Stephen H. Hughes

29.5k citations

374 papers · 21.1k indexed · 6 hit papers · h-index 79

Molecular Biology top 0.2%
Virology top 0.02%
Infectious Diseases top 0.05%
Genetics top 0.5%
Epidemiology top 0.5%

Co-authors: Eddy Arnold Paul L. Boyer Stefan G. Sarafianos Kalyan Das Andrea L. Ferris Arthur D. Clark Christos J. Petropoulos P Sutrave
Topics: HIV Research and Treatment (195 papers)HIV/AIDS drug development and treatment (194 papers)HIV/AIDS Research and Interventions (59 papers)
Cited by: Virology Infectious Diseases Molecular Biology
Journals: Nature Science Cell
Partner nations: United States United Kingdom France

In The Last Decade

Stephen H. Hughes

363 papers receiving 20.3k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

1986 639 citations Stephen H. Hughes et al. profile →
Adaptor plasmids simplify the insertion of foreign DNA into helper-independent retroviral vectors

1987 599 citations Stephen H. Hughes et al. Journal of Virology profile →
Specific HIV integration sites are linked to clonal expansion and persistence of infected cells

2014 598 citations Frank Maldarelli, Xiaolin Wu et al. Science profile →
Mapping unintegrated avian sarcoma virus DNA: Termini of linear DNA bear 300 nucleotides present once or twice in two species of circular DNA

1978 368 citations Stephen H. Hughes et al. profile →
Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites

1978 308 citations Stephen H. Hughes et al. profile →
Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues

2021 162 citations Liguo Zhang, Alexsia Richards et al. Proceedings of the National Academy of Sciences profile →

Peers

Countries citing papers authored by Stephen H. Hughes

Since Specialization

Citations

This map shows the geographic impact of Stephen H. Hughes's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Stephen H. Hughes with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Stephen H. Hughes more than expected).

Fields of papers citing papers by Stephen H. Hughes

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Stephen H. Hughes. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Stephen H. Hughes. The network helps show where Stephen H. Hughes may publish in the future.

Co-authorship network of co-authors of Stephen H. Hughes

This figure shows the co-authorship network connecting the top 25 collaborators of Stephen H. Hughes. A scholar is included among the top collaborators of Stephen H. Hughes based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Stephen H. Hughes. Stephen H. Hughes is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	BPS2025 - Structural and mechanistic insights into cabotegravir resistance in HIV-1 integrase 2025 ·Biophysical Journal ·Indrani Choudhuri,Tao Jing,Avik Biswas,Min Li,Steven J. Smith,Robert Craigie,Eric O. Freed,Terrence R. Burke,Stephen H. Hughes,Ronald M. Levy,Dmitry Lyumkis	0
2	Novel use of oral chloramphenicol for treatment-resistantMycoplasma genitalium 2023 ·Sexually Transmitted Infections ·(unknown),Stephen H. Hughes,(unknown),Rachael M. Jones,Luke Moore,Michael Rayment	3
3	Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants 2023 ·Science Advances ·(unknown),Dario Oliveira Passos,(unknown),Steven J. Smith,(unknown),Avik Biswas,Indrani Choudhuri,Timothy S. Strutzenberg,Allan Haldane,Nanjie Deng,Zhaoyang Li,Xue Zhi Zhao,(unknown),Mamuka Kvaratskhelia,Terrence R. Burke,Ronald M. Levy,Stephen H. Hughes,Robert Craigie,Dmitry Lyumkis	17
4	Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissuesbreakdown → 2021 ·Proceedings of the National Academy of Sciences ·Liguo Zhang,Alexsia Richards,M. Inmaculada Barrasa,Stephen H. Hughes,Richard A. Young,Rudolf Jaenisch	162
5	Publisher Correction: Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures 2021 ·Nature Communications ·(unknown),(unknown),Xue Zhi Zhao,Steven J. Smith,Allison Ballandras-Colas,Nora Cronin,Valerie E. Pye,Stephen H. Hughes,Terrence R. Burke,Peter Cherepanov,Goedele N. Maertens	1
6	Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures 2021 ·Nature Communications ·(unknown),(unknown),Xue Zhi Zhao,Steven J. Smith,Allison Ballandras-Colas,Nora Cronin,Valerie E. Pye,Stephen H. Hughes,Terrence R. Burke,Peter Cherepanov,Goedele N. Maertens	10
7	Tracking HIV-1-Infected Cell Clones Using Integration Site-Specific qPCR 2021 ·Viruses ·Leah D. Brandt,Shuang Guo,(unknown),Jana L. Jacobs,Asma Naqvi,John M. Coffin,Mary F. Kearney,Elias K. Halvas,Xiaolin Wu,Stephen H. Hughes,John W. Mellors	10
8	Insertional activation of STAT3 and LCK by HIV-1 proviruses in T cell lymphomas 2021 ·Science Advances ·John W. Mellors,Shuang Guo,Asma Naqvi,Leah D. Brandt,Ling Su,Zhonghe Sun,(unknown),Dimiter Demirov,Elias K. Halvas,Donna Butcher,(unknown),Aaron T. Hamilton,Marintha Heil,Baktiar Karim,Xiaolin Wu,Stephen H. Hughes	24
9	Integration in oncogenes plays only a minor role in determining the in vivo distribution of HIV integration sites before or during suppressive antiretroviral therapy 2021 ·PLoS Pathogens ·John M. Coffin,Michael J. Bale,(unknown),Shuang Guo,Brian T. Luke,Jennifer M. Zerbato,Michele D. Sobolewski,(unknown),Wei Shao,Xiaolin Wu,Frank Maldarelli,Mary F. Kearney,John W. Mellors,Stephen H. Hughes	36
10	HIV-1 viremia not suppressible by antiretroviral therapy can originate from large T cell clones producing infectious virus 2020 ·Journal of Clinical Investigation ·Elias K. Halvas,(unknown),Leah D. Brandt,Shuang Guo,Michele D. Sobolewski,Jana L. Jacobs,Camille Tumiotto,John Bui,Joshua C. Cyktor,Brandon F. Keele,Gene D. Morse,Michael J. Bale,Wei Shao,Mary F. Kearney,John M. Coffin,Jason W. Rausch,Xiaolin Wu,Stephen H. Hughes,John W. Mellors	87
11	Clonal expansion of SIV-infected cells in macaques on antiretroviral therapy is similar to that of HIV-infected cells in humans 2019 ·PLoS Pathogens ·Andrea L. Ferris,David W. Wells,Shuang Guo,Gregory Q. Del Prete,Adrienne E. Swanstrom,John M. Coffin,Xiaolin Wu,Jeffrey D. Lifson,Stephen H. Hughes	26
12	Specific HIV integration sites are linked to clonal expansion and persistence of infected cellsbreakdown → 2014 ·Science ·Frank Maldarelli,Xiaolin Wu,Li Su,Francesco R. Simonetti,Wei Shao,(unknown),Jonathan Spindler,Andrea L. Ferris,John W. Mellors,Mary F. Kearney,John M. Coffin,Stephen H. Hughes	598
13	Nature, Position, and Frequency of Mutations Made in a Single Cycle of HIV-1 Replication 2010 ·Journal of Virology ·Michael E. Abram,Andrea L. Ferris,Wei Shao,W. Gregory Alvord,Stephen H. Hughes	188
14	Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance 2009 ·Journal of Biological Chemistry ·Kalyan Das,Rajiv P. Bandwar,Kirsten White,Joy Y. Feng,Stefan G. Sarafianos,Steven Tuske,(unknown),Arthur D. Clark,Paul L. Boyer,Xiaorong Hou,Barbara L. Gaffney,Roger A. Jones,Michael D. Miller,Stephen H. Hughes,Eddy Arnold	71
15	Differential regulation of vitamin D receptor and its ligand in human dendritic cells: A paracrine mechanism for regulation of antigen presentation 2003 ·(unknown),Kathy S. Evans,Stephen H. Hughes,(unknown),Ronjon Chakraverty,Martin Hewison	1
16	Crystal Structures of 8-Cl and 9-Cl TIBO Complexed with Wild-type HIV-1 RT and 8-Cl TIBO Complexed with the Tyr181Cys HIV-1 RT Drug-resistant Mutant 1996 ·Journal of Molecular Biology ·Kalyan Das,Jianping Ding,Y. Hsiou,Arthur D. Clark,Henri Moereels,Luc Koymans,Koen Andries,Rudi Pauwels,Paul A. J. Janssen,Paul L. Boyer,Patrick K. Clark,Richard H. Smith,Marilyn B. Kroeger Smith,Christopher J. Michejda,Stephen H. Hughes,Eddy Arnold	159
17	Enzymatic Properties of Two Mutants of Reverse Transcriptase of Human Immunodeficiency Virus Type 1 (Tyrosine 181 → Isoleucine and Tyrosine 188→ Leucine), Resistant to Nonnucleoside Inhibitors 1994 ·AIDS Research and Human Retroviruses ·Shoshana Loya,Mary Bakhanashvili,R. Tal,Stephen H. Hughes,Paul L. Boyer,(unknown)	17
18	HIV-1 Reverse Transcriptase Purified from a Recombinant Strain of Escherichia coli 1990 ·AIDS Research and Human Retroviruses ·Patrick K. Clark,Andrea L. Ferris,D.A. Miller,Amnon Hizi,(unknown),(unknown),(unknown),Arthur D. Clark,Gail Ferstandig Arnold,William B. Lebherz,Eddy Arnold,Gary M. Muschik,Stephen H. Hughes	68
19	APPENDIX D Sequences of Retroviral LTRs 1982 ·Cold Spring Harbor Monograph Archive ·Stephen H. Hughes	1
20	APPENDIX E Complete Nucleotide Sequences of Three Retroviral Genomes and a Cellular onc Gene 1982 ·Cold Spring Harbor Monograph Archive ·Stephen H. Hughes	1

About Stephen H. Hughes

Stephen H. Hughes is a scholar working on Virology, Infectious Diseases and Molecular Biology, having authored 374 papers that have together received 21.1k indexed citations. Recurring topics across this work include HIV Research and Treatment (195 papers), HIV/AIDS drug development and treatment (194 papers) and HIV/AIDS Research and Interventions (59 papers). The work is most often cited by research in Virology (9.3k citations), Infectious Diseases (9.3k citations) and Molecular Biology (11.3k citations). Stephen H. Hughes has collaborated with scholars based in United States, United Kingdom and France. Frequent co-authors include Eddy Arnold, Paul L. Boyer, Stefan G. Sarafianos, Kalyan Das, Andrea L. Ferris, Arthur D. Clark, Christos J. Petropoulos, P Sutrave, Harold Varmus and Mariano Barbacid. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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