Stephen H. Hughes

29.5k total citations · 6 hit papers
374 papers, 21.1k citations indexed

About

Stephen H. Hughes is a scholar working on Infectious Diseases, Virology and Molecular Biology. According to data from OpenAlex, Stephen H. Hughes has authored 374 papers receiving a total of 21.1k indexed citations (citations by other indexed papers that have themselves been cited), including 202 papers in Infectious Diseases, 195 papers in Virology and 190 papers in Molecular Biology. Recurrent topics in Stephen H. Hughes's work include HIV Research and Treatment (195 papers), HIV/AIDS drug development and treatment (194 papers) and HIV/AIDS Research and Interventions (59 papers). Stephen H. Hughes is often cited by papers focused on HIV Research and Treatment (195 papers), HIV/AIDS drug development and treatment (194 papers) and HIV/AIDS Research and Interventions (59 papers). Stephen H. Hughes collaborates with scholars based in United States, United Kingdom and France. Stephen H. Hughes's co-authors include Eddy Arnold, Paul L. Boyer, Stefan G. Sarafianos, Kalyan Das, Andrea L. Ferris, Arthur D. Clark, Christos J. Petropoulos, P Sutrave, Harold Varmus and Mariano Barbacid and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Stephen H. Hughes

363 papers receiving 20.3k citations

Hit Papers

A human oncogene formed by the fusion of truncated tropom... 1978 2026 1994 2010 1986 1987 2014 1978 1978 200 400 600
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences
    1986 639 citations Stephen H. Hughes et al. profile →
  2. Adaptor plasmids simplify the insertion of foreign DNA into helper-independent retroviral vectors
    1987 599 citations Stephen H. Hughes et al. Journal of Virology profile →
  3. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells
    2014 598 citations Frank Maldarelli, Xiaolin Wu et al. Science profile →
  4. Mapping unintegrated avian sarcoma virus DNA: Termini of linear DNA bear 300 nucleotides present once or twice in two species of circular DNA
    1978 368 citations Stephen H. Hughes, Harold Varmus et al. profile →
  5. Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites
    1978 308 citations Stephen H. Hughes, Harold Varmus et al. profile →
  6. Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues
    2021 162 citations Liguo Zhang, Alexsia Richards et al. Proceedings of the National Academy of Sciences profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Stephen H. Hughes United States 79 11.3k 9.3k 9.3k 3.0k 2.9k 374 21.1k
Naoki Yamamoto Japan 81 9.9k 0.9× 6.0k 0.6× 5.5k 0.6× 1.5k 0.5× 5.1k 1.7× 741 30.6k
John H. Elder United States 52 5.3k 0.5× 3.6k 0.4× 1.9k 0.2× 2.8k 0.9× 2.8k 1.0× 178 12.5k
Dominique Schols Belgium 77 7.1k 0.6× 8.7k 0.9× 7.5k 0.8× 757 0.2× 3.8k 1.3× 560 23.8k
David A. Jans Australia 75 11.3k 1.0× 1.7k 0.2× 4.6k 0.5× 3.0k 1.0× 2.1k 0.7× 369 19.5k
Hermann Katinger Austria 59 6.0k 0.5× 8.8k 0.9× 3.5k 0.4× 875 0.3× 2.4k 0.8× 208 15.0k
Warner C. Greene United States 97 11.0k 1.0× 11.2k 1.2× 6.2k 0.7× 1.8k 0.6× 4.4k 1.5× 281 33.3k
John J. Rossi United States 83 24.5k 2.2× 2.8k 0.3× 1.4k 0.2× 4.3k 1.4× 1.4k 0.5× 415 29.6k
Louis E. Henderson United States 49 4.5k 0.4× 4.4k 0.5× 2.5k 0.3× 871 0.3× 1.5k 0.5× 94 8.9k
Jonathan Karn United States 62 8.1k 0.7× 5.1k 0.6× 2.5k 0.3× 955 0.3× 913 0.3× 133 12.5k
Jianping Ding China 49 7.8k 0.7× 3.0k 0.3× 3.5k 0.4× 921 0.3× 1.1k 0.4× 187 11.8k

Countries citing papers authored by Stephen H. Hughes

Since Specialization
Citations

This map shows the geographic impact of Stephen H. Hughes's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Stephen H. Hughes with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Stephen H. Hughes more than expected).

Fields of papers citing papers by Stephen H. Hughes

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Stephen H. Hughes. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Stephen H. Hughes. The network helps show where Stephen H. Hughes may publish in the future.

Co-authorship network of co-authors of Stephen H. Hughes

This figure shows the co-authorship network connecting the top 25 collaborators of Stephen H. Hughes. A scholar is included among the top collaborators of Stephen H. Hughes based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Stephen H. Hughes. Stephen H. Hughes is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
2.
Choudhuri, Indrani, Tao Jing, Avik Biswas, et al.. (2025). BPS2025 - Structural and mechanistic insights into cabotegravir resistance in HIV-1 integrase. Biophysical Journal. 124(3). 176a–177a.
3.
Zhao, Xue Zhi, Steven J. Smith, Allison Ballandras-Colas, et al.. (2021). Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures. Nature Communications. 12(1). 4996–4996. 10 indexed citations
4.
Mellors, John W., Shuang Guo, Asma Naqvi, et al.. (2021). Insertional activation of STAT3 and LCK by HIV-1 proviruses in T cell lymphomas. Science Advances. 7(42). eabi8795–eabi8795. 24 indexed citations
5.
Zhang, Liguo, Alexsia Richards, M. Inmaculada Barrasa, et al.. (2021). Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues. Proceedings of the National Academy of Sciences. 118(21). 162 indexed citations breakdown →
6.
Halvas, Elias K., Leah D. Brandt, Shuang Guo, et al.. (2020). HIV-1 viremia not suppressible by antiretroviral therapy can originate from large T cell clones producing infectious virus. Journal of Clinical Investigation. 130(11). 5847–5857. 87 indexed citations
7.
Ferris, Andrea L., David W. Wells, Shuang Guo, et al.. (2019). Clonal expansion of SIV-infected cells in macaques on antiretroviral therapy is similar to that of HIV-infected cells in humans. PLoS Pathogens. 15(7). e1007869–e1007869. 26 indexed citations
8.
Maldarelli, Frank, Xiaolin Wu, Li Su, et al.. (2014). Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science. 345(6193). 179–183. 598 indexed citations breakdown →
9.
Johnson, Barry C., Gary T. Pauly, Ganesha Rai, et al.. (2012). A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants. Retrovirology. 9(1). 99–99. 31 indexed citations
10.
Abram, Michael E., Andrea L. Ferris, Wei Shao, W. Gregory Alvord, & Stephen H. Hughes. (2010). Nature, Position, and Frequency of Mutations Made in a Single Cycle of HIV-1 Replication. Journal of Virology. 84(19). 9864–9878. 188 indexed citations
11.
Das, Kalyan, Rajiv P. Bandwar, Kirsten White, et al.. (2009). Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance. Journal of Biological Chemistry. 284(50). 35092–35100. 71 indexed citations
12.
Evans, Kathy S., et al.. (2003). Differential regulation of vitamin D receptor and its ligand in human dendritic cells: A paracrine mechanism for regulation of antigen presentation. 1 indexed citations
13.
Muir, S. R., Geoff Collins, Susan Robinson, et al.. (2001). Overexpression of petunia chalcone isomerase in tomato results in fruit containing increased levels of flavonols. Nature Biotechnology. 19(5). 470–474. 406 indexed citations
14.
Sarafianos, Stefan G., Kalyan Das, Chris Tantillo, et al.. (2001). Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA. The EMBO Journal. 20(6). 1449–1461. 341 indexed citations
15.
Coffin, John M., Stephen H. Hughes, & Harold E Varmus. (1997). Retroviral “Lifestyles”: Simple versus Complex. Biochemical and Biophysical Research Communications. 525(4). 823–829. 1 indexed citations
16.
Coffin, John M., Stephen H. Hughes, & Harold Varmus. (1997). Synthesis and Organization of Env Glycoproteins. Scandinavian Journal of Immunology. 40(1). 26–36. 1 indexed citations
17.
Das, Kalyan, Jianping Ding, Y. Hsiou, et al.. (1996). Crystal Structures of 8-Cl and 9-Cl TIBO Complexed with Wild-type HIV-1 RT and 8-Cl TIBO Complexed with the Tyr181Cys HIV-1 RT Drug-resistant Mutant. Journal of Molecular Biology. 264(5). 1085–1100. 159 indexed citations
18.
19.
Clark, Patrick K., Andrea L. Ferris, D.A. Miller, et al.. (1990). HIV-1 Reverse Transcriptase Purified from a Recombinant Strain of Escherichia coli. AIDS Research and Human Retroviruses. 6(6). 753–764. 68 indexed citations
20.
Hughes, Stephen H.. (1982). APPENDIX E Complete Nucleotide Sequences of Three Retroviral Genomes and a Cellular onc Gene. Cold Spring Harbor Monograph Archive. 1337–1375. 1 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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