Philip W. Howard

4.4k citations

88 papers · 2.8k indexed · h-index 29

Organic Chemistry top 1%
- Synthesis and pharmacology of benzodiazepine derivatives 62
- Synthetic Organic Chemistry Methods 6
Oncology top 2%
- Cancer Treatment and Pharmacology 33
- HER2/EGFR in Cancer Research 14
- CAR-T cell therapy research 7
Radiology, Nuclear Medicine and Imaging top 2%
- Monoclonal and Polyclonal Antibodies Research 8
Molecular Biology top 5%
- Cancer therapeutics and mechanisms 52
Process Chemistry and Technology top 10%
Infectious Diseases
- HIV/AIDS drug development and treatment 6

Co-authors: David E. Thurston John A. Hartley Stephen J. Gregson Terence C. Jenkins Arnaud Tiberghien Lloyd R. Kèlland Luke A. Masterson G. R. Stephenson
Cited by: Organic Chemistry Oncology Radiology, Nuclear Medicine and Imaging
Journals: Blood (4 papers)Biochemistry (1 paper)Cancer Research (4 papers)
Partner nations: United Kingdom United States Italy

In The Last Decade

Philip W. Howard

88 papers receiving 2.6k citations

Peers

Countries citing papers authored by Philip W. Howard

Since Specialization

Citations

This map shows the geographic impact of Philip W. Howard's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Philip W. Howard with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Philip W. Howard more than expected).

Fields of papers citing papers by Philip W. Howard

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Philip W. Howard. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Philip W. Howard. The network helps show where Philip W. Howard may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Philip W. Howard, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Philip W. Howard Line = papers co-authored together Philip W. Howard links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Integrin-αvβ6 targeted peptide-toxin therapy in a novel αvβ6-expressing immunocompetent model of pancreatic cancer Pancreatology ·Nicholas F. Brown,Elizabeth Murray,Lauren C. Cutmore,Philip W. Howard,Luke A. Masterson,Francesca Zammarchi,John A. Hartley,Patrick H. van Berkel,John F. Marshall	2024	5
2	Comparison of Pyrrolobenzodiazepine Dimer Bis-imine versus Mono-imine: DNA Interstrand Cross-linking, Cytotoxicity, Antibody–Drug Conjugate Efficacy and Toxicity Molecular Cancer Therapeutics ·Arnaud Tiberghien,Balakumar Vijayakrishnan,Arman Esfandiari,Mahammad Ahmed,Raul Pardo,John P. Bingham,Lauren Adams,Kathleen Santos,Gyoung‐Dong Kang,Kathryn Pugh,Shameen Afif-Rider,Kapil Vashisht,Kemal Haque,Ravinder Tammali,Edward Rosfjord,Adriana Savoca,John A. Hartley,Philip W. Howard	2022	3
3	Efficacy, Tolerability, and Pharmacokinetic Studies of Antibody–Drug Conjugates Containing a Low-Potency Pyrrolobenzodiazepine Dimer Molecular Cancer Therapeutics ·Stephen J. Gregson,Kathryn Pugh,Neki V. Patel,Shameen Afif-Rider,Balakumar Vijayakrishnan,Kathleen Santos,Jitka Riedl,Ian Hutchinson,Gyoung‐Dong Kang,K. Phin Chooi,Rhiannon Beard,Lauren Adams,Conor S. Barry,Kathryn Ball,Luke A. Masterson,Mary McFarlane,John A. Hartley,Philip W. Howard	2022	4
4	The Role of Specific ATP-Binding Cassette Transporters in the Acquired Resistance to Pyrrolobenzodiazepine Dimer–Containing Antibody–Drug Conjugates Molecular Cancer Therapeutics ·Simon Corbett,Shiran Huang,Francesca Zammarchi,Philip W. Howard,Patrick H. van Berkel,John A. Hartley	2020	14
5	A Reactive Antibody Platform for One-Step Production of Antibody–Drug Conjugates through a Diels–Alder Reaction with Maleimide Bioconjugate Chemistry ·André H. St. Amant,Feng‐Ying Huang,Jia Lin,Daniel Lemen,Chacko Chakiath,Shenlan Mao,Christine Fazenbaker,Haihong Zhong,Jay Harper,Wenshu Xu,Neki V. Patel,Lauren Adams,Balakumar Vijayakrishnan,Philip W. Howard,Marcello Marelli,Herren Wu,Changshou Gao,Javier Read de Alaniz,R. James Christie	2019	21
6	SLC46A3 as a Potential Predictive Biomarker for Antibody–Drug Conjugates Bearing Noncleavable Linked Maytansinoid and Pyrrolobenzodiazepine Warheads Clinical Cancer Research ·Krista Kinneer,John Meekin,Arnaud Tiberghien,Yu‐Tzu Tai,Sandrina Phipps,Christine Mione Kiefer,Marlon C. Rebelatto,Nazzareno Dimasi,Alyssa Moriarty,Kyriakos P. Papadopoulos,Sriram Sridhar,Stephen J. Gregson,Michael J. Wick,Luke A. Masterson,Kenneth C. Anderson,Ronald Herbst,Philip W. Howard,David A. Tice	2018	58
7	Synthesis of a heterotrifunctional linker for the site-specific preparation of antibody-drug conjugates with two distinct warheads Bioorganic & Medicinal Chemistry Letters ·Amit Kumar,Krista Kinneer,Luke A. Masterson,Ebele Ezeadi,Philip W. Howard,Herren Wu,Changshou Gao,Nazzareno Dimasi	2018	58
8	Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine Scientific Reports ·John A. Hartley,Michael Flynn,John P. Bingham,Simon Corbett,Halla W. Reinert,Arnaud Tiberghien,Luke A. Masterson,Dyeison Antonow,Lauren Adams,Sajidah Chowdhury,David G. Williams,Shenlan Mao,Jay Harper,Carin E.G. Havenith,Francesca Zammarchi,Simon Chivers,Patrick H. van Berkel,Philip W. Howard	2018	85
9	Evaluation of Pyrrolobenzodiazepine-Loaded Nanoparticles: A Targeted Drug Delivery Approach Journal of Pharmaceutical Sciences ·Puneet Tyagi,Sergei Pechenov,Jonathan Rios‐Doria,Luke A. Masterson,Niall J. Dickinson,Philip W. Howard,Shenlan Mao,Jay Harper,Leslie Wetzel,Kwok Yo,J. Anand Subramony	2018	2
10	Pyrrolobenzodiazepine Dimer Antibody–Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers Journal of Medicinal Chemistry ·Stephen J. Gregson,Luke A. Masterson,BinQing Wei,Thomas H. Pillow,Susan D. Spencer,Gyoung‐Dong Kang,Shang‐Fan Yu,Helga Raab,Jeffrey Lau,Guangmin Li,Gail D. Lewis Phillips,Janet Gunzner-Toste,Brian S. Safina,Rachana Ohri,Martine Darwish,Katherine R. Kozak,Josefa dela Cruz-Chuh,Andrew G. Polson,John A. Flygare,Philip W. Howard	2017	27
11	ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer–Containing Antibody–Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies Molecular Cancer Therapeutics ·Michael Flynn,Francesca Zammarchi,Peter Tyrer,Ayse U. Akarca,Narinder Janghra,Charles E. Britten,Carin E.G. Havenith,Jean-Noel Levy,Arnaud Tiberghien,Luke A. Masterson,Conor S. Barry,François D’Hooge,Teresa Marafioti,Paul W.H.I. Parren,David G. Williams,Philip W. Howard,Patrick H. van Berkel,John A. Hartley	2016	85
12	Antistaphylococcal activity of DNA-interactive pyrrolobenzodiazepine (PBD) dimers and PBD-biaryl conjugates Journal of Antimicrobial Chemotherapy ·Khondaker Miraz Rahman,Helena Rosado,Joao B. Moreira,Eva-Anne Feuerbaum,Keith R. Fox,Eva Stecher,Philip W. Howard,Stephen J. Gregson,C. James,María de la Fuente,Denise E. Waldron,David E. Thurston,Peter W. Taylor	2012	21
13	SG2285, a Novel C2-Aryl-Substituted Pyrrolobenzodiazepine Dimer Prodrug That Cross-links DNA and Exerts Highly Potent Antitumor Activity Cancer Research ·John A. Hartley,Anzu Hamaguchi,Marissa Coffils,Christopher R. Martin,Marie Suggitt,Zhizhi Chen,Stephen J. Gregson,Luke A. Masterson,Arnaud Tiberghien,Janet M. Hartley,Chris Pepper,Thet Thet Lin,Chris Fegan,David E. Thurston,Philip W. Howard	2010	43
14	Synthesis of a novel C2/C2′-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate Bioorganic & Medicinal Chemistry Letters ·Philip W. Howard,Zhizhi Chen,Stephen J. Gregson,Luke A. Masterson,Arnaud Tiberghien,Nectaroula Cooper,Min Fang,Marissa Coffils,S. Klee,John A. Hartley,David E. Thurston	2009	24
15	An asymmetric C8/C8′-tripyrrole-linked sequence-selective pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs Bioorganic & Medicinal Chemistry Letters ·Arnaud Tiberghien,David A. Evans,Konstantinos Kiakos,Christopher R. Martin,John A. Hartley,David E. Thurston,Philip W. Howard	2008	15
16	A novel approach to the synthesis of cytotoxic C2–C3 unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) with conjugated acrylyl C2-substituents Bioorganic & Medicinal Chemistry Letters ·Zhizhi Chen,Stephen J. Gregson,Philip W. Howard,David E. Thurston	2004	14
17	Effect of C2-exo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines Bioorganic & Medicinal Chemistry Letters ·Stephen J. Gregson,Philip W. Howard,Kathryn E. Corcoran,Simona Barcella,Maqsood M. Yasin,Abigail A. Hurst,Terence C. Jenkins,Lloyd R. Kèlland,David E. Thurston	2000	34
18	Synthesis of novel C7-aryl substituted pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) via pro-N10-troc protection and Suzuki coupling Bioorganic & Medicinal Chemistry Letters ·Andrea Guiotto,Philip W. Howard,Pier Giovanni Baraldi,David E. Thurston	1998	7
19	Interaction of the Pyrrolobenzodiazepine Antitumour Agent Anthramycin with Glutathione: A Possible Role in Metabolism Pharmacy and Pharmacology Communications ·G. Zioga,Philip W. Howard,Lesley M. Canfield,A. Gescher,David E. Thurston	1996	1
20	π-Complexes with planar chirality: control centres for stereoselective synthesis Philosophical Transactions of the Royal Society of London Series A Mathematical and Physical Sciences ·G. R. Stephenson,Rikki Alexander,Christopher P. Morley,Philip W. Howard	1988	32

About Philip W. Howard

Philip W. Howard is a scholar working on Organic Chemistry, Oncology and Molecular Biology, having authored 88 papers that have together received 2.8k indexed citations. Recurring topics across this work include Synthesis and pharmacology of benzodiazepine derivatives (62 papers), Cancer therapeutics and mechanisms (52 papers), Cancer Treatment and Pharmacology (33 papers), HER2/EGFR in Cancer Research (14 papers), Monoclonal and Polyclonal Antibodies Research (8 papers), CAR-T cell therapy research (7 papers), HIV/AIDS drug development and treatment (6 papers) and Synthetic Organic Chemistry Methods (6 papers). The work is most often cited by research in Organic Chemistry (1.7k citations), Oncology (1.3k citations) and Radiology, Nuclear Medicine and Imaging (551 citations). Philip W. Howard has collaborated with scholars based in United Kingdom, United States and Italy. Frequent co-authors include David E. Thurston, John A. Hartley, Stephen J. Gregson, Terence C. Jenkins, Arnaud Tiberghien, Lloyd R. Kèlland, Luke A. Masterson, G. R. Stephenson, Stephen Taylor and David G. Williams. Their work appears in journals such as Blood, Biochemistry and Cancer Research.

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