Stephen H. Hughes

29.5k citations

374 papers · 21.1k indexed · 6 hit papers · h-index 79

Virology top 0.02%
- HIV Research and Treatment 195
Infectious Diseases top 0.05%
- HIV/AIDS drug development and treatment 194
- HIV/AIDS Research and Interventions 59
Molecular Biology top 0.2%
- Biochemical and Molecular Research 51
- CRISPR and Genetic Engineering 36
Genetics top 0.5%
- Virus-based gene therapy research 51
Epidemiology top 0.5%
Plant Science
- Plant Virus Research Studies 27
Animal Science and Zoology
- Animal Virus Infections Studies 26

Co-authors: Eddy Arnold Paul L. Boyer Stefan G. Sarafianos Kalyan Das Andrea L. Ferris Arthur D. Clark Christos J. Petropoulos P Sutrave
Cited by: Virology Infectious Diseases Molecular Biology
Journals: Nature (1 paper)Science (2 papers)Cell (5 papers)
Partner nations: United States United Kingdom France

In The Last Decade

Stephen H. Hughes

363 papers receiving 20.3k citations

Hit Papers

6 papers align trajectories log scale

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

2021 Proceedings of the National Academy of Sciences
2014 Science
1987 Journal of Virology
1986 Nature
1978 Cell
1978 Cell

Peers

Countries citing papers authored by Stephen H. Hughes

Since Specialization

Citations

This map shows the geographic impact of Stephen H. Hughes's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Stephen H. Hughes with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Stephen H. Hughes more than expected).

Fields of papers citing papers by Stephen H. Hughes

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Stephen H. Hughes. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Stephen H. Hughes. The network helps show where Stephen H. Hughes may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Stephen H. Hughes, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Stephen H. Hughes Line = papers co-authored together Stephen H. Hughes links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	BPS2025 - Structural and mechanistic insights into cabotegravir resistance in HIV-1 integrase Biophysical Journal ·Indrani Choudhuri,Tao Jing,Avik Biswas,Min Li,Steven J. Smith,Robert Craigie,Eric O. Freed,Terrence R. Burke,Stephen H. Hughes,Ronald M. Levy,Dmitry Lyumkis	2025	0
2	Novel use of oral chloramphenicol for treatment-resistantMycoplasma genitalium Sexually Transmitted Infections ·Jonathan Joseph Goodfellow,Stephen H. Hughes,Jo Smith,Rachael M. Jones,Luke Moore,Michael Rayment	2023	3
3	Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants Science Advances ·Min Li,Dario Oliveira Passos,Zelin Shan,Steven J. Smith,Qinfang Sun,Avik Biswas,Indrani Choudhuri,Timothy S. Strutzenberg,Allan Haldane,Nanjie Deng,Zhaoyang Li,Xue Zhi Zhao,Lorenzo Briganti,Mamuka Kvaratskhelia,Terrence R. Burke,Ronald M. Levy,Stephen H. Hughes,Robert Craigie,Dmitry Lyumkis	2023	17
4	Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissuesbreakdown → Proceedings of the National Academy of Sciences ·Liguo Zhang,Alexsia Richards,M. Inmaculada Barrasa,Stephen H. Hughes,Richard A. Young,Rudolf Jaenisch	2021	162
5	Publisher Correction: Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures Nature Communications ·M.S. Barski,Teresa Vanzo,Xue Zhi Zhao,Steven J. Smith,Allison Ballandras-Colas,Nora Cronin,Valerie E. Pye,Stephen H. Hughes,Terrence R. Burke,Peter Cherepanov,Goedele N. Maertens	2021	1
6	Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures Nature Communications ·M.S. Barski,Teresa Vanzo,Xue Zhi Zhao,Steven J. Smith,Allison Ballandras-Colas,Nora Cronin,Valerie E. Pye,Stephen H. Hughes,Terrence R. Burke,Peter Cherepanov,Goedele N. Maertens	2021	10
7	Tracking HIV-1-Infected Cell Clones Using Integration Site-Specific qPCR Viruses ·Leah D. Brandt,Shuang Guo,Kevin W. Joseph,Jana L. Jacobs,Asma Naqvi,John M. Coffin,Mary F. Kearney,Elias K. Halvas,Xiaolin Wu,Stephen H. Hughes,John W. Mellors	2021	10
8	Insertional activation of STAT3 and LCK by HIV-1 proviruses in T cell lymphomas Science Advances ·John W. Mellors,Shuang Guo,Asma Naqvi,Leah D. Brandt,Ling Su,Zhonghe Sun,Kevin W. Joseph,Dimiter Demirov,Elias K. Halvas,Donna Butcher,Beth Scott,Aaron T. Hamilton,Marintha Heil,Baktiar Karim,Xiaolin Wu,Stephen H. Hughes	2021	24
9	Integration in oncogenes plays only a minor role in determining the in vivo distribution of HIV integration sites before or during suppressive antiretroviral therapy PLoS Pathogens ·John M. Coffin,Michael J. Bale,Daria Wells,Shuang Guo,Brian T. Luke,Jennifer M. Zerbato,Michele D. Sobolewski,Twan Sia,Wei Shao,Xiaolin Wu,Frank Maldarelli,Mary F. Kearney,John W. Mellors,Stephen H. Hughes	2021	36
10	HIV-1 viremia not suppressible by antiretroviral therapy can originate from large T cell clones producing infectious virus Journal of Clinical Investigation ·Elias K. Halvas,Kevin W. Joseph,Leah D. Brandt,Shuang Guo,Michele D. Sobolewski,Jana L. Jacobs,Camille Tumiotto,John Bui,Joshua C. Cyktor,Brandon F. Keele,Gene D. Morse,Michael J. Bale,Wei Shao,Mary F. Kearney,John M. Coffin,Jason W. Rausch,Xiaolin Wu,Stephen H. Hughes,John W. Mellors	2020	87
11	Clonal expansion of SIV-infected cells in macaques on antiretroviral therapy is similar to that of HIV-infected cells in humans PLoS Pathogens ·Andrea L. Ferris,David W. Wells,Shuang Guo,Gregory Q. Del Prete,Adrienne E. Swanstrom,John M. Coffin,Xiaolin Wu,Jeffrey D. Lifson,Stephen H. Hughes	2019	26
12	Specific HIV integration sites are linked to clonal expansion and persistence of infected cellsbreakdown → Science ·Frank Maldarelli,Xiaolin Wu,Li Su,Francesco R. Simonetti,Wei Shao,S. Hill,Jonathan Spindler,Andrea L. Ferris,John W. Mellors,Mary F. Kearney,John M. Coffin,Stephen H. Hughes	2014	598
13	Nature, Position, and Frequency of Mutations Made in a Single Cycle of HIV-1 Replication Journal of Virology ·Michael E. Abram,Andrea L. Ferris,Wei Shao,W. Gregory Alvord,Stephen H. Hughes	2010	188
14	Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance Journal of Biological Chemistry ·Kalyan Das,Rajiv P. Bandwar,Kirsten White,Joy Y. Feng,Stefan G. Sarafianos,Steven Tuske,Xiongying Tu,Arthur D. Clark,Paul L. Boyer,Xiaorong Hou,Barbara L. Gaffney,Roger A. Jones,Michael D. Miller,Stephen H. Hughes,Eddy Arnold	2009	71
15	Differential regulation of vitamin D receptor and its ligand in human dendritic cells: A paracrine mechanism for regulation of antigen presentation L. Freeman,Kathy S. Evans,Stephen H. Hughes,P D Moss,Ronjon Chakraverty,Martin Hewison	2003	1
16	Crystal Structures of 8-Cl and 9-Cl TIBO Complexed with Wild-type HIV-1 RT and 8-Cl TIBO Complexed with the Tyr181Cys HIV-1 RT Drug-resistant Mutant Journal of Molecular Biology ·Kalyan Das,Jianping Ding,Y. Hsiou,Arthur D. Clark,Henri Moereels,Luc Koymans,Koen Andries,Rudi Pauwels,Paul A. J. Janssen,Paul L. Boyer,Patrick K. Clark,Richard H. Smith,Marilyn B. Kroeger Smith,Christopher J. Michejda,Stephen H. Hughes,Eddy Arnold	1996	159
17	Enzymatic Properties of Two Mutants of Reverse Transcriptase of Human Immunodeficiency Virus Type 1 (Tyrosine 181 → Isoleucine and Tyrosine 188→ Leucine), Resistant to Nonnucleoside Inhibitors AIDS Research and Human Retroviruses ·Shoshana Loya,Mary Bakhanashvili,R. Tal,Stephen H. Hughes,Paul L. Boyer,AMNON HIZ	1994	17
18	HIV-1 Reverse Transcriptase Purified from a Recombinant Strain of Escherichia coli AIDS Research and Human Retroviruses ·Patrick K. Clark,Andrea L. Ferris,D.A. Miller,Amnon Hizi,K.-W. KIM,S.M. DERINGER-BOYER,M Mellini,Arthur D. Clark,Gail Ferstandig Arnold,William B. Lebherz,Eddy Arnold,Gary M. Muschik,Stephen H. Hughes	1990	68
19	APPENDIX D Sequences of Retroviral LTRs Cold Spring Harbor Monograph Archive ·Stephen H. Hughes	1982	1
20	APPENDIX E Complete Nucleotide Sequences of Three Retroviral Genomes and a Cellular onc Gene Cold Spring Harbor Monograph Archive ·Stephen H. Hughes	1982	1

About Stephen H. Hughes

Stephen H. Hughes is a scholar working on Virology, Infectious Diseases and Molecular Biology, having authored 374 papers that have together received 21.1k indexed citations. Recurring topics across this work include HIV Research and Treatment (195 papers), HIV/AIDS drug development and treatment (194 papers), HIV/AIDS Research and Interventions (59 papers), Biochemical and Molecular Research (51 papers), Virus-based gene therapy research (51 papers), CRISPR and Genetic Engineering (36 papers), Plant Virus Research Studies (27 papers) and Animal Virus Infections Studies (26 papers). The work is most often cited by research in Virology (9.3k citations), Infectious Diseases (9.3k citations) and Molecular Biology (11.3k citations). Stephen H. Hughes has collaborated with scholars based in United States, United Kingdom and France. Frequent co-authors include Eddy Arnold, Paul L. Boyer, Stefan G. Sarafianos, Kalyan Das, Andrea L. Ferris, Arthur D. Clark, Christos J. Petropoulos, P Sutrave, Harold Varmus and Mariano Barbacid. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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