent model of pancreatic cancer 2024 ·Pancreatology ·Nicholas F. Brown,Elizabeth Murray,(unknown),Philip W. Howard,Luke A. Masterson,Francesca Zammarchi,John A. Hartley,Patrick H. van Berkel,John F. Marshall	5
2	Comparison of Pyrrolobenzodiazepine Dimer Bis-imine versus Mono-imine: DNA Interstrand Cross-linking, Cytotoxicity, Antibody–Drug Conjugate Efficacy and Toxicity 2022 ·Molecular Cancer Therapeutics ·Arnaud Tiberghien,Balakumar Vijayakrishnan,(unknown),(unknown),(unknown),John P. Bingham,Lauren Adams,(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),Ravinder Tammali,Edward Rosfjord,(unknown),John A. Hartley,Philip W. Howard	3
3	Efficacy, Tolerability, and Pharmacokinetic Studies of Antibody–Drug Conjugates Containing a Low-Potency Pyrrolobenzodiazepine Dimer 2022 ·Molecular Cancer Therapeutics ·Stephen J. Gregson,(unknown),Neki V. Patel,(unknown),Balakumar Vijayakrishnan,(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),Lauren Adams,Conor S. Barry,Kathryn Ball,Luke A. Masterson,Mary McFarlane,John A. Hartley,Philip W. Howard	4
4	The Role of Specific ATP-Binding Cassette Transporters in the Acquired Resistance to Pyrrolobenzodiazepine Dimer–Containing Antibody–Drug Conjugates 2020 ·Molecular Cancer Therapeutics ·Simon Corbett,Shiran Huang,Francesca Zammarchi,Philip W. Howard,Patrick H. van Berkel,John A. Hartley	14
5	A Reactive Antibody Platform for One-Step Production of Antibody–Drug Conjugates through a Diels–Alder Reaction with Maleimide 2019 ·Bioconjugate Chemistry ·André H. St. Amant,Feng‐Ying Huang,(unknown),(unknown),(unknown),Shenlan Mao,Christine Fazenbaker,Haihong Zhong,Jay Harper,Wenshu Xu,Neki V. Patel,Lauren Adams,Balakumar Vijayakrishnan,Philip W. Howard,Marcello Marelli,Herren Wu,Changshou Gao,Javier Read de Alaniz,R. James Christie	21
6	SLC46A3 as a Potential Predictive Biomarker for Antibody–Drug Conjugates Bearing Noncleavable Linked Maytansinoid and Pyrrolobenzodiazepine Warheads 2018 ·Clinical Cancer Research ·Krista Kinneer,John Meekin,Arnaud Tiberghien,Yu‐Tzu Tai,Sandrina Phipps,Christine Mione Kiefer,Marlon C. Rebelatto,Nazzareno Dimasi,Alyssa Moriarty,Kyriakos P. Papadopoulos,Sriram Sridhar,Stephen J. Gregson,Michael J. Wick,Luke A. Masterson,Kenneth C. Anderson,Ronald Herbst,Philip W. Howard,David A. Tice	58
7	Synthesis of a heterotrifunctional linker for the site-specific preparation of antibody-drug conjugates with two distinct warheads 2018 ·Bioorganic & Medicinal Chemistry Letters ·Amit Kumar,Krista Kinneer,Luke A. Masterson,(unknown),Philip W. Howard,Herren Wu,Changshou Gao,Nazzareno Dimasi	58
8	Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine 2018 ·Scientific Reports ·John A. Hartley,Michael Flynn,John P. Bingham,Simon Corbett,(unknown),Arnaud Tiberghien,Luke A. Masterson,Dyeison Antonow,Lauren Adams,(unknown),David G. Williams,Shenlan Mao,Jay Harper,Carin E.G. Havenith,Francesca Zammarchi,Simon Chivers,Patrick H. van Berkel,Philip W. Howard	85
9	Evaluation of Pyrrolobenzodiazepine-Loaded Nanoparticles: A Targeted Drug Delivery Approach 2018 ·Journal of Pharmaceutical Sciences ·Puneet Tyagi,Sergei Pechenov,Jonathan Rios‐Doria,Luke A. Masterson,(unknown),Philip W. Howard,Shenlan Mao,Jay Harper,Leslie Wetzel,(unknown),J. Anand Subramony	2
10	Pyrrolobenzodiazepine Dimer Antibody–Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers 2017 ·Journal of Medicinal Chemistry ·Stephen J. Gregson,Luke A. Masterson,BinQing Wei,Thomas H. Pillow,Susan D. Spencer,(unknown),Shang‐Fan Yu,Helga Raab,Jeffrey Lau,Guangmin Li,Gail D. Lewis Phillips,Janet Gunzner-Toste,Brian S. Safina,Rachana Ohri,Martine Darwish,Katherine R. Kozak,Josefa dela Cruz-Chuh,Andrew G. Polson,John A. Flygare,Philip W. Howard	27
11	ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer–Containing Antibody–Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies 2016 ·Molecular Cancer Therapeutics ·Michael Flynn,Francesca Zammarchi,Peter Tyrer,Ayse U. Akarca,Narinder Janghra,(unknown),Carin E.G. Havenith,(unknown),Arnaud Tiberghien,Luke A. Masterson,Conor S. Barry,François D’Hooge,Teresa Marafioti,Paul W.H.I. Parren,David G. Williams,Philip W. Howard,Patrick H. van Berkel,John A. Hartley	85
12	Antistaphylococcal activity of DNA-interactive pyrrolobenzodiazepine (PBD) dimers and PBD-biaryl conjugates 2012 ·Journal of Antimicrobial Chemotherapy ·Khondaker Miraz Rahman,(unknown),(unknown),(unknown),Keith R. Fox,(unknown),Philip W. Howard,Stephen J. Gregson,C. James,María de la Fuente,(unknown),David E. Thurston,Peter W. Taylor	21
13	SG2285, a Novel C2-Aryl-Substituted Pyrrolobenzodiazepine Dimer Prodrug That Cross-links DNA and Exerts Highly Potent Antitumor Activity 2010 ·Cancer Research ·John A. Hartley,(unknown),(unknown),(unknown),Marie Suggitt,Zhizhi Chen,Stephen J. Gregson,Luke A. Masterson,Arnaud Tiberghien,Janet M. Hartley,Chris Pepper,Thet Thet Lin,Chris Fegan,David E. Thurston,Philip W. Howard	43
14	Synthesis of a novel C2/C2′-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate 2009 ·Bioorganic & Medicinal Chemistry Letters ·Philip W. Howard,Zhizhi Chen,Stephen J. Gregson,Luke A. Masterson,Arnaud Tiberghien,(unknown),Min Fang,(unknown),(unknown),John A. Hartley,David E. Thurston	24
15	An asymmetric C8/C8′-tripyrrole-linked sequence-selective pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs 2008 ·Bioorganic & Medicinal Chemistry Letters ·Arnaud Tiberghien,David A. Evans,Konstantinos Kiakos,(unknown),John A. Hartley,David E. Thurston,Philip W. Howard	15
16	A novel approach to the synthesis of cytotoxic C2–C3 unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) with conjugated acrylyl C2-substituents 2004 ·Bioorganic & Medicinal Chemistry Letters ·Zhizhi Chen,Stephen J. Gregson,Philip W. Howard,David E. Thurston	14
17	Effect of C2-exo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines 2000 ·Bioorganic & Medicinal Chemistry Letters ·Stephen J. Gregson,Philip W. Howard,(unknown),(unknown),(unknown),(unknown),Terence C. Jenkins,Lloyd R. Kèlland,David E. Thurston	34
18	Synthesis of novel C7-aryl substituted pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) via pro-N10-troc protection and Suzuki coupling 1998 ·Bioorganic & Medicinal Chemistry Letters ·Andrea Guiotto,Philip W. Howard,Pier Giovanni Baraldi,David E. Thurston	7
19	Interaction of the Pyrrolobenzodiazepine Antitumour Agent Anthramycin with Glutathione: A Possible Role in Metabolism 1996 ·Pharmacy and Pharmacology Communications ·(unknown),Philip W. Howard,(unknown),A. Gescher,David E. Thurston	1
20	π-Complexes with planar chirality: control centres for stereoselective synthesis 1988 ·Philosophical Transactions of the Royal Society of London Series A Mathematical and Physical Sciences ·G. R. Stephenson,Rikki Alexander,Christopher P. Morley,Philip W. Howard	32

About Philip W. Howard

Philip W. Howard is a scholar working on Organic Chemistry, Oncology and Molecular Biology, having authored 88 papers that have together received 2.8k indexed citations. Recurring topics across this work include Synthesis and pharmacology of benzodiazepine derivatives (62 papers), Cancer therapeutics and mechanisms (52 papers) and Cancer Treatment and Pharmacology (33 papers). The work is most often cited by research in Organic Chemistry (1.7k citations), Oncology (1.3k citations) and Radiology, Nuclear Medicine and Imaging (551 citations). Philip W. Howard has collaborated with scholars based in United Kingdom, United States and Italy. Frequent co-authors include David E. Thurston, John A. Hartley, Stephen J. Gregson, Terence C. Jenkins, Arnaud Tiberghien, Lloyd R. Kèlland, Luke A. Masterson, G. R. Stephenson, Stephen Taylor and David G. Williams. Their work appears in journals such as Blood, Biochemistry and Cancer Research.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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