Lloyd J. Old

112.1k total citations · 29 hit papers
722 papers, 85.7k citations indexed

About

Lloyd J. Old is a scholar working on Immunology, Molecular Biology and Radiology, Nuclear Medicine and Imaging. According to data from OpenAlex, Lloyd J. Old has authored 722 papers receiving a total of 85.7k indexed citations (citations by other indexed papers that have themselves been cited), including 402 papers in Immunology, 372 papers in Molecular Biology and 251 papers in Radiology, Nuclear Medicine and Imaging. Recurrent topics in Lloyd J. Old's work include Immunotherapy and Immune Responses (312 papers), Monoclonal and Polyclonal Antibodies Research (231 papers) and Glycosylation and Glycoproteins Research (143 papers). Lloyd J. Old is often cited by papers focused on Immunotherapy and Immune Responses (312 papers), Monoclonal and Polyclonal Antibodies Research (231 papers) and Glycosylation and Glycoproteins Research (143 papers). Lloyd J. Old collaborates with scholars based in United States, Germany and Australia. Lloyd J. Old's co-authors include Robert D. Schreiber, Gavin P. Dunn, Edward A. Boyse, Elisabeth Stockert, Mark J. Smyth, Hiroaki Ikeda, Barbara Williamson, Achim A. Jungbluth, Yao‐Tseng Chen and E A Carswell and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Lloyd J. Old

712 papers receiving 81.4k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion

2011 4.6k citations Lloyd J. Old et al. profile →
Cancer immunoediting: from immunosurveillance to tumor escape

2002 3.7k citations Hiroaki Ikeda, Lloyd J. Old et al. profile →
An endotoxin-induced serum factor that causes necrosis of tumors.

1975 3.5k citations E A Carswell, Lloyd J. Old et al. Proceedings of the National Academy of Sciences profile →
The Three Es of Cancer Immunoediting

2004 2.2k citations Lloyd J. Old et al. profile →
The Immunobiology of Cancer Immunosurveillance and Immunoediting

2004 2.1k citations Lloyd J. Old et al. profile →
IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

2001 2.1k citations Hiroaki Ikeda, Lloyd J. Old et al. profile →
Intraepithelial CD8⁺tumor-infiltrating lymphocytes and a high CD8⁺/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

2005 1.9k citations Eiichi Sato, Hiroyoshi Nishikawa et al. Proceedings of the National Academy of Sciences profile →
Antibody therapy of cancer

2012 1.7k citations Andrew M. Scott, Lloyd J. Old et al. profile →
Tumor Necrosis Factor (TNF)

1985 1.6k citations Lloyd J. Old profile →
Cancer/testis antigens, gametogenesis and cancer

2005 1.3k citations Andrew J.G. Simpson, Achim A. Jungbluth et al. profile →
Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice

1998 1.1k citations Elisabeth Stockert, Lloyd J. Old et al. Proceedings of the National Academy of Sciences profile →
Adaptive immunity maintains occult cancer in an equilibrium state

2007 1.0k citations Lloyd J. Old et al. profile →
A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening

1997 1.0k citations Ali O. Güre, Barbara Williamson et al. Proceedings of the National Academy of Sciences profile →
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

2012 932 citations James P. Allison, Lloyd J. Old et al. profile →
The roles of IFNγ in protection against tumor development and cancer immunoediting

2002 724 citations Hiroaki Ikeda, Lloyd J. Old et al. profile →
Cancer/testis antigens: an expanding family of targets for cancer immunotherapy

2002 713 citations Ali O. Güre, Achim A. Jungbluth et al. profile →
Tumor-infiltrating NY-ESO-1–specific CD8 ⁺ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer

2010 695 citations Junko Matsuzaki, Sacha Gnjatic et al. Proceedings of the National Academy of Sciences profile →
Characterization of tumor necrosis factor-deficient mice

1997 675 citations Barbara Williamson, Lloyd J. Old et al. Proceedings of the National Academy of Sciences profile →
A new class of murine leukemia virus associated with development of spontaneous lymphomas.

1977 634 citations Lloyd J. Old et al. Proceedings of the National Academy of Sciences profile →
Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers.

1990 604 citations Pilar Garin‐Chesa, Lloyd J. Old et al. Proceedings of the National Academy of Sciences profile →
Simultaneous Humoral and Cellular Immune Response against Cancer–Testis Antigen NY-ESO-1: Definition of Human Histocompatibility Leukocyte Antigen (HLA)-A2–binding Peptide Epitopes

1998 594 citations Elke Jäger, Julia Karbach et al. profile →
A Survey of the Humoral Immune Response of Cancer Patients to a Panel of Human Tumor Antigens

1998 593 citations Elisabeth Stockert, Elke Jäger et al. profile →
The cancer/testis genes: review, standardization, and commentary.

2004 560 citations Andrew J.G. Simpson, Lloyd J. Old et al. PubMed profile →
Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse.

1979 536 citations Lloyd J. Old et al. Proceedings of the National Academy of Sciences profile →
ANTIGENIC PROPERTIES OF CHEMICALLY INDUCED TUMORS*

1962 408 citations Lloyd J. Old, E A Carswell et al. profile →
Effect of Bacillus Calmette-Guérin Infection on Transplanted Tumours in the Mouse

1959 387 citations Lloyd J. Old, Baruj Benacerraf et al. profile →
Cell surface antigens of human malignant melanoma: mixed hemadsorption assays for humoral immunity to cultured autologous melanoma cells.

1976 376 citations Lloyd J. Old et al. Proceedings of the National Academy of Sciences profile →
Immunology of Experimental Tumors

1964 359 citations Lloyd J. Old et al. profile →
Integrated NY-ESO-1 antibody and CD8⁺T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab

2011 254 citations Erika Ritter, Gerd Ritter et al. Proceedings of the National Academy of Sciences profile →

Peers

Countries citing papers authored by Lloyd J. Old

Since Specialization

Citations

This map shows the geographic impact of Lloyd J. Old's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Lloyd J. Old with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Lloyd J. Old more than expected).

Fields of papers citing papers by Lloyd J. Old

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Lloyd J. Old. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Lloyd J. Old. The network helps show where Lloyd J. Old may publish in the future.

Co-authorship network of co-authors of Lloyd J. Old

This figure shows the co-authorship network connecting the top 25 collaborators of Lloyd J. Old. A scholar is included among the top collaborators of Lloyd J. Old based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Lloyd J. Old. Lloyd J. Old is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Nonclassical Antigen-Processing Pathways Are Required for MHC Class II–Restricted Direct Tumor Recognition by NY-ESO-1–Specific CD4+ T Cells 2013 ·Cancer Immunology Research ·Junko Matsuzaki, Takemasa Tsuji, Immanuel F. Luescher, Lloyd J. Old, Protul Shrikant, Sacha Gnjatic, Kunle Odunsi	38
2	Phase I Clinical Trial of Mixed Bacterial Vaccine (Coley's Toxins) in Patients with NY-ESO-1 Expressing Cancers: Immunological Effects and Clinical Activity 2012 ·Clinical Cancer Research ·Julia Karbach, Antje Neumann, Kathrin Brand, Claudia Wahle, Ekkehard Siegel, Markus Maeurer, Erika Ritter, (unknown), Sacha Gnjatic, Lloyd J. Old, Gerd Ritter, Elke Jäger	79
3	Novel Mechanistic Insights into Arginine Deiminase Pharmacology Suggest ¹⁸F-FDG Is Not Suitable to Evaluate Clinical Response in Melanoma 2012 ·Journal of Nuclear Medicine ·Lars Stelter, Michael J. Evans, Achim A. Jungbluth, Pat Zanzonico, Gerd Ritter, Thomas W. Ku, Eric Rosenfeld, John S. Bomalaski, Lloyd J. Old, Steven M. Larson	14
4	MAGE-A Inhibits Apoptosis in Proliferating Myeloma Cells through Repression of Bax and Maintenance of Survivin 2011 ·Clinical Cancer Research ·(unknown), Achim A. Jungbluth, (unknown), Maurizio DiLiberto, Xiangao Huang, (unknown), Valéria C.C. Andrade, (unknown), Scott Ely, Rubén Niesvizky, Roger Pearse, Morton Coleman, David Jayabalan, Nina Bhardwaj, Lloyd J. Old, Selina Chen‐Kiang, Hearn Jay Cho	79
5	Two Distinct Mechanisms of Augmented Antitumor Activity by Modulation of Immunostimulatory/Inhibitory Signals 2010 ·Clinical Cancer Research ·(unknown), Hiroyoshi Nishikawa, Daisuke Muraoka, Linan Wang, Takuro Noguchi, Eiichi Sato, Satoshi Kondo, James P. Allison, Shimon Sakaguchi, Lloyd J. Old, Takuma Kato, Hiroshi Shiku	106
6	Efficient In vivo Priming by Vaccination with Recombinant NY-ESO-1 Protein and CpG in Antigen Naïve Prostate Cancer Patients 2010 ·Clinical Cancer Research ·Julia Karbach, Antje Neumann, Akin Atmaca, Claudia Wahle, Kathrin Brand, Lotta von Boehmer, Alexander Knuth, Armin Bender, Gerd Ritter, Lloyd J. Old, Elke Jäger	63
7	NY-ESO-1 DNA Vaccine Induces T-Cell Responses That Are Suppressed by Regulatory T Cells 2009 ·Clinical Cancer Research ·Sacha Gnjatic, Nasser K. Altorki, Derek Ng Tang, Shi‐Ming Tu, Vikas Kundra, Gerd Ritter, Lloyd J. Old, Christopher J. Logothetis, Padmanee Sharma	58
8	Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer 2009 ·Cancer Research ·Feng Qian, Jeannine Villella, Paul K. Wallace, Paulette Mhawech‐Fauceglia, Joseph D. Tario, Chris Andrews, Junko Matsuzaki, Danila Valmori, Maha Ayyoub, Peter J. Frederick, Amy Beck, Jianqun Liao, Richard Cheney, Kirsten B. Moysich, Shashikant Lele, Protul Shrikant, Lloyd J. Old, Kunle Odunsi	118
9	Regulatory T Cell–Resistant CD8+ T Cells Induced by Glucocorticoid-Induced Tumor Necrosis Factor Receptor Signaling 2008 ·Cancer Research ·Hiroyoshi Nishikawa, Takuma Kato, (unknown), Yuki Orito, Eiichi Sato, Naozumi Harada, Sacha Gnjatic, Lloyd J. Old, Hiroshi Shiku	66
10	HLA Class I–Associated Immunodominance Affects CTL Responsiveness to an ESO Recombinant Protein Tumor Antigen Vaccine 2008 ·Clinical Cancer Research ·Gilles Bioley, Philippe Guillaume, Immanuel F. Luescher, (unknown), Bo Dupont, Nina Bhardwaj, Gregory Mears, Lloyd J. Old, Danila Valmori, Maha Ayyoub	15
11	Development of Monoclonal Antibodies Specific for the Human Sodium-dependent Phosphate Co-transporter NaPi2b 2008 ·Hybridoma ·Ramziya Kiyamova, Vitalina Gryshkova, (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), Beatrice W.T. Yin, Gerd Ritter, Lloyd J. Old, Valeriy Filonenko, Ivan Gout	18
12	Cancer-Testis Antigens: Expression and Correlation with Survival in Human Urothelial Carcinoma 2006 ·Clinical Cancer Research ·Padmanee Sharma, Yu Shen, Sijin Wen, Dean F. Bajorin, Victor E. Reuter, Lloyd J. Old, Achim A. Jungbluth	75
13	Cancer-Testis Genes Are Coordinately Expressed and Are Markers of Poor Outcome in Non–Small Cell Lung Cancer 2005 ·Clinical Cancer Research ·Ali O. Güre, Ramon Chua, Barbara Williamson, Mithat Gönen, Cathy A. Ferrera, Sacha Gnjatic, Gerd Ritter, Andrew J.G. Simpson, (unknown), Lloyd J. Old, Nasser K. Altorki	294
14	Unlocking the semantics of Roget's Thesaurus. 2004 ·Edinburgh Napier Research Repository (Edinburgh Napier University) ·Lloyd J. Old	2
15	Role of SEREX-defined immunogenic wild-type cellular molecules in the development of tumor-specific immunity 2001 ·Proceedings of the National Academy of Sciences ·Hiroyoshi Nishikawa, (unknown), Hiroaki Ikeda, Miho Sakakura, Yoshihiro Miyahara, (unknown), Katsumi Mukai, Masato Watanabe, Kagemasa Kuribayashi, Lloyd J. Old, Hiroshi Shiku	62
16	Population pharmacokinetics of antifibroblast activation protein monoclonal antibody F19 in cancer patients 2001 ·British Journal of Clinical Pharmacology ·P. Tanswell, Pilar Garin‐Chesa, Wolfgang J. Rettig, Sydney Welt, Chaitanya Divgi, Ephraim S. Casper, Ronald D. Finn, Steven M. Larson, Lloyd J. Old, Andrew M. Scott	1
17	Population pharmacokinetics of antifibroblast activation protein monoclonal antibody F19 in cancer patients 2001 ·British Journal of Clinical Pharmacology ·P. Tanswell, Pilar Garin‐Chesa, Wolfgang J. Rettig, Sydney Welt, Chaitanya Divgi, Ephraim S. Casper, Ronald D. Finn, Steven M. Larson, Lloyd J. Old, Andrew M. Scott	37
18	Regulation and heteromeric structure of the fibroblast activation protein in normal and transformed cells of mesenchymal and neuroectodermal origin. 1993 ·PubMed ·Wolfgang J. Rettig, Pilar Garin‐Chesa, John H. Healey, Sai L. Su, H L Ozer, Matthias Schwab, Anthony P. Albino, Lloyd J. Old	161
19	Monoclonal Antibodies to Three Widely Distributed Human Cell Surface Antigens 1983 ·Hybridoma ·M. Jules Mattes, J. Gregory Cairncross, Lloyd J. Old, Kenneth O. Lloyd	52
20	Increased phagocytic activity of the res produced by transmissible agent derived from transplantable tumors. Abstr. 1961 ·The Mouseion at the JAXlibrary (Jackson Laboratory) ·Lloyd J. Old, (unknown), Baruj Benacerraf, Elisabeth Stockert, E A Carswell, Brandi N. Williamson	1

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